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The map label for this gene is gntP

Identifier: 30065423

GI number: 30065423

Start: 4364235

End: 4365578

Strand: Direct

Name: gntP

Synonym: S4455

Alternate gene names: 30065423

Gene position: 4364235-4365578 (Clockwise)

Preceding gene: 30065416

Following gene: 30065434

Centisome position: 94.89

GC content: 52.9

Gene sequence:

>1344_bases
ATGCATGTGCTTAACATTCTCTGGGTGGTATTCGGCATTGGCCTGATGCTGATACTGAATTTGAAGTTCAAAATCAATTC
AATGGTGGCTTTGTTGGTGGCGGCGCTGTCCGTCGGGATGCTGGCAGGCATGGATTTGATGTCGCTGCTGCACACCATGA
AAGCGGGCTTCGGCAACACGCTGGGAGAACTGGCTATCATCGTGGTGTTCGGTGCGGTCATCGGTAAATTGATGGTCGAC
TCCGGCGCGGCTCACCAGATAGCACATACGCTGCTGGCGCGTCTCGGTCTGCGCTATGTACAGCTGTCGGTGATTATCAT
CGGCCTTATTTTCGGTCTGGCGATGTTCTATGAAGTGGCCTTTATCATGTTAGCGCCGCTGGTTATTGTTATTGCCGCCG
AAGCTAAAATTCCGTTCCTGAAACTGGCGATCCCGGCAGTAGCAGCTGCCACTACCGCACATTCACTGTTCCCACCGCAG
CCGGGTCCGGTGGCGCTGGTGAATGCTTATGGCGCGGATATGGGGATGGTTTATATCTATGGCGTACTGGTGACGATCCC
AAGTGTAATCTGCGCAGGTCTGATCCTGCCGAAGTTCCTCGGCAATCTTGAGCGCCCAACGCCATCATTCCTGAAAGCAG
ATCAACCGGTAGATATGAATAATCTGCCCTCTTTCGGCGTTTCGATTCTGGTGCCGCTGATCCCGGCGATCATTATGATC
TCTACCACCATCGCCAATATCTGGCTGGTAAAAGATACCCCTGCCTGGGAAGTGGTTAACTTTATTGGTTCCTCGCCGAT
TGCGATGTTTATTGCGATGGTGGTTGCATTCGTACTCTTTGGCACCGCGCGTGGTCATGACATGCAGTGGGTGATGAACG
CTTTTGAAAGCGCGGTGAAGAGTATTGCAATGGTGATTCTGATCATCGGTGCGGGTGGCGTGCTGAAGCAGACCATCATC
GACACCGGCATTGGCGACACCATCGGCATGTTGATGTCCCACGGCAATATCTCGCCCTACATTATGGCATGGCTGATCAC
TGTGCTAATTCGTCTGGCGACGGGTCAGGGTGTCGTTTCGGCGATGACCGCCGCCGGGATTATCAGTGCTGCAATCCTTG
ATCCAGCAACCGGTCAGCTGGTTGGCGTGAATCCGGCGCTGCTGGTACTGGCGACGGCTGCGGGTTCCAACACCCTCACC
CACATTAATGATGCATCTTTCTGGTTGTTCAAAGGTTACTTTGACCTGTCAGTAAAAGACACGTTGAAAACCTGGGGTCT
GCTGGAGCTGGTCAACTCCGTGGTTGGGCTGATTATTGTGCTGATTATTAGCATGGTAGCGTAA

Upstream 100 bases:

>100_bases
ATTGATCAGAGGATGTGACATTCATCGCAACAATGGTTGACCAATTTACATAACATGTCGCCCAAAATAACAACGGTTCA
ACCAAGTAAGGTAAAACGTT

Downstream 100 bases:

>100_bases
AAGAACACCAGAGCCTGCCAATGGCAGGCTCAGACTGATGACTAAAGTCTAAAAATGTGCCCGGACAGTCCCCTCGCCCC
TCCGGGGAGAGGGTTAGGGT

Product: fructuronate transporter

Products: Proton [Cytoplasm]; gluconate [Cytoplasm] [C]

Alternate protein names: Gluconate permease 3; Gnt-III system [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MHVLNILWVVFGIGLMLILNLKFKINSMVALLVAALSVGMLAGMDLMSLLHTMKAGFGNTLGELAIIVVFGAVIGKLMVD
SGAAHQIAHTLLARLGLRYVQLSVIIIGLIFGLAMFYEVAFIMLAPLVIVIAAEAKIPFLKLAIPAVAAATTAHSLFPPQ
PGPVALVNAYGADMGMVYIYGVLVTIPSVICAGLILPKFLGNLERPTPSFLKADQPVDMNNLPSFGVSILVPLIPAIIMI
STTIANIWLVKDTPAWEVVNFIGSSPIAMFIAMVVAFVLFGTARGHDMQWVMNAFESAVKSIAMVILIIGAGGVLKQTII
DTGIGDTIGMLMSHGNISPYIMAWLITVLIRLATGQGVVSAMTAAGIISAAILDPATGQLVGVNPALLVLATAAGSNTLT
HINDASFWLFKGYFDLSVKDTLKTWGLLELVNSVVGLIIVLIISMVA

Sequences:

>Translated_447_residues
MHVLNILWVVFGIGLMLILNