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The map label for this gene is pcp1

Identifier: 34498631

GI number: 34498631

Start: 3457804

End: 3458436

Strand: Direct

Name: pcp1

Synonym: CV_3176

Alternate gene names: 34498631

Gene position: 3457804-3458436 (Clockwise)

Preceding gene: 34498630

Following gene: 34498636

Centisome position: 72.78

GC content: 69.19

Gene sequence:

>633_bases
ATGAAAACCGTCCTGCTGACCGGCTTCGAGCCTTTCGGCGGCGAAACCGTCAACCCATCCTGGGAAGCCGCGCGCCAGTT
GGACGGCGAAACCATAGCCGGCGCCCGCGTGCACGCGCGGCTGCTCCCCTGCGAGTTCGGCGCGGCGCTGGATGAGCTCT
ACCGTCAGCTGGACGCGCTGCGGCCCGACGTCGCCATCGCGGTGGGACAGGCTGGGGGGCGGCCCGACATCGCGGTGGAG
CGCGTGGCGATCAATGTCGACGATGCCCGCTTCCCCGACAACGCGGGCCGGCAGCCGATAGACGAGCCAGTCGTCGCGAA
CGGCCCCGCCGCCTATTTCGCCACCCTGCCGATCAAGGCCATCGTCGCCGGGCTGCGCGAGCGCGGCCTGCCGGCGACGG
TGTCTCAGAGCGCCGGCACCTTCGTCTGCAATCACGTGATGTATGGGCTGTTGCACCGCGGCGGCCCGCGCGCCGGCTTC
ATCCATTTGCCCTTCCTGCCGGAACAGGCGATCCGGCATCCCGGCGCCTTCAGCCTGAAGCTGGACGACTGCGTGGCAGC
GTTGCGGCTGGCGGTGGAGCTGTCGCTGACACGCGGGAAGGATGAAAAGCGGGAGGGCGGGACCATTCATTGA

Upstream 100 bases:

>100_bases
CAATGCGGTGATCAAGGCCCAATTGCCGACCGCGCTGGCCTTGCTGGCGGTGAATGCAGTATTGTTGGACTGGCTGATGT
TCCGCTGAGGAAATGACCGC

Downstream 100 bases:

>100_bases
ACACCGCAGGCGCCCCCTGCCCTGCGCCGACAAGCTTCCGTGCCGGCGCGCTCCGGCCCTGGGAAGCTTGGCCGGCGGCT
CAACGCCGTCGCGCACGCCA

Product: pyroglutamyl-peptidase I

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKTVLLTGFEPFGGETVNPSWEAARQLDGETIAGARVHARLLPCEFGAALDELYRQLDALRPDVAIAVGQAGGRPDIAVE
RVAINVDDARFPDNAGRQPIDEPVVANGPAAYFATLPIKAIVAGLRERGLPATVSQSAGTFVCNHVMYGLLHRGGPRAGF
IHLPFLPEQAIRHPGAFSLKLDDCVAALRLAVELSLTRGKDEKREGGTIH

Sequences:

>Translated_210_residues
MKTVLLTGFEPFGGETVNPSWEAARQLDGETIAGARVHARLLPCEFGAALDELYRQLDALRPDVAIAVGQAGGRPDIAVE
RVAINVDDARFPDNAGRQPIDEPVVANGPAAYFATLPIKAIVAGLRERGLPATVSQSAGTFVCNHVMYGLLHRGGPRAGF
IHLPFLPEQAIRHPGAFSLKLDDCVAALRLAVELSLTRGKDEKREGGTIH
>Mature_210_residues
MKTVLLTGFEPFGGETVNPSWEAARQLDGETIAGARVHARLLPCEFGAALDELYRQLDALRPDVAIAVGQAGGRPDIAVE
RVAINVDDARFPDNAGRQPIDEPVVANGPAAYFATLPIKAIVAGLRERGLPATVSQSAGTFVCNHVMYGLLHRGGPRAGF
IHLPFLPEQAIRHPGAFSLKLDDCVAALRLAVELSLTRGKDEKREGGTIH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

Organism=Homo sapiens, GI8923198, Length=171, Percent_Identity=26.9005847953216, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_CHRVO (Q7NT84)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902846.1
- ProteinModelPortal:   Q7NT84
- SMR:   Q7NT84
- MEROPS:   C15.001
- GeneID:   2548541
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3176
- NMPDR:   fig|243365.1.peg.3176
- HOGENOM:   HBG360405
- OMA:   LERCAIN
- BioCyc:   CVIO243365:CV_3176-MONOMER
- BRENDA:   3.4.19.3
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 22434; Mature: 22434

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 80-80 ACT_SITE 143-143 ACT_SITE 162-162

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVLLTGFEPFGGETVNPSWEAARQLDGETIAGARVHARLLPCEFGAALDELYRQLDAL
CCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
RPDVAIAVGQAGGRPDIAVERVAINVDDARFPDNAGRQPIDEPVVANGPAAYFATLPIKA
CCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
IVAGLRERGLPATVSQSAGTFVCNHVMYGLLHRGGPRAGFIHLPFLPEQAIRHPGAFSLK
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHCCCCCEEEE
LDDCVAALRLAVELSLTRGKDEKREGGTIH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTVLLTGFEPFGGETVNPSWEAARQLDGETIAGARVHARLLPCEFGAALDELYRQLDAL
CCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
RPDVAIAVGQAGGRPDIAVERVAINVDDARFPDNAGRQPIDEPVVANGPAAYFATLPIKA
CCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
IVAGLRERGLPATVSQSAGTFVCNHVMYGLLHRGGPRAGFIHLPFLPEQAIRHPGAFSLK
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHCCCCCEEEE
LDDCVAALRLAVELSLTRGKDEKREGGTIH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782