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The map label for this gene is emrE [H]

Identifier: 34498135

GI number: 34498135

Start: 2903547

End: 2903879

Strand: Reverse

Name: emrE [H]

Synonym: CV_2680

Alternate gene names: 34498135

Gene position: 2903879-2903547 (Counterclockwise)

Preceding gene: 34498136

Following gene: 34498134

Centisome position: 61.12

GC content: 63.66

Gene sequence:

>333_bases
ATGAAAGTCTGGCTGTTCCTGATGGGGGCCATCCTGTCCGAAGTGGTGGCCACCTCCGCGCTGAAGGCCTCCGACGGTTT
TACCCGGCTGTGGCCGTCGTTGTTGACCGCCGGCGGCTACGTGCTGGCCTTCTACCTGTTGTCCCAGACACTGCGCCACA
TTCCGGTGGGCATCGCCTACGCGCTGTGGTCGGGCATCGGCATCGTGTTGGTGTCGCTGATCGCCTGGCTGCTGTACGGC
CAGAAGCTGGATCTGGCTGCGGTGGCGGGCATGGGCTTGATCATCGCCGGCGTGGCGGTGATCAATCTGTTTTCGCATAG
CGCCGCGCACTGA

Upstream 100 bases:

>100_bases
CTTTTTCCTGCCTTATACCTATGTGTTCAACTGGCTGTACGACCACCTGCGCGAGCGTCTGATCGCCCGCCGGAGTCTGG
CGGCCGCAGTGGAGTGATGG

Downstream 100 bases:

>100_bases
CAATTTCCCATTGGCTTAAAAGATTTTGCAGATGCCCGTTTCATGTGCCATCATGAATTGATTTTGTTTGTTTTGTTATA
ACACAAATCACAATTTCTAA

Product: quaternary ammonium compound resistance protein / ethidium bromide resistant protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant F [H]

Number of amino acids: Translated: 110; Mature: 110

Protein sequence:

>110_residues
MKVWLFLMGAILSEVVATSALKASDGFTRLWPSLLTAGGYVLAFYLLSQTLRHIPVGIAYALWSGIGIVLVSLIAWLLYG
QKLDLAAVAGMGLIIAGVAVINLFSHSAAH

Sequences:

>Translated_110_residues
MKVWLFLMGAILSEVVATSALKASDGFTRLWPSLLTAGGYVLAFYLLSQTLRHIPVGIAYALWSGIGIVLVSLIAWLLYG
QKLDLAAVAGMGLIIAGVAVINLFSHSAAH
>Mature_110_residues
MKVWLFLMGAILSEVVATSALKASDGFTRLWPSLLTAGGYVLAFYLLSQTLRHIPVGIAYALWSGIGIVLVSLIAWLLYG
QKLDLAAVAGMGLIIAGVAVINLFSHSAAH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=110, Percent_Identity=57.2727272727273, Blast_Score=129, Evalue=4e-32,
Organism=Escherichia coli, GI87082378, Length=103, Percent_Identity=35.9223300970874, Blast_Score=64, Evalue=3e-12,
Organism=Escherichia coli, GI1787883, Length=94, Percent_Identity=40.4255319148936, Blast_Score=59, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11656; Mature: 11656

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVWLFLMGAILSEVVATSALKASDGFTRLWPSLLTAGGYVLAFYLLSQTLRHIPVGIAY
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHH
ALWSGIGIVLVSLIAWLLYGQKLDLAAVAGMGLIIAGVAVINLFSHSAAH
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVWLFLMGAILSEVVATSALKASDGFTRLWPSLLTAGGYVLAFYLLSQTLRHIPVGIAY
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHH
ALWSGIGIVLVSLIAWLLYGQKLDLAAVAGMGLIIAGVAVINLFSHSAAH
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9756755 [H]