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The map label for this gene is pdhB [H]

Identifier: 37521099

GI number: 37521099

Start: 1650902

End: 1651885

Strand: Direct

Name: pdhB [H]

Synonym: glr1530

Alternate gene names: 37521099

Gene position: 1650902-1651885 (Clockwise)

Preceding gene: 37521098

Following gene: 37521101

Centisome position: 35.43

GC content: 58.64

Gene sequence:

>984_bases
ATGCCGGTCAAACTGTTTTACGAAGCGCTCAAAGACGCCATGGCCGAAGAAATGCGCCGCGACCCCAATGTCTACGTCTT
AGGCGAAGATGTCGGACACTACGGCGGCTCCTACAAAGCCACCAAGGACCTCTACAAAGAATTCGGCGAACTGCGATTGC
TAGACACCCCCATCTGCGAAAACGCCTTCACAGGACTGGCCGTCGGCTCCGCCATGACTGGCCTGCGGCCCATCATCGAA
GGGATGAACATGGGCTTTTTGCTGTTGGCCTTCAACCAGATCGCCAACAACGGCGGCATGCTGCGCTACACCAGCGGCGG
ACAGTTCAAAATCCCGATGGTCGTGCGCGGTCCCGGCGGGGTCGGCAAACAACTGGGGGCTGAGCACTCCCAAAGGCTCG
AAGGTTACTTCAACAACGTCCCCGGCCTGAAGATCGTGCACACTTCGACTGTCTACAACGCCAAGGGCCTGCTCAAAGCG
GCGATCCGCGACGACAACCCGGTGATGTTTTTTGAGCATGTGCTGTTGTACAACCTCAAGGAGGATATCCCCGAGGAGGA
ATACCTATTGCCTTTGGACAAAGCCGAAATGGTCAAGGAAGGCCGCGATGTGACGGTGCTGACGTATGGGCGGATGCGCC
ACCACTGCACCGAGGCGCTCCAGGAGCTGGCCGCGCGCGACATCGATGTGGAAGTGATCGACCTGATATCGCTGAAGCCG
CTGGACCTGGAGACGATTGGCCGCTCGCTCAAAAAGACGCACCGGGTGGTGATTGTCGAGGAGGACATGAAATCCGGCGG
GGTGGGTGCGGAGATTGTGGCAAGTATCGACGAGCACTATTTCGATTATCTGGACGCGCCGGTGTTGCGTCTGGCGTCGA
AGGATGTGCCGGTGCCGTACAACGGCCGGATGGAGGCGACGGTGATCCCGCAGCCGCAGGATATCGTCCAGGCTGTCGAA
AACATGCTTGCTCTGCGCGTTTGA

Upstream 100 bases:

>100_bases
AGAGCCGAAATCGACGATGCGGTCCTCTTTGCCGAGGAGTCCCCCGAGCCACCCATCGACGAACTCTATCGCTTCCAGTT
TGCGGAGGACGCATAGCTTT

Downstream 100 bases:

>100_bases
GCGCATTCCAGGCGGCAGAGATGTGCTCGCCGCCTGGAATCCAAATTAGATGCGCTTCTCTAGATACTGGCCAATCATCT
GCTGCTCGCCGAGGCGCGAG

Product: pyruvate dehydrogenase E1 component beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MPVKLFYEALKDAMAEEMRRDPNVYVLGEDVGHYGGSYKATKDLYKEFGELRLLDTPICENAFTGLAVGSAMTGLRPIIE
GMNMGFLLLAFNQIANNGGMLRYTSGGQFKIPMVVRGPGGVGKQLGAEHSQRLEGYFNNVPGLKIVHTSTVYNAKGLLKA
AIRDDNPVMFFEHVLLYNLKEDIPEEEYLLPLDKAEMVKEGRDVTVLTYGRMRHHCTEALQELAARDIDVEVIDLISLKP
LDLETIGRSLKKTHRVVIVEEDMKSGGVGAEIVASIDEHYFDYLDAPVLRLASKDVPVPYNGRMEATVIPQPQDIVQAVE
NMLALRV

Sequences:

>Translated_327_residues
MPVKLFYEALKDAMAEEMRRDPNVYVLGEDVGHYGGSYKATKDLYKEFGELRLLDTPICENAFTGLAVGSAMTGLRPIIE
GMNMGFLLLAFNQIANNGGMLRYTSGGQFKIPMVVRGPGGVGKQLGAEHSQRLEGYFNNVPGLKIVHTSTVYNAKGLLKA
AIRDDNPVMFFEHVLLYNLKEDIPEEEYLLPLDKAEMVKEGRDVTVLTYGRMRHHCTEALQELAARDIDVEVIDLISLKP
LDLETIGRSLKKTHRVVIVEEDMKSGGVGAEIVASIDEHYFDYLDAPVLRLASKDVPVPYNGRMEATVIPQPQDIVQAVE
NMLALRV
>Mature_326_residues
PVKLFYEALKDAMAEEMRRDPNVYVLGEDVGHYGGSYKATKDLYKEFGELRLLDTPICENAFTGLAVGSAMTGLRPIIEG
MNMGFLLLAFNQIANNGGMLRYTSGGQFKIPMVVRGPGGVGKQLGAEHSQRLEGYFNNVPGLKIVHTSTVYNAKGLLKAA
IRDDNPVMFFEHVLLYNLKEDIPEEEYLLPLDKAEMVKEGRDVTVLTYGRMRHHCTEALQELAARDIDVEVIDLISLKPL
DLETIGRSLKKTHRVVIVEEDMKSGGVGAEIVASIDEHYFDYLDAPVLRLASKDVPVPYNGRMEATVIPQPQDIVQAVEN
MLALRV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=321, Percent_Identity=41.4330218068536, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI291084858, Length=321, Percent_Identity=39.2523364485981, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI4557353, Length=324, Percent_Identity=33.9506172839506, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI34101272, Length=324, Percent_Identity=33.9506172839506, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17538422, Length=321, Percent_Identity=42.3676012461059, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17506935, Length=296, Percent_Identity=36.8243243243243, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319698, Length=324, Percent_Identity=44.7530864197531, Blast_Score=278, Evalue=6e-76,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=40.7975460122699, Blast_Score=271, Evalue=5e-73,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=40.7975460122699, Blast_Score=271, Evalue=5e-73,
Organism=Drosophila melanogaster, GI160714832, Length=321, Percent_Identity=36.1370716510903, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI160714828, Length=321, Percent_Identity=36.1370716510903, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24650943, Length=85, Percent_Identity=45.8823529411765, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24650945, Length=85, Percent_Identity=45.8823529411765, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36358; Mature: 36226

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKLFYEALKDAMAEEMRRDPNVYVLGEDVGHYGGSYKATKDLYKEFGELRLLDTPICE
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCEEEECCCHHH
NAFTGLAVGSAMTGLRPIIEGMNMGFLLLAFNQIANNGGMLRYTSGGQFKIPMVVRGPGG
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCC
VGKQLGAEHSQRLEGYFNNVPGLKIVHTSTVYNAKGLLKAAIRDDNPVMFFEHVLLYNLK
CCHHHCHHHHHHHHHHHCCCCCEEEEEECCEECHHHHHHHHHCCCCCCHHHHHHHHHHHH
EDIPEEEYLLPLDKAEMVKEGRDVTVLTYGRMRHHCTEALQELAARDIDVEVIDLISLKP
HHCCCCCEECCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCC
LDLETIGRSLKKTHRVVIVEEDMKSGGVGAEIVASIDEHYFDYLDAPVLRLASKDVPVPY
CCHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCC
NGRMEATVIPQPQDIVQAVENMLALRV
CCEEEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVKLFYEALKDAMAEEMRRDPNVYVLGEDVGHYGGSYKATKDLYKEFGELRLLDTPICE
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCEEEECCCHHH
NAFTGLAVGSAMTGLRPIIEGMNMGFLLLAFNQIANNGGMLRYTSGGQFKIPMVVRGPGG
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCC
VGKQLGAEHSQRLEGYFNNVPGLKIVHTSTVYNAKGLLKAAIRDDNPVMFFEHVLLYNLK
CCHHHCHHHHHHHHHHHCCCCCEEEEEECCEECHHHHHHHHHCCCCCCHHHHHHHHHHHH
EDIPEEEYLLPLDKAEMVKEGRDVTVLTYGRMRHHCTEALQELAARDIDVEVIDLISLKP
HHCCCCCEECCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCC
LDLETIGRSLKKTHRVVIVEEDMKSGGVGAEIVASIDEHYFDYLDAPVLRLASKDVPVPY
CCHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCC
NGRMEATVIPQPQDIVQAVENMLALRV
CCEEEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]