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The map label for this gene is lpxH

Identifier: 34498641

GI number: 34498641

Start: 3466551

End: 3467264

Strand: Direct

Name: lpxH

Synonym: CV_3186

Alternate gene names: 34498641

Gene position: 3466551-3467264 (Clockwise)

Preceding gene: 34498640

Following gene: 34498643

Centisome position: 72.96

GC content: 68.91

Gene sequence:

>714_bases
ATGGCCATTCACTTCATTTCCGACCTGCATCTCGCCGACGACACCCCGGCGCTCAACCAGCTGTTCCTGGACACGCTCGC
CGCCTGGCGGGGCCGGATCGCCGCGCTGTACATCCTGGGCGACCTGTTCGAATACTGGGTGGGCGACGACGACGACTCAC
CCTATCTGGCAGCGCCGCTGGCGGCGATGCGCGACTTCGCCGCGCAAACCCCGCTCTACGTGATGCGCGGCAACCGCGAT
TTCCTGCTGGGCGCCGGCTTCGAGGCCCGCAGCGGCGCCAGGCTGCTGGACGACCCGACGCTGATCGAAGCGCACGGGCA
GCGCATCCTGCTCAGCCACGGCGACGCGCTGTGCACCGACGACGCCGCCTACCAGCAATTCCGCGCGATGAGCCGCAACC
CGCAGTGGCAGCAGGCGATGCTGGCCAAGCCGCTGGCCGAACGCCATGCCATCGCCCGCCATGCCCGCGCGCAAAGCGAG
ATGAACAAGCAGCAGACCGGCCTGACCGACATTTCCGATGTCACCGAGAACGCGGTGCGCGAGCTGCTGGCCGCCCATGG
TTGGCCGACGCTGATCCATGGCCACACCCATCGGCCCGCCCACCACCTTCACGACGCGTCCAGCCGCTGGGTGATCCAGG
ACTGGCACGGCGGCCGCGGCGGCTATCTGCTGCTGGACGACGGCGGCATCCGTTCGCTGCCGCTCGGCAACTGA

Upstream 100 bases:

>100_bases
GGTGGTGATCCAGAAGGCCGAGATCGTCTAAACCCGTCTCGCCGAAAAACCAGCCGGGGCCCCGCCCCGGCTTTGTCTTG
CCCCGGATAAGGCAGCAGCC

Downstream 100 bases:

>100_bases
GAGTTGTCCTGTGGGCGGCCCGCGACGCCGCCCCTCCCCTCCAACGACATTTCATGCCATTCAACTACAATGGCAGCCCA
TCACTTAATCCTTACAATTC

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MAIHFISDLHLADDTPALNQLFLDTLAAWRGRIAALYILGDLFEYWVGDDDDSPYLAAPLAAMRDFAAQTPLYVMRGNRD
FLLGAGFEARSGARLLDDPTLIEAHGQRILLSHGDALCTDDAAYQQFRAMSRNPQWQQAMLAKPLAERHAIARHARAQSE
MNKQQTGLTDISDVTENAVRELLAAHGWPTLIHGHTHRPAHHLHDASSRWVIQDWHGGRGGYLLLDDGGIRSLPLGN

Sequences:

>Translated_237_residues
MAIHFISDLHLADDTPALNQLFLDTLAAWRGRIAALYILGDLFEYWVGDDDDSPYLAAPLAAMRDFAAQTPLYVMRGNRD
FLLGAGFEARSGARLLDDPTLIEAHGQRILLSHGDALCTDDAAYQQFRAMSRNPQWQQAMLAKPLAERHAIARHARAQSE
MNKQQTGLTDISDVTENAVRELLAAHGWPTLIHGHTHRPAHHLHDASSRWVIQDWHGGRGGYLLLDDGGIRSLPLGN
>Mature_236_residues
AIHFISDLHLADDTPALNQLFLDTLAAWRGRIAALYILGDLFEYWVGDDDDSPYLAAPLAAMRDFAAQTPLYVMRGNRDF
LLGAGFEARSGARLLDDPTLIEAHGQRILLSHGDALCTDDAAYQQFRAMSRNPQWQQAMLAKPLAERHAIARHARAQSEM
NKQQTGLTDISDVTENAVRELLAAHGWPTLIHGHTHRPAHHLHDASSRWVIQDWHGGRGGYLLLDDGGIRSLPLGN

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=223, Percent_Identity=46.1883408071749, Blast_Score=171, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_CHRVO (Q7NT75)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902856.1
- ProteinModelPortal:   Q7NT75
- GeneID:   2548304
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3186
- NMPDR:   fig|243365.1.peg.3186
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- PhylomeDB:   Q7NT75
- ProtClustDB:   PRK05340
- BioCyc:   CVIO243365:CV_3186-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: 3.6.1.-

Molecular weight: Translated: 26325; Mature: 26194

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHFISDLHLADDTPALNQLFLDTLAAWRGRIAALYILGDLFEYWVGDDDDSPYLAAPL
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AAMRDFAAQTPLYVMRGNRDFLLGAGFEARSGARLLDDPTLIEAHGQRILLSHGDALCTD
HHHHHHHHCCCEEEEECCCCEEEECCCCCCCCCEECCCCCEEECCCCEEEEECCCCCCCC
DAAYQQFRAMSRNPQWQQAMLAKPLAERHAIARHARAQSEMNKQQTGLTDISDVTENAVR
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ELLAAHGWPTLIHGHTHRPAHHLHDASSRWVIQDWHGGRGGYLLLDDGGIRSLPLGN
HHHHHCCCCEEEECCCCCCHHHHCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure 
AIHFISDLHLADDTPALNQLFLDTLAAWRGRIAALYILGDLFEYWVGDDDDSPYLAAPL
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AAMRDFAAQTPLYVMRGNRDFLLGAGFEARSGARLLDDPTLIEAHGQRILLSHGDALCTD
HHHHHHHHCCCEEEEECCCCEEEECCCCCCCCCEECCCCCEEECCCCEEEEECCCCCCCC
DAAYQQFRAMSRNPQWQQAMLAKPLAERHAIARHARAQSEMNKQQTGLTDISDVTENAVR
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ELLAAHGWPTLIHGHTHRPAHHLHDASSRWVIQDWHGGRGGYLLLDDGGIRSLPLGN
HHHHHCCCCEEEECCCCCCHHHHCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782