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The map label for this gene is dnaX [H]

Identifier: 37521178

GI number: 37521178

Start: 1724209

End: 1726107

Strand: Direct

Name: dnaX [H]

Synonym: gvip228

Alternate gene names: 37521178

Gene position: 1724209-1726107 (Clockwise)

Preceding gene: 37521177

Following gene: 37521179

Centisome position: 37.01

GC content: 65.24

Gene sequence:

>1899_bases
ATGGCCTACGAGCCCCTGCACCATAAATACCGCCCCCAGCGCTTCGGTGATGTGGTGGGGCAGGGACCGATCGTCACCAC
CCTCACCAACGCCCTCAAAGCGGGTCGCATCGCCCATGCGTATTTATTCACCGGCTCGCGGGGCACCGGTAAAACCACTA
CCGCCCGGTTGATCGCCAAGGCCCTCAACTGCATCCACGGTCCCACCCCCGACCCCTGCGGGCGCTGCGAACAGTGCCTG
GCCATCGCCACCGGCAGCGCCCTCGATGTCATCGAGATCGACGCCGCCTCGAACACCGGCGTCGACAACATCCGCGAACT
CATCGAGCGCGCCCAGTTCGCTCCGGTCCAGAGCAGACAAAAAGTATACATACTTGACGAAGTTCATATGCTCAGCTCTG
CAGCGTTCAATTGCCTGCTCAAGACGCTGGAGGAGCCCCCCGCGCATGTAACCTTTGTACTGGCTACTACCGATCCCCAA
AAAGTGTTGCCCACGGTGATTTCGCGCTGCCAGCGCTTCGATTTTCGGCGTATCCCGCTTACGGACATGGTCAAGCATCT
GGAGGAGATCGCCTGGAAAGAGGACATCGACATCGAGCACGAAGCGGTCGAACTGGTGGCGCAGATTGCCCAGGGGGGAT
TGCGCGACGCTGAGAGTCTGCTCGATCAACTCGCTTTGCTCGAAGGGACTATCGGGGCAGAACGGATCTGGCAACTGGTG
GGGGCGGTTCCCGAGCGGGAGTTGCTCGTCATCGGCGAGTGCATCCAGGCCGGGGACAGCACGCGGCTCATCGAGCAGGT
GCGCCGGTTGCTCGACAGCGGTAAGGAGCCTTTGCAGGTACTGCAGGATCTGCTCGGGTTCTACCGGGATCTGCTCATCG
CCCACACCGCCCCCGATCGGCGGGATCTGGTGGCGGTGACCGCCGCGAGCTGGCAGCAGATGTGCGAGCGGGCTAAGACC
CTGAGTATTCCGCAGCTGCTGGCGCTGCAGGAGCGATTGCGCCAGGCGGAACCGCAGATCAAAACCTCCACCCAACCGAG
GCTGTGGCTGGAGGTGGGGTTGCTGGGACTGCTGGCTTCCCCCAGCCAAAATCAGCCGGTTGCACTCGCCCCGGCTGCGG
CCAGACCCGCCGCTCCAGTCCCGGTCCCGCCGCCGCGCCCGGCTGAGGAGCGGCCGACCCCACCGCCTCCTGCTGCGCCG
CGTGGGGTCGAGGAGCGGCCCAACTCCGTACCGCAACCGCCGGTCGAGCCAACTCCGCCCCAGCGCCCACAAGTTCCACC
CCCGTCGATTGAACCGGCGGCAGCCATTCACCGGCCGGCCAGACCGTCGGGGTCCACCCCCGACGGCACCGGCCTGCGCG
AGCGGTGGCCGGAGTGGATCCGCCTGATTCCCCAGCCGACCCAGAGCTTGATGTCTTCGAGCTTCTGGCTGGAGGAGACT
CCCAAGCGCCTGGTCATCGGCTTTACCACCGAGCCCCTGGTAAAGCGGGCCAGCGAGCCCCGGCGCCTCAAGCAGATTCA
GGAAGTGCTCCAGCAATTTTTGGGCCGGCCGATCGAAGTGCAGTTCCATATCGGCAAAGCCCCTGCTGCCGCACCGGCCG
TTGCGGTTGCCTCTTCCCAGTCGGCCGCCTACACTCCGCCACCGGTGAGTTTTAGCCCGCCGGCACCTCCTGAAGTAACC
CCTGTTTCTCCGACGACCGTCGCGCCGCCGAGCGCGGCAAAGCCGCCGCTCAGCGACGAGGAACCGGACGAACTCGACCG
CGCCGCCCGCGGCCTCGCCGAATTTTTTAACGGCGAGGTGATCAGTTTCGACGGCGAAGCGGAGGAGCTGCCGGGTGCCA
CCCAGCCCGGCGCCGCCGAGGTGAGCGACATCGACGATGACGAAGACATTCCGTTTTGA

Upstream 100 bases:

>100_bases
GGTTCTGGAGCGGCGCCTGCGCGAACTGGGCGTCGATCCTGACGGTTGAAGGGCGGCCCGCCGCCAGTGGTCATAATGGA
ACTTTCCACCGGTCCTTGCC

Downstream 100 bases:

>100_bases
GCGTTCCCGGACTGCTTCTCGGCTTGCCGGAGACTTTCACGCATATACTCTTTGAGTGATAATTCCCAGGTCACAGGATC
TCGGCATCAGGTGAGCACCG

Product: DNA polymerase III gamma and tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MAYEPLHHKYRPQRFGDVVGQGPIVTTLTNALKAGRIAHAYLFTGSRGTGKTTTARLIAKALNCIHGPTPDPCGRCEQCL
AIATGSALDVIEIDAASNTGVDNIRELIERAQFAPVQSRQKVYILDEVHMLSSAAFNCLLKTLEEPPAHVTFVLATTDPQ
KVLPTVISRCQRFDFRRIPLTDMVKHLEEIAWKEDIDIEHEAVELVAQIAQGGLRDAESLLDQLALLEGTIGAERIWQLV
GAVPERELLVIGECIQAGDSTRLIEQVRRLLDSGKEPLQVLQDLLGFYRDLLIAHTAPDRRDLVAVTAASWQQMCERAKT
LSIPQLLALQERLRQAEPQIKTSTQPRLWLEVGLLGLLASPSQNQPVALAPAAARPAAPVPVPPPRPAEERPTPPPPAAP
RGVEERPNSVPQPPVEPTPPQRPQVPPPSIEPAAAIHRPARPSGSTPDGTGLRERWPEWIRLIPQPTQSLMSSSFWLEET
PKRLVIGFTTEPLVKRASEPRRLKQIQEVLQQFLGRPIEVQFHIGKAPAAAPAVAVASSQSAAYTPPPVSFSPPAPPEVT
PVSPTTVAPPSAAKPPLSDEEPDELDRAARGLAEFFNGEVISFDGEAEELPGATQPGAAEVSDIDDDEDIPF

Sequences:

>Translated_632_residues
MAYEPLHHKYRPQRFGDVVGQGPIVTTLTNALKAGRIAHAYLFTGSRGTGKTTTARLIAKALNCIHGPTPDPCGRCEQCL
AIATGSALDVIEIDAASNTGVDNIRELIERAQFAPVQSRQKVYILDEVHMLSSAAFNCLLKTLEEPPAHVTFVLATTDPQ
KVLPTVISRCQRFDFRRIPLTDMVKHLEEIAWKEDIDIEHEAVELVAQIAQGGLRDAESLLDQLALLEGTIGAERIWQLV
GAVPERELLVIGECIQAGDSTRLIEQVRRLLDSGKEPLQVLQDLLGFYRDLLIAHTAPDRRDLVAVTAASWQQMCERAKT
LSIPQLLALQERLRQAEPQIKTSTQPRLWLEVGLLGLLASPSQNQPVALAPAAARPAAPVPVPPPRPAEERPTPPPPAAP
RGVEERPNSVPQPPVEPTPPQRPQVPPPSIEPAAAIHRPARPSGSTPDGTGLRERWPEWIRLIPQPTQSLMSSSFWLEET
PKRLVIGFTTEPLVKRASEPRRLKQIQEVLQQFLGRPIEVQFHIGKAPAAAPAVAVASSQSAAYTPPPVSFSPPAPPEVT
PVSPTTVAPPSAAKPPLSDEEPDELDRAARGLAEFFNGEVISFDGEAEELPGATQPGAAEVSDIDDDEDIPF
>Mature_631_residues
AYEPLHHKYRPQRFGDVVGQGPIVTTLTNALKAGRIAHAYLFTGSRGTGKTTTARLIAKALNCIHGPTPDPCGRCEQCLA
IATGSALDVIEIDAASNTGVDNIRELIERAQFAPVQSRQKVYILDEVHMLSSAAFNCLLKTLEEPPAHVTFVLATTDPQK
VLPTVISRCQRFDFRRIPLTDMVKHLEEIAWKEDIDIEHEAVELVAQIAQGGLRDAESLLDQLALLEGTIGAERIWQLVG
AVPERELLVIGECIQAGDSTRLIEQVRRLLDSGKEPLQVLQDLLGFYRDLLIAHTAPDRRDLVAVTAASWQQMCERAKTL
SIPQLLALQERLRQAEPQIKTSTQPRLWLEVGLLGLLASPSQNQPVALAPAAARPAAPVPVPPPRPAEERPTPPPPAAPR
GVEERPNSVPQPPVEPTPPQRPQVPPPSIEPAAAIHRPARPSGSTPDGTGLRERWPEWIRLIPQPTQSLMSSSFWLEETP
KRLVIGFTTEPLVKRASEPRRLKQIQEVLQQFLGRPIEVQFHIGKAPAAAPAVAVASSQSAAYTPPPVSFSPPAPPEVTP
VSPTTVAPPSAAKPPLSDEEPDELDRAARGLAEFFNGEVISFDGEAEELPGATQPGAAEVSDIDDDEDIPF

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=310, Percent_Identity=27.0967741935484, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI31881687, Length=310, Percent_Identity=27.0967741935484, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI6677723, Length=239, Percent_Identity=29.2887029288703, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI194306571, Length=237, Percent_Identity=28.6919831223629, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI194306567, Length=237, Percent_Identity=28.6919831223629, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI31563534, Length=243, Percent_Identity=25.5144032921811, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786676, Length=299, Percent_Identity=44.1471571906354, Blast_Score=263, Evalue=3e-71,
Organism=Escherichia coli, GI1787341, Length=152, Percent_Identity=34.2105263157895, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787119, Length=235, Percent_Identity=26.3829787234043, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=309, Percent_Identity=24.5954692556634, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17554730, Length=227, Percent_Identity=25.9911894273128, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17541988, Length=236, Percent_Identity=26.271186440678, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322528, Length=308, Percent_Identity=25.3246753246753, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324478, Length=237, Percent_Identity=26.5822784810127, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324039, Length=249, Percent_Identity=26.9076305220884, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18859927, Length=295, Percent_Identity=25.7627118644068, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921076, Length=241, Percent_Identity=26.1410788381743, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647857, Length=316, Percent_Identity=25.6329113924051, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 68716; Mature: 68585

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYEPLHHKYRPQRFGDVVGQGPIVTTLTNALKAGRIAHAYLFTGSRGTGKTTTARLIAK
CCCCCCHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHH
ALNCIHGPTPDPCGRCEQCLAIATGSALDVIEIDAASNTGVDNIRELIERAQFAPVQSRQ
HHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
KVYILDEVHMLSSAAFNCLLKTLEEPPAHVTFVLATTDPQKVLPTVISRCQRFDFRRIPL
EEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCH
TDMVKHLEEIAWKEDIDIEHEAVELVAQIAQGGLRDAESLLDQLALLEGTIGAERIWQLV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
GAVPERELLVIGECIQAGDSTRLIEQVRRLLDSGKEPLQVLQDLLGFYRDLLIAHTAPDR
CCCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
RDLVAVTAASWQQMCERAKTLSIPQLLALQERLRQAEPQIKTSTQPRLWLEVGLLGLLAS
CCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
PSQNQPVALAPAAARPAAPVPVPPPRPAEERPTPPPPAAPRGVEERPNSVPQPPVEPTPP
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCC
QRPQVPPPSIEPAAAIHRPARPSGSTPDGTGLRERWPEWIRLIPQPTQSLMSSSFWLEET
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHCC
PKRLVIGFTTEPLVKRASEPRRLKQIQEVLQQFLGRPIEVQFHIGKAPAAAPAVAVASSQ
CCEEEEECCCHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHEECCC
SAAYTPPPVSFSPPAPPEVTPVSPTTVAPPSAAKPPLSDEEPDELDRAARGLAEFFNGEV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCE
ISFDGEAEELPGATQPGAAEVSDIDDDEDIPF
EEECCCHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AYEPLHHKYRPQRFGDVVGQGPIVTTLTNALKAGRIAHAYLFTGSRGTGKTTTARLIAK
CCCCCHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHH
ALNCIHGPTPDPCGRCEQCLAIATGSALDVIEIDAASNTGVDNIRELIERAQFAPVQSRQ
HHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
KVYILDEVHMLSSAAFNCLLKTLEEPPAHVTFVLATTDPQKVLPTVISRCQRFDFRRIPL
EEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCH
TDMVKHLEEIAWKEDIDIEHEAVELVAQIAQGGLRDAESLLDQLALLEGTIGAERIWQLV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
GAVPERELLVIGECIQAGDSTRLIEQVRRLLDSGKEPLQVLQDLLGFYRDLLIAHTAPDR
CCCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
RDLVAVTAASWQQMCERAKTLSIPQLLALQERLRQAEPQIKTSTQPRLWLEVGLLGLLAS
CCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
PSQNQPVALAPAAARPAAPVPVPPPRPAEERPTPPPPAAPRGVEERPNSVPQPPVEPTPP
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCC
QRPQVPPPSIEPAAAIHRPARPSGSTPDGTGLRERWPEWIRLIPQPTQSLMSSSFWLEET
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHCC
PKRLVIGFTTEPLVKRASEPRRLKQIQEVLQQFLGRPIEVQFHIGKAPAAAPAVAVASSQ
CCEEEEECCCHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHEECCC
SAAYTPPPVSFSPPAPPEVTPVSPTTVAPPSAAKPPLSDEEPDELDRAARGLAEFFNGEV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCE
ISFDGEAEELPGATQPGAAEVSDIDDDEDIPF
EEECCCHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]