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The map label for this gene is phoR [H]

Identifier: 37521156

GI number: 37521156

Start: 1704641

End: 1705279

Strand: Direct

Name: phoR [H]

Synonym: glr1587

Alternate gene names: 37521156

Gene position: 1704641-1705279 (Clockwise)

Preceding gene: 37521155

Following gene: 37521157

Centisome position: 36.59

GC content: 68.39

Gene sequence:

>639_bases
GTGGATTTCGACCGCCTCGCCCACCAGTTGCGCAACCCCGTGATGGTGATTCGCACCCTCGCGCGTCTTGTGGGCAAGCG
CCTCGGGCCGGACGATCCCAACCAGGTGCTGCTCGAGCAAATCGCCCGCGAGTGCCGCCGCCTCGACGCGCTCCTGGAGG
ACAAACTGGAGGTGCACGCGCCGGGTCCGGTGCCCTTGGAGCCGCTGGTGGCCGAGGTGGAGCGGGCGGCAAACGCCCTG
GCGCGCGAACGGCAGATCCGCTTCGAGCGGGAAGGCCAGGCGTCCTGTCAGGTCAAAGCCGACGGACGCGCCCTCTACGA
AGTGCTGATGAACCTGCTCGACAACGCCTTCAAGTACACCCCGCCCGGGGGGCAGGTGCGCCTGGAGGTGCGGCCCGGCC
AGAATGCCTGCACCATCGACATCGCCGACACCGGCAGCGGCATCGAGGCAGTCGATCTCGAACGCATCTTCGACGCCTAC
TACCGCGGCAGCCGCAACGGCGATCGGCCCGGCCGGGGGTTGGGGCTCGCCATCGCCCGAGACCTGATCGAGCAAATGGG
GGGTTCTATCGACGCGCGCAACGGCGAAGGCGGCGGCAGCCGCTTTTGTGTAACCTTACCCACCGCCCAGGAGGACTGA

Upstream 100 bases:

>100_bases
CAGGGATTGGTGGCGGCGATGGGCGGCAAACTCACCCTGCGCCTGCGCCCCGAGGGCGAAAGCAGTACGCTGACGTTGTA
CCTTCCCATTCAAAGTTGAC

Downstream 100 bases:

>100_bases
CATGGCCGCTCACCTGTTACTGGTCGACGACGATCCCGGTATTCGCCTGGCGCTGCAGGCCTATCTGGAGGACGAGGGCT
TCGGCGTCACTACCGCCCGC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MDFDRLAHQLRNPVMVIRTLARLVGKRLGPDDPNQVLLEQIARECRRLDALLEDKLEVHAPGPVPLEPLVAEVERAANAL
ARERQIRFEREGQASCQVKADGRALYEVLMNLLDNAFKYTPPGGQVRLEVRPGQNACTIDIADTGSGIEAVDLERIFDAY
YRGSRNGDRPGRGLGLAIARDLIEQMGGSIDARNGEGGGSRFCVTLPTAQED

Sequences:

>Translated_212_residues
MDFDRLAHQLRNPVMVIRTLARLVGKRLGPDDPNQVLLEQIARECRRLDALLEDKLEVHAPGPVPLEPLVAEVERAANAL
ARERQIRFEREGQASCQVKADGRALYEVLMNLLDNAFKYTPPGGQVRLEVRPGQNACTIDIADTGSGIEAVDLERIFDAY
YRGSRNGDRPGRGLGLAIARDLIEQMGGSIDARNGEGGGSRFCVTLPTAQED
>Mature_212_residues
MDFDRLAHQLRNPVMVIRTLARLVGKRLGPDDPNQVLLEQIARECRRLDALLEDKLEVHAPGPVPLEPLVAEVERAANAL
ARERQIRFEREGQASCQVKADGRALYEVLMNLLDNAFKYTPPGGQVRLEVRPGQNACTIDIADTGSGIEAVDLERIFDAY
YRGSRNGDRPGRGLGLAIARDLIEQMGGSIDARNGEGGGSRFCVTLPTAQED

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=30.188679245283, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=30.3571428571429, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=29.951690821256, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=110, Percent_Identity=37.2727272727273, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1787374, Length=212, Percent_Identity=30.188679245283, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=213, Percent_Identity=27.2300469483568, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=218, Percent_Identity=29.8165137614679, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1786783, Length=213, Percent_Identity=27.6995305164319, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788549, Length=210, Percent_Identity=27.1428571428571, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=28.3783783783784, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=112, Percent_Identity=39.2857142857143, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=112, Percent_Identity=35.7142857142857, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790346, Length=216, Percent_Identity=29.6296296296296, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1786600, Length=216, Percent_Identity=22.6851851851852, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790300, Length=219, Percent_Identity=30.1369863013699, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=35.6521739130435, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1789149, Length=216, Percent_Identity=28.2407407407407, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 23315; Mature: 23315

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDRLAHQLRNPVMVIRTLARLVGKRLGPDDPNQVLLEQIARECRRLDALLEDKLEVHA
CCHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECC
PGPVPLEPLVAEVERAANALARERQIRFEREGQASCQVKADGRALYEVLMNLLDNAFKYT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCEEC
PPGGQVRLEVRPGQNACTIDIADTGSGIEAVDLERIFDAYYRGSRNGDRPGRGLGLAIAR
CCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
DLIEQMGGSIDARNGEGGGSRFCVTLPTAQED
HHHHHHCCCEECCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MDFDRLAHQLRNPVMVIRTLARLVGKRLGPDDPNQVLLEQIARECRRLDALLEDKLEVHA
CCHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECC
PGPVPLEPLVAEVERAANALARERQIRFEREGQASCQVKADGRALYEVLMNLLDNAFKYT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCEEC
PPGGQVRLEVRPGQNACTIDIADTGSGIEAVDLERIFDAYYRGSRNGDRPGRGLGLAIAR
CCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
DLIEQMGGSIDARNGEGGGSRFCVTLPTAQED
HHHHHHCCCEECCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]