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The map label for this gene is umuC [H]

Identifier: 33862911

GI number: 33862911

Start: 689823

End: 691097

Strand: Direct

Name: umuC [H]

Synonym: PMT0638

Alternate gene names: 33862911

Gene position: 689823-691097 (Clockwise)

Preceding gene: 33862908

Following gene: 33862916

Centisome position: 28.61

GC content: 55.76

Gene sequence:

>1275_bases
ATGTCTCGGGTCACAGCCCTGATCGACGGCAACAATTTCTATGCCTCCTGTGAGCAAAGCCTTGACGCCTCGCTGATCGG
TCGTCCTCTGGTCGTGCTCTCCAACAACGATGGCTGCATTGTTGCTCGCAGCTCCGAAGCGCGTGCTCTCGGAATCAGCA
TGGGCACGCCCTATTTCAAGGTCCGTCACAAATTGGACCGACTTGGCGTTGTCGTGCGCAGCTCCAACTACGCCCTCTAC
GGCGATATGAGCCAACGACTGATGAGCTTGCTGGAAGCCCATTGTGAGGAGCTGGAGATTTACTCGATTGATGAAGCCTT
TGCTTACATCAATGGTCCCTCTGATGACAACCTAAAGCCCTGGGCCCGTCAACTACGGGCCCTGGTGCATCGCAACCTGG
GCCTACCGATAGCAATCGGACTTGGCGCCAGTAAAGGTCAGGCCAAACTCGCCAACCACCTGGCCAAGGCCATACCGGCT
CACGCTGGAGTGTTCAACCTACTCACCGCTAGTGATCCAGATACATGGCTTGAGAGCGTCGCTATCGAAAATGTATGGGG
GATCGGTCGCAAGTTGGCCCATTGGTGCCGACTTAGAGGCGTAACCAATGCCCGGCAATTGCGCGATATGCCACGTAGCC
AACTTCATGCCCGCTGCGGCGTTGTAGGCATACGCCTACAACGAGAATTACAAGGTTATGCCTGCCTTCCTCTAGCCCTA
GCCCCAACATCAAAACAGGAAACCTGCGTTAGCCGCAGTTTTAGCCGACCAATCGCCAACCTAGAGGAATTACGCCAGGC
AATCGCAACCTACGTGGTGCGCGCCAGTGAAAAACTGCGACGACAACAGCAACGGGCCGGGATCCTCACCGTATTCACAC
GTACCAGCCCATTTGCACCATCGTTTTACAGCCAAGCCGCTACCATTCAACTGGATTTGCCAAGCAACGACACTGCAATC
TTGCTAGCAGCAGCCTTGCCACTAGTCGAGCGAATCTACCGGCCCCATCGCCGCTTAAACAAAGCCGGGGTGCTGATGCA
AAACCTACAGAGCGCAGACCATCTGCAACAACACCTGTTGGTAGCAGTTCATGCCGATGAGCAGCATCGTAGCGATCGAC
TAATGAACACCGTCGACCGACTTAATCACCGTTACGGCAGCGGAACCGTGAGTTGGGCTGTTTGTGGCATGCAGCCAGGA
TGGAGCATGCGTCGTCATCAACTCAGCCGCGCGGCCACAACTCGCCTCAATGACGTGCCGTTGGTGCTGGCCTGA

Upstream 100 bases:

>100_bases
GCGACTGGCTGTCACAGCAAAGCACGTTCTCGCCATCAAACAGGCACTAGTATCTTTGTACTAGGATAGGGCATAGTTTC
GCTCGCTTCTCTTCAGTGCC

Downstream 100 bases:

>100_bases
AATTTAGAATTGAATGTCAACAGATCTCATTAGTTAGTGGATTGGGCTGGATTTGATTTGCTCGGTTCCATCCACATCTC
CAATCCATAAAGAATGCGCC

Product: UmuC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSRVTALIDGNNFYASCEQSLDASLIGRPLVVLSNNDGCIVARSSEARALGISMGTPYFKVRHKLDRLGVVVRSSNYALY
GDMSQRLMSLLEAHCEELEIYSIDEAFAYINGPSDDNLKPWARQLRALVHRNLGLPIAIGLGASKGQAKLANHLAKAIPA
HAGVFNLLTASDPDTWLESVAIENVWGIGRKLAHWCRLRGVTNARQLRDMPRSQLHARCGVVGIRLQRELQGYACLPLAL
APTSKQETCVSRSFSRPIANLEELRQAIATYVVRASEKLRRQQQRAGILTVFTRTSPFAPSFYSQAATIQLDLPSNDTAI
LLAAALPLVERIYRPHRRLNKAGVLMQNLQSADHLQQHLLVAVHADEQHRSDRLMNTVDRLNHRYGSGTVSWAVCGMQPG
WSMRRHQLSRAATTRLNDVPLVLA

Sequences:

>Translated_424_residues
MSRVTALIDGNNFYASCEQSLDASLIGRPLVVLSNNDGCIVARSSEARALGISMGTPYFKVRHKLDRLGVVVRSSNYALY
GDMSQRLMSLLEAHCEELEIYSIDEAFAYINGPSDDNLKPWARQLRALVHRNLGLPIAIGLGASKGQAKLANHLAKAIPA
HAGVFNLLTASDPDTWLESVAIENVWGIGRKLAHWCRLRGVTNARQLRDMPRSQLHARCGVVGIRLQRELQGYACLPLAL
APTSKQETCVSRSFSRPIANLEELRQAIATYVVRASEKLRRQQQRAGILTVFTRTSPFAPSFYSQAATIQLDLPSNDTAI
LLAAALPLVERIYRPHRRLNKAGVLMQNLQSADHLQQHLLVAVHADEQHRSDRLMNTVDRLNHRYGSGTVSWAVCGMQPG
WSMRRHQLSRAATTRLNDVPLVLA
>Mature_423_residues
SRVTALIDGNNFYASCEQSLDASLIGRPLVVLSNNDGCIVARSSEARALGISMGTPYFKVRHKLDRLGVVVRSSNYALYG
DMSQRLMSLLEAHCEELEIYSIDEAFAYINGPSDDNLKPWARQLRALVHRNLGLPIAIGLGASKGQAKLANHLAKAIPAH
AGVFNLLTASDPDTWLESVAIENVWGIGRKLAHWCRLRGVTNARQLRDMPRSQLHARCGVVGIRLQRELQGYACLPLALA
PTSKQETCVSRSFSRPIANLEELRQAIATYVVRASEKLRRQQQRAGILTVFTRTSPFAPSFYSQAATIQLDLPSNDTAIL
LAAALPLVERIYRPHRRLNKAGVLMQNLQSADHLQQHLLVAVHADEQHRSDRLMNTVDRLNHRYGSGTVSWAVCGMQPGW
SMRRHQLSRAATTRLNDVPLVLA

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=420, Percent_Identity=39.2857142857143, Blast_Score=280, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 47016; Mature: 46884

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVTALIDGNNFYASCEQSLDASLIGRPLVVLSNNDGCIVARSSEARALGISMGTPYFK
CCCEEEEEECCCEEEHHHHCCCHHHCCCCEEEEECCCCEEEEECCCCCEEEEECCCCHHH
VRHKLDRLGVVVRSSNYALYGDMSQRLMSLLEAHCEELEIYSIDEAFAYINGPSDDNLKP
HHHHHHHHCEEEECCCEEEECCHHHHHHHHHHHHHHHCEEEEECHHHEEECCCCCCCCCH
WARQLRALVHRNLGLPIAIGLGASKGQAKLANHLAKAIPAHAGVFNLLTASDPDTWLESV
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCHHCCHHHEEECCCHHHHHHHH
AIENVWGIGRKLAHWCRLRGVTNARQLRDMPRSQLHARCGVVGIRLQRELQGYACLPLAL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHCEEEEEEHHHHCCCEEEEEEE
APTSKQETCVSRSFSRPIANLEELRQAIATYVVRASEKLRRQQQRAGILTVFTRTSPFAP
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
SFYSQAATIQLDLPSNDTAILLAAALPLVERIYRPHRRLNKAGVLMQNLQSADHLQQHLL
HHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
VAVHADEQHRSDRLMNTVDRLNHRYGSGTVSWAVCGMQPGWSMRRHQLSRAATTRLNDVP
EEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
LVLA
EEEC
>Mature Secondary Structure 
SRVTALIDGNNFYASCEQSLDASLIGRPLVVLSNNDGCIVARSSEARALGISMGTPYFK
CCEEEEEECCCEEEHHHHCCCHHHCCCCEEEEECCCCEEEEECCCCCEEEEECCCCHHH
VRHKLDRLGVVVRSSNYALYGDMSQRLMSLLEAHCEELEIYSIDEAFAYINGPSDDNLKP
HHHHHHHHCEEEECCCEEEECCHHHHHHHHHHHHHHHCEEEEECHHHEEECCCCCCCCCH
WARQLRALVHRNLGLPIAIGLGASKGQAKLANHLAKAIPAHAGVFNLLTASDPDTWLESV
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCHHCCHHHEEECCCHHHHHHHH
AIENVWGIGRKLAHWCRLRGVTNARQLRDMPRSQLHARCGVVGIRLQRELQGYACLPLAL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHCEEEEEEHHHHCCCEEEEEEE
APTSKQETCVSRSFSRPIANLEELRQAIATYVVRASEKLRRQQQRAGILTVFTRTSPFAP
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
SFYSQAATIQLDLPSNDTAILLAAALPLVERIYRPHRRLNKAGVLMQNLQSADHLQQHLL
HHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
VAVHADEQHRSDRLMNTVDRLNHRYGSGTVSWAVCGMQPGWSMRRHQLSRAATTRLNDVP
EEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
LVLA
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609 [H]