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The map label for this gene is clpC [H]

Identifier: 37521111

GI number: 37521111

Start: 1662655

End: 1664991

Strand: Direct

Name: clpC [H]

Synonym: glr1542

Alternate gene names: 37521111

Gene position: 1662655-1664991 (Clockwise)

Preceding gene: 37521110

Following gene: 37521112

Centisome position: 35.69

GC content: 66.5

Gene sequence:

>2337_bases
ATGTTTGAGCAATTCAGCCCGTCGGCTCTCCAGGTGCTCAACCTGGCCAAGCAGGAGTCATTGCGCCTCGGCCAGAACGC
CGTCGGTACCGAGCAGCTTCTGCTTGGACTGCTGGCCCATTCCGACGCCGTCGCCGCCCAGGTGCTGACCGAGCTGGGCC
TCAGCCTGGCCGGTGCCCGCCGCGAGGTGGAGAGCATCGTGGGCAAAGGTGAGAGCCGTCCGAGCCAGCGCGTCGCCTTT
ACCCCCCGGGCGGGGCGGCTTATCGAGCAGGCGCTCATCGAGGCCAACGGCTTCGGCCAGCGCCTGGTCGAACCGGAGCA
CTTGCTTTTGAGCATGCTGCGCGACAACGAAGGGGTGGCAAGCCGCGTGCTCGATGAATTCGGCGTCGACCGCGACAAGG
CCCGCCAGATGCTGCTCGAAAGCCTGGGGGATGCGGCCAAAGCGACCTCTGCTTCGCGCGGCAACGAGCAACCGCGCCGC
AGCGACAGAGCTTCCCGCAGCGGCGGACCGCTCGAACGCTTTGGTCGGGATCTGACCGAACTGGCCCGCGGCGGCAAAAT
CGATCCGGTCGTGGGGCGGGCCGAGCAGATCGAGCGGGTGATCCAAATTCTGGGTCGCCGTACCAAAAATAACCCCGTAC
TCATCGGCGAACCGGGCGTCGGCAAGACCGCCATCGCCGAGGGCCTCGCCGTGCGCATCGCCGAGGGCGACGTGCCCGAG
ATGCTTTTCGATCGCCGCATCGTGAGCCTGGACATGGGCCAGGTTTTGGCCGGCACCCAGATGCGCGGCGAATTTGAGGA
GCGCCTCAAGGGCGTCATGCAGGAAGTGATCGCCTCCAAGGGGCAGATTGTCCTGTTCATCGACGAACTGCACACCCTGG
TGGGAGCCGGGGCGAGCGAGGGCGGCATGGACGCCGCCAACTTGCTCAAGCCCGCCCTGGCGCGCGGCGAACTGCAATGC
ATCGGGGCGACCACCCTCGATGAGTACCGCAAGCACATCGAGCGCGACGCCGCCCTGGAGCGCCGCTTCCAGCCGGTAAC
GGTGGGTGAACCGAGTGTGGATGAGGCGATTGCCATCCTGCAGGGCCTCAAGGTGCGCTACGAGGAGCACCACAAGCTGC
GCTACACCGACGCCGCCCTCGAAGCGGCGGTGCGCCTATCGGATCGCTACATCGCCGATCGCTTCTTGCCGGACAAGGCC
ATCGATCTGATCGACGAAGCCGGTTCGATGATCCGGGTGAAACTTGCCCGGGGCGCCGAGTTGCCCGCCATCGTCGATAG
CGAAGCGATTGCCCAGGTGCTCTCGGAGTGGACAAACATTCCGGTGGGCAAGCTCACGGGCGAAGAGGCCACCAGTCTGG
TGCACCTCGAAGCGCGGCTGCACGAGCGCATCATCGGCCAGCACCCCGCGGTGAGTGCGGTGGCCAGGGCAGTTCGCCGG
GCGCGCGCCGGCATGAAGTCTCCCGAGCGTCCGCAGGCGAGCTTCATCTTCGCCGGCCCTACCGGTGTCGGCAAGACGGA
GCTGGCCAAGGCGCTCGCGGCTACGGTCTTCGGCTCTGAAGACGCGATGATCCGCCTCGACATGTCCGAATTCATGGAGT
CCTACACGGTGAGCAAGCTGATCGGCTCGCCCCCCGGCTACGTGGGCTACGACGAGGGCGGTCAGCTCACCGAGGCGGTG
CGCCGCCGGCCCTACACGGTGATCCTGCTCGATGAAATCGAGAAGGCCCACCCGGATGTGTTCAACATCCTGCTGCAACT
CCTCGACGACGGCCGGCTCACCGACGCCAAGGGCCGCACCGTGAGCTTCAAGAACGCGCTCATCATCATGACCAGCAACC
TCGGTTCGCGGGTCATCGAGCGCGGCGGCGGCGGACTCGGGTTCAACACCACCGGCAGCGCGGGCGAGCGGCGCTACGTC
GCCATCCGCGACCGGGTTCAAGAAGAGCTCAAGCAGGTCTTCCGCCCCGAGTTCCTCAACCGCCTCGACGAGGTGATCGT
CTTCCAGCCGCTGGACCGCGAGGAACTGGGCCAGGTGGCCCGGCTGCTTCTGAACGAGTCGCTGGAGCGGGTACGCGAAC
TGGGCATCGAACTGGAGGCGAGTCCCGCCTTCATCGACAAGGTCATCGCCGAGGGCTACTCCCCGGCCTGGGGCGCCCGT
CCTTTGCGCCGCGCCGTGCAGCGCCTGCTGGAGGATTCTGTCGCCGACGCCGTCCTACTCGGGCGGCTGGTGAGCGGTGA
GCGCTACTTGGTAGATGTCGACGCCGACGGCAAGGTGATCTTCATCTACCCGGATCTGGCCGACGCCAAGGCGGAGATGG
CCATGAGCGCCCGATAG

Upstream 100 bases:

>100_bases
CGCAGGACTTCTGGCAGAGCGTCCGCCCGAACGCATGAGTTTTCCGCAAGTTTAATCTTTCGCTCAACGGCCGTCGCAGG
GCGGTACTTAAGGAGGTTCC

Downstream 100 bases:

>100_bases
TTCAGTTTCTCAGTCACTCGGACGGCCCCTTCCTGGAAGCAGGAAGGGGCTTTTTTTGCACCTGCTGCATGGCCAGGGGG
TTCCGACTCGCCTTGAGATC

Product: endopeptidase Clp ATP-binding chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MFEQFSPSALQVLNLAKQESLRLGQNAVGTEQLLLGLLAHSDAVAAQVLTELGLSLAGARREVESIVGKGESRPSQRVAF
TPRAGRLIEQALIEANGFGQRLVEPEHLLLSMLRDNEGVASRVLDEFGVDRDKARQMLLESLGDAAKATSASRGNEQPRR
SDRASRSGGPLERFGRDLTELARGGKIDPVVGRAEQIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLAVRIAEGDVPE
MLFDRRIVSLDMGQVLAGTQMRGEFEERLKGVMQEVIASKGQIVLFIDELHTLVGAGASEGGMDAANLLKPALARGELQC
IGATTLDEYRKHIERDAALERRFQPVTVGEPSVDEAIAILQGLKVRYEEHHKLRYTDAALEAAVRLSDRYIADRFLPDKA
IDLIDEAGSMIRVKLARGAELPAIVDSEAIAQVLSEWTNIPVGKLTGEEATSLVHLEARLHERIIGQHPAVSAVARAVRR
ARAGMKSPERPQASFIFAGPTGVGKTELAKALAATVFGSEDAMIRLDMSEFMESYTVSKLIGSPPGYVGYDEGGQLTEAV
RRRPYTVILLDEIEKAHPDVFNILLQLLDDGRLTDAKGRTVSFKNALIIMTSNLGSRVIERGGGGLGFNTTGSAGERRYV
AIRDRVQEELKQVFRPEFLNRLDEVIVFQPLDREELGQVARLLLNESLERVRELGIELEASPAFIDKVIAEGYSPAWGAR
PLRRAVQRLLEDSVADAVLLGRLVSGERYLVDVDADGKVIFIYPDLADAKAEMAMSAR

Sequences:

