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The map label for this gene is tpx [C]

Identifier: 33863026

GI number: 33863026

Start: 822609

End: 823211

Strand: Direct

Name: tpx [C]

Synonym: PMT0754

Alternate gene names: 33863026

Gene position: 822609-823211 (Clockwise)

Preceding gene: 33863024

Following gene: 33863029

Centisome position: 34.12

GC content: 42.62

Gene sequence:

>603_bases
ATGACGACCAACGAATGCCTACGGGTGGGTCAGCAGGCCCCAGACTTCAACGCTACAGCTGTTGTTGATCAAGAGTTTAA
GGAAATAAGCCTATCCCAATACAGGGGGAAGTATGTGGTTTTATTCTTTTATCCTCTAGATTTCACTTTTGTATGCCCAA
CAGAAATTACAGCATTTAGTGATCGTTACACTGATTTCTCAAGCCGAAACACAGAGGTATTAGGTGTTTCAGTTGATAGT
CAGTTCAGCCATCTTGCATGGATCCAGACATCACGTAAGGAAGGAGGTCTTGGTGACATCAACTATCCACTAATAGCTGA
TCTCAAGAAAGAGATTTCGACAGCCTATAACGTTTTAGATGATGAAGCTGGAGTAGCCCTACGTGGTTTGTTTATCATTG
ACCCAGATGGAGTAATAATGCATTCAACAATTAACAACCTACCAGTAGGAAGGAACGTGGATGAGACATTACGTGTACTG
CAGGCCTTTCAGTATGTACAGTCACATCCAGATGAGGTATGCCCTGCTAATTGGACACCAGGAGAGAAAACAATGAAACC
AGATCCAGTTGGAAGCAAGGAGTTCTTCGCCTCAATAAATTAA

Upstream 100 bases:

>100_bases
GCATGATAAATTTGAGTAGCCTACTAGAAGTCATACCGACTTCACTTTAGCTCTGGTTAAGCACATCTCTTGCAGAGCCA
TCAACTCTTAACTCTCCATC

Downstream 100 bases:

>100_bases
TCATTAATCTATCAATACATCATTAATTTAATTGATCTGCTGCCTTAATTGGTGGCAGATCATTTCTATTCAAATACACT
GCTTTATTGCTTGATCCGTC

Product: thioredoxin peroxidase

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MTTNECLRVGQQAPDFNATAVVDQEFKEISLSQYRGKYVVLFFYPLDFTFVCPTEITAFSDRYTDFSSRNTEVLGVSVDS
QFSHLAWIQTSRKEGGLGDINYPLIADLKKEISTAYNVLDDEAGVALRGLFIIDPDGVIMHSTINNLPVGRNVDETLRVL
QAFQYVQSHPDEVCPANWTPGEKTMKPDPVGSKEFFASIN

Sequences:

>Translated_200_residues
MTTNECLRVGQQAPDFNATAVVDQEFKEISLSQYRGKYVVLFFYPLDFTFVCPTEITAFSDRYTDFSSRNTEVLGVSVDS
QFSHLAWIQTSRKEGGLGDINYPLIADLKKEISTAYNVLDDEAGVALRGLFIIDPDGVIMHSTINNLPVGRNVDETLRVL
QAFQYVQSHPDEVCPANWTPGEKTMKPDPVGSKEFFASIN
>Mature_199_residues
TTNECLRVGQQAPDFNATAVVDQEFKEISLSQYRGKYVVLFFYPLDFTFVCPTEITAFSDRYTDFSSRNTEVLGVSVDSQ
FSHLAWIQTSRKEGGLGDINYPLIADLKKEISTAYNVLDDEAGVALRGLFIIDPDGVIMHSTINNLPVGRNVDETLRVLQ
AFQYVQSHPDEVCPANWTPGEKTMKPDPVGSKEFFASIN

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=192, Percent_Identity=63.0208333333333, Blast_Score=261, Evalue=4e-70,
Organism=Homo sapiens, GI32483377, Length=198, Percent_Identity=61.6161616161616, Blast_Score=259, Evalue=7e-70,
Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=63.7305699481865, Blast_Score=257, Evalue=4e-69,
Organism=Homo sapiens, GI5453549, Length=193, Percent_Identity=58.0310880829015, Blast_Score=242, Evalue=1e-64,
Organism=Homo sapiens, GI4505591, Length=191, Percent_Identity=58.6387434554974, Blast_Score=241, Evalue=3e-64,
Organism=Homo sapiens, GI32455266, Length=191, Percent_Identity=58.6387434554974, Blast_Score=241, Evalue=3e-64,
Organism=Homo sapiens, GI32455264, Length=191, Percent_Identity=58.6387434554974, Blast_Score=241, Evalue=3e-64,
Organism=Homo sapiens, GI33188454, Length=87, Percent_Identity=70.1149425287356, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI4758638, Length=189, Percent_Identity=31.2169312169312, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1786822, Length=172, Percent_Identity=37.7906976744186, Blast_Score=139, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32565831, Length=188, Percent_Identity=61.1702127659574, Blast_Score=240, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI193204376, Length=188, Percent_Identity=61.1702127659574, Blast_Score=240, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17554494, Length=187, Percent_Identity=57.2192513368984, Blast_Score=233, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI25153706, Length=190, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=193, Percent_Identity=58.0310880829015, Blast_Score=223, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6320661, Length=192, Percent_Identity=54.6875, Blast_Score=213, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319407, Length=197, Percent_Identity=32.48730964467, Blast_Score=105, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17738015, Length=195, Percent_Identity=59.4871794871795, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24656348, Length=192, Percent_Identity=59.8958333333333, Blast_Score=241, Evalue=3e-64,
Organism=Drosophila melanogaster, GI17864676, Length=192, Percent_Identity=59.8958333333333, Blast_Score=241, Evalue=3e-64,
Organism=Drosophila melanogaster, GI17157991, Length=191, Percent_Identity=57.5916230366492, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24641739, Length=191, Percent_Identity=57.5916230366492, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=51.0526315789474, Blast_Score=209, Evalue=8e-55,
Organism=Drosophila melanogaster, GI17975518, Length=188, Percent_Identity=36.7021276595745, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24652434, Length=188, Percent_Identity=36.7021276595745, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24652436, Length=188, Percent_Identity=36.7021276595745, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24581278, Length=192, Percent_Identity=31.7708333333333, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22372; Mature: 22241

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNECLRVGQQAPDFNATAVVDQEFKEISLSQYRGKYVVLFFYPLDFTFVCPTEITAFS
CCHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCHHHHHC
DRYTDFSSRNTEVLGVSVDSQFSHLAWIQTSRKEGGLGDINYPLIADLKKEISTAYNVLD
CCCCCCCCCCCEEEEEECCCCCHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
DEAGVALRGLFIIDPDGVIMHSTINNLPVGRNVDETLRVLQAFQYVQSHPDEVCPANWTP
CCCCEEEEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GEKTMKPDPVGSKEFFASIN
CCCCCCCCCCCCHHHEEECC
>Mature Secondary Structure 
TTNECLRVGQQAPDFNATAVVDQEFKEISLSQYRGKYVVLFFYPLDFTFVCPTEITAFS
CHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCHHHHHC
DRYTDFSSRNTEVLGVSVDSQFSHLAWIQTSRKEGGLGDINYPLIADLKKEISTAYNVLD
CCCCCCCCCCCEEEEEECCCCCHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
DEAGVALRGLFIIDPDGVIMHSTINNLPVGRNVDETLRVLQAFQYVQSHPDEVCPANWTP
CCCCEEEEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GEKTMKPDPVGSKEFFASIN
CCCCCCCCCCCCHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]