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The map label for this gene is cobU/cobP [H]

Identifier: 33863021

GI number: 33863021

Start: 817736

End: 818296

Strand: Direct

Name: cobU/cobP [H]

Synonym: PMT0749

Alternate gene names: 33863021

Gene position: 817736-818296 (Clockwise)

Preceding gene: 33863020

Following gene: 33863022

Centisome position: 33.92

GC content: 45.45

Gene sequence:

>561_bases
ATGGTAGTAGCTAACACTATTCCTATACTTAATGGCCTTACCCTAGTTTCAGGCCCGAGCAGAGGTGGAAAGAGTCGATG
GGCTGAACACTTGGTCAAACAGTTCAAGTCTGTAACTTATATCGCCACCTCGCCGAGAAGAGCTGGCGACAAGAATTGGG
AGCAAAGGCTTGAAAAACATCGTAATCGTCGACCAAAGCACTGGTCAGTAATTGAATCTGGCCCAGACCTTAAAAAGGCA
ATCATTCAAATGCCAAGATCAGATATTGTTTTAATTGAAGCGTTGGGTGGTTTTGTTGCATGGCATCTCGACCAACCTTC
GAGCAATTGGAGAGCCCTGAAGAACGATCTACTACAAACGATTAAACAACATGATGCATCCATCGTGATTGTCATTGAGG
AAACTGGCTGGGGTGTTGTACCCAGTACATCCAATGGAGGTCTTTTTAGAGATCGTCTTGGGAAGCTATCTCAGGAACTG
GAACCGTTGGCATCAAACAGCTGGCTTGTCATACAGGGTCGAGCATTGAATCTCAAACAACTTGGTATTGCGGTGCCATG
A

Upstream 100 bases:

>100_bases
GCCACCTTCCCTGTGATACTTGCAACCATCTTTAAGTACTGGATTTTCCGTTATCTCAATCGTGTCTCTCCCTCTTCTGT
TGCAACCCTACGCGGAATGA

Downstream 100 bases:

>100_bases
ACGATCCAAATAAACGTTCACCATTACGCGTAGCTCTATACGAGCCACGTATTCCACCAAATACAGGAAATATCGCCAGA
ACCTGTGCAGCCTTCCGCAT

Product: cobinamide kinase

Products: NA

Alternate protein names: Adenosylcobinamide kinase; Adenosylcobinamide-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MVVANTIPILNGLTLVSGPSRGGKSRWAEHLVKQFKSVTYIATSPRRAGDKNWEQRLEKHRNRRPKHWSVIESGPDLKKA
IIQMPRSDIVLIEALGGFVAWHLDQPSSNWRALKNDLLQTIKQHDASIVIVIEETGWGVVPSTSNGGLFRDRLGKLSQEL
EPLASNSWLVIQGRALNLKQLGIAVP

Sequences:

>Translated_186_residues
MVVANTIPILNGLTLVSGPSRGGKSRWAEHLVKQFKSVTYIATSPRRAGDKNWEQRLEKHRNRRPKHWSVIESGPDLKKA
IIQMPRSDIVLIEALGGFVAWHLDQPSSNWRALKNDLLQTIKQHDASIVIVIEETGWGVVPSTSNGGLFRDRLGKLSQEL
EPLASNSWLVIQGRALNLKQLGIAVP
>Mature_186_residues
MVVANTIPILNGLTLVSGPSRGGKSRWAEHLVKQFKSVTYIATSPRRAGDKNWEQRLEKHRNRRPKHWSVIESGPDLKKA
IIQMPRSDIVLIEALGGFVAWHLDQPSSNWRALKNDLLQTIKQHDASIVIVIEETGWGVVPSTSNGGLFRDRLGKLSQEL
EPLASNSWLVIQGRALNLKQLGIAVP

Specific function: ATP-dependent phosphorylation of adenosylcobinamide and adds GMP to adenosylcobinamide phosphate [H]

COG id: COG2087

COG function: function code H; Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788302, Length=182, Percent_Identity=31.8681318681319, Blast_Score=85, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003203 [H]

Pfam domain/function: PF02283 CobU [H]

EC number: =2.7.1.156; =2.7.7.62 [H]

Molecular weight: Translated: 20720; Mature: 20720

Theoretical pI: Translated: 10.92; Mature: 10.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVANTIPILNGLTLVSGPSRGGKSRWAEHLVKQFKSVTYIATSPRRAGDKNWEQRLEKH
CEECCCCHHHCCEEEECCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHH
RNRRPKHWSVIESGPDLKKAIIQMPRSDIVLIEALGGFVAWHLDQPSSNWRALKNDLLQT
HCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHH
IKQHDASIVIVIEETGWGVVPSTSNGGLFRDRLGKLSQELEPLASNSWLVIQGRALNLKQ
HHHCCCEEEEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LGIAVP
CCCCCC
>Mature Secondary Structure
MVVANTIPILNGLTLVSGPSRGGKSRWAEHLVKQFKSVTYIATSPRRAGDKNWEQRLEKH
CEECCCCHHHCCEEEECCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHH
RNRRPKHWSVIESGPDLKKAIIQMPRSDIVLIEALGGFVAWHLDQPSSNWRALKNDLLQT
HCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHH
IKQHDASIVIVIEETGWGVVPSTSNGGLFRDRLGKLSQELEPLASNSWLVIQGRALNLKQ
HHHCCCEEEEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LGIAVP
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]