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The map label for this gene is ppx [H]

Identifier: 37520079

GI number: 37520079

Start: 548143

End: 549807

Strand: Reverse

Name: ppx [H]

Synonym: gvip052

Alternate gene names: 37520079

Gene position: 549807-548143 (Counterclockwise)

Preceding gene: 37520080

Following gene: 37520078

Centisome position: 11.8

GC content: 64.5

Gene sequence:

>1665_bases
ATGCCCGAACCCGCGGCTGACGCAGAGAAGACCCTGGCTGCCATCGACATCGGCACCAACTCCATCCACATGGTGGTGGT
TCATATCCAGCCCCGGCTGGCCAGCTACACGATCGTCGCCCGCGAGAAGCAGATGGTGCGCCTGGGTGAGTACTGCCAGA
AGACCGGCTGGCTGACGCCGGAGGCGATGGTGCGCGCCCTCGACGCGCTGCGTCACTGCAAAGCCTTTGCTGAGGGCCTG
GGAGCGCAGGAAATGATCGCCGTCGCCACCAGTGCCGTGCGCGAGGCACCGAACGGGCCGGAATTCTTGCTGCAGATCCA
GCGGGTGGTCGGGCTCAAAGTCGACTTGATTTCGGGGGAGGAGGAGGCGCGGCGCATCTACCTCGGGGTGCTCTCCGCCA
TCGAGTTCGACAACCGTACCCACGCCGTCATCGACATCGGCGGCGGTTCGACGGAGCTAATTCTGGGCGACGGCCGCGAG
CCGCGCTATCTGGCGAGCGTCAAGGCGGGGGCGGTGCGCCTCAGCGAACAGTTCGTGCAGAGCGACCCGATCTCGGGCCG
CGACTACGGCCGCCTGCGCAACCAGGTGCGCAATTTGATCGAGCCTGCCGTGGACAAACTGCTGGCCCTAGGGCCGTTCG
AGCGCTTGGTCGGCACCTCCGGGACGATCATGACCTTAGCTGAGATCGATGCGCGCCGGGGGGGCAGCTTTCCTACCTCG
CTGCAGGGCTACGAGTTGACGCTTGCCAGTCTTGAGCAGATCGCAGCGCAGTTGCGCGAACTCGATCTCGAAGCGCGCCG
CCGTCTACCCGGAGTCTCCGAGCGCCGCGCCGACATCATCGTCGCCGGGGCGACCATTCTGCTCGAAGCGATGCAGATGC
TGGGGGTGGGCTCGATCACCGTCTGTGAGGCGGCGTTGCGCGAGGGGCTCATCGTCGACTGGATGATCGGCCGGGGACTG
ATTGCCGATCGGTTGCGCTACCAGGGTTCGGTGCGCGAGCGCAGTGTGCTGCAGCTGGCCGACAAATTCAACCTCGACAC
CACCCACGCCGAGCAGGTGACGCGTCTGTCCTTAAGCCTTTTTGATCAGTCCCGGGGCCGGTTGCACCGCTGGAGCGACG
CCGATCGCGAGCTACTGTGGGCGGCGGCGATGTTGCACAACTGCGGCCACTTCATCAACCATTCCAGTCACCACAAGCAT
TCGTACTACCTGATCCGCCACGGCGGCATGCTCGGTTTTACCGAAGAAGAGATCGAGGTGATCGCCAACGTCGCCCGCTA
CCACCGCAAGAGCACCCCCAAAAGCAAGCACCGCGAATTCCAGCACCTTGTCAAAGAACACAAGCGCCTGGTGCGCCAGA
TGAGCGTGTTTTTGCGGCTCGCCTCCGCCCTCGATCGCCGCCACAAAGGGGCCGTACGGGGCGTCCGGCTCGCCTTTGCT
CCTGGAGAAGTCGAGCTTTTTGTCCAACCGCACGACCCGGCCGACCCGTGCGAGATGGAGCTGTGGAACGCCGAATTCAA
AAAAGCCGAGTTCGAACAGGAGTTCGGCCGCACCCTGGCCATTGCCCTGGAGTCGGCTGTGGCCGAACCGCTCGCGGTCC
TGGGCGCCAAGGCCGAAACGCAACCCGACGCGGTGAGAGTGCCGCAGGGTAGTTGGGTATCCTAA

Upstream 100 bases:

>100_bases
CCGCCTGTGCGGGGTTTTTTGCAGGTGGGTGCGCGGCGATTCCGCCGCGTTGGGGTGTATCTTCTCCGTTACAATTGGAG
CAAACTTTGCATGAAACCCC

Downstream 100 bases:

>100_bases
GACCACGTTCGCCCCGGACTGCAGCGCAATGGACCGCAAGCTGGAACCAGCAACCGACGCGTGGCCCCTACCGCCTTTGA
CCCGCGGTACTCTCCTGGAC

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MPEPAADAEKTLAAIDIGTNSIHMVVVHIQPRLASYTIVAREKQMVRLGEYCQKTGWLTPEAMVRALDALRHCKAFAEGL
GAQEMIAVATSAVREAPNGPEFLLQIQRVVGLKVDLISGEEEARRIYLGVLSAIEFDNRTHAVIDIGGGSTELILGDGRE
PRYLASVKAGAVRLSEQFVQSDPISGRDYGRLRNQVRNLIEPAVDKLLALGPFERLVGTSGTIMTLAEIDARRGGSFPTS
LQGYELTLASLEQIAAQLRELDLEARRRLPGVSERRADIIVAGATILLEAMQMLGVGSITVCEAALREGLIVDWMIGRGL
IADRLRYQGSVRERSVLQLADKFNLDTTHAEQVTRLSLSLFDQSRGRLHRWSDADRELLWAAAMLHNCGHFINHSSHHKH
SYYLIRHGGMLGFTEEEIEVIANVARYHRKSTPKSKHREFQHLVKEHKRLVRQMSVFLRLASALDRRHKGAVRGVRLAFA
PGEVELFVQPHDPADPCEMELWNAEFKKAEFEQEFGRTLAIALESAVAEPLAVLGAKAETQPDAVRVPQGSWVS

Sequences:

>Translated_554_residues
MPEPAADAEKTLAAIDIGTNSIHMVVVHIQPRLASYTIVAREKQMVRLGEYCQKTGWLTPEAMVRALDALRHCKAFAEGL
GAQEMIAVATSAVREAPNGPEFLLQIQRVVGLKVDLISGEEEARRIYLGVLSAIEFDNRTHAVIDIGGGSTELILGDGRE
PRYLASVKAGAVRLSEQFVQSDPISGRDYGRLRNQVRNLIEPAVDKLLALGPFERLVGTSGTIMTLAEIDARRGGSFPTS
LQGYELTLASLEQIAAQLRELDLEARRRLPGVSERRADIIVAGATILLEAMQMLGVGSITVCEAALREGLIVDWMIGRGL
IADRLRYQGSVRERSVLQLADKFNLDTTHAEQVTRLSLSLFDQSRGRLHRWSDADRELLWAAAMLHNCGHFINHSSHHKH
SYYLIRHGGMLGFTEEEIEVIANVARYHRKSTPKSKHREFQHLVKEHKRLVRQMSVFLRLASALDRRHKGAVRGVRLAFA
PGEVELFVQPHDPADPCEMELWNAEFKKAEFEQEFGRTLAIALESAVAEPLAVLGAKAETQPDAVRVPQGSWVS
>Mature_553_residues
PEPAADAEKTLAAIDIGTNSIHMVVVHIQPRLASYTIVAREKQMVRLGEYCQKTGWLTPEAMVRALDALRHCKAFAEGLG
AQEMIAVATSAVREAPNGPEFLLQIQRVVGLKVDLISGEEEARRIYLGVLSAIEFDNRTHAVIDIGGGSTELILGDGREP
RYLASVKAGAVRLSEQFVQSDPISGRDYGRLRNQVRNLIEPAVDKLLALGPFERLVGTSGTIMTLAEIDARRGGSFPTSL
QGYELTLASLEQIAAQLRELDLEARRRLPGVSERRADIIVAGATILLEAMQMLGVGSITVCEAALREGLIVDWMIGRGLI
ADRLRYQGSVRERSVLQLADKFNLDTTHAEQVTRLSLSLFDQSRGRLHRWSDADRELLWAAAMLHNCGHFINHSSHHKHS
YYLIRHGGMLGFTEEEIEVIANVARYHRKSTPKSKHREFQHLVKEHKRLVRQMSVFLRLASALDRRHKGAVRGVRLAFAP
GEVELFVQPHDPADPCEMELWNAEFKKAEFEQEFGRTLAIALESAVAEPLAVLGAKAETQPDAVRVPQGSWVS

