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The map label for this gene is moeA-2 [H]

Identifier: 30263514

GI number: 30263514

Start: 3327296

End: 3328603

Strand: Reverse

Name: moeA-2 [H]

Synonym: BA_3623

Alternate gene names: 30263514

Gene position: 3328603-3327296 (Counterclockwise)

Preceding gene: 30263515

Following gene: 30263513

Centisome position: 63.68

GC content: 39.22

Gene sequence:

>1308_bases
ATGGAAAGAAGAGTGCCAATTACGGTTGAAGAAGCTGTTCGTAAAGTAATGGAATTTGCTAATGAGGGTTTAAAGGAGCT
ACTACCTATTGAATTAGCTTATGGACGTGTATTAGCGGAGGATTTAGTAGCTGACTATGACGTACCTTCATTCAATCGTT
CCCCGTATGACGGATTTGCTATTAGAGCAGAAGATACGAATGTAGCAAGTTATGAAACGCCAATTGTATTTGAAGTAGTG
GGTGAAATTGGTGCAGGATCGCTATTCGATGAGAAAGTAGGTCCGTTTCAAGCAGTTCGAATTATGACGGGAGCGCAAAT
TCCGAATGGATGTGATGCAGTTGTTATGCTAGAGCTGACTCGTCAATATGAGGAGGCTGGCAGTAAGTATATGGAATTGA
AGCGGTCATTCAAAGCGGGCGATAATATTTCTTTTCAAGGTGAAGATGCTCGTAAAGGAACGGTTCTTGCAAAGAAAGGA
ACATACATTAATCCAGGTATTTCAGCTCTTCTTGCTACATTCGGGTATAGCGAGGTGCCAGTTGCGAGAAAGCCTGTAGT
TGGACTATTAGCGACTGGCAGTGAATTACTGGATGTAAACGATTCATTACAGCCAGGGAAAATCCGAAATAGTAATACGT
ATATGATATTGTCTCAAATCCGAAGAGCAGGCGGAAGAGTAAAATATTTTGGGAAGTTTAGCGATGATTTTCATACGTGT
TTTACGGCTGTAAAAGAAGCATTAAGCCAAGTAGATATGCTCATTACAACAGGTGGTGTATCAGTAGGGGATTACGATTA
TTTGCCAGCTATATATGAAAAATTAGGTGCATCAGTTCTTTTCAATAAAGTTGCAATGCGGCCAGGAAGTGTAACGACTG
TAGCGCAATTAAATGGAAAGTTATTATTTGGTTTATCAGGAAATCCATCTGCTTGTTACGTAGGGTTTGAATTGTTTGTA
AGACCTTGTATTCGGACGTATATGTTTAGTGAAAAAGCACATGTAAAAAGAGAAAAAGCGTTATTAGGAGAAGACTTTTT
AAAGCCAAATCCATTTACAAGGTTTGTACGAGGAAAACTAACATATAACGAAGGGCAGTTAATCGCTTATCCGTCAGGGT
TTGATAAATCTAGCTCAGTTTCCTCTCTAGCGGAGACAAATATATTTATTGTACTTCCAGGTGGTACGAGAGGTTATAAA
AAAGATATGTTCGTAGATGTGCTCTTGTTGGAAGATAACGAAGGTAGTGAATGGCCTTGGACATTTTATAAAGTGAGAGG
TGATTCTAATGGGACAAGTGCTATTTGA

Upstream 100 bases:

>100_bases
TTTTCGAGATGGTCGTGTTTTCATTCATGGTACAAATGATATTTCAAAAGCGAAACAGTTATATTATCGCGTATTCGGTT
AATAGAAAGGGTTGTCAATA

Downstream 100 bases:

>100_bases
AATTGTAGATATACCGATTGTAGTTGAAGAAGTAACGAATAAGGTTGCAAGAAGAGAAGCAGGTGCAATTACAACTTTTA
TTGGTACAGTGAGAGAATTA

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MERRVPITVEEAVRKVMEFANEGLKELLPIELAYGRVLAEDLVADYDVPSFNRSPYDGFAIRAEDTNVASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI

Sequences:

>Translated_435_residues
MERRVPITVEEAVRKVMEFANEGLKELLPIELAYGRVLAEDLVADYDVPSFNRSPYDGFAIRAEDTNVASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI
>Mature_435_residues
MERRVPITVEEAVRKVMEFANEGLKELLPIELAYGRVLAEDLVADYDVPSFNRSPYDGFAIRAEDTNVASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=420, Percent_Identity=34.5238095238095, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI10880983, Length=420, Percent_Identity=34.5238095238095, Blast_Score=202, Evalue=6e-52,
Organism=Escherichia coli, GI1787049, Length=370, Percent_Identity=35.1351351351351, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI25147659, Length=397, Percent_Identity=28.7153652392947, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=393, Percent_Identity=27.9898218829517, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI17136978, Length=366, Percent_Identity=28.9617486338798, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24638841, Length=366, Percent_Identity=28.9617486338798, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47829; Mature: 47829

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRVPITVEEAVRKVMEFANEGLKELLPIELAYGRVLAEDLVADYDVPSFNRSPYDGFA
CCCCCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNVASYETPIVFEVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPNGCDAVVMLELT
EEECCCCCCCCCCCCCEEEHHCCCCCCCCHHCCCCHHEEEEEECCCCCCCCCCEEHHHHH
RQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKGTYINPGISALLATFGYSEVP
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCEECCCHHHHHHHCCCCCCC
VARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHHHHH
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKL
EEEEECCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEE
TYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKDMFVDVLLLEDNEGSEWPW
EECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGDSNGTSAI
EEEEEECCCCCCCCC
>Mature Secondary Structure
MERRVPITVEEAVRKVMEFANEGLKELLPIELAYGRVLAEDLVADYDVPSFNRSPYDGFA
CCCCCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNVASYETPIVFEVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPNGCDAVVMLELT
EEECCCCCCCCCCCCCEEEHHCCCCCCCCHHCCCCHHEEEEEECCCCCCCCCCEEHHHHH
RQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKGTYINPGISALLATFGYSEVP
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCEECCCHHHHHHHCCCCCCC
VARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHHHHH
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKL
EEEEECCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEE
TYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKDMFVDVLLLEDNEGSEWPW
EECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGDSNGTSAI
EEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]