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The map label for this gene is lepB [H]

Identifier: 33863522

GI number: 33863522

Start: 1343431

End: 1344135

Strand: Reverse

Name: lepB [H]

Synonym: PMT1254

Alternate gene names: 33863522

Gene position: 1344135-1343431 (Counterclockwise)

Preceding gene: 33863524

Following gene: 33863519

Centisome position: 55.75

GC content: 51.06

Gene sequence:

>705_bases
TTGTCTGACGCGCAGCAGCAGGACCATCCCACAAACGATAAGGCGTCTGCTCCCCGGGGAGCATCAACCTCTCAACCTCA
TCCATTTTGGGATTTCTGGGGACCAGTCTTCTTTACTTTGGGCCTGTATTTCGGCATTCGTCATTACGTCGCTGAGGCGA
GATACATTCCCTCTGAATCGATGATCCCAGGGCTGCAAGTCCAGGATCGTTTGCTGGTTGAGAAAGTCAGCCTTCGCAGT
CGACCTCCACGTCGTGGGGAGATCGTGGTGTTTAACACGCCCTATTCCTTTAATGCTGCGTTGAATTTGAAGAGTGGTCA
GAGTTCCCTTCCTTGCTTTGTGGTGAACCTTCCTTTTATGAACTGGATAGGACTAACCAATCCCAGCTGTGATGCTTGGA
TTAAGCGTGTTGTCGCCGTGGGGGGAGACCAGGTTTCGATCAATCCCAGGGGAGAAGTGAGCGTGAATGGACAGAGGCTG
AAGGAGCCCTATGTAACCCAATATTGCCCTGTGAATAACAGGGGAATGGGACCTTGCAATTCCCTTGTCGCGACAGTTCC
CAGCGATCATGTTTTGGTGCTGGGAGATAACCGAAGCAATAGCACTGATGGACGAATTTGGGGATTTCTGCCTGAGAAAG
AGATCCTCGGGCGTGCTTTATGGCGTTTTTGGCCTTTTGATCGTTTCGGGTCACTTATTCCCTGA

Upstream 100 bases:

>100_bases
GCCAGCGGGGACGCACCATGGGCTGAGGTTGCTTTGATCACGCTAAGGGGCCGGACAGGCTGGCCTTATCGTTAAGCATC
GAATTCATAACAGGGCTGAG

Downstream 100 bases:

>100_bases
GTCCACATGCCACGACACGGCCTTGCAGTTGGCAGCCCTGCCAGGGTTGATTAGCGGCTTTGGGGGCATCATCACTGTGC
CGATCTTGGATCCAGAGCTG

Product: Signal peptidase I

Products: NA

Alternate protein names: SPase I-2; Leader peptidase I-2 [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MSDAQQQDHPTNDKASAPRGASTSQPHPFWDFWGPVFFTLGLYFGIRHYVAEARYIPSESMIPGLQVQDRLLVEKVSLRS
RPPRRGEIVVFNTPYSFNAALNLKSGQSSLPCFVVNLPFMNWIGLTNPSCDAWIKRVVAVGGDQVSINPRGEVSVNGQRL
KEPYVTQYCPVNNRGMGPCNSLVATVPSDHVLVLGDNRSNSTDGRIWGFLPEKEILGRALWRFWPFDRFGSLIP

Sequences:

>Translated_234_residues
MSDAQQQDHPTNDKASAPRGASTSQPHPFWDFWGPVFFTLGLYFGIRHYVAEARYIPSESMIPGLQVQDRLLVEKVSLRS
RPPRRGEIVVFNTPYSFNAALNLKSGQSSLPCFVVNLPFMNWIGLTNPSCDAWIKRVVAVGGDQVSINPRGEVSVNGQRL
KEPYVTQYCPVNNRGMGPCNSLVATVPSDHVLVLGDNRSNSTDGRIWGFLPEKEILGRALWRFWPFDRFGSLIP
>Mature_233_residues
SDAQQQDHPTNDKASAPRGASTSQPHPFWDFWGPVFFTLGLYFGIRHYVAEARYIPSESMIPGLQVQDRLLVEKVSLRSR
PPRRGEIVVFNTPYSFNAALNLKSGQSSLPCFVVNLPFMNWIGLTNPSCDAWIKRVVAVGGDQVSINPRGEVSVNGQRLK
EPYVTQYCPVNNRGMGPCNSLVATVPSDHVLVLGDNRSNSTDGRIWGFLPEKEILGRALWRFWPFDRFGSLIP

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 26192; Mature: 26061

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAQQQDHPTNDKASAPRGASTSQPHPFWDFWGPVFFTLGLYFGIRHYVAEARYIPSES
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
MIPGLQVQDRLLVEKVSLRSRPPRRGEIVVFNTPYSFNAALNLKSGQSSLPCFVVNLPFM
CCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEECCCH
NWIGLTNPSCDAWIKRVVAVGGDQVSINPRGEVSVNGQRLKEPYVTQYCPVNNRGMGPCN
HCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCEEECHHHHCCCCCCEECCCCCCCCCCHH
SLVATVPSDHVLVLGDNRSNSTDGRIWGFLPEKEILGRALWRFWPFDRFGSLIP
HHHEECCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure 
SDAQQQDHPTNDKASAPRGASTSQPHPFWDFWGPVFFTLGLYFGIRHYVAEARYIPSES
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
MIPGLQVQDRLLVEKVSLRSRPPRRGEIVVFNTPYSFNAALNLKSGQSSLPCFVVNLPFM
CCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEECCCH
NWIGLTNPSCDAWIKRVVAVGGDQVSINPRGEVSVNGQRLKEPYVTQYCPVNNRGMGPCN
HCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCEEECHHHHCCCCCCEECCCCCCCCCCHH
SLVATVPSDHVLVLGDNRSNSTDGRIWGFLPEKEILGRALWRFWPFDRFGSLIP
HHHEECCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]