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The map label for this gene is tcrA [H]

Identifier: 37521380

GI number: 37521380

Start: 1930041

End: 1930712

Strand: Direct

Name: tcrA [H]

Synonym: glr1811

Alternate gene names: 37521380

Gene position: 1930041-1930712 (Clockwise)

Preceding gene: 37521379

Following gene: 37521383

Centisome position: 41.43

GC content: 61.46

Gene sequence:

>672_bases
GTGCACCTGCTGTTGGTCGAGGACGAAGCGGAACTGGCCGATCCCCTGGCTGCGATGCTGAAACGCGAAGGCCACGTGGT
CGAAACAAGCTACGACGGGGAGCACGCCTGGGATCTGCTTTCAAGCCAGAGCTTCGATTTGGTCATCCTCGATTGGATGC
TGCCTGGTCACTCGGGACTGGATTTGTGCCGCCGGCTGCGCGCCGGGGGGCGCTCGGTACCGGTGTTGATGCTCACCGCC
CGCGACACGATCGACAGCAAACTCGCCGGTTTTGAGGCCGGCGCGGACGATTATTTGGTCAAACCCTTCGAGCTGCGCGA
GTTGCTTGCCCGGGTGCGGGCCTTGTTGCGCCGTCCTCCCGAGCGACAGTCCGACGAGTTGCGTCTGGGTGATCTGGTGC
TCGATGTCAGCAACAAGCTTGTCCGCCGCGCCGGTCGTCCCATCGATCTGTCGGCCAAAGAATATCAGTTGCTCGAATAC
TTCATGCGCCATCCCGGCCAGTTGCTCACCCATGAGCAGATCCTGGAGCACGTTTGGGACTCGGGGGCCGAACCGAACAG
CAACGTGGTGGCAGCCCAGGTTAAACTGCTGCGTCGCAAAATCGACAAAGACGCCGGCACTGCCCTGATTCACACAGTCT
ACGGGCAGGGTTACCGCTTCGGGATGCCGTAA

Upstream 100 bases:

>100_bases
AGTCGGTGGTGACGGCCCTTTTGACGATTTTTATCGTCAATTTCATCCTCTCGGCCTTGATGTTTCGGGGAGCGGGCGAG
GCCCTGCAAAGGGGGTTCTA

Downstream 100 bases:

>100_bases
GACTATCAAAATACAAAAGTGAGCAAAGCCACCAGCACGATCGAAAAAATAATGGCGATACTGTAGCCGATTATGAGCAG
TGAATATTTAATCAACGTCT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MHLLLVEDEAELADPLAAMLKREGHVVETSYDGEHAWDLLSSQSFDLVILDWMLPGHSGLDLCRRLRAGGRSVPVLMLTA
RDTIDSKLAGFEAGADDYLVKPFELRELLARVRALLRRPPERQSDELRLGDLVLDVSNKLVRRAGRPIDLSAKEYQLLEY
FMRHPGQLLTHEQILEHVWDSGAEPNSNVVAAQVKLLRRKIDKDAGTALIHTVYGQGYRFGMP

Sequences:

>Translated_223_residues
MHLLLVEDEAELADPLAAMLKREGHVVETSYDGEHAWDLLSSQSFDLVILDWMLPGHSGLDLCRRLRAGGRSVPVLMLTA
RDTIDSKLAGFEAGADDYLVKPFELRELLARVRALLRRPPERQSDELRLGDLVLDVSNKLVRRAGRPIDLSAKEYQLLEY
FMRHPGQLLTHEQILEHVWDSGAEPNSNVVAAQVKLLRRKIDKDAGTALIHTVYGQGYRFGMP
>Mature_223_residues
MHLLLVEDEAELADPLAAMLKREGHVVETSYDGEHAWDLLSSQSFDLVILDWMLPGHSGLDLCRRLRAGGRSVPVLMLTA
RDTIDSKLAGFEAGADDYLVKPFELRELLARVRALLRRPPERQSDELRLGDLVLDVSNKLVRRAGRPIDLSAKEYQLLEY
FMRHPGQLLTHEQILEHVWDSGAEPNSNVVAAQVKLLRRKIDKDAGTALIHTVYGQGYRFGMP

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=42.8571428571429, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=40.7239819004525, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=34.6846846846847, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=38.5321100917431, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35.9090909090909, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.4801762114537, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1790860, Length=217, Percent_Identity=37.7880184331797, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=35.2678571428571, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=34.6666666666667, Blast_Score=126, Evalue=9e-31,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=33.1877729257642, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=32.8828828828829, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=36.4444444444444, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=29.7413793103448, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=32.2314049586777, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=29.0909090909091, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790299, Length=133, Percent_Identity=27.8195488721804, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25143; Mature: 25143

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLLLVEDEAELADPLAAMLKREGHVVETSYDGEHAWDLLSSQSFDLVILDWMLPGHSGL
CEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCCEEEEEEECCCCCHH
DLCRRLRAGGRSVPVLMLTARDTIDSKLAGFEAGADDYLVKPFELRELLARVRALLRRPP
HHHHHHHCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCC
ERQSDELRLGDLVLDVSNKLVRRAGRPIDLSAKEYQLLEYFMRHPGQLLTHEQILEHVWD
CCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
SGAEPNSNVVAAQVKLLRRKIDKDAGTALIHTVYGQGYRFGMP
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEECCCC
>Mature Secondary Structure
MHLLLVEDEAELADPLAAMLKREGHVVETSYDGEHAWDLLSSQSFDLVILDWMLPGHSGL
CEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCCEEEEEEECCCCCHH
DLCRRLRAGGRSVPVLMLTARDTIDSKLAGFEAGADDYLVKPFELRELLARVRALLRRPP
HHHHHHHCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCC
ERQSDELRLGDLVLDVSNKLVRRAGRPIDLSAKEYQLLEYFMRHPGQLLTHEQILEHVWD
CCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
SGAEPNSNVVAAQVKLLRRKIDKDAGTALIHTVYGQGYRFGMP
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]