>Translated_778_residues
MFEQFSPSALQVLNLAKQESLRLGQNAVGTEQLLLGLLAHSDAVAAQVLTELGLSLAGARREVESIVGKGESRPSQRVAF
TPRAGRLIEQALIEANGFGQRLVEPEHLLLSMLRDNEGVASRVLDEFGVDRDKARQMLLESLGDAAKATSASRGNEQPRR
SDRASRSGGPLERFGRDLTELARGGKIDPVVGRAEQIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLAVRIAEGDVPE
MLFDRRIVSLDMGQVLAGTQMRGEFEERLKGVMQEVIASKGQIVLFIDELHTLVGAGASEGGMDAANLLKPALARGELQC
IGATTLDEYRKHIERDAALERRFQPVTVGEPSVDEAIAILQGLKVRYEEHHKLRYTDAALEAAVRLSDRYIADRFLPDKA
IDLIDEAGSMIRVKLARGAELPAIVDSEAIAQVLSEWTNIPVGKLTGEEATSLVHLEARLHERIIGQHPAVSAVARAVRR
ARAGMKSPERPQASFIFAGPTGVGKTELAKALAATVFGSEDAMIRLDMSEFMESYTVSKLIGSPPGYVGYDEGGQLTEAV
RRRPYTVILLDEIEKAHPDVFNILLQLLDDGRLTDAKGRTVSFKNALIIMTSNLGSRVIERGGGGLGFNTTGSAGERRYV
AIRDRVQEELKQVFRPEFLNRLDEVIVFQPLDREELGQVARLLLNESLERVRELGIELEASPAFIDKVIAEGYSPAWGAR
PLRRAVQRLLEDSVADAVLLGRLVSGERYLVDVDADGKVIFIYPDLADAKAEMAMSAR
>Mature_778_residues
MFEQFSPSALQVLNLAKQESLRLGQNAVGTEQLLLGLLAHSDAVAAQVLTELGLSLAGARREVESIVGKGESRPSQRVAF
TPRAGRLIEQALIEANGFGQRLVEPEHLLLSMLRDNEGVASRVLDEFGVDRDKARQMLLESLGDAAKATSASRGNEQPRR
SDRASRSGGPLERFGRDLTELARGGKIDPVVGRAEQIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLAVRIAEGDVPE
MLFDRRIVSLDMGQVLAGTQMRGEFEERLKGVMQEVIASKGQIVLFIDELHTLVGAGASEGGMDAANLLKPALARGELQC
IGATTLDEYRKHIERDAALERRFQPVTVGEPSVDEAIAILQGLKVRYEEHHKLRYTDAALEAAVRLSDRYIADRFLPDKA
IDLIDEAGSMIRVKLARGAELPAIVDSEAIAQVLSEWTNIPVGKLTGEEATSLVHLEARLHERIIGQHPAVSAVARAVRR
ARAGMKSPERPQASFIFAGPTGVGKTELAKALAATVFGSEDAMIRLDMSEFMESYTVSKLIGSPPGYVGYDEGGQLTEAV
RRRPYTVILLDEIEKAHPDVFNILLQLLDDGRLTDAKGRTVSFKNALIIMTSNLGSRVIERGGGGLGFNTTGSAGERRYV
AIRDRVQEELKQVFRPEFLNRLDEVIVFQPLDREELGQVARLLLNESLERVRELGIELEASPAFIDKVIAEGYSPAWGAR
PLRRAVQRLLEDSVADAVLLGRLVSGERYLVDVDADGKVIFIYPDLADAKAEMAMSAR

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=336, Percent_Identity=38.9880952380952, Blast_Score=206, Evalue=5e-53,
Organism=Escherichia coli, GI1787109, Length=774, Percent_Identity=40.5684754521964, Blast_Score=537, Evalue=1e-153,
Organism=Escherichia coli, GI1788943, Length=333, Percent_Identity=51.9519519519519, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6320464, Length=260, Percent_Identity=58.0769230769231, Blast_Score=310, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6323002, Length=307, Percent_Identity=46.5798045602606, Blast_Score=268, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 84917; Mature: 84917

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50045 SIGMA54_INTERACT_4 ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEQFSPSALQVLNLAKQESLRLGQNAVGTEQLLLGLLAHSDAVAAQVLTELGLSLAGAR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
REVESIVGKGESRPSQRVAFTPRAGRLIEQALIEANGFGQRLVEPEHLLLSMLRDNEGVA
HHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCHH
SRVLDEFGVDRDKARQMLLESLGDAAKATSASRGNEQPRRSDRASRSGGPLERFGRDLTE
HHHHHHHCCCHHHHHHHHHHHHCHHHHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHH
LARGGKIDPVVGRAEQIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLAVRIAEGDVPE
HHCCCCCCHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHCCCEEEEECCCCHH
MLFDRRIVSLDMGQVLAGTQMRGEFEERLKGVMQEVIASKGQIVLFIDELHTLVGAGASE
HHHCCHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCC
GGMDAANLLKPALARGELQCIGATTLDEYRKHIERDAALERRFQPVTVGEPSVDEAIAIL
CCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
QGLKVRYEEHHKLRYTDAALEAAVRLSDRYIADRFLPDKAIDLIDEAGSMIRVKLARGAE
HHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCC
LPAIVDSEAIAQVLSEWTNIPVGKLTGEEATSLVHLEARLHERIIGQHPAVSAVARAVRR
CCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ARAGMKSPERPQASFIFAGPTGVGKTELAKALAATVFGSEDAMIRLDMSEFMESYTVSKL
HHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHH
IGSPPGYVGYDEGGQLTEAVRRRPYTVILLDEIEKAHPDVFNILLQLLDDGRLTDAKGRT
HCCCCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCE
VSFKNALIIMTSNLGSRVIERGGGGLGFNTTGSAGERRYVAIRDRVQEELKQVFRPEFLN
EEECCEEEEEECCHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCHHHHH
RLDEVIVFQPLDREELGQVARLLLNESLERVRELGIELEASPAFIDKVIAEGYSPAWGAR
HHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCCCCCCH
PLRRAVQRLLEDSVADAVLLGRLVSGERYLVDVDADGKVIFIYPDLADAKAEMAMSAR
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCHHHHHHHHCCC
>Mature Secondary Structure
MFEQFSPSALQVLNLAKQESLRLGQNAVGTEQLLLGLLAHSDAVAAQVLTELGLSLAGAR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
REVESIVGKGESRPSQRVAFTPRAGRLIEQALIEANGFGQRLVEPEHLLLSMLRDNEGVA
HHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCHH
SRVLDEFGVDRDKARQMLLESLGDAAKATSASRGNEQPRRSDRASRSGGPLERFGRDLTE
HHHHHHHCCCHHHHHHHHHHHHCHHHHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHH
LARGGKIDPVVGRAEQIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLAVRIAEGDVPE
HHCCCCCCHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHCCCEEEEECCCCHH
MLFDRRIVSLDMGQVLAGTQMRGEFEERLKGVMQEVIASKGQIVLFIDELHTLVGAGASE
HHHCCHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCC
GGMDAANLLKPALARGELQCIGATTLDEYRKHIERDAALERRFQPVTVGEPSVDEAIAIL
CCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
QGLKVRYEEHHKLRYTDAALEAAVRLSDRYIADRFLPDKAIDLIDEAGSMIRVKLARGAE
HHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCC
LPAIVDSEAIAQVLSEWTNIPVGKLTGEEATSLVHLEARLHERIIGQHPAVSAVARAVRR
CCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ARAGMKSPERPQASFIFAGPTGVGKTELAKALAATVFGSEDAMIRLDMSEFMESYTVSKL
HHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHH
IGSPPGYVGYDEGGQLTEAVRRRPYTVILLDEIEKAHPDVFNILLQLLDDGRLTDAKGRT
HCCCCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCE
VSFKNALIIMTSNLGSRVIERGGGGLGFNTTGSAGERRYVAIRDRVQEELKQVFRPEFLN
EEECCEEEEEECCHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCHHHHH
RLDEVIVFQPLDREELGQVARLLLNESLERVRELGIELEASPAFIDKVIAEGYSPAWGAR
HHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCCCCCCH
PLRRAVQRLLEDSVADAVLLGRLVSGERYLVDVDADGKVIFIYPDLADAKAEMAMSAR
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]