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The map label for this gene is map [C]

Identifier: 33863573

GI number: 33863573

Start: 1392798

End: 1393637

Strand: Reverse

Name: map [C]

Synonym: PMT1305

Alternate gene names: 33863573

Gene position: 1393637-1392798 (Counterclockwise)

Preceding gene: 33863577

Following gene: 33863571

Centisome position: 57.81

GC content: 55.36

Gene sequence:

>840_bases
ATGAACCTCTTCGCTGATCTGCTGGCCTCAACTTCAGAGGCGCGCGCAACGGCTACAGGGCCTCGAATACAACAGCGTCG
AGGAGTGGAAATCAAGTCTTCAAGGGAGTTGGCGATCATGCGCAAGGCAAGCCACATCGTGGCCACGGTTCTGCGCGAGA
TCATGGAGATGGCCGAGCCTGGCCAGACGACTGCTGATCTTGACGTTTATGCCGAGCGCAGGATTCGTGAGATGGGCGCA
ACCCCTAGTTTCAAGGGCTATCACGGCTTCCCTGCCTCGATCTGCGCGAGCATCAACAATGAAGTTGTGCATGGCATTCC
AGGCCCTAAGCGAGTGATCAAGTCCGGGGATCTTCTCAAAGTCGACACCGGGGCTTACTACGAGGGATATCACGGTGACA
GTTGCATCACCATTTGCGTTGGGGAGGTGCCTGAATCTGGGCAGAAACTTAGTCGCGTGGCCCAAGAGTCCTTGATGGCA
GGGCTCTCTAAGATTCGAGCCGGCAACACTCTTCTTGATATCGCAGGAGCTGTTGAGGATCATGTCAAGGCTCATGGCTA
CAGCGTGGTGGAGGATTACACCGGCCACGGTGTGGGTCGTAACTTGCATGAAGAGCCTTCCGTTTTCAACTTCCGCACGG
ATGACTTGCCCAATATCACTTTGCGTTCAGGGATGACTTTGGCCGTCGAGCCGATACTCAATGCTGGCAGTAAGGCTTGC
CGCACACTTAAAGATCGCTGGACTGTTGTGACTCAAGACGGCAGTCTTTCGGCTCAGTGGGAGCACACCATCGTGGTCAC
CTCAGATGGCTGCGACATCCTCACTGATCGGGGCGACTAA

Upstream 100 bases:

>100_bases
CCTAGGACAAAGATTGATAGCGTGACGAATGGAAAGATGGAAGTCGGGCAGAGCCGATAACCGTTCATTTGATTTCTCAT
ATCAGTTTTTCTTCAGCCCT

Downstream 100 bases:

>100_bases
TGCTGGAGTCGACTTGTTATTGATTGTCTGTGGATCCACTACCTAACAATCGGGAGTAAATCATTCGCCCTAGTTCGGTC
AGGGGCATCAGTAGATACGT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MNLFADLLASTSEARATATGPRIQQRRGVEIKSSRELAIMRKASHIVATVLREIMEMAEPGQTTADLDVYAERRIREMGA
TPSFKGYHGFPASICASINNEVVHGIPGPKRVIKSGDLLKVDTGAYYEGYHGDSCITICVGEVPESGQKLSRVAQESLMA
GLSKIRAGNTLLDIAGAVEDHVKAHGYSVVEDYTGHGVGRNLHEEPSVFNFRTDDLPNITLRSGMTLAVEPILNAGSKAC
RTLKDRWTVVTQDGSLSAQWEHTIVVTSDGCDILTDRGD

Sequences:

>Translated_279_residues
MNLFADLLASTSEARATATGPRIQQRRGVEIKSSRELAIMRKASHIVATVLREIMEMAEPGQTTADLDVYAERRIREMGA
TPSFKGYHGFPASICASINNEVVHGIPGPKRVIKSGDLLKVDTGAYYEGYHGDSCITICVGEVPESGQKLSRVAQESLMA
GLSKIRAGNTLLDIAGAVEDHVKAHGYSVVEDYTGHGVGRNLHEEPSVFNFRTDDLPNITLRSGMTLAVEPILNAGSKAC
RTLKDRWTVVTQDGSLSAQWEHTIVVTSDGCDILTDRGD
>Mature_279_residues
MNLFADLLASTSEARATATGPRIQQRRGVEIKSSRELAIMRKASHIVATVLREIMEMAEPGQTTADLDVYAERRIREMGA
TPSFKGYHGFPASICASINNEVVHGIPGPKRVIKSGDLLKVDTGAYYEGYHGDSCITICVGEVPESGQKLSRVAQESLMA
GLSKIRAGNTLLDIAGAVEDHVKAHGYSVVEDYTGHGVGRNLHEEPSVFNFRTDDLPNITLRSGMTLAVEPILNAGSKAC
RTLKDRWTVVTQDGSLSAQWEHTIVVTSDGCDILTDRGD

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=36.2903225806452, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI164420681, Length=251, Percent_Identity=35.0597609561753, Blast_Score=165, Evalue=4e-41,
Organism=Escherichia coli, GI1786364, Length=253, Percent_Identity=43.0830039525692, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71996291, Length=255, Percent_Identity=34.5098039215686, Blast_Score=164, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6323273, Length=258, Percent_Identity=34.4961240310078, Blast_Score=164, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=36.9918699186992, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI21355531, Length=253, Percent_Identity=36.3636363636364, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 30211; Mature: 30211

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFADLLASTSEARATATGPRIQQRRGVEIKSSRELAIMRKASHIVATVLREIMEMAEP
CCHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GQTTADLDVYAERRIREMGATPSFKGYHGFPASICASINNEVVHGIPGPKRVIKSGDLLK
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEECCCCHHHHHCCCCEEE
VDTGAYYEGYHGDSCITICVGEVPESGQKLSRVAQESLMAGLSKIRAGNTLLDIAGAVED
ECCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HVKAHGYSVVEDYTGHGVGRNLHEEPSVFNFRTDDLPNITLRSGMTLAVEPILNAGSKAC
HHHHCCCHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCEEECCCCEEEEHHHHCCCHHHH
RTLKDRWTVVTQDGSLSAQWEHTIVVTSDGCDILTDRGD
HHHHHCEEEEEECCCCCEEEEEEEEEECCCCEEECCCCC
>Mature Secondary Structure
MNLFADLLASTSEARATATGPRIQQRRGVEIKSSRELAIMRKASHIVATVLREIMEMAEP
CCHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GQTTADLDVYAERRIREMGATPSFKGYHGFPASICASINNEVVHGIPGPKRVIKSGDLLK
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEECCCCHHHHHCCCCEEE
VDTGAYYEGYHGDSCITICVGEVPESGQKLSRVAQESLMAGLSKIRAGNTLLDIAGAVED
ECCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HVKAHGYSVVEDYTGHGVGRNLHEEPSVFNFRTDDLPNITLRSGMTLAVEPILNAGSKAC
HHHHCCCHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCEEECCCCEEEEHHHHCCCHHHH
RTLKDRWTVVTQDGSLSAQWEHTIVVTSDGCDILTDRGD
HHHHHCEEEEEECCCCCEEEEEEEEEECCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]