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=423, Percent_Identity=30.4964539007092, Blast_Score=189, Evalue=6e-49,
Organism=Escherichia coli, GI48994966, Length=464, Percent_Identity=29.0948275862069, Blast_Score=162, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 61476; Mature: 61345

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEPAADAEKTLAAIDIGTNSIHMVVVHIQPRLASYTIVAREKQMVRLGEYCQKTGWLTP
CCCCCCCHHHHEEEEEECCCCEEEEEEEECCCCHHEEEEHHHHHHHHHHHHHHHCCCCCH
EAMVRALDALRHCKAFAEGLGAQEMIAVATSAVREAPNGPEFLLQIQRVVGLKVDLISGE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCH
EEARRIYLGVLSAIEFDNRTHAVIDIGGGSTELILGDGREPRYLASVKAGAVRLSEQFVQ
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHH
SDPISGRDYGRLRNQVRNLIEPAVDKLLALGPFERLVGTSGTIMTLAEIDARRGGSFPTS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEHHHHHHHCCCCCCCC
LQGYELTLASLEQIAAQLRELDLEARRRLPGVSERRADIIVAGATILLEAMQMLGVGSIT
CCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHH
VCEAALREGLIVDWMIGRGLIADRLRYQGSVRERSVLQLADKFNLDTTHAEQVTRLSLSL
HHHHHHHCCCEEEEHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
FDQSRGRLHRWSDADRELLWAAAMLHNCGHFINHSSHHKHSYYLIRHGGMLGFTEEEIEV
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHH
IANVARYHRKSTPKSKHREFQHLVKEHKRLVRQMSVFLRLASALDRRHKGAVRGVRLAFA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PGEVELFVQPHDPADPCEMELWNAEFKKAEFEQEFGRTLAIALESAVAEPLAVLGAKAET
CCCEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCC
QPDAVRVPQGSWVS
CCCCEECCCCCCCC
>Mature Secondary Structure 
PEPAADAEKTLAAIDIGTNSIHMVVVHIQPRLASYTIVAREKQMVRLGEYCQKTGWLTP
CCCCCCHHHHEEEEEECCCCEEEEEEEECCCCHHEEEEHHHHHHHHHHHHHHHCCCCCH
EAMVRALDALRHCKAFAEGLGAQEMIAVATSAVREAPNGPEFLLQIQRVVGLKVDLISGE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCH
EEARRIYLGVLSAIEFDNRTHAVIDIGGGSTELILGDGREPRYLASVKAGAVRLSEQFVQ
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHH
SDPISGRDYGRLRNQVRNLIEPAVDKLLALGPFERLVGTSGTIMTLAEIDARRGGSFPTS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEHHHHHHHCCCCCCCC
LQGYELTLASLEQIAAQLRELDLEARRRLPGVSERRADIIVAGATILLEAMQMLGVGSIT
CCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHH
VCEAALREGLIVDWMIGRGLIADRLRYQGSVRERSVLQLADKFNLDTTHAEQVTRLSLSL
HHHHHHHCCCEEEEHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
FDQSRGRLHRWSDADRELLWAAAMLHNCGHFINHSSHHKHSYYLIRHGGMLGFTEEEIEV
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHH
IANVARYHRKSTPKSKHREFQHLVKEHKRLVRQMSVFLRLASALDRRHKGAVRGVRLAFA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PGEVELFVQPHDPADPCEMELWNAEFKKAEFEQEFGRTLAIALESAVAEPLAVLGAKAET
CCCEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCC
QPDAVRVPQGSWVS
CCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]