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The map label for this gene is rnr [C]

Identifier: 33863013

GI number: 33863013

Start: 807496

End: 809562

Strand: Direct

Name: rnr [C]

Synonym: PMT0741

Alternate gene names: 33863013

Gene position: 807496-809562 (Clockwise)

Preceding gene: 33863012

Following gene: 33863015

Centisome position: 33.49

GC content: 47.17

Gene sequence:

>2067_bases
CTGACTGCAACAGCTTTGACGCCTTCTCTAAAGCAAGGTGATTTAGTTGGCTTTGTTTTAAAAGGTCAACCACAAATTGG
ACTGCTAACTTCACTGAAGGGAAGCCGAGCAATCCTAAGAGTTGCAGGAACACGGCGAGAACAACAGCTAGCCAGTCGAG
AACTATCCATTCTAAAGCAAAATCACAACATGTTAGAGATGGAGACATCTCTACCCACCATCAGTGAAGTTCGCAAACTT
AGTCTTAATTCACGCGATTTAATTGCTGGTTGGCGATTGCTCGAAGGCGAAAGGCGTAAAAGCAAGACTTCACCAACAGC
ACTCAAAATCACAGAACTAGCTGGTTTACTACTTAATAATGATGATCCTATCCATCTCGCAGCATTGTGGTTTTGGCTTA
ATAGCGACCAACCTTTATTTCGAGTTCGACGTGACCACATGGTTGAAGCACGTCAACTTATTGACCTACGCCGCATCCGC
CAGCTGCGCCGTAAGCAACAATCTCGAGCGCAGCAACGCCTAGATGCTCTTGCATTGCTTATAGCAGATTCACCTCTGAG
CAAAGATCAGTGGCAGGATTTACCCTCGGATCTTCAGTTCACTATCAACCGTTTAATCGAGCTGGCTGACGGTCCAGAGG
ATGCTTTTTTGGCAGATGAACAAGCTCTTCAGTTGATTAAAGATTTAAAGTTGGGTAGATCGCTGAGCGACCTCCGTTAT
TGGTTGATCAAGAAAGGCTGGCGCGATCCACACGATCTAACAACTCTCAAAGGCAGTATCTGGACAAAATCATTTGAAGG
GAGTGTACAAGCTCAAGCGGACCAATTACTCAATAAGTTTGAGCAACTATCTTTCGGTGGCGATGATAATCGTCTTGATT
TGAGTGATTTAAGAACCTACACCCTCGACGATCATCAAACTCAGGAAATTGATGATGCAATCTCTTTGCAGTGTGTTGAT
CAAGACAACTGGATTTGGATCCATATCGCCGATCCGGCAAGACTTATTCCTGTGGACAGTCCCTTAGATCTTGAGGCTCG
TGCAAGAGCAACCAGCCTCTACTTGGCTGATGGCCTAAGAACAATGCTGCCATTGAGTGTTGCAGTAGAAGTTCTCAGTC
TTAGAGCTGGCCGTCGCTGTGCAGCGTTGAGTGTTGCTGTGGTTCTAGACGAATCAGGGTGTATTGCCGGCACTCGTGTT
TGTCGTACTTGGATTCGCCCATGCTATCGGCTCACTTATGAAGATGGGGATGAATTGATAGAGCTTGCGCCTCCTGGTGA
TGAAGATCTTTCAACACTCGCAAGCCTACTCACAACACGCCAATTATGGCGTGAGCGACAAGGTGCACTGCTGCTTGAAC
AATCTGAAGGGCGATTCAAAGTCAAGGATGATCAGCCTGAACTTCATATTGTTGAGTCAAGTCCAGCCAGACGGCTAGTC
AGCGAAGCCATGATTTTGATGGGTACTGTTATTGCTGAATTTGGAAAGCGTCAAAACATTGCTCTGCCCTATCGCAGCCA
ACCTCCGACTCAACTACCCAGTGCAACTGAATTATCACAGTTGATTGAAGGACCTGTAAGACATGCTGCGATCAAGCGTT
GCCTTAGCCGAGGTGTCCTTGGTACTCGTCCGATGGCCCATTTCAGTCTTGGCCTCTCTGCCTACGTACAAGCCAGTTCG
CCGATCCGTCGCTATGCAGATTTACTTGCCCATCGACAAGTGGTGGCTCACTTAGGAGGCTCAGTTCCATTAAGCGAGCA
CGCTCTCATGGAGCAGTTGGATGTACTTGAAGACCCTCTTCGCCAAGCACAGCAAATTCAACGCGAAGACCAGCGACACT
GGCAAAAGGTGTGGTTTTTAAAACATCGCCATGAACAATGGCCTGCCCTATTTCTGCGATGGTTGAAGCCTCAAGATCAG
ATTGCACTTGTGCATGTGGAATGCCTGGCTATGGATCTTGCCTGCAAGATCCATGGTTTGATCGACCCTAGTCCAGGTCT
TGCATTGATAATGAGAGTTCTTGTTATTGATCCATTGACTGATCAGATTGAGCTGGTCGCCAAGTAG

Upstream 100 bases:

>100_bases
GACGCCTTACAGGTCTAACGTCTAAGCAACAACGTGACCTTACTAATGCAGTAAAACGTGCACGTATTATTGCACTTTTA
CCATTTGTCAATCCAGAAGG

Downstream 100 bases:

>100_bases
CTTCTCAAATCATAGAAACAAACAAACTACCAAAAGCTGTTATTAATCTAAAACGCGAATCAACCTCAGCCATGGTCCCC
ATGGATTAGCAACTGCTAGA

Product: ribonuclease II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MTATALTPSLKQGDLVGFVLKGQPQIGLLTSLKGSRAILRVAGTRREQQLASRELSILKQNHNMLEMETSLPTISEVRKL
SLNSRDLIAGWRLLEGERRKSKTSPTALKITELAGLLLNNDDPIHLAALWFWLNSDQPLFRVRRDHMVEARQLIDLRRIR
QLRRKQQSRAQQRLDALALLIADSPLSKDQWQDLPSDLQFTINRLIELADGPEDAFLADEQALQLIKDLKLGRSLSDLRY
WLIKKGWRDPHDLTTLKGSIWTKSFEGSVQAQADQLLNKFEQLSFGGDDNRLDLSDLRTYTLDDHQTQEIDDAISLQCVD
QDNWIWIHIADPARLIPVDSPLDLEARARATSLYLADGLRTMLPLSVAVEVLSLRAGRRCAALSVAVVLDESGCIAGTRV
CRTWIRPCYRLTYEDGDELIELAPPGDEDLSTLASLLTTRQLWRERQGALLLEQSEGRFKVKDDQPELHIVESSPARRLV
SEAMILMGTVIAEFGKRQNIALPYRSQPPTQLPSATELSQLIEGPVRHAAIKRCLSRGVLGTRPMAHFSLGLSAYVQASS
PIRRYADLLAHRQVVAHLGGSVPLSEHALMEQLDVLEDPLRQAQQIQREDQRHWQKVWFLKHRHEQWPALFLRWLKPQDQ
IALVHVECLAMDLACKIHGLIDPSPGLALIMRVLVIDPLTDQIELVAK

Sequences:

>Translated_688_residues
MTATALTPSLKQGDLVGFVLKGQPQIGLLTSLKGSRAILRVAGTRREQQLASRELSILKQNHNMLEMETSLPTISEVRKL
SLNSRDLIAGWRLLEGERRKSKTSPTALKITELAGLLLNNDDPIHLAALWFWLNSDQPLFRVRRDHMVEARQLIDLRRIR
QLRRKQQSRAQQRLDALALLIADSPLSKDQWQDLPSDLQFTINRLIELADGPEDAFLADEQALQLIKDLKLGRSLSDLRY
WLIKKGWRDPHDLTTLKGSIWTKSFEGSVQAQADQLLNKFEQLSFGGDDNRLDLSDLRTYTLDDHQTQEIDDAISLQCVD
QDNWIWIHIADPARLIPVDSPLDLEARARATSLYLADGLRTMLPLSVAVEVLSLRAGRRCAALSVAVVLDESGCIAGTRV
CRTWIRPCYRLTYEDGDELIELAPPGDEDLSTLASLLTTRQLWRERQGALLLEQSEGRFKVKDDQPELHIVESSPARRLV
SEAMILMGTVIAEFGKRQNIALPYRSQPPTQLPSATELSQLIEGPVRHAAIKRCLSRGVLGTRPMAHFSLGLSAYVQASS
PIRRYADLLAHRQVVAHLGGSVPLSEHALMEQLDVLEDPLRQAQQIQREDQRHWQKVWFLKHRHEQWPALFLRWLKPQDQ
IALVHVECLAMDLACKIHGLIDPSPGLALIMRVLVIDPLTDQIELVAK
>Mature_687_residues
TATALTPSLKQGDLVGFVLKGQPQIGLLTSLKGSRAILRVAGTRREQQLASRELSILKQNHNMLEMETSLPTISEVRKLS
LNSRDLIAGWRLLEGERRKSKTSPTALKITELAGLLLNNDDPIHLAALWFWLNSDQPLFRVRRDHMVEARQLIDLRRIRQ
LRRKQQSRAQQRLDALALLIADSPLSKDQWQDLPSDLQFTINRLIELADGPEDAFLADEQALQLIKDLKLGRSLSDLRYW
LIKKGWRDPHDLTTLKGSIWTKSFEGSVQAQADQLLNKFEQLSFGGDDNRLDLSDLRTYTLDDHQTQEIDDAISLQCVDQ
DNWIWIHIADPARLIPVDSPLDLEARARATSLYLADGLRTMLPLSVAVEVLSLRAGRRCAALSVAVVLDESGCIAGTRVC
RTWIRPCYRLTYEDGDELIELAPPGDEDLSTLASLLTTRQLWRERQGALLLEQSEGRFKVKDDQPELHIVESSPARRLVS
EAMILMGTVIAEFGKRQNIALPYRSQPPTQLPSATELSQLIEGPVRHAAIKRCLSRGVLGTRPMAHFSLGLSAYVQASSP
IRRYADLLAHRQVVAHLGGSVPLSEHALMEQLDVLEDPLRQAQQIQREDQRHWQKVWFLKHRHEQWPALFLRWLKPQDQI
ALVHVECLAMDLACKIHGLIDPSPGLALIMRVLVIDPLTDQIELVAK

Specific function: 3'-5'Exoribonuclease That Participates In An Essential Cell Function. Acts Nonspecifically On Poly(A), Poly(U) And Ribosomal RNAs. Required For The Expression Of VIrulence Genes In Enteroinvasive Strains Of E.Coli. [C]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonuclease II (RNB) family [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=391, Percent_Identity=28.3887468030691, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI219521928, Length=394, Percent_Identity=24.3654822335025, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI19115966, Length=394, Percent_Identity=24.3654822335025, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI156105695, Length=265, Percent_Identity=27.1698113207547, Blast_Score=67, Evalue=8e-11,
Organism=Escherichia coli, GI87082383, Length=346, Percent_Identity=25.4335260115607, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI212645896, Length=337, Percent_Identity=26.1127596439169, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323943, Length=385, Percent_Identity=25.974025974026, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324552, Length=351, Percent_Identity=26.2108262108262, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24649634, Length=341, Percent_Identity=27.2727272727273, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19922976, Length=359, Percent_Identity=26.7409470752089, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24654597, Length=359, Percent_Identity=26.7409470752089, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24654592, Length=359, Percent_Identity=26.7409470752089, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001900
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00773 RNB [H]

EC number: 3.1.13.1

Molecular weight: Translated: 77755; Mature: 77623

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATALTPSLKQGDLVGFVLKGQPQIGLLTSLKGSRAILRVAGTRREQQLASRELSILKQ
CCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHH
NHNMLEMETSLPTISEVRKLSLNSRDLIAGWRLLEGERRKSKTSPTALKITELAGLLLNN
CCCEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHCCHHHCCCCCCCEEEHHHHHHHHCCC
DDPIHLAALWFWLNSDQPLFRVRRDHMVEARQLIDLRRIRQLRRKQQSRAQQRLDALALL
CCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IADSPLSKDQWQDLPSDLQFTINRLIELADGPEDAFLADEQALQLIKDLKLGRSLSDLRY
HCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHCCCHHHHHH
WLIKKGWRDPHDLTTLKGSIWTKSFEGSVQAQADQLLNKFEQLSFGGDDNRLDLSDLRTY
HHHHCCCCCCCHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCEE
TLDDHQTQEIDDAISLQCVDQDNWIWIHIADPARLIPVDSPLDLEARARATSLYLADGLR
ECCCCCHHHHCCCEEEEEECCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
TMLPLSVAVEVLSLRAGRRCAALSVAVVLDESGCIAGTRVCRTWIRPCYRLTYEDGDELI
HHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCCCEE
ELAPPGDEDLSTLASLLTTRQLWRERQGALLLEQSEGRFKVKDDQPELHIVESSPARRLV
EECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCEEEECCCHHHHHH
SEAMILMGTVIAEFGKRQNIALPYRSQPPTQLPSATELSQLIEGPVRHAAIKRCLSRGVL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GTRPMAHFSLGLSAYVQASSPIRRYADLLAHRQVVAHLGGSVPLSEHALMEQLDVLEDPL
CCCCHHHHHHCHHHHEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
RQAQQIQREDQRHWQKVWFLKHRHEQWPALFLRWLKPQDQIALVHVECLAMDLACKIHGL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCC
IDPSPGLALIMRVLVIDPLTDQIELVAK
CCCCCCHHHHHHHHHHCCCCCCHHEECC
>Mature Secondary Structure 
TATALTPSLKQGDLVGFVLKGQPQIGLLTSLKGSRAILRVAGTRREQQLASRELSILKQ
CCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHH
NHNMLEMETSLPTISEVRKLSLNSRDLIAGWRLLEGERRKSKTSPTALKITELAGLLLNN
CCCEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHCCHHHCCCCCCCEEEHHHHHHHHCCC
DDPIHLAALWFWLNSDQPLFRVRRDHMVEARQLIDLRRIRQLRRKQQSRAQQRLDALALL
CCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IADSPLSKDQWQDLPSDLQFTINRLIELADGPEDAFLADEQALQLIKDLKLGRSLSDLRY
HCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHCCCHHHHHH
WLIKKGWRDPHDLTTLKGSIWTKSFEGSVQAQADQLLNKFEQLSFGGDDNRLDLSDLRTY
HHHHCCCCCCCHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCEE
TLDDHQTQEIDDAISLQCVDQDNWIWIHIADPARLIPVDSPLDLEARARATSLYLADGLR
ECCCCCHHHHCCCEEEEEECCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
TMLPLSVAVEVLSLRAGRRCAALSVAVVLDESGCIAGTRVCRTWIRPCYRLTYEDGDELI
HHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCCCEE
ELAPPGDEDLSTLASLLTTRQLWRERQGALLLEQSEGRFKVKDDQPELHIVESSPARRLV
EECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCEEEECCCHHHHHH
SEAMILMGTVIAEFGKRQNIALPYRSQPPTQLPSATELSQLIEGPVRHAAIKRCLSRGVL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GTRPMAHFSLGLSAYVQASSPIRRYADLLAHRQVVAHLGGSVPLSEHALMEQLDVLEDPL
CCCCHHHHHHCHHHHEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
RQAQQIQREDQRHWQKVWFLKHRHEQWPALFLRWLKPQDQIALVHVECLAMDLACKIHGL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCC
IDPSPGLALIMRVLVIDPLTDQIELVAK
CCCCCCHHHHHHHHHHCCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]