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The map label for this gene is pdhA [H]

Identifier: 37521098

GI number: 37521098

Start: 1649893

End: 1650897

Strand: Direct

Name: pdhA [H]

Synonym: glr1529

Alternate gene names: 37521098

Gene position: 1649893-1650897 (Clockwise)

Preceding gene: 37521096

Following gene: 37521099

Centisome position: 35.41

GC content: 62.29

Gene sequence:

>1005_bases
ATGACGATGGTCCAGCAACAACTACCTCCGACGCGCTACCACATCGACCGCCCAGAGGCGCTGGTCCTCTACCGCGACAT
GGTCCTCGGGCGGACCTTCGAGGACACCTGCGCCCAGATGTACTACCGCGGCAAGATGTTCGGCTTTGTGCACCTCTACA
ACGGTCAGGAAGCCGTCTCCACAGGCGTCATCAAGGCTATGCGCCCCGACGATTATGTGACGAGCACCTACCGTGACCAC
GTCCATGCCCTCTCGAAGGGGGTGCCGGCGCGCTCGGTGATGGCGGAGCTGTTCGGCAAGGCCACCGGTTGCTCCAAGGG
CCGCGGCGGCTCGATGCACCTGTTCTCGGCGGAGCACAATCTGTTGGGAGGTTTCGCCTTCGTGGCCGAAGGGATCCCGA
TTGCCACGGGAGCGGGCTTCACGGCGGTCTACAAAGGCACCGATCAGGTGAGCGCCTGCTTTTTTGGCGACGGCGCCACC
AACAACGGCCAGTTTTTTGAGTGCTTGAACATGGCGGCCCTCTGGAATCTGCCGGTGCTGTACGTGGTCGAGAACAACCT
CTGGTCGATCGGCATGTACCACCACCGCGCCTCCTCGGTCATCGAAATCTACAAAAAAGCGGACGCCTTCGGTATTCCCG
GGGTACGCGTGGACGGGATGGACGTGCTCGCCGTGCGCGCGGTGGCCAAAGAAGCGATCGAACGCGCCCGCGCGGGCGGC
GGCCCGACTTTAATCGAATGCACGACCTATCGCTTTCGGGGCCATTCGCTGGCGGACCCGGACGAGCTGCGCGACCCGGC
CGAAAAAGAATTCTGGCGCAAACAAGATCCGATCCCGCGCCTGGCGGCCTTTGTCCGCGAGCAGGAACTGGCCAGCGCCG
AGGAACTCAAAGCCATCGATCAAGAAATAAGAGCCGAAATCGACGATGCGGTCCTCTTTGCCGAGGAGTCCCCCGAGCCA
CCCATCGACGAACTCTATCGCTTCCAGTTTGCGGAGGACGCATAG

Upstream 100 bases:

>100_bases
GATTCTGGAACAATCGACACCGTTTGTCCGATTCAAACTCATAGTATGGTGGGGCTACGACAGGGCCGAAGCGCAACACT
TCGTGACTTTCACCCAGAGG

Downstream 100 bases:

>100_bases
CTTTATGCCGGTCAAACTGTTTTACGAAGCGCTCAAAGACGCCATGGCCGAAGAAATGCGCCGCGACCCCAATGTCTACG
TCTTAGGCGAAGATGTCGGA

Product: pyruvate dehydrogenase E1 component alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTMVQQQLPPTRYHIDRPEALVLYRDMVLGRTFEDTCAQMYYRGKMFGFVHLYNGQEAVSTGVIKAMRPDDYVTSTYRDH
VHALSKGVPARSVMAELFGKATGCSKGRGGSMHLFSAEHNLLGGFAFVAEGIPIATGAGFTAVYKGTDQVSACFFGDGAT
NNGQFFECLNMAALWNLPVLYVVENNLWSIGMYHHRASSVIEIYKKADAFGIPGVRVDGMDVLAVRAVAKEAIERARAGG
GPTLIECTTYRFRGHSLADPDELRDPAEKEFWRKQDPIPRLAAFVREQELASAEELKAIDQEIRAEIDDAVLFAEESPEP
PIDELYRFQFAEDA

Sequences:

>Translated_334_residues
MTMVQQQLPPTRYHIDRPEALVLYRDMVLGRTFEDTCAQMYYRGKMFGFVHLYNGQEAVSTGVIKAMRPDDYVTSTYRDH
VHALSKGVPARSVMAELFGKATGCSKGRGGSMHLFSAEHNLLGGFAFVAEGIPIATGAGFTAVYKGTDQVSACFFGDGAT
NNGQFFECLNMAALWNLPVLYVVENNLWSIGMYHHRASSVIEIYKKADAFGIPGVRVDGMDVLAVRAVAKEAIERARAGG
GPTLIECTTYRFRGHSLADPDELRDPAEKEFWRKQDPIPRLAAFVREQELASAEELKAIDQEIRAEIDDAVLFAEESPEP
PIDELYRFQFAEDA
>Mature_333_residues
TMVQQQLPPTRYHIDRPEALVLYRDMVLGRTFEDTCAQMYYRGKMFGFVHLYNGQEAVSTGVIKAMRPDDYVTSTYRDHV
HALSKGVPARSVMAELFGKATGCSKGRGGSMHLFSAEHNLLGGFAFVAEGIPIATGAGFTAVYKGTDQVSACFFGDGATN
NGQFFECLNMAALWNLPVLYVVENNLWSIGMYHHRASSVIEIYKKADAFGIPGVRVDGMDVLAVRAVAKEAIERARAGGG
PTLIECTTYRFRGHSLADPDELRDPAEKEFWRKQDPIPRLAAFVREQELASAEELKAIDQEIRAEIDDAVLFAEESPEPP
IDELYRFQFAEDA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=328, Percent_Identity=41.4634146341463, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI291084742, Length=327, Percent_Identity=41.2844036697248, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI4505685, Length=327, Percent_Identity=41.2844036697248, Blast_Score=237, Evalue=9e-63,
Organism=Homo sapiens, GI291084744, Length=334, Percent_Identity=40.4191616766467, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI291084757, Length=327, Percent_Identity=38.5321100917431, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI11386135, Length=315, Percent_Identity=30.1587301587302, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI258645172, Length=320, Percent_Identity=30, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17536047, Length=320, Percent_Identity=40, Blast_Score=237, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI32564172, Length=320, Percent_Identity=40, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI86563357, Length=320, Percent_Identity=26.5625, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI86563355, Length=320, Percent_Identity=26.5625, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=314, Percent_Identity=38.2165605095541, Blast_Score=225, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24639744, Length=327, Percent_Identity=38.5321100917431, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI28571106, Length=327, Percent_Identity=38.5321100917431, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24639740, Length=327, Percent_Identity=38.5321100917431, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24639748, Length=327, Percent_Identity=39.7553516819572, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=39.344262295082, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI21355903, Length=314, Percent_Identity=24.8407643312102, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37094; Mature: 36963

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMVQQQLPPTRYHIDRPEALVLYRDMVLGRTFEDTCAQMYYRGKMFGFVHLYNGQEAVS
CCCCHHHCCCCCEECCCCCEEHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEEECCCHHHH
TGVIKAMRPDDYVTSTYRDHVHALSKGVPARSVMAELFGKATGCSKGRGGSMHLFSAEHN
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
LLGGFAFVAEGIPIATGAGFTAVYKGTDQVSACFFGDGATNNGQFFECLNMAALWNLPVL
HHHHHHHHHCCCCEECCCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEE
YVVENNLWSIGMYHHRASSVIEIYKKADAFGIPGVRVDGMDVLAVRAVAKEAIERARAGG
EEEECCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCC
GPTLIECTTYRFRGHSLADPDELRDPAEKEFWRKQDPIPRLAAFVREQELASAEELKAID
CCEEEEEEEEEECCCCCCCHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
QEIRAEIDDAVLFAEESPEPPIDELYRFQFAEDA
HHHHHHHHHHEEEECCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TMVQQQLPPTRYHIDRPEALVLYRDMVLGRTFEDTCAQMYYRGKMFGFVHLYNGQEAVS
CCCHHHCCCCCEECCCCCEEHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEEECCCHHHH
TGVIKAMRPDDYVTSTYRDHVHALSKGVPARSVMAELFGKATGCSKGRGGSMHLFSAEHN
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
LLGGFAFVAEGIPIATGAGFTAVYKGTDQVSACFFGDGATNNGQFFECLNMAALWNLPVL
HHHHHHHHHCCCCEECCCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEE
YVVENNLWSIGMYHHRASSVIEIYKKADAFGIPGVRVDGMDVLAVRAVAKEAIERARAGG
EEEECCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCC
GPTLIECTTYRFRGHSLADPDELRDPAEKEFWRKQDPIPRLAAFVREQELASAEELKAID
CCEEEEEEEEEECCCCCCCHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
QEIRAEIDDAVLFAEESPEPPIDELYRFQFAEDA
HHHHHHHHHHEEEECCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]