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The map label for this gene is aldH [H]

Identifier: 34498279

GI number: 34498279

Start: 3075158

End: 3076729

Strand: Reverse

Name: aldH [H]

Synonym: CV_2824

Alternate gene names: 34498279

Gene position: 3076729-3075158 (Counterclockwise)

Preceding gene: 34498280

Following gene: 34498278

Centisome position: 64.76

GC content: 73.92

Gene sequence:

>1572_bases
ATGAATCTGACAGGCAAGATGCTGATCGGCGGGCAGGCTGTGGCCGGCCGCCGCAACATGATACGGGCGCTGGACCCATC
CACCGATCAGCCGCTGGAGCCGGGCTATGCCGGCGCGGACCGCGAACAGGTGGAGCAGGCCTGCGCATTGGCCTGGGAGG
CGTTTGACGCCTACCGCGAAACCGCGCCGGAGGCCAGGGCGCGCTTGCTCGAAACCATCGCCGAAGAGATAGAAGCGCTG
GGCGATGCGCTGATAGAACGCGCGATGGCCGAGACCGGCCTGCCGCGCGCCCGTCTGCAGGGCGAGCGCGGCCGCACCTG
CGGCCAGCTGCGGCTGTTCGCCCACACGCTGCGGGCGGGAGAGTGGCTGGACGCGCGGGTGGACCCGGCCATGCCGCAAC
GCCAGCCGCTGCCGCGCGCCGACCTGCGCCAGCGCCAGGTGGCGCTGGGGCCGGTGGCGGTATTCGGCGCCAGCAATTTC
CCCCTGGCCTTTTCGGTGGCTGGCGGCGACACCGCCTCCGCGCTGGCGGCCGGCTGCCCGGTCATCGTCAAGGCCCACAG
CGCCCATCCCGGCGCCAGCGAGCTGGCGGGGCGAGCCATCGCGCGGGCGGTGGAAAAATGCCGGCTGCCGGCCGGCGTGT
TCGCGCTGCTGTTCGGCGAAGGCCGCGAGGCGGGGCAGGCGCTGGTGGCCGATCCGCGCGTCAAGGCGGTGGGCTTCACC
GGCTCGCGCGGCGGCGGGCTGGCCTTGTGCCGGCTGGCGCAAAGCCGCCCGGAGCCGATTCCGGTGTTCGCGGAAATGAG
CTCCACCAATCCGGTGTTCCTGTTGCCGGCGGCGCTGCGGGCGCGCGGCGAGGCGCTGGCGCAGGGCTTTGTCGGCTCGC
TGACGCTGGGCGCGGGGCAGTTCTGCACCAATCCCGGCCTGATCGTTGCCCTGCAGGGGCCGGCGCTGGATGGCTTCATC
GCCGCCGCGGCCGCCGTGCTGAGCCGCAGCCCGGCGCAGACCATGCTGACGCCCGGCATCTTCCGCGCTTACCAGGCCGG
CGTGGACGCGCTGTCCGGCCATGCCCGGCTGGCGGCCGCCGGCCTGCCGGCCACCGGGACCAACCAGTGCCAGGCCCAGC
TGTGGCTGGCCGAGGCGCGCGACTATCTGGCCAAGCCGGCGCTGCGGGCCGAAGTGTTCGGCGCCGCCGCCCTGATCGTG
GCATGCCGGGACGCGGCGGAGCTTGGCCAGCTTGCCGAGCAGCTGGAAGGGCAGCTCACCGCCACGCTGCAGCTGGACGA
CGGCGATCTGGACCTGGCTCACGCGCTGCTGCCCACGCTGGAGCGCAAGGCCGGCCGCATCCTGGTGAACGGCTGGCCCA
CCGGCGTGGAGGTGTGCGAGGCCATGGTGCACGGCGGACCGTACCCGGCCACCTCGGACGCGCGCGCCACCTCGGTGGGC
ACCGCGGCCATCCGGCGCTTCCTGCGGCCGGTCTGCTACCAGGACTTCCCGGACGCGCTGCTGCCGCCGGCATTGCGGCA
GGCCAACCCGCTGGCGCTGCGCCGCCTGTTGGACGGCCGGCGGGAGGGCTGA

Upstream 100 bases:

>100_bases
CGGCAGTCTACTTGCAGCCGCCGGCAACACCTCGCAGAGCGCCTGAGCCCAGGCGGGATCAGGGGCGTTGTCCGTGGTCC
TCAATCGCGCAGGAAACATG

Downstream 100 bases:

>100_bases
GTCATGGACGCTCTTGCCCCCGGCGCGGCCGTCATCGTGGTGGGCGCCGGCGTGGTCGGCATCGCCGCGGCCTTGCAGCT
GCGCCTGGCCGGTTTCGAGG

Product: ketoglutarate semialdehyde dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MNLTGKMLIGGQAVAGRRNMIRALDPSTDQPLEPGYAGADREQVEQACALAWEAFDAYRETAPEARARLLETIAEEIEAL
GDALIERAMAETGLPRARLQGERGRTCGQLRLFAHTLRAGEWLDARVDPAMPQRQPLPRADLRQRQVALGPVAVFGASNF
PLAFSVAGGDTASALAAGCPVIVKAHSAHPGASELAGRAIARAVEKCRLPAGVFALLFGEGREAGQALVADPRVKAVGFT
GSRGGGLALCRLAQSRPEPIPVFAEMSSTNPVFLLPAALRARGEALAQGFVGSLTLGAGQFCTNPGLIVALQGPALDGFI
AAAAAVLSRSPAQTMLTPGIFRAYQAGVDALSGHARLAAAGLPATGTNQCQAQLWLAEARDYLAKPALRAEVFGAAALIV
ACRDAAELGQLAEQLEGQLTATLQLDDGDLDLAHALLPTLERKAGRILVNGWPTGVEVCEAMVHGGPYPATSDARATSVG
TAAIRRFLRPVCYQDFPDALLPPALRQANPLALRRLLDGRREG

Sequences:

>Translated_523_residues
MNLTGKMLIGGQAVAGRRNMIRALDPSTDQPLEPGYAGADREQVEQACALAWEAFDAYRETAPEARARLLETIAEEIEAL
GDALIERAMAETGLPRARLQGERGRTCGQLRLFAHTLRAGEWLDARVDPAMPQRQPLPRADLRQRQVALGPVAVFGASNF
PLAFSVAGGDTASALAAGCPVIVKAHSAHPGASELAGRAIARAVEKCRLPAGVFALLFGEGREAGQALVADPRVKAVGFT
GSRGGGLALCRLAQSRPEPIPVFAEMSSTNPVFLLPAALRARGEALAQGFVGSLTLGAGQFCTNPGLIVALQGPALDGFI
AAAAAVLSRSPAQTMLTPGIFRAYQAGVDALSGHARLAAAGLPATGTNQCQAQLWLAEARDYLAKPALRAEVFGAAALIV
ACRDAAELGQLAEQLEGQLTATLQLDDGDLDLAHALLPTLERKAGRILVNGWPTGVEVCEAMVHGGPYPATSDARATSVG
TAAIRRFLRPVCYQDFPDALLPPALRQANPLALRRLLDGRREG
>Mature_523_residues
MNLTGKMLIGGQAVAGRRNMIRALDPSTDQPLEPGYAGADREQVEQACALAWEAFDAYRETAPEARARLLETIAEEIEAL
GDALIERAMAETGLPRARLQGERGRTCGQLRLFAHTLRAGEWLDARVDPAMPQRQPLPRADLRQRQVALGPVAVFGASNF
PLAFSVAGGDTASALAAGCPVIVKAHSAHPGASELAGRAIARAVEKCRLPAGVFALLFGEGREAGQALVADPRVKAVGFT
GSRGGGLALCRLAQSRPEPIPVFAEMSSTNPVFLLPAALRARGEALAQGFVGSLTLGAGQFCTNPGLIVALQGPALDGFI
AAAAAVLSRSPAQTMLTPGIFRAYQAGVDALSGHARLAAAGLPATGTNQCQAQLWLAEARDYLAKPALRAEVFGAAALIV
ACRDAAELGQLAEQLEGQLTATLQLDDGDLDLAHALLPTLERKAGRILVNGWPTGVEVCEAMVHGGPYPATSDARATSVG
TAAIRRFLRPVCYQDFPDALLPPALRQANPLALRRLLDGRREG

Specific function: Catalyzes the oxidation of long-chain aliphatic aldehydes to acids. May be implicated in controlling luminescence as it catalyzes the oxidation of the fatty aldehyde substrate for the light-emitting reaction [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87081896, Length=452, Percent_Identity=27.212389380531, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788042, Length=337, Percent_Identity=30.2670623145401, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1787715, Length=316, Percent_Identity=30.379746835443, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787250, Length=303, Percent_Identity=30.3630363036304, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319478, Length=254, Percent_Identity=27.1653543307087, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320917, Length=275, Percent_Identity=26.5454545454545, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24666674, Length=338, Percent_Identity=26.6272189349112, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.4 [H]

Molecular weight: Translated: 54800; Mature: 54800

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTGKMLIGGQAVAGRRNMIRALDPSTDQPLEPGYAGADREQVEQACALAWEAFDAYRE
CCCCCCEEECCCHHCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TAPEARARLLETIAEEIEALGDALIERAMAETGLPRARLQGERGRTCGQLRLFAHTLRAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHCC
EWLDARVDPAMPQRQPLPRADLRQRQVALGPVAVFGASNFPLAFSVAGGDTASALAAGCP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCHHHHHHCCCC
VIVKAHSAHPGASELAGRAIARAVEKCRLPAGVFALLFGEGREAGQALVADPRVKAVGFT
EEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHCCEEECCCCEEEEECC
GSRGGGLALCRLAQSRPEPIPVFAEMSSTNPVFLLPAALRARGEALAQGFVGSLTLGAGQ
CCCCCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHCCHHHEECCCCC
FCTNPGLIVALQGPALDGFIAAAAAVLSRSPAQTMLTPGIFRAYQAGVDALSGHARLAAA
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHCCCHHEEEC
GLPATGTNQCQAQLWLAEARDYLAKPALRAEVFGAAALIVACRDAAELGQLAEQLEGQLT
CCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEE
ATLQLDDGDLDLAHALLPTLERKAGRILVNGWPTGVEVCEAMVHGGPYPATSDARATSVG
EEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHH
TAAIRRFLRPVCYQDFPDALLPPALRQANPLALRRLLDGRREG
HHHHHHHHHHHHHCCCCHHHCCHHHHCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MNLTGKMLIGGQAVAGRRNMIRALDPSTDQPLEPGYAGADREQVEQACALAWEAFDAYRE
CCCCCCEEECCCHHCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TAPEARARLLETIAEEIEALGDALIERAMAETGLPRARLQGERGRTCGQLRLFAHTLRAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHCC
EWLDARVDPAMPQRQPLPRADLRQRQVALGPVAVFGASNFPLAFSVAGGDTASALAAGCP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCHHHHHHCCCC
VIVKAHSAHPGASELAGRAIARAVEKCRLPAGVFALLFGEGREAGQALVADPRVKAVGFT
EEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHCCEEECCCCEEEEECC
GSRGGGLALCRLAQSRPEPIPVFAEMSSTNPVFLLPAALRARGEALAQGFVGSLTLGAGQ
CCCCCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHCCHHHEECCCCC
FCTNPGLIVALQGPALDGFIAAAAAVLSRSPAQTMLTPGIFRAYQAGVDALSGHARLAAA
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHCCCHHEEEC
GLPATGTNQCQAQLWLAEARDYLAKPALRAEVFGAAALIVACRDAAELGQLAEQLEGQLT
CCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEE
ATLQLDDGDLDLAHALLPTLERKAGRILVNGWPTGVEVCEAMVHGGPYPATSDARATSVG
EEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHH
TAAIRRFLRPVCYQDFPDALLPPALRQANPLALRRLLDGRREG
HHHHHHHHHHHHHCCCCHHHCCHHHHCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8527447; 10903148 [H]