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The map label for this gene is algA [H]

Identifier: 33863355

GI number: 33863355

Start: 1171017

End: 1171400

Strand: Reverse

Name: algA [H]

Synonym: PMT1084

Alternate gene names: 33863355

Gene position: 1171400-1171017 (Counterclockwise)

Preceding gene: 33863356

Following gene: 33863354

Centisome position: 48.59

GC content: 52.6

Gene sequence:

>384_bases
ATGCTGAACGCAACTGCTCGCAGAGGCATGAGCAAGGCCCCCCAGAGAGTTGAGCGTCCTTGGGGTTGGTATGAAGATCT
GCTCGAAGGAGAGGGCTATAAGGTCAAGCGTTTTTTGGTCTTTGCCGGTCAACAGCTCAGCCTTCAGCGCCATCAACATC
GCAGTGAAAATTGGACTGTGGTCTCAGGCCAGGGGCAGCTTTTCTGTAAAAACACTTGGCACGATGCTCAAGCTGGCACC
ACGTTGTATATCCCTCTGGGAGTGCTTCACCGAGCTCGTGGAGGCCAAAGCGATTTGGTGGTCATTGAGGTTCAGCATGG
TCAGCTATTGCAGGAATCAGATATTGAACGCCTCGAGGATGACTACGGACGGGTGATAAGTTAG

Upstream 100 bases:

>100_bases
AGGAAACTTCTCTACACTGCTATCACGCGCGCGCGAAAGCGAGTGGATCTCGTTACTGCAATGCCATCTGCTCGTAGTGA
CGGCTGAGGCTGACACCGCC

Downstream 100 bases:

>100_bases
GCAATCAACCTTTGAAGAAAAGGCGAGGCAGCACAACGCGGCTATCCGCGTATGGGGCGTTGTCTGCCTGATTTAAAGGA
TCAATCAGGTAGACAACGCC

Product: sugar-phosphate nucleotidyl transferase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 127; Mature: 127

Protein sequence:

>127_residues
MLNATARRGMSKAPQRVERPWGWYEDLLEGEGYKVKRFLVFAGQQLSLQRHQHRSENWTVVSGQGQLFCKNTWHDAQAGT
TLYIPLGVLHRARGGQSDLVVIEVQHGQLLQESDIERLEDDYGRVIS

Sequences:

>Translated_127_residues
MLNATARRGMSKAPQRVERPWGWYEDLLEGEGYKVKRFLVFAGQQLSLQRHQHRSENWTVVSGQGQLFCKNTWHDAQAGT
TLYIPLGVLHRARGGQSDLVVIEVQHGQLLQESDIERLEDDYGRVIS
>Mature_127_residues
MLNATARRGMSKAPQRVERPWGWYEDLLEGEGYKVKRFLVFAGQQLSLQRHQHRSENWTVVSGQGQLFCKNTWHDAQAGT
TLYIPLGVLHRARGGQSDLVVIEVQHGQLLQESDIERLEDDYGRVIS

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0662

COG function: function code G; Mannose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=112, Percent_Identity=40.1785714285714, Blast_Score=87, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 14546; Mature: 14546

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNATARRGMSKAPQRVERPWGWYEDLLEGEGYKVKRFLVFAGQQLSLQRHQHRSENWTV
CCCCHHHCCCCCCHHHHCCCCCHHHHHHCCCCCEEEEEEEECCCCHHHHHHHCCCCCEEE
VSGQGQLFCKNTWHDAQAGTTLYIPLGVLHRARGGQSDLVVIEVQHGQLLQESDIERLED
ECCCCCEEECCCCCCCCCCCEEEEEHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHH
DYGRVIS
HHCCCCC
>Mature Secondary Structure
MLNATARRGMSKAPQRVERPWGWYEDLLEGEGYKVKRFLVFAGQQLSLQRHQHRSENWTV
CCCCHHHCCCCCCHHHHCCCCCHHHHHHCCCCCEEEEEEEECCCCHHHHHHHCCCCCEEE
VSGQGQLFCKNTWHDAQAGTTLYIPLGVLHRARGGQSDLVVIEVQHGQLLQESDIERLED
ECCCCCEEECCCCCCCCCCCEEEEEHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHH
DYGRVIS
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]