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The map label for this gene is pepD [H]

Identifier: 34498149

GI number: 34498149

Start: 2917214

End: 2918668

Strand: Reverse

Name: pepD [H]

Synonym: CV_2694

Alternate gene names: 34498149

Gene position: 2918668-2917214 (Counterclockwise)

Preceding gene: 34498150

Following gene: 34498148

Centisome position: 61.43

GC content: 66.25

Gene sequence:

>1455_bases
GTGACCGATATCGCCAAGCTCGAACCGACCGCTGTCTGGGAACATTTCCAAACCCTGTGCGACATTCCGCGCCCGTCCAA
GCATGAGGAACAAGTGCGCGACTACATGAAAGGCTGGGCGGAACTGCGCGGCCTGGAAACCGTGGTCGACAAGGTCGGCA
ACCTGATCATCCGCAAGCCGGCCACGCCGGGCTACGAAGATCGCGCCGGCGTGGTGCTGCAGGGCCATCTGGACATGGTG
TGCCAGGCCAATAGCGGCACCGAACACGACTTCTTCAAGGATCCTATCCGTCCGGTATTGAAGGATGGCTGGCTGGTGGC
CGAAAACACTACGCTGGGCGCCGACAACGGTATCGGCGTGGCGCTGGGCATGGCGGTGCTGTCCGGCGACGACGTTGCCC
ATGGCCCGGTGGAAGTGCTGCTCACGCTGGATGAAGAAGCCGGCATGGGCGGCGCGCTGGGCCTGGAAACCGGCTTGCTG
CGCGGCCAGTACCTGATCAACATCGATACCGAGGAGTGGGGCGAGTTCTACATGGGCTGCGCCGGCGGCGTGGACGTCAA
CGTCACCCGCGAATACGCCGTTGAGGCGGTTCCGGCCGGCTTCCAGACCGCCAGCCTGACCATCAAGGGCTTGAAGGGCG
GCCACTCCGGCGCCGACATCCACCTGGGCCGCGGCAACGCCAACAAGATCCTGATCCGCCTGCTTCGCGAACTGGAAGCC
GAAACCGAGTTGCGCCTGTCCTCGCTGCAGGGCGGCACCGCCCGCAACGCGCTGTCGCGCGAAGCCTTCGCCGTGGTGGC
TTACCCGACTGCCGACGCCGCCAAGGTGGCGGCCAAGCTGGACGCGTTCCAGGCGCTGATGCGCTTCGAGTTGGCCGGCG
TCGACGAAGGCGTGTCCGTTCTGTCCGAGGCGGCCCCCGCCGCCGGCGTGCTGGCGCGCGCCGACCAGGATGTGATCCTG
GCCGCGCTGCATGCGGCGCCGCATGGCGTCAAACGCATGAGTCAGCGCGTGGAGGGGGTGGTGGAAACCTCGAACAACCT
GGGGGTGGTCAGCGTGGCGGACGGCAAGGTGTTCGCCAACCTGATGGTGCGCTCGCTGCTGGATTCCGGCACCTGGATGC
TGGCGCGCGAAGCGGAAAGCCTGTTCAAGCTGGCGGCGTTCAAGGTGGAGATGGAAGGCGGATACCCGGGCTGGGCGCCG
AATCCGCAGTCCAAGCTGCTGGCTTTGTTCAAGGATGTGTACCGCCGGGAGTTCGGCGCCGAGGCCGAGGTGCAGGTGAT
CCACGCCGGTCTGGAATGCGGCATCCTGGGCTCCAAGTATCCGAACCTGGACATGGTGTCATTCGGCCCGAACATCCGCG
GCGCGCACGCGCCCGGCGAACGCGTCGAAGTGGAGTCGGTCGGCAAGGCCTGGCAGTTGCTGCAGGCGGTGCTGAAGGCG
ATTCCGGCGCGTTGA

Upstream 100 bases:

>100_bases
GGCGTCATATATTTCCAGCCTTCGCCGCAATGGCGGATGTTGTACCCGGCGGTGCGGCCAACCGTGAGCCTCGCCGCGAC
ACCGAATCAAGGAATGCGTT

Downstream 100 bases:

>100_bases
GCGGTTTCACCCGAAGATGAAGAACGGTCTGGCTTTGCCAGGCCGTTTTTTTATTTCGGCCGCGGGCTGATCATGGCAAG
CTGCGGGTTTGCCAAAATTC

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MTDIAKLEPTAVWEHFQTLCDIPRPSKHEEQVRDYMKGWAELRGLETVVDKVGNLIIRKPATPGYEDRAGVVLQGHLDMV
CQANSGTEHDFFKDPIRPVLKDGWLVAENTTLGADNGIGVALGMAVLSGDDVAHGPVEVLLTLDEEAGMGGALGLETGLL
RGQYLINIDTEEWGEFYMGCAGGVDVNVTREYAVEAVPAGFQTASLTIKGLKGGHSGADIHLGRGNANKILIRLLRELEA
ETELRLSSLQGGTARNALSREAFAVVAYPTADAAKVAAKLDAFQALMRFELAGVDEGVSVLSEAAPAAGVLARADQDVIL
AALHAAPHGVKRMSQRVEGVVETSNNLGVVSVADGKVFANLMVRSLLDSGTWMLAREAESLFKLAAFKVEMEGGYPGWAP
NPQSKLLALFKDVYRREFGAEAEVQVIHAGLECGILGSKYPNLDMVSFGPNIRGAHAPGERVEVESVGKAWQLLQAVLKA
IPAR

Sequences:

>Translated_484_residues
MTDIAKLEPTAVWEHFQTLCDIPRPSKHEEQVRDYMKGWAELRGLETVVDKVGNLIIRKPATPGYEDRAGVVLQGHLDMV
CQANSGTEHDFFKDPIRPVLKDGWLVAENTTLGADNGIGVALGMAVLSGDDVAHGPVEVLLTLDEEAGMGGALGLETGLL
RGQYLINIDTEEWGEFYMGCAGGVDVNVTREYAVEAVPAGFQTASLTIKGLKGGHSGADIHLGRGNANKILIRLLRELEA
ETELRLSSLQGGTARNALSREAFAVVAYPTADAAKVAAKLDAFQALMRFELAGVDEGVSVLSEAAPAAGVLARADQDVIL
AALHAAPHGVKRMSQRVEGVVETSNNLGVVSVADGKVFANLMVRSLLDSGTWMLAREAESLFKLAAFKVEMEGGYPGWAP
NPQSKLLALFKDVYRREFGAEAEVQVIHAGLECGILGSKYPNLDMVSFGPNIRGAHAPGERVEVESVGKAWQLLQAVLKA
IPAR
>Mature_483_residues
TDIAKLEPTAVWEHFQTLCDIPRPSKHEEQVRDYMKGWAELRGLETVVDKVGNLIIRKPATPGYEDRAGVVLQGHLDMVC
QANSGTEHDFFKDPIRPVLKDGWLVAENTTLGADNGIGVALGMAVLSGDDVAHGPVEVLLTLDEEAGMGGALGLETGLLR
GQYLINIDTEEWGEFYMGCAGGVDVNVTREYAVEAVPAGFQTASLTIKGLKGGHSGADIHLGRGNANKILIRLLRELEAE
TELRLSSLQGGTARNALSREAFAVVAYPTADAAKVAAKLDAFQALMRFELAGVDEGVSVLSEAAPAAGVLARADQDVILA
ALHAAPHGVKRMSQRVEGVVETSNNLGVVSVADGKVFANLMVRSLLDSGTWMLAREAESLFKLAAFKVEMEGGYPGWAPN
PQSKLLALFKDVYRREFGAEAEVQVIHAGLECGILGSKYPNLDMVSFGPNIRGAHAPGERVEVESVGKAWQLLQAVLKAI
PAR

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=486, Percent_Identity=48.7654320987654, Blast_Score=479, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 51766; Mature: 51635

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIAKLEPTAVWEHFQTLCDIPRPSKHEEQVRDYMKGWAELRGLETVVDKVGNLIIRKP
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
ATPGYEDRAGVVLQGHLDMVCQANSGTEHDFFKDPIRPVLKDGWLVAENTTLGADNGIGV
CCCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEECCEECCCCCCHH
ALGMAVLSGDDVAHGPVEVLLTLDEEAGMGGALGLETGLLRGQYLINIDTEEWGEFYMGC
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCEEEEEECHHHHHHHHHCC
AGGVDVNVTREYAVEAVPAGFQTASLTIKGLKGGHSGADIHLGRGNANKILIRLLRELEA
CCCCEEEEEHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHH
ETELRLSSLQGGTARNALSREAFAVVAYPTADAAKVAAKLDAFQALMRFELAGVDEGVSV
HHHHHHHHCCCCHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LSEAAPAAGVLARADQDVILAALHAAPHGVKRMSQRVEGVVETSNNLGVVSVADGKVFAN
HHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
LMVRSLLDSGTWMLAREAESLFKLAAFKVEMEGGYPGWAPNPQSKLLALFKDVYRREFGA
HHHHHHHCCCCEEEHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
EAEVQVIHAGLECGILGSKYPNLDMVSFGPNIRGAHAPGERVEVESVGKAWQLLQAVLKA
CCEEEEEEECCEECCCCCCCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHH
IPAR
CCCC
>Mature Secondary Structure 
TDIAKLEPTAVWEHFQTLCDIPRPSKHEEQVRDYMKGWAELRGLETVVDKVGNLIIRKP
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
ATPGYEDRAGVVLQGHLDMVCQANSGTEHDFFKDPIRPVLKDGWLVAENTTLGADNGIGV
CCCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEECCEECCCCCCHH
ALGMAVLSGDDVAHGPVEVLLTLDEEAGMGGALGLETGLLRGQYLINIDTEEWGEFYMGC
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCEEEEEECHHHHHHHHHCC
AGGVDVNVTREYAVEAVPAGFQTASLTIKGLKGGHSGADIHLGRGNANKILIRLLRELEA
CCCCEEEEEHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHH
ETELRLSSLQGGTARNALSREAFAVVAYPTADAAKVAAKLDAFQALMRFELAGVDEGVSV
HHHHHHHHCCCCHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LSEAAPAAGVLARADQDVILAALHAAPHGVKRMSQRVEGVVETSNNLGVVSVADGKVFAN
HHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
LMVRSLLDSGTWMLAREAESLFKLAAFKVEMEGGYPGWAPNPQSKLLALFKDVYRREFGA
HHHHHHHCCCCEEEHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
EAEVQVIHAGLECGILGSKYPNLDMVSFGPNIRGAHAPGERVEVESVGKAWQLLQAVLKA
CCEEEEEEECCEECCCCCCCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHH
IPAR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]