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The map label for this gene is srrA [H]

Identifier: 37521157

GI number: 37521157

Start: 1705281

End: 1705943

Strand: Direct

Name: srrA [H]

Synonym: glr1588

Alternate gene names: 37521157

Gene position: 1705281-1705943 (Clockwise)

Preceding gene: 37521156

Following gene: 37521158

Centisome position: 36.6

GC content: 64.86

Gene sequence:

>663_bases
ATGGCCGCTCACCTGTTACTGGTCGACGACGATCCCGGTATTCGCCTGGCGCTGCAGGCCTATCTGGAGGACGAGGGCTT
CGGCGTCACTACCGCCCGCAATGCCATCGAAGGGCTGGAACTGGCCGAAAAACACCAGCCGGATCTGGTGATCACCGACA
TCATGATGCCCCAGGTGGACGGCTACCGGTTCTTGCAGAAATTGCGCGCCCTGCCGCGCTTTCGCTATACGCCGGTGGTG
TTCCTGACCGCCAAGGGCCAGACCGCCGATCGCATCCAGGGCTACCGCCACGGCTGCGACGCCTACATGCCCAAGCCCGG
CGACCCGGAGGAACTGGTGGCCATCGTGCGCAACCTGCTCGATCGCTCTCGCCAGGTCCAATCGGAGATCGTCAGTTTGG
TGAGCGAACTGAACCATCGCCCGGCCCCGGTCGCTATCGAAGCGATCGACCTGGATCTCACCCCCCGCGAGCAGGAGGTG
CTGCTGCTGGTCTACGCGGGTCTGATGAACAAAGAAATCGCCGGCCGCCTGGAGCGCTCCACCCGCAACGTCGAGAAGTA
TGTCAGCCGCCTGCTCGCCAAGACCGGCACCAGCAGCCGCACCGAGCTGGTGCGCTTCGCCCTCGAACACGGCCTGGTCA
GCCCCGGCAGCGCTGCGGGTTAA

Upstream 100 bases:

>100_bases
GACCTGATCGAGCAAATGGGGGGTTCTATCGACGCGCGCAACGGCGAAGGCGGCGGCAGCCGCTTTTGTGTAACCTTACC
CACCGCCCAGGAGGACTGAC

Downstream 100 bases:

>100_bases
CACGCCCATCACCTGGCCATGAACTCGGCTTAATGCTTTGCTGGCACAATGGCTGCCGGTCTGCATGTCCTGGAGTTGTC
TGATGCGATACTTTTATTCT

Product: two-component response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MAAHLLLVDDDPGIRLALQAYLEDEGFGVTTARNAIEGLELAEKHQPDLVITDIMMPQVDGYRFLQKLRALPRFRYTPVV
FLTAKGQTADRIQGYRHGCDAYMPKPGDPEELVAIVRNLLDRSRQVQSEIVSLVSELNHRPAPVAIEAIDLDLTPREQEV
LLLVYAGLMNKEIAGRLERSTRNVEKYVSRLLAKTGTSSRTELVRFALEHGLVSPGSAAG

Sequences:

>Translated_220_residues
MAAHLLLVDDDPGIRLALQAYLEDEGFGVTTARNAIEGLELAEKHQPDLVITDIMMPQVDGYRFLQKLRALPRFRYTPVV
FLTAKGQTADRIQGYRHGCDAYMPKPGDPEELVAIVRNLLDRSRQVQSEIVSLVSELNHRPAPVAIEAIDLDLTPREQEV
LLLVYAGLMNKEIAGRLERSTRNVEKYVSRLLAKTGTSSRTELVRFALEHGLVSPGSAAG
>Mature_219_residues
AAHLLLVDDDPGIRLALQAYLEDEGFGVTTARNAIEGLELAEKHQPDLVITDIMMPQVDGYRFLQKLRALPRFRYTPVVF
LTAKGQTADRIQGYRHGCDAYMPKPGDPEELVAIVRNLLDRSRQVQSEIVSLVSELNHRPAPVAIEAIDLDLTPREQEVL
LLVYAGLMNKEIAGRLERSTRNVEKYVSRLLAKTGTSSRTELVRFALEHGLVSPGSAAG

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=118, Percent_Identity=38.135593220339, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790860, Length=124, Percent_Identity=36.2903225806452, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=35.2459016393443, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87082012, Length=199, Percent_Identity=29.1457286432161, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1788905, Length=121, Percent_Identity=35.5371900826446, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1790552, Length=215, Percent_Identity=34.4186046511628, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1786784, Length=161, Percent_Identity=34.1614906832298, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1790299, Length=123, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI2367329, Length=210, Percent_Identity=32.8571428571429, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788394, Length=120, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787229, Length=130, Percent_Identity=33.0769230769231, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790863, Length=153, Percent_Identity=30.0653594771242, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=124, Percent_Identity=33.8709677419355, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786911, Length=119, Percent_Identity=35.2941176470588, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788222, Length=214, Percent_Identity=25.2336448598131, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787375, Length=129, Percent_Identity=29.4573643410853, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1786747, Length=217, Percent_Identity=24.4239631336406, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787473, Length=202, Percent_Identity=31.1881188118812, Blast_Score=64, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24428; Mature: 24297

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAHLLLVDDDPGIRLALQAYLEDEGFGVTTARNAIEGLELAEKHQPDLVITDIMMPQVD
CCEEEEEEECCCCCEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCC
GYRFLQKLRALPRFRYTPVVFLTAKGQTADRIQGYRHGCDAYMPKPGDPEELVAIVRNLL
HHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
DRSRQVQSEIVSLVSELNHRPAPVAIEAIDLDLTPREQEVLLLVYAGLMNKEIAGRLERS
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TRNVEKYVSRLLAKTGTSSRTELVRFALEHGLVSPGSAAG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AAHLLLVDDDPGIRLALQAYLEDEGFGVTTARNAIEGLELAEKHQPDLVITDIMMPQVD
CEEEEEEECCCCCEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCC
GYRFLQKLRALPRFRYTPVVFLTAKGQTADRIQGYRHGCDAYMPKPGDPEELVAIVRNLL
HHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
DRSRQVQSEIVSLVSELNHRPAPVAIEAIDLDLTPREQEVLLLVYAGLMNKEIAGRLERS
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TRNVEKYVSRLLAKTGTSSRTELVRFALEHGLVSPGSAAG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA