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The map label for this gene is htpG [H]

Identifier: 37521383

GI number: 37521383

Start: 1933239

End: 1935083

Strand: Direct

Name: htpG [H]

Synonym: gvip249

Alternate gene names: 37521383

Gene position: 1933239-1935083 (Clockwise)

Preceding gene: 37521380

Following gene: 37521384

Centisome position: 41.49

GC content: 56.42

Gene sequence:

>1845_bases
ATGCAAGAGAGAGGCAGTATCACCGTCCACACCGAGAACATCTTCCCGATCATCAAGCGTTGGCTGTACTCCGACAAAGA
CATCTTTCTGCGCGAGCTTATCTCCAACGCCGCCGACGCGATCAGCAAGCTTAAGATGCTCGGCTACTCCGGGGAATTTC
ACAATAGCGGCGAGGAATTCGAGATCCACGTCACCCTCGATAAAGAGGCTAAAACGCTGAGTGTGACCGACAACGGCATC
GGCATGACCGCCGAGGAAGTCAAAAAGTATATCAACCAGGTGGCTTTTTCGAGCGCCGAAGAATTCTTGCAAAAGTACCA
GGGCGATGATGTCAAGCAGCAGATCATCGGCCACTTCGGCCTGGGCTTCTACTCGGCGTTCATGGTGGCAGGCAAAGTCG
AGATCGACACGCTCTCCTATAAAAGTGGCGCCGAGGCGGTGCTGTGGAGTTGCGACGGCACTACCGCCTTCGAACTCACC
TCTTCCGGGCGTACCGAGCGGGGCACGACCGTCCGGCTCTTGATCGACACCGAGAACGAAGAGTTTCTCGATGAGGTCAA
GGTCCGGCAACTTATCCGCAACTACTGCGACTTTCTACCGGTACCCATCAAATTCAACGGTGAGGCGGCCAACCGCCAAA
AGCCGCTTTGGACCCAATCGCCGAGCAGTCTCAAAGACGAGGATTACAAGGAATTCTACAGTTACTTGTATCCCCTGGAT
GACGAGCCGCTCTTCTGGATCCACCTCAATACCGATTATCCCTTCAACCTGCAGGGCATTCTCTATTTTCCGCGCCTACG
CTCCGACATCGATTGGACCAAGGGACAGATTCGCCTTTTTTGCAATCAGGTGTTCGTGAGCAACAACGTCGAGGAAATTA
TTCCCCAGTTTCTAACACCATTGCAAGGAGCGGTCGACAGCCCCGACATTCCGCTCAACGTCTCGCGCTCCTTTTTGCAG
AACGACCGCACCGTGCGCCGCATCGCCGATTACATCACCAAAAAAGTCGGCGATCGCCTCAAGGAACTGCACCGCGACGA
CTACGAGCGCTATGTGCAGTGCTGGAAAGACATCAACATGTTCATCAAGTACGGCGTGATGAACTCCGACAAATTTTATG
AGCAGGTCAAGGACATCTTGATCTTCCCGGTGGCCCTGGGTGAGAGCTACACCACCCTCAAAGACTACCTGGAGCACAAC
AAAGAAAAGACCGGGGGCAAAGTCTACTACGCCAGCGACACCGGTGCCCAAGCGCCTTACATCGAACTGCTCAAAAGCCA
GGATATCGAAGTGCTGTTGCTCGATGCCTACATCGACACCCACTTCGTCTCGTTCCTGGAGCGGCACAACAGCGAGGCGC
GCTTCGCCCGGGTCGACTCCGACCTGGACGAAAACGTCCTGAGCAAAGACAAAGCCGCCGAACTGGTGGACCCGGCCACC
AACAAGACCCGCAGTGAGCAACTGGTGGAATTATTTCAGCGGCAGCTCGGCCAGGCCAAGCTCAAAGTGCGCGCCGAGGC
GCTCAAAAGCGAGGCCACCCCGGCGGTGCTGTTGCTCCCGGAGTCGCTTCGGCGCATCAAGGAGATGACCGCCCTGGTGC
AGCAAAAACCGATGGAGTTCTTGGACGACCATACCCTGGTGCTCAACACCAGCAATCCCCTCATCCAGAACGTCCAGCGG
CTGGCGGATACCGGCCGCGACGACGCGCTGGTGACGCTCGTTTGCCAACATGTCTACGATCTGGCGCTGCTGTCACAAAA
GAGCTTCGATGCGGCGGCGATGGGTCAGTTCATCCAGCGCTCCAACGACGTGCTGACCCGCCTGTCGAACCGGGCGGTGG
AGTAA

Upstream 100 bases:

>100_bases
CTGTCGCGAAGGTACAACCCACACACCAGCGAGGCGGGGAGCGGTTACAGCTGTGGGAGCGGTCTTGCTATTGTGATAAC
TGAGCGTTCTGGTTACATCG

Downstream 100 bases:

>100_bases
GGCACCGACTCACGGCCGGGACGCCCGTACTCAGCTCCCGGCCGCCCCCCCAATATGAACTAGTAAATTTATAGCAAATT
TCTGTCAATTTGCAGGATAT

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G [H]

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MQERGSITVHTENIFPIIKRWLYSDKDIFLRELISNAADAISKLKMLGYSGEFHNSGEEFEIHVTLDKEAKTLSVTDNGI
GMTAEEVKKYINQVAFSSAEEFLQKYQGDDVKQQIIGHFGLGFYSAFMVAGKVEIDTLSYKSGAEAVLWSCDGTTAFELT
SSGRTERGTTVRLLIDTENEEFLDEVKVRQLIRNYCDFLPVPIKFNGEAANRQKPLWTQSPSSLKDEDYKEFYSYLYPLD
DEPLFWIHLNTDYPFNLQGILYFPRLRSDIDWTKGQIRLFCNQVFVSNNVEEIIPQFLTPLQGAVDSPDIPLNVSRSFLQ
NDRTVRRIADYITKKVGDRLKELHRDDYERYVQCWKDINMFIKYGVMNSDKFYEQVKDILIFPVALGESYTTLKDYLEHN
KEKTGGKVYYASDTGAQAPYIELLKSQDIEVLLLDAYIDTHFVSFLERHNSEARFARVDSDLDENVLSKDKAAELVDPAT
NKTRSEQLVELFQRQLGQAKLKVRAEALKSEATPAVLLLPESLRRIKEMTALVQQKPMEFLDDHTLVLNTSNPLIQNVQR
LADTGRDDALVTLVCQHVYDLALLSQKSFDAAAMGQFIQRSNDVLTRLSNRAVE

Sequences:

>Translated_614_residues
MQERGSITVHTENIFPIIKRWLYSDKDIFLRELISNAADAISKLKMLGYSGEFHNSGEEFEIHVTLDKEAKTLSVTDNGI
GMTAEEVKKYINQVAFSSAEEFLQKYQGDDVKQQIIGHFGLGFYSAFMVAGKVEIDTLSYKSGAEAVLWSCDGTTAFELT
SSGRTERGTTVRLLIDTENEEFLDEVKVRQLIRNYCDFLPVPIKFNGEAANRQKPLWTQSPSSLKDEDYKEFYSYLYPLD
DEPLFWIHLNTDYPFNLQGILYFPRLRSDIDWTKGQIRLFCNQVFVSNNVEEIIPQFLTPLQGAVDSPDIPLNVSRSFLQ
NDRTVRRIADYITKKVGDRLKELHRDDYERYVQCWKDINMFIKYGVMNSDKFYEQVKDILIFPVALGESYTTLKDYLEHN
KEKTGGKVYYASDTGAQAPYIELLKSQDIEVLLLDAYIDTHFVSFLERHNSEARFARVDSDLDENVLSKDKAAELVDPAT
NKTRSEQLVELFQRQLGQAKLKVRAEALKSEATPAVLLLPESLRRIKEMTALVQQKPMEFLDDHTLVLNTSNPLIQNVQR
LADTGRDDALVTLVCQHVYDLALLSQKSFDAAAMGQFIQRSNDVLTRLSNRAVE
>Mature_614_residues
MQERGSITVHTENIFPIIKRWLYSDKDIFLRELISNAADAISKLKMLGYSGEFHNSGEEFEIHVTLDKEAKTLSVTDNGI
GMTAEEVKKYINQVAFSSAEEFLQKYQGDDVKQQIIGHFGLGFYSAFMVAGKVEIDTLSYKSGAEAVLWSCDGTTAFELT
SSGRTERGTTVRLLIDTENEEFLDEVKVRQLIRNYCDFLPVPIKFNGEAANRQKPLWTQSPSSLKDEDYKEFYSYLYPLD
DEPLFWIHLNTDYPFNLQGILYFPRLRSDIDWTKGQIRLFCNQVFVSNNVEEIIPQFLTPLQGAVDSPDIPLNVSRSFLQ
NDRTVRRIADYITKKVGDRLKELHRDDYERYVQCWKDINMFIKYGVMNSDKFYEQVKDILIFPVALGESYTTLKDYLEHN
KEKTGGKVYYASDTGAQAPYIELLKSQDIEVLLLDAYIDTHFVSFLERHNSEARFARVDSDLDENVLSKDKAAELVDPAT
NKTRSEQLVELFQRQLGQAKLKVRAEALKSEATPAVLLLPESLRRIKEMTALVQQKPMEFLDDHTLVLNTSNPLIQNVQR
LADTGRDDALVTLVCQHVYDLALLSQKSFDAAAMGQFIQRSNDVLTRLSNRAVE

Specific function: Molecular chaperone. Has ATPase activity [H]

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family [H]

Homologues:

Organism=Homo sapiens, GI155722983, Length=636, Percent_Identity=28.1446540880503, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI4507677, Length=686, Percent_Identity=25.801749271137, Blast_Score=202, Evalue=1e-51,
Organism=Homo sapiens, GI154146191, Length=250, Percent_Identity=30, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI153792590, Length=250, Percent_Identity=30, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI20149594, Length=389, Percent_Identity=23.1362467866324, Blast_Score=108, Evalue=2e-23,
Organism=Escherichia coli, GI1786679, Length=632, Percent_Identity=30.379746835443, Blast_Score=265, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI115535205, Length=639, Percent_Identity=26.9170579029734, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI115535167, Length=420, Percent_Identity=28.8095238095238, Blast_Score=209, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17559162, Length=500, Percent_Identity=27.8, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17542208, Length=509, Percent_Identity=27.8978388998035, Blast_Score=205, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6323840, Length=678, Percent_Identity=25.0737463126844, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6325016, Length=424, Percent_Identity=24.7641509433962, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24586016, Length=599, Percent_Identity=28.7145242070117, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI21357739, Length=518, Percent_Identity=29.1505791505791, Blast_Score=193, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17647529, Length=396, Percent_Identity=25.2525252525253, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568 [H]

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90 [H]

EC number: NA

Molecular weight: Translated: 70333; Mature: 70333

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQERGSITVHTENIFPIIKRWLYSDKDIFLRELISNAADAISKLKMLGYSGEFHNSGEEF
CCCCCCEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
EIHVTLDKEAKTLSVTDNGIGMTAEEVKKYINQVAFSSAEEFLQKYQGDDVKQQIIGHFG
EEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LGFYSAFMVAGKVEIDTLSYKSGAEAVLWSCDGTTAFELTSSGRTERGTTVRLLIDTENE
HHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEEEEECCCH
EFLDEVKVRQLIRNYCDFLPVPIKFNGEAANRQKPLWTQSPSSLKDEDYKEFYSYLYPLD
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
DEPLFWIHLNTDYPFNLQGILYFPRLRSDIDWTKGQIRLFCNQVFVSNNVEEIIPQFLTP
CCCEEEEEECCCCCCCCCEEEECCHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
LQGAVDSPDIPLNVSRSFLQNDRTVRRIADYITKKVGDRLKELHRDDYERYVQCWKDINM
HHCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIKYGVMNSDKFYEQVKDILIFPVALGESYTTLKDYLEHNKEKTGGKVYYASDTGAQAPY
HHHHCCCCCHHHHHHHHHHEEEEHHCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHH
IELLKSQDIEVLLLDAYIDTHFVSFLERHNSEARFARVDSDLDENVLSKDKAAELVDPAT
HHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCC
NKTRSEQLVELFQRQLGQAKLKVRAEALKSEATPAVLLLPESLRRIKEMTALVQQKPMEF
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHCCHHH
LDDHTLVLNTSNPLIQNVQRLADTGRDDALVTLVCQHVYDLALLSQKSFDAAAMGQFIQR
HCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SNDVLTRLSNRAVE
HHHHHHHHHHCCCC
>Mature Secondary Structure
MQERGSITVHTENIFPIIKRWLYSDKDIFLRELISNAADAISKLKMLGYSGEFHNSGEEF
CCCCCCEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
EIHVTLDKEAKTLSVTDNGIGMTAEEVKKYINQVAFSSAEEFLQKYQGDDVKQQIIGHFG
EEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LGFYSAFMVAGKVEIDTLSYKSGAEAVLWSCDGTTAFELTSSGRTERGTTVRLLIDTENE
HHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEEEEECCCH
EFLDEVKVRQLIRNYCDFLPVPIKFNGEAANRQKPLWTQSPSSLKDEDYKEFYSYLYPLD
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
DEPLFWIHLNTDYPFNLQGILYFPRLRSDIDWTKGQIRLFCNQVFVSNNVEEIIPQFLTP
CCCEEEEEECCCCCCCCCEEEECCHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
LQGAVDSPDIPLNVSRSFLQNDRTVRRIADYITKKVGDRLKELHRDDYERYVQCWKDINM
HHCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIKYGVMNSDKFYEQVKDILIFPVALGESYTTLKDYLEHNKEKTGGKVYYASDTGAQAPY
HHHHCCCCCHHHHHHHHHHEEEEHHCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHH
IELLKSQDIEVLLLDAYIDTHFVSFLERHNSEARFARVDSDLDENVLSKDKAAELVDPAT
HHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCC
NKTRSEQLVELFQRQLGQAKLKVRAEALKSEATPAVLLLPESLRRIKEMTALVQQKPMEF
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHCCHHH
LDDHTLVLNTSNPLIQNVQRLADTGRDDALVTLVCQHVYDLALLSQKSFDAAAMGQFIQR
HCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SNDVLTRLSNRAVE
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11807048 [H]