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The map label for this gene is lepB [H]

Identifier: 33862680

GI number: 33862680

Start: 458097

End: 458717

Strand: Direct

Name: lepB [H]

Synonym: PMT0407

Alternate gene names: 33862680

Gene position: 458097-458717 (Clockwise)

Preceding gene: 33862673

Following gene: 33862681

Centisome position: 19.0

GC content: 55.56

Gene sequence:

>621_bases
ATGACCCCGACACCTTCTCCTCCTCGAAAAGAAGCAAGCGGTAGCTGGCGCAGCCTGCTGCTCTGGGTAGTTCTGGCCTT
GTTGATGCGCTGGCAGGTGGTGGAGCCTCGCTGGATTCCCTCCGGTTCAATGCTGCCAACCCTTCAGTTGAAGGATCGCA
TTCTTGTTGAGAAGGTTCGCCCTCGACTTGCACGTCAACAAGAACAGCCTTTGCCACTGGGCAGCGTGGTGGTGTTTCAC
CCGCCATCCGCACTACTGGATGCTGGCTACGACCCTAAAGCGGCCTTGATTAAACGCGTGGTGGGGCGTCCGGGCGATCA
ACTGGAAGTTCATCATGGTCAGCTCTTGCGCAACGAGATCGCCATCAAGGATGACTGCCGTGATGCACCAATGAACTACG
AGATGGCGAAGGTGACCGTTCCTGAGCATGAACTTTGGGTGATGGGGGACAACCGCAATTCCAGTCTTGACTCTCATCTC
TGGGGGCCATTACCAGAAGAAGCTGTGATCGGAACAGCTATTTGGAGGTACTGGCCACTCAATCGGTTCGGTCCAATACG
GTTCCCCTCCCAAGGCAAGAGTGGATCAAACGACCTAGCTGCGATAGGGTCAACATCGTGA

Upstream 100 bases:

>100_bases
CAAACCAACAGATTGTTGTGAGCAAGAGACAGAGCTTGAGCCTTAGCCAATGCGATTCTCGGTCAATACCGACCGGCGAG
GGCCGACTTAATCAGTTTCG

Downstream 100 bases:

>100_bases
CGAAAAGCACACCGGATGTTCAACCCGGAGTTCCTGACCACCGATAACAGCGATTGCCAGGACGGTAATGGGCTAATTCA
GTACCTTCAGGATCAATCCC

Product: leader peptidase I

Products: NA

Alternate protein names: SPase I-1; Leader peptidase I-1 [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTPTPSPPRKEASGSWRSLLLWVVLALLMRWQVVEPRWIPSGSMLPTLQLKDRILVEKVRPRLARQQEQPLPLGSVVVFH
PPSALLDAGYDPKAALIKRVVGRPGDQLEVHHGQLLRNEIAIKDDCRDAPMNYEMAKVTVPEHELWVMGDNRNSSLDSHL
WGPLPEEAVIGTAIWRYWPLNRFGPIRFPSQGKSGSNDLAAIGSTS

Sequences:

>Translated_206_residues
MTPTPSPPRKEASGSWRSLLLWVVLALLMRWQVVEPRWIPSGSMLPTLQLKDRILVEKVRPRLARQQEQPLPLGSVVVFH
PPSALLDAGYDPKAALIKRVVGRPGDQLEVHHGQLLRNEIAIKDDCRDAPMNYEMAKVTVPEHELWVMGDNRNSSLDSHL
WGPLPEEAVIGTAIWRYWPLNRFGPIRFPSQGKSGSNDLAAIGSTS
>Mature_205_residues
TPTPSPPRKEASGSWRSLLLWVVLALLMRWQVVEPRWIPSGSMLPTLQLKDRILVEKVRPRLARQQEQPLPLGSVVVFHP
PSALLDAGYDPKAALIKRVVGRPGDQLEVHHGQLLRNEIAIKDDCRDAPMNYEMAKVTVPEHELWVMGDNRNSSLDSHLW
GPLPEEAVIGTAIWRYWPLNRFGPIRFPSQGKSGSNDLAAIGSTS

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Homo sapiens, GI21450679, Length=156, Percent_Identity=28.2051282051282, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 23087; Mature: 22956

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTPSPPRKEASGSWRSLLLWVVLALLMRWQVVEPRWIPSGSMLPTLQLKDRILVEKVR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHH
PRLARQQEQPLPLGSVVVFHPPSALLDAGYDPKAALIKRVVGRPGDQLEVHHGQLLRNEI
HHHHHHCCCCCCCCCEEEECCCHHHHHCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHC
AIKDDCRDAPMNYEMAKVTVPEHELWVMGDNRNSSLDSHLWGPLPEEAVIGTAIWRYWPL
CCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHCCC
NRFGPIRFPSQGKSGSNDLAAIGSTS
CCCCCCCCCCCCCCCCCCEEECCCCC
>Mature Secondary Structure 
TPTPSPPRKEASGSWRSLLLWVVLALLMRWQVVEPRWIPSGSMLPTLQLKDRILVEKVR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHH
PRLARQQEQPLPLGSVVVFHPPSALLDAGYDPKAALIKRVVGRPGDQLEVHHGQLLRNEI
HHHHHHCCCCCCCCCEEEECCCHHHHHCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHC
AIKDDCRDAPMNYEMAKVTVPEHELWVMGDNRNSSLDSHLWGPLPEEAVIGTAIWRYWPL
CCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHCCC
NRFGPIRFPSQGKSGSNDLAAIGSTS
CCCCCCCCCCCCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]