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The map label for this gene is lysP [H]

Identifier: 34498185

GI number: 34498185

Start: 2959342

End: 2960868

Strand: Reverse

Name: lysP [H]

Synonym: CV_2730

Alternate gene names: 34498185

Gene position: 2960868-2959342 (Counterclockwise)

Preceding gene: 34498186

Following gene: 34498184

Centisome position: 62.32

GC content: 65.09

Gene sequence:

>1527_bases
ATGAGCAAGAAACAAGACGCGCCGGAGCTGCGGCGCTCGCTGCAGGCTCGACACCTGTCGATGATCGCCATCGGCGGCTC
GATCGGCACCGGCCTGTTCCTGGCGTCCGGCGCCACCATCTCGGGCGCGGGCGCCGGCGGCGCGCTGCTGGCCTACGCGC
TGGTCGGCCTGATGGTGTACTTCCTGATGACCAGCCTGGGCGAAATGGCCGCCTTCATGCCGGTGTCCGGCTCCTTCCAG
GCCTACGGCTCGCGTTTCGTCGATCCGGCCTTCGGCTTCGCGCAGGGCTGGAACTACTGGTACAACTGGGCGATCACCGT
CGCGGTGGAACTGGCCGCGGCCGCCATCATCATGAACTACTGGTATCCCGGGATACCGGGCGTGGTGTGGAGCGGGGGCT
TCCTGGCCATCATCTTCGCGCTCAACTATTTCTCGGTGAAGGGCTTCGGCGAGGCCGAGTTCTGGTGCTCGATGCTGAAG
GTGGCCACCATCATCGCCTTCATCGTCATCGGCTTCCTGATGATTCTGGGCATCATGACCGAGCCGAACCCGAGCCGCAT
CGCGCCGGGTCTGCAAGTGATGATGCAGGGCGAGGGGCCCTTCGTCGGCGGCCTGGCGGCCTTCGTCGGCGTGGCCATGG
TGGTGGGCTTCTCCTTCCAGGGCACCGAGCTGATCGGCGTCGCCGCGGGCGAGTCGGCCAACCCCGGCCGCACCATTCCG
CGCGCCGTGCGCCAGATCTTCTGGCGCATCCTGATGTTCTACATGCTGTCCATCCTGATCATCGGTCTGATCCTGCCGCA
CAACGATCCGTCGCTGCTGAAGAACGACATGAAGGATGTCGGCGCCAGCCCGTTCACGCTGGTGTTCAACCGCGCCGGCC
TCGCTTTCGCCGCCAGTCTGATGAACGCGGTGATCCTGTCCGCCATCCTGTCGGCCGGCAACTCCGGCATGTACGCGTCC
ACCCGCATGCTGTACGCGATGGCCAAGAACGGCATGGCGCCCAAGGTTTTCGGCAAGCTGACCGACAACGGCGTGCCGCG
CAACGCGCTGTACGCCACCACGCTGGTGGCCTGCCTGTGCTTCCTGACGTCGTTGTTCCAGAGCAACGCTGTCTACATGT
GGCTGTTGAACTCGTCCGGCATGACCGGCTTCATCGCCTGGCTGGGCGTGGCGATCAGCCATTACCGCTTCCGCCGCGCC
TACGTGAAGCAGGGCTACAGCCTGGACGACCTGCCGTACAAGGCCAAATGGTTCCCGCTGGGCCCGCTGTTCGCCTTCGC
GCTGTGCCTGCTGATCATGCTGGGCCAGAACTACACCGCCTTCACCGCCGCCAAGGTGGATTGGAACGGCGTCATCGCCA
CCTATCTGGGCATTCCGCTGTTCCTGGCGCTGTGGTGGGGCTACCGCGTCAAGCACAATACCCGCATGGTGCCCTTGGAA
AAGGTGGAACTGGCGGAGGCGCATCGCAACGCCTTGATGCAGCGAGAGGAAAATCGCGGCGGCAAGCCCGCCGCCGCCCA
GGCCTGA

Upstream 100 bases:

>100_bases
TCGATGTCATTCTTTGCCGCTTTGATTGTCCCGAGCCCGGCGAACCGCCCGGGCGGCGCCGGCTCAGGCCCGCGCGGCAG
AACAACAGAGTGAGTTGGAT

Downstream 100 bases:

>100_bases
GCGGGCTGGAAAAATGGTTGACCAAGCCCGCTGGCAAGCGGGCTTTTTTTATGGTTTCATCCGCTATCCTGACAACATTT
TAAACCTTCCAGGCGGGGTG

Product: lysine-specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSKKQDAPELRRSLQARHLSMIAIGGSIGTGLFLASGATISGAGAGGALLAYALVGLMVYFLMTSLGEMAAFMPVSGSFQ
AYGSRFVDPAFGFAQGWNYWYNWAITVAVELAAAAIIMNYWYPGIPGVVWSGGFLAIIFALNYFSVKGFGEAEFWCSMLK
VATIIAFIVIGFLMILGIMTEPNPSRIAPGLQVMMQGEGPFVGGLAAFVGVAMVVGFSFQGTELIGVAAGESANPGRTIP
RAVRQIFWRILMFYMLSILIIGLILPHNDPSLLKNDMKDVGASPFTLVFNRAGLAFAASLMNAVILSAILSAGNSGMYAS
TRMLYAMAKNGMAPKVFGKLTDNGVPRNALYATTLVACLCFLTSLFQSNAVYMWLLNSSGMTGFIAWLGVAISHYRFRRA
YVKQGYSLDDLPYKAKWFPLGPLFAFALCLLIMLGQNYTAFTAAKVDWNGVIATYLGIPLFLALWWGYRVKHNTRMVPLE
KVELAEAHRNALMQREENRGGKPAAAQA

Sequences:

>Translated_508_residues
MSKKQDAPELRRSLQARHLSMIAIGGSIGTGLFLASGATISGAGAGGALLAYALVGLMVYFLMTSLGEMAAFMPVSGSFQ
AYGSRFVDPAFGFAQGWNYWYNWAITVAVELAAAAIIMNYWYPGIPGVVWSGGFLAIIFALNYFSVKGFGEAEFWCSMLK
VATIIAFIVIGFLMILGIMTEPNPSRIAPGLQVMMQGEGPFVGGLAAFVGVAMVVGFSFQGTELIGVAAGESANPGRTIP
RAVRQIFWRILMFYMLSILIIGLILPHNDPSLLKNDMKDVGASPFTLVFNRAGLAFAASLMNAVILSAILSAGNSGMYAS
TRMLYAMAKNGMAPKVFGKLTDNGVPRNALYATTLVACLCFLTSLFQSNAVYMWLLNSSGMTGFIAWLGVAISHYRFRRA
YVKQGYSLDDLPYKAKWFPLGPLFAFALCLLIMLGQNYTAFTAAKVDWNGVIATYLGIPLFLALWWGYRVKHNTRMVPLE
KVELAEAHRNALMQREENRGGKPAAAQA
>Mature_507_residues
SKKQDAPELRRSLQARHLSMIAIGGSIGTGLFLASGATISGAGAGGALLAYALVGLMVYFLMTSLGEMAAFMPVSGSFQA
YGSRFVDPAFGFAQGWNYWYNWAITVAVELAAAAIIMNYWYPGIPGVVWSGGFLAIIFALNYFSVKGFGEAEFWCSMLKV
ATIIAFIVIGFLMILGIMTEPNPSRIAPGLQVMMQGEGPFVGGLAAFVGVAMVVGFSFQGTELIGVAAGESANPGRTIPR
AVRQIFWRILMFYMLSILIIGLILPHNDPSLLKNDMKDVGASPFTLVFNRAGLAFAASLMNAVILSAILSAGNSGMYAST
RMLYAMAKNGMAPKVFGKLTDNGVPRNALYATTLVACLCFLTSLFQSNAVYMWLLNSSGMTGFIAWLGVAISHYRFRRAY
VKQGYSLDDLPYKAKWFPLGPLFAFALCLLIMLGQNYTAFTAAKVDWNGVIATYLGIPLFLALWWGYRVKHNTRMVPLEK
VELAEAHRNALMQREENRGGKPAAAQA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=489, Percent_Identity=64.2126789366053, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=487, Percent_Identity=39.8357289527721, Blast_Score=341, Evalue=7e-95,
Organism=Escherichia coli, GI48994972, Length=483, Percent_Identity=33.9544513457557, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1786302, Length=435, Percent_Identity=35.1724137931034, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1786789, Length=433, Percent_Identity=34.4110854503464, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1789017, Length=486, Percent_Identity=32.0987654320988, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1790653, Length=354, Percent_Identity=35.3107344632768, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87081915, Length=483, Percent_Identity=31.4699792960663, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1786602, Length=397, Percent_Identity=35.7682619647355, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87081869, Length=342, Percent_Identity=22.5146198830409, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082023, Length=348, Percent_Identity=25, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=491, Percent_Identity=39.3075356415479, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324061, Length=494, Percent_Identity=36.8421052631579, Blast_Score=349, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6324059, Length=501, Percent_Identity=37.9241516966068, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6324990, Length=513, Percent_Identity=36.0623781676413, Blast_Score=316, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6322892, Length=503, Percent_Identity=34.5924453280318, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6324924, Length=515, Percent_Identity=33.3980582524272, Blast_Score=290, Evalue=5e-79,
Organism=Saccharomyces cerevisiae, GI6321629, Length=496, Percent_Identity=32.8629032258064, Blast_Score=277, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6324553, Length=435, Percent_Identity=35.632183908046, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6319824, Length=511, Percent_Identity=30.3326810176125, Blast_Score=256, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6320717, Length=517, Percent_Identity=29.7872340425532, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6320251, Length=514, Percent_Identity=29.9610894941634, Blast_Score=253, Evalue=7e-68,
Organism=Saccharomyces cerevisiae, GI6319542, Length=509, Percent_Identity=29.4695481335953, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6319543, Length=496, Percent_Identity=28.6290322580645, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6322967, Length=505, Percent_Identity=30.4950495049505, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321053, Length=516, Percent_Identity=29.6511627906977, Blast_Score=227, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6319608, Length=482, Percent_Identity=29.8755186721992, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6324981, Length=506, Percent_Identity=32.6086956521739, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6320364, Length=560, Percent_Identity=24.8214285714286, Blast_Score=167, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 55019; Mature: 54887

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKQDAPELRRSLQARHLSMIAIGGSIGTGLFLASGATISGAGAGGALLAYALVGLMVY
CCCCCCCHHHHHHHHHHHHEEEEECCCCCCCCEEECCCEECCCCCCHHHHHHHHHHHHHH
FLMTSLGEMAAFMPVSGSFQAYGSRFVDPAFGFAQGWNYWYNWAITVAVELAAAAIIMNY
HHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
WYPGIPGVVWSGGFLAIIFALNYFSVKGFGEAEFWCSMLKVATIIAFIVIGFLMILGIMT
CCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EPNPSRIAPGLQVMMQGEGPFVGGLAAFVGVAMVVGFSFQGTELIGVAAGESANPGRTIP
CCCHHHCCCCHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHH
RAVRQIFWRILMFYMLSILIIGLILPHNDPSLLKNDMKDVGASPFTLVFNRAGLAFAASL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
MNAVILSAILSAGNSGMYASTRMLYAMAKNGMAPKVFGKLTDNGVPRNALYATTLVACLC
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
FLTSLFQSNAVYMWLLNSSGMTGFIAWLGVAISHYRFRRAYVKQGYSLDDLPYKAKWFPL
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCC
GPLFAFALCLLIMLGQNYTAFTAAKVDWNGVIATYLGIPLFLALWWGYRVKHNTRMVPLE
CHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEECCCEECCHH
KVELAEAHRNALMQREENRGGKPAAAQA
HHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SKKQDAPELRRSLQARHLSMIAIGGSIGTGLFLASGATISGAGAGGALLAYALVGLMVY
CCCCCCHHHHHHHHHHHHEEEEECCCCCCCCEEECCCEECCCCCCHHHHHHHHHHHHHH
FLMTSLGEMAAFMPVSGSFQAYGSRFVDPAFGFAQGWNYWYNWAITVAVELAAAAIIMNY
HHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
WYPGIPGVVWSGGFLAIIFALNYFSVKGFGEAEFWCSMLKVATIIAFIVIGFLMILGIMT
CCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EPNPSRIAPGLQVMMQGEGPFVGGLAAFVGVAMVVGFSFQGTELIGVAAGESANPGRTIP
CCCHHHCCCCHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHH
RAVRQIFWRILMFYMLSILIIGLILPHNDPSLLKNDMKDVGASPFTLVFNRAGLAFAASL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
MNAVILSAILSAGNSGMYASTRMLYAMAKNGMAPKVFGKLTDNGVPRNALYATTLVACLC
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
FLTSLFQSNAVYMWLLNSSGMTGFIAWLGVAISHYRFRRAYVKQGYSLDDLPYKAKWFPL
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCC
GPLFAFALCLLIMLGQNYTAFTAAKVDWNGVIATYLGIPLFLALWWGYRVKHNTRMVPLE
CHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEECCCEECCHH
KVELAEAHRNALMQREENRGGKPAAAQA
HHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]