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The map label for this gene is hemH

Identifier: 37520408

GI number: 37520408

Start: 893846

End: 894829

Strand: Reverse

Name: hemH

Synonym: gvip102

Alternate gene names: 37520408

Gene position: 894829-893846 (Counterclockwise)

Preceding gene: 37520411

Following gene: 37520407

Centisome position: 19.21

GC content: 60.16

Gene sequence:

>984_bases
ATGGCTGAAGTCGGAGTGCTGTTGCTCAACCTGGGGGGGCCGGACAAACAAGAGGACGTCAGGCCTTTTCTGTATAACCT
GTTTGCCGACCCGGAAATTATTCGCATTCCGGTGCCGCCCTTGCAAAAGCCGCTCGCCTGGTTGATTTCGACTTTGCGCG
CTCCCAAATCGCGCAAGAATTATCAGGCCATCGGCGGCGGTTCGCCCCTCAGGGCGATCACCAACCAGCAGGGCCGGGTG
CTCAAAAAAGCGCTCGCCGCCCGCGGACTCGACATCGAAGTCTACGTCGGTATGCGCTACTGGCACCCGTTTACCGAGGA
AGCCGTGCGCAAAATCAAAGCCGACGGCATTCGCCGCCTGGTGCTTCTGCCCCTCTACCCGCAGTACTCGATTTCCACCA
GCGGTTCGAGCTTCAAATTGCTCGACCAGATCTGGGCGCGCGATCCGTCCCTCAAAGCCATCGAGCGCATCACGATCAAC
TCCTGGTACAGCCGCCCCGGCTACATCCGGGCGATGGGCGAGCGCGTGCGCGAGGGCCTCGACAAATTCGACAACCCCGA
CGGGGTGCATATTCTTTTTTCCGCCCACGGTGTGCCCCGCACCTACGTCGATCAAGACGGCGATCCGTACCAGCGCCAGA
CCGAGGAAACGGTCGACCTGGTCATGCAATCGCTTGGACGCCCCAACGCCCATTCGCTCGCCTATCAGAGCCGGGTCGGC
CCGGTGGAGTGGCTGAAGCCCTACACAGAAGACACCATCAACGAACTGGCCCAAAAAGGGGTGCGCTCCCTGCTGGCGGT
GCCGGTGAGCTTTATTTCCGAGCACATCGAGACCCTGCAAGAAATCGAGATCGAATACCGCGAAGTGGCTGAAGCTGCCG
GCATTCACGACTTTCGCCGCGCCAAGGCCCTCAACGTCAACAAGACGTTCATCGACGATCTAGCCGAGATGGTGATCGAG
AATCTGGGTGTCTACTCGCGCTAG

Upstream 100 bases:

>100_bases
CAGGATCAGCGGCCGGGATCGCTTCTTGGGCGCGATGTCTTTTCGGGAAACCAAATCGGAGCTAGCCTGATTGAGGATCG
TTGTGTAGTCAGGGTGGCGC

Downstream 100 bases:

>100_bases
TTGGCGCAGTGCCTTGACTTAGAGCGCGCTCCAAGTTCTAAGGTGATCCCATACCTACCGCACTCACCATCCAGCAATTT
TGCAGGAGCAACAACCATGA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MAEVGVLLLNLGGPDKQEDVRPFLYNLFADPEIIRIPVPPLQKPLAWLISTLRAPKSRKNYQAIGGGSPLRAITNQQGRV
LKKALAARGLDIEVYVGMRYWHPFTEEAVRKIKADGIRRLVLLPLYPQYSISTSGSSFKLLDQIWARDPSLKAIERITIN
SWYSRPGYIRAMGERVREGLDKFDNPDGVHILFSAHGVPRTYVDQDGDPYQRQTEETVDLVMQSLGRPNAHSLAYQSRVG
PVEWLKPYTEDTINELAQKGVRSLLAVPVSFISEHIETLQEIEIEYREVAEAAGIHDFRRAKALNVNKTFIDDLAEMVIE
NLGVYSR

Sequences:

>Translated_327_residues
MAEVGVLLLNLGGPDKQEDVRPFLYNLFADPEIIRIPVPPLQKPLAWLISTLRAPKSRKNYQAIGGGSPLRAITNQQGRV
LKKALAARGLDIEVYVGMRYWHPFTEEAVRKIKADGIRRLVLLPLYPQYSISTSGSSFKLLDQIWARDPSLKAIERITIN
SWYSRPGYIRAMGERVREGLDKFDNPDGVHILFSAHGVPRTYVDQDGDPYQRQTEETVDLVMQSLGRPNAHSLAYQSRVG
PVEWLKPYTEDTINELAQKGVRSLLAVPVSFISEHIETLQEIEIEYREVAEAAGIHDFRRAKALNVNKTFIDDLAEMVIE
NLGVYSR
>Mature_326_residues
AEVGVLLLNLGGPDKQEDVRPFLYNLFADPEIIRIPVPPLQKPLAWLISTLRAPKSRKNYQAIGGGSPLRAITNQQGRVL
KKALAARGLDIEVYVGMRYWHPFTEEAVRKIKADGIRRLVLLPLYPQYSISTSGSSFKLLDQIWARDPSLKAIERITINS
WYSRPGYIRAMGERVREGLDKFDNPDGVHILFSAHGVPRTYVDQDGDPYQRQTEETVDLVMQSLGRPNAHSLAYQSRVGP
VEWLKPYTEDTINELAQKGVRSLLAVPVSFISEHIETLQEIEIEYREVAEAAGIHDFRRAKALNVNKTFIDDLAEMVIEN
LGVYSR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=326, Percent_Identity=38.9570552147239, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI60499025, Length=326, Percent_Identity=38.9570552147239, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1786681, Length=324, Percent_Identity=34.2592592592593, Blast_Score=144, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6324750, Length=325, Percent_Identity=37.8461538461538, Blast_Score=199, Evalue=7e-52,
Organism=Drosophila melanogaster, GI17864156, Length=326, Percent_Identity=37.4233128834356, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=37.109375, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45552018, Length=167, Percent_Identity=40.7185628742515, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_GLOVI (Q7NMC7)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923785.1
- ProteinModelPortal:   Q7NMC7
- SMR:   Q7NMC7
- GeneID:   2599265
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.839
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- ProtClustDB:   PRK00035
- BioCyc:   GVIO251221:GLL0839-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36993; Mature: 36862

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVGVLLLNLGGPDKQEDVRPFLYNLFADPEIIRIPVPPLQKPLAWLISTLRAPKSRKN
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCC
YQAIGGGSPLRAITNQQGRVLKKALAARGLDIEVYVGMRYWHPFTEEAVRKIKADGIRRL
CEECCCCCCHHHHHCCHHHHHHHHHHHCCCCEEEEECCHHCCCHHHHHHHHHHHHHHHEE
VLLPLYPQYSISTSGSSFKLLDQIWARDPSLKAIERITINSWYSRPGYIRAMGERVREGL
EEEECCCCCEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DKFDNPDGVHILFSAHGVPRTYVDQDGDPYQRQTEETVDLVMQSLGRPNAHSLAYQSRVG
HHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
PVEWLKPYTEDTINELAQKGVRSLLAVPVSFISEHIETLQEIEIEYREVAEAAGIHDFRR
CHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AKALNVNKTFIDDLAEMVIENLGVYSR
HHHCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AEVGVLLLNLGGPDKQEDVRPFLYNLFADPEIIRIPVPPLQKPLAWLISTLRAPKSRKN
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCC
YQAIGGGSPLRAITNQQGRVLKKALAARGLDIEVYVGMRYWHPFTEEAVRKIKADGIRRL
CEECCCCCCHHHHHCCHHHHHHHHHHHCCCCEEEEECCHHCCCHHHHHHHHHHHHHHHEE
VLLPLYPQYSISTSGSSFKLLDQIWARDPSLKAIERITINSWYSRPGYIRAMGERVREGL
EEEECCCCCEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DKFDNPDGVHILFSAHGVPRTYVDQDGDPYQRQTEETVDLVMQSLGRPNAHSLAYQSRVG
HHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
PVEWLKPYTEDTINELAQKGVRSLLAVPVSFISEHIETLQEIEIEYREVAEAAGIHDFRR
CHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AKALNVNKTFIDDLAEMVIENLGVYSR
HHHCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292