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The map label for this gene is lpxD

Identifier: 33862803

GI number: 33862803

Start: 578003

End: 579046

Strand: Direct

Name: lpxD

Synonym: PMT0530

Alternate gene names: 33862803

Gene position: 578003-579046 (Clockwise)

Preceding gene: 33862802

Following gene: 33862804

Centisome position: 23.97

GC content: 56.23

Gene sequence:

>1044_bases
ATGCGCTTCAGCCAGTTGATCGCCTCCCTCCAACAAGGAAGCGCTGGGCTGCAGGACCACCAGCTAGCTGAAGATCCTGA
ACTGCTTAGCGGCGCATCTCTCGATCAAGCAAAGGCCAATCAGCTCAGTTTTCTGGAACAGGGCAATGCACTAACCACTC
AGCTAAGCCACAGCAAGGTTGGGGCCGTATTGATTCCACCTCAGGATGATCTACGTGTCATCGCTGAACAAAGAGGGCTG
GCCTTTGCGGTGTTGCGAGATCCTCGCCTGGCATTCGCTGAAGCCTTGGAACAATTGCATCCACGCTCGCGGCCCAAGGC
AGGTGTTCACCCCACAGCCGTGATCGGAGATCAAGTGCATCTTGGCCAAGGGATCTCAATCGGTGCGCACGTCGTCATCG
GTGATGGCAGCCGTATCGGTGCCTATAGCGTGGTCCATCCAGGCGTAGTGATTTACGAAGATGTGGTGGTGGGGGAAGCT
AATGAACTTCATGCCAATGCTGTTCTTCAGCCTGGTTCCAGGCTAGGTCTGAACTGCGTTGTGCACTCCAATGCCGTTGT
GGGATCAGAGGGTTTCGGCTTCGTACCTACCGCCAATGGATGGAGAAAGATGCCCCAAACCGGTTTGGTGGTTCTTGAAG
ACGGTGTAGAAGTGGGCTGCGGGTCGACCATCGACCGTCCATCGGTGGGTGAGACTCGCATCGGCGCTGGGACCAAAATT
GACAACCTCGTGCAAATCGGCCACGGGGTGGTTACAGGCCAAGGATGTGCCCTTGCCTCACAGGTGGGGATTGCCGGCGG
TGCTCGCCTGGGTGAAGGTGTAATCCTCGCCGGTCAGGTTGGAGTCGCTAATCGCGCTGTAATCGGCGATCGTGCCATCG
CTAGCTCGAAGAGCGGTATTCATGGCGAAGTTGAAGCGGGGGAAGTTGTCAGCGGCTATCCCGCGATTCCAAATCGCCTC
TGGTTGCGCTGTTCCGCCACCTTCAGCAAATTACCGGAGATGGCCAAAATGTTGAGGAAGCTGACAAGAGATACACCTCA
GTAA

Upstream 100 bases:

>100_bases
CGGTCGTGGTGCATAGGGACGTGTTGGTTCTCCGCAACGCGTGACTTGATTGAACATCACCAACACATCACGCCTACGAT
CCGCCGAAAAGTGATTTGAC

Downstream 100 bases:

>100_bases
CCTCACAGGAGGCACAAGCCATTTTGGAGTTCTCCACATGCGCCAGCACCGCATCGTTCTGCTGCCTGGTGATGGTATCG
GTCCTGAAATCACTGCTGTA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRFSQLIASLQQGSAGLQDHQLAEDPELLSGASLDQAKANQLSFLEQGNALTTQLSHSKVGAVLIPPQDDLRVIAEQRGL
AFAVLRDPRLAFAEALEQLHPRSRPKAGVHPTAVIGDQVHLGQGISIGAHVVIGDGSRIGAYSVVHPGVVIYEDVVVGEA
NELHANAVLQPGSRLGLNCVVHSNAVVGSEGFGFVPTANGWRKMPQTGLVVLEDGVEVGCGSTIDRPSVGETRIGAGTKI
DNLVQIGHGVVTGQGCALASQVGIAGGARLGEGVILAGQVGVANRAVIGDRAIASSKSGIHGEVEAGEVVSGYPAIPNRL
WLRCSATFSKLPEMAKMLRKLTRDTPQ

Sequences:

>Translated_347_residues
MRFSQLIASLQQGSAGLQDHQLAEDPELLSGASLDQAKANQLSFLEQGNALTTQLSHSKVGAVLIPPQDDLRVIAEQRGL
AFAVLRDPRLAFAEALEQLHPRSRPKAGVHPTAVIGDQVHLGQGISIGAHVVIGDGSRIGAYSVVHPGVVIYEDVVVGEA
NELHANAVLQPGSRLGLNCVVHSNAVVGSEGFGFVPTANGWRKMPQTGLVVLEDGVEVGCGSTIDRPSVGETRIGAGTKI
DNLVQIGHGVVTGQGCALASQVGIAGGARLGEGVILAGQVGVANRAVIGDRAIASSKSGIHGEVEAGEVVSGYPAIPNRL
WLRCSATFSKLPEMAKMLRKLTRDTPQ
>Mature_347_residues
MRFSQLIASLQQGSAGLQDHQLAEDPELLSGASLDQAKANQLSFLEQGNALTTQLSHSKVGAVLIPPQDDLRVIAEQRGL
AFAVLRDPRLAFAEALEQLHPRSRPKAGVHPTAVIGDQVHLGQGISIGAHVVIGDGSRIGAYSVVHPGVVIYEDVVVGEA
NELHANAVLQPGSRLGLNCVVHSNAVVGSEGFGFVPTANGWRKMPQTGLVVLEDGVEVGCGSTIDRPSVGETRIGAGTKI
DNLVQIGHGVVTGQGCALASQVGIAGGARLGEGVILAGQVGVANRAVIGDRAIASSKSGIHGEVEAGEVVSGYPAIPNRL
WLRCSATFSKLPEMAKMLRKLTRDTPQ

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=317, Percent_Identity=30.9148264984227, Blast_Score=154, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_PROMM (Q7V843)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894363.1
- ProteinModelPortal:   Q7V843
- SMR:   Q7V843
- STRING:   Q7V843
- GeneID:   1729501
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0530
- NMPDR:   fig|74547.1.peg.530
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   PRLLFAK
- ProtClustDB:   PRK00892
- BioCyc:   PMAR74547:PMT0530-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 36064; Mature: 36064

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSQLIASLQQGSAGLQDHQLAEDPELLSGASLDQAKANQLSFLEQGNALTTQLSHSKV
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCC
GAVLIPPQDDLRVIAEQRGLAFAVLRDPRLAFAEALEQLHPRSRPKAGVHPTAVIGDQVH
CEEEECCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEE
LGQGISIGAHVVIGDGSRIGAYSVVHPGVVIYEDVVVGEANELHANAVLQPGSRLGLNCV
CCCCCCCCEEEEEECCCCCCEEEEECCCEEEEEEEEECCCCHHCCCEEECCCCCCCEEEE
VHSNAVVGSEGFGFVPTANGWRKMPQTGLVVLEDGVEVGCGSTIDRPSVGETRIGAGTKI
EECCEEECCCCCCCCCCCCCHHHCCCCCEEEEECCCEECCCCCCCCCCCCCCCCCCCCCH
DNLVQIGHGVVTGQGCALASQVGIAGGARLGEGVILAGQVGVANRAVIGDRAIASSKSGI
HHHHHHCCCEEECCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEECCHHHHCCCCCC
HGEVEAGEVVSGYPAIPNRLWLRCSATFSKLPEMAKMLRKLTRDTPQ
CCCCCCCCEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRFSQLIASLQQGSAGLQDHQLAEDPELLSGASLDQAKANQLSFLEQGNALTTQLSHSKV
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCC
GAVLIPPQDDLRVIAEQRGLAFAVLRDPRLAFAEALEQLHPRSRPKAGVHPTAVIGDQVH
CEEEECCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEE
LGQGISIGAHVVIGDGSRIGAYSVVHPGVVIYEDVVVGEANELHANAVLQPGSRLGLNCV
CCCCCCCCEEEEEECCCCCCEEEEECCCEEEEEEEEECCCCHHCCCEEECCCCCCCEEEE
VHSNAVVGSEGFGFVPTANGWRKMPQTGLVVLEDGVEVGCGSTIDRPSVGETRIGAGTKI
EECCEEECCCCCCCCCCCCCHHHCCCCCEEEEECCCEECCCCCCCCCCCCCCCCCCCCCH
DNLVQIGHGVVTGQGCALASQVGIAGGARLGEGVILAGQVGVANRAVIGDRAIASSKSGI
HHHHHHCCCEEECCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEECCHHHHCCCCCC
HGEVEAGEVVSGYPAIPNRLWLRCSATFSKLPEMAKMLRKLTRDTPQ
CCCCCCCCEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642