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The map label for this gene is degP [H]

Identifier: 37521416

GI number: 37521416

Start: 1966812

End: 1967801

Strand: Reverse

Name: degP [H]

Synonym: gll1847

Alternate gene names: 37521416

Gene position: 1967801-1966812 (Counterclockwise)

Preceding gene: 37521420

Following gene: 37521415

Centisome position: 42.24

GC content: 66.77

Gene sequence:

>990_bases
ATGCAAAAACAGGATAAGCCTTGGGCGGAACGTTGTGGCGTTTCCGGCGTCTTTATCTGGTATCTCACCCCTGCGACAAC
CACGATGAAGATCCAGTCTGCCCTTGCCGCCTTGGCTGTAGCCGCGCTCCCGTTGAATTTTCCTGCTGCCCTCCTCGCCT
TCGACCCGGAGGAGACGACGACCATCGACGTCTACGACCGGACGAGTCGGGCCGTGGTCAGTATCCGCACTTCCGGCGGC
ATCGGCGCCGGGGCGATTATCGACCCGCGCGGGGTGGTGATTACCAACAACCACGTGGTGCGCGGCAGCACCCGGGTGCA
GGTGCAGACCGCCGACGGGCGGGTGTATCCGGGGGCGGTGCGCGCCCTCGACCGGCGCAACGACCTGGCGATTGTCGACA
TCCGTCCGGAGCGGCCTTTGCCGAGCATCGATCTGGCGCGCTCCTCGGCCAGGGTCGGCCAGCGCGTCTACGCCATCGGC
AACCCCTTCGGCCTCGATCGCACTTTGACGGTGGGCATTTTGAGCCGCATCGCCCCCAACGGCGACCTGCAGACCGACGC
CGCCCTCAACCCGGGCAACTCCGGGGGGCCGTTGCTCAATTCCGACGGCGAAATCATCGGCATCAACAAAGCGATTTTAA
GCCGCACCGGCGGCAACGTCGGCATTGGTTTCGCCACCCCCACCGGTGCGGTGCGCTCGTTGGTGGCAGCCAGTCCAAAC
CCGGACAGCGGTCGGGTGGCCGTCCGGCCGGGGCCGCAGCGCGGCCTGGGCGTGGTGCTCGACGCCCGCTCTTTGACGGT
GCTCGAGGTCCAGCCGGGTTCCGCCGCCGAGCGCGCCGGGCTGCTTCCGGGAGATCAACTGCTCGGGGTGGGCGATGCCG
GCCTCGAAAACTCTGCCCAACTGCAGCAGATTCTGCAGCGCAATCCGGGCACACTGGTACTGACCGTTGTCCGCGACCGT
CAGGTCGGCAGGATCCGGGTCGAGTTGTAG

Upstream 100 bases:

>100_bases
CTTTCGAGCGCCGCATCGTATCGGTCATCGCCTTGCCCGGTATCTCTATCGAGATTTAGCAATTATTCGAGCGTTTGTCA
TGTGAAGCTGCTCACACCCC

Downstream 100 bases:

>100_bases
TGCCGTGGTCTGTCGAACGCGATGCAGAAAGTCTGGTGGCTGGCGGTGGCGCTGGTCTGCTTGGGGGGTTCGGTAAGGGC
CGCCGCGGCGCCCATCGGGG

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQKQDKPWAERCGVSGVFIWYLTPATTTMKIQSALAALAVAALPLNFPAALLAFDPEETTTIDVYDRTSRAVVSIRTSGG
IGAGAIIDPRGVVITNNHVVRGSTRVQVQTADGRVYPGAVRALDRRNDLAIVDIRPERPLPSIDLARSSARVGQRVYAIG
NPFGLDRTLTVGILSRIAPNGDLQTDAALNPGNSGGPLLNSDGEIIGINKAILSRTGGNVGIGFATPTGAVRSLVAASPN
PDSGRVAVRPGPQRGLGVVLDARSLTVLEVQPGSAAERAGLLPGDQLLGVGDAGLENSAQLQQILQRNPGTLVLTVVRDR
QVGRIRVEL

Sequences:

>Translated_329_residues
MQKQDKPWAERCGVSGVFIWYLTPATTTMKIQSALAALAVAALPLNFPAALLAFDPEETTTIDVYDRTSRAVVSIRTSGG
IGAGAIIDPRGVVITNNHVVRGSTRVQVQTADGRVYPGAVRALDRRNDLAIVDIRPERPLPSIDLARSSARVGQRVYAIG
NPFGLDRTLTVGILSRIAPNGDLQTDAALNPGNSGGPLLNSDGEIIGINKAILSRTGGNVGIGFATPTGAVRSLVAASPN
PDSGRVAVRPGPQRGLGVVLDARSLTVLEVQPGSAAERAGLLPGDQLLGVGDAGLENSAQLQQILQRNPGTLVLTVVRDR
QVGRIRVEL
>Mature_329_residues
MQKQDKPWAERCGVSGVFIWYLTPATTTMKIQSALAALAVAALPLNFPAALLAFDPEETTTIDVYDRTSRAVVSIRTSGG
IGAGAIIDPRGVVITNNHVVRGSTRVQVQTADGRVYPGAVRALDRRNDLAIVDIRPERPLPSIDLARSSARVGQRVYAIG
NPFGLDRTLTVGILSRIAPNGDLQTDAALNPGNSGGPLLNSDGEIIGINKAILSRTGGNVGIGFATPTGAVRSLVAASPN
PDSGRVAVRPGPQRGLGVVLDARSLTVLEVQPGSAAERAGLLPGDQLLGVGDAGLENSAQLQQILQRNPGTLVLTVVRDR
QVGRIRVEL

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=267, Percent_Identity=30.7116104868914, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI22129776, Length=278, Percent_Identity=31.6546762589928, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI7019477, Length=272, Percent_Identity=33.0882352941176, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI24308541, Length=167, Percent_Identity=38.9221556886228, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1786356, Length=268, Percent_Identity=37.6865671641791, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1789629, Length=277, Percent_Identity=37.5451263537906, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789630, Length=292, Percent_Identity=33.2191780821918, Blast_Score=111, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646839, Length=312, Percent_Identity=31.0897435897436, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 34428; Mature: 34428

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKQDKPWAERCGVSGVFIWYLTPATTTMKIQSALAALAVAALPLNFPAALLAFDPEETT
CCCCCCCHHHHCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCE
TIDVYDRTSRAVVSIRTSGGIGAGAIIDPRGVVITNNHVVRGSTRVQVQTADGRVYPGAV
EEEEEECCCEEEEEEEECCCCCCCEEECCCCEEEECCEEEECCEEEEEECCCCEECCHHH
RALDRRNDLAIVDIRPERPLPSIDLARSSARVGQRVYAIGNPFGLDRTLTVGILSRIAPN
HHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHCCC
GDLQTDAALNPGNSGGPLLNSDGEIIGINKAILSRTGGNVGIGFATPTGAVRSLVAASPN
CCCCCCCCCCCCCCCCCEECCCCCEEEECHHHHHCCCCCEEEEEECCHHHHHHHHHCCCC
PDSGRVAVRPGPQRGLGVVLDARSLTVLEVQPGSAAERAGLLPGDQLLGVGDAGLENSAQ
CCCCEEEECCCCCCCCEEEEECCCEEEEEECCCCHHHHCCCCCCCCEEECCCCCCCCHHH
LQQILQRNPGTLVLTVVRDRQVGRIRVEL
HHHHHHCCCCEEEEEEEECCCCCEEEEEC
>Mature Secondary Structure
MQKQDKPWAERCGVSGVFIWYLTPATTTMKIQSALAALAVAALPLNFPAALLAFDPEETT
CCCCCCCHHHHCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCE
TIDVYDRTSRAVVSIRTSGGIGAGAIIDPRGVVITNNHVVRGSTRVQVQTADGRVYPGAV
EEEEEECCCEEEEEEEECCCCCCCEEECCCCEEEECCEEEECCEEEEEECCCCEECCHHH
RALDRRNDLAIVDIRPERPLPSIDLARSSARVGQRVYAIGNPFGLDRTLTVGILSRIAPN
HHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHCCC
GDLQTDAALNPGNSGGPLLNSDGEIIGINKAILSRTGGNVGIGFATPTGAVRSLVAASPN
CCCCCCCCCCCCCCCCCEECCCCCEEEECHHHHHCCCCCEEEEEECCHHHHHHHHHCCCC
PDSGRVAVRPGPQRGLGVVLDARSLTVLEVQPGSAAERAGLLPGDQLLGVGDAGLENSAQ
CCCCEEEECCCCCCCCEEEEECCCEEEEEECCCCHHHHCCCCCCCCEEECCCCCCCCHHH
LQQILQRNPGTLVLTVVRDRQVGRIRVEL
HHHHHHCCCCEEEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]