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The map label for this gene is fadA [H]

Identifier: 34498174

GI number: 34498174

Start: 2945182

End: 2946384

Strand: Reverse

Name: fadA [H]

Synonym: CV_2719

Alternate gene names: 34498174

Gene position: 2946384-2945182 (Counterclockwise)

Preceding gene: 34498175

Following gene: 34498170

Centisome position: 62.02

GC content: 67.0

Gene sequence:

>1203_bases
ATGAGCAAACAAGTACAAGAAGCTTACATCGTCGCCGCCACCCGCACCCCGGTGGGCAAGGCGCCGCGCGGCATGATGCG
CCATGTGCGCCCGGACGACATGCTGGCGCATGTGATCACCGGCGCGCTGGCCCAGGTGCCGAGCCTGGATCCCAAGCTGA
TTTCCGACTGCGTGGTGGGTTGCGCCTTCCCGGAGGCGGAGCAGGGCCTGAACATGGCGCGCATCGGCGTGCTGCTGGCC
GGCCTGCCCAATACCGTGGGCGGCATCACCATCAACCGCTACTGCTCGTCCGGCATCAACGCGGTGCAGATGGCGGCCGA
CCGCATCCGCCTGGGTGAAGCCGACGTGGTGATCGCGGCCGGTTCCGAATCGATGTCGCTGGTGCCGATGATGGGCAACA
AGGTGTCGCTGAACCCGGAAATCTTCGCCAAGGACGAGAACTACGGCATCGCCTACGGCATGGGCCTGACCGCTGAAAAA
GTGGCGCAGCAATGGGGCGTGTCGCGCGAGGATCAGGACGCGTTCGCGGTGGAGTCGCACCGCCGCGCGCTGGCCGCGAT
CGACGGCGGCAAGTTCAAGAACGAGATCACTCCGCTGGAAGTGACCTACCGCACGCCGAATCTGGAAACCGGCGAAGTGG
TGGTGAAGAAGCGCGTGCTGGACACCGACGAAGGCCCGCGCCGCGAAACCACGCTGGAAGGCCTGGCCAAGCTGAAGACC
GTGTTCGACGCCAAGGGCTCCGTCACCGCCGGCAACTCTTCGCAGATGTCCGACGGCGCCGGCGCGGTGATCCTGGTGTC
CGAACGCGTGCTGAAGGAGTTCAACCTCACGCCGCTGGCCCGCTACGTGACCTTCTCGGTCAAGGGCGTGCCGCCGGAGA
TCATGGGCATCGGCCCCAAGGAAGCCATCCCGGCCGCGCTGGCCCAGGCCGGCCTGAAGCAGGATGACCTGAAGTGGATC
GAACTGAACGAAGCCTTCGCCGCCCAGGCGCTGGCCGTGATCCGCGATCTGAACCTGGACACGTCCAAGGTGAACCCGCA
CGGCGGCGCCATCGCCCTGGGCCACCCGCTGGGCGCGACCGGCGCCATCCGCACCGCCACCCTGGTGCACGGCATGCGCG
ACGCCGGCCTGAAGGGCCACGGCATGGTGACGATGTGCATCGGCACCGGCATGGGCGCGGCAGGCATCATCGAGGTGCTG
TAA

Upstream 100 bases:

>100_bases
CCCGCTCGCGACGAATCCTCCCGCAAGTACGGCCAATAGCCAGATGACAGGCCGCTTGATCGCCGTAGAGGCGATCAAGC
GGCCGACAGGAGAATCGAAA

Downstream 100 bases:

>100_bases
TCCGGCTGGTCCGCCATCGCTTGGAACAAACGCCACGGCTTCGCGCCGTGGCGTTTTTCATGGCGCCGGCCGAGCGGGCG
CTGGCGATCTTCGGGAGCGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSKQVQEAYIVAATRTPVGKAPRGMMRHVRPDDMLAHVITGALAQVPSLDPKLISDCVVGCAFPEAEQGLNMARIGVLLA
GLPNTVGGITINRYCSSGINAVQMAADRIRLGEADVVIAAGSESMSLVPMMGNKVSLNPEIFAKDENYGIAYGMGLTAEK
VAQQWGVSREDQDAFAVESHRRALAAIDGGKFKNEITPLEVTYRTPNLETGEVVVKKRVLDTDEGPRRETTLEGLAKLKT
VFDAKGSVTAGNSSQMSDGAGAVILVSERVLKEFNLTPLARYVTFSVKGVPPEIMGIGPKEAIPAALAQAGLKQDDLKWI
ELNEAFAAQALAVIRDLNLDTSKVNPHGGAIALGHPLGATGAIRTATLVHGMRDAGLKGHGMVTMCIGTGMGAAGIIEVL

Sequences:

>Translated_400_residues
MSKQVQEAYIVAATRTPVGKAPRGMMRHVRPDDMLAHVITGALAQVPSLDPKLISDCVVGCAFPEAEQGLNMARIGVLLA
GLPNTVGGITINRYCSSGINAVQMAADRIRLGEADVVIAAGSESMSLVPMMGNKVSLNPEIFAKDENYGIAYGMGLTAEK
VAQQWGVSREDQDAFAVESHRRALAAIDGGKFKNEITPLEVTYRTPNLETGEVVVKKRVLDTDEGPRRETTLEGLAKLKT
VFDAKGSVTAGNSSQMSDGAGAVILVSERVLKEFNLTPLARYVTFSVKGVPPEIMGIGPKEAIPAALAQAGLKQDDLKWI
ELNEAFAAQALAVIRDLNLDTSKVNPHGGAIALGHPLGATGAIRTATLVHGMRDAGLKGHGMVTMCIGTGMGAAGIIEVL
>Mature_399_residues
SKQVQEAYIVAATRTPVGKAPRGMMRHVRPDDMLAHVITGALAQVPSLDPKLISDCVVGCAFPEAEQGLNMARIGVLLAG
LPNTVGGITINRYCSSGINAVQMAADRIRLGEADVVIAAGSESMSLVPMMGNKVSLNPEIFAKDENYGIAYGMGLTAEKV
AQQWGVSREDQDAFAVESHRRALAAIDGGKFKNEITPLEVTYRTPNLETGEVVVKKRVLDTDEGPRRETTLEGLAKLKTV
FDAKGSVTAGNSSQMSDGAGAVILVSERVLKEFNLTPLARYVTFSVKGVPPEIMGIGPKEAIPAALAQAGLKQDDLKWIE
LNEAFAAQALAVIRDLNLDTSKVNPHGGAIALGHPLGATGAIRTATLVHGMRDAGLKGHGMVTMCIGTGMGAAGIIEVL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=43.3673469387755, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI167614485, Length=400, Percent_Identity=39.75, Blast_Score=264, Evalue=9e-71,
Organism=Homo sapiens, GI148539872, Length=401, Percent_Identity=37.6558603491272, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI4557237, Length=408, Percent_Identity=36.0294117647059, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=31.9796954314721, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI4504327, Length=444, Percent_Identity=29.2792792792793, Blast_Score=142, Evalue=5e-34,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=42.8571428571429, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=42.2330097087379, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=39.3564356435644, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1788554, Length=409, Percent_Identity=39.8533007334963, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1788683, Length=432, Percent_Identity=31.712962962963, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=400, Percent_Identity=38.5, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI25147385, Length=406, Percent_Identity=33.2512315270936, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17535921, Length=407, Percent_Identity=33.9066339066339, Blast_Score=191, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=30.0254452926209, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17551802, Length=405, Percent_Identity=28.3950617283951, Blast_Score=128, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=408, Percent_Identity=38.7254901960784, Blast_Score=266, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6325229, Length=409, Percent_Identity=37.4083129584352, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24655093, Length=405, Percent_Identity=38.2716049382716, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI17648125, Length=413, Percent_Identity=38.7409200968523, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24640423, Length=412, Percent_Identity=34.7087378640777, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17137578, Length=447, Percent_Identity=29.5302013422819, Blast_Score=138, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42117; Mature: 41986

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQVQEAYIVAATRTPVGKAPRGMMRHVRPDDMLAHVITGALAQVPSLDPKLISDCVVG
CCCCCCEEEEEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAFPEAEQGLNMARIGVLLAGLPNTVGGITINRYCSSGINAVQMAADRIRLGEADVVIAA
CCCCCHHHCCCHHHHHHHHHCCCCCCCCEEEEHHHHCCCHHHHHHHHHHCCCCCCEEEEE
GSESMSLVPMMGNKVSLNPEIFAKDENYGIAYGMGLTAEKVAQQWGVSREDQDAFAVESH
CCCCCEEEEECCCEEECCCEEEEECCCCCEEEECCCCHHHHHHHHCCCCCCCCHHHHHHH
RRALAAIDGGKFKNEITPLEVTYRTPNLETGEVVVKKRVLDTDEGPRRETTLEGLAKLKT
HHEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHEEHHHCCCCCCCCHHHHHHHHHHHHH
VFDAKGSVTAGNSSQMSDGAGAVILVSERVLKEFNLTPLARYVTFSVKGVPPEIMGIGPK
HHCCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCCEEEEEEEEECCCCHHHCCCCCH
EAIPAALAQAGLKQDDLKWIELNEAFAAQALAVIRDLNLDTSKVNPHGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRTATLVHGMRDAGLKGHGMVTMCIGTGMGAAGIIEVL
CHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHCCC
>Mature Secondary Structure 
SKQVQEAYIVAATRTPVGKAPRGMMRHVRPDDMLAHVITGALAQVPSLDPKLISDCVVG
CCCCCEEEEEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAFPEAEQGLNMARIGVLLAGLPNTVGGITINRYCSSGINAVQMAADRIRLGEADVVIAA
CCCCCHHHCCCHHHHHHHHHCCCCCCCCEEEEHHHHCCCHHHHHHHHHHCCCCCCEEEEE
GSESMSLVPMMGNKVSLNPEIFAKDENYGIAYGMGLTAEKVAQQWGVSREDQDAFAVESH
CCCCCEEEEECCCEEECCCEEEEECCCCCEEEECCCCHHHHHHHHCCCCCCCCHHHHHHH
RRALAAIDGGKFKNEITPLEVTYRTPNLETGEVVVKKRVLDTDEGPRRETTLEGLAKLKT
HHEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHEEHHHCCCCCCCCHHHHHHHHHHHHH
VFDAKGSVTAGNSSQMSDGAGAVILVSERVLKEFNLTPLARYVTFSVKGVPPEIMGIGPK
HHCCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCCEEEEEEEEECCCCHHHCCCCCH
EAIPAALAQAGLKQDDLKWIELNEAFAAQALAVIRDLNLDTSKVNPHGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRTATLVHGMRDAGLKGHGMVTMCIGTGMGAAGIIEVL
CHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]