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The map label for this gene is lpdA-1 [H]

Identifier: 308535184

GI number: 308535184

Start: 836754

End: 837164

Strand: Direct

Name: lpdA-1 [H]

Synonym: NA

Alternate gene names: 308535184

Gene position: 836754-837164 (Clockwise)

Preceding gene: 197117101

Following gene: 197117102

Centisome position: 18.13

GC content: 64.96

Gene sequence:

>411_bases
ATGGCAGAAGAAATTTTCGATCTGGTGGTTATCGGGGCGGGGCCCGGCGGCTACGTCGCCGCCATACGCGCAGCGCAGCT
GGGGATGACGGTGGCAGTGGTGGAGAAGCGGGGGACACTCGGTGGCGTCTGCCTCAACGAGGGGTGCATCCCCAGCAAGG
CGCTCCTTGACTCCAGCGAGCTCTTTCATCTGGCCGGGCACCGCTTCTCCGCGCACGGCATAGAGGTGGCGCCCCCGACC
CTCAACCTCGGGCAGATGATGGCCAGAAAGGACGACGTGGTGAAGAAGCTCACCGACGGCGTCACCTACCTCTTCAAGAA
AAACAAGATCAGGAGCGTGAACGGCACGGCAAGGCTTGCCGGCAGCGAGGCGGGCGGGGTGCACAAGGTCGAGGTGCAGG
GAGCGCAGGGG

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: 2-oxoglutarate dehydrogenase complex, E3 protein, dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase 3; LPD-3 [H]

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:
NA

Sequences:

>Translated_137_residues
MAEEIFDLVVIGAGPGGYVAAIRAAQLGMTVAVVEKRGTLGGVCLNEGCIPSKALLDSSELFHLAGHRFSAHGIEVAPPT
LNLGQMMARKDDVVKKLTDGVTYLFKKNKIRSVNGTARLAGSEAGGVHKVEVQGAQG
>Mature_136_residues
AEEIFDLVVIGAGPGGYVAAIRAAQLGMTVAVVEKRGTLGGVCLNEGCIPSKALLDSSELFHLAGHRFSAHGIEVAPPTL
NLGQMMARKDDVVKKLTDGVTYLFKKNKIRSVNGTARLAGSEAGGVHKVEVQGAQG

Specific function: LPD-3 may substitute for lipoamide dehydrogenase of the 2-oxoglutarate dehydrogenase and pyruvate multienzyme complexes when the latter is inactive or missing [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=116, Percent_Identity=55.1724137931034, Blast_Score=132, Evalue=1e-31,
Organism=Escherichia coli, GI1786307, Length=138, Percent_Identity=40.5797101449275, Blast_Score=98, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32565766, Length=115, Percent_Identity=59.1304347826087, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6321091, Length=111, Percent_Identity=54.954954954955, Blast_Score=119, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6325240, Length=130, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21358499, Length=132, Percent_Identity=47.7272727272727, Blast_Score=120, Evalue=4e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 14257; Mature: 14126

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEEIFDLVVIGAGPGGYVAAIRAAQLGMTVAVVEKRGTLGGVCLNEGCIPSKALLDSSE
CCCCEEEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCCCCCEEECCCCCCCHHHCCCHH
LFHLAGHRFSAHGIEVAPPTLNLGQMMARKDDVVKKLTDGVTYLFKKNKIRSVNGTARLA
HHHHCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCEEEC
GSEAGGVHKVEVQGAQG
CCCCCCEEEEEEECCCC
>Mature Secondary Structure 
AEEIFDLVVIGAGPGGYVAAIRAAQLGMTVAVVEKRGTLGGVCLNEGCIPSKALLDSSE
CCCEEEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCCCCCEEECCCCCCCHHHCCCHH
LFHLAGHRFSAHGIEVAPPTLNLGQMMARKDDVVKKLTDGVTYLFKKNKIRSVNGTARLA
HHHHCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCEEEC
GSEAGGVHKVEVQGAQG
CCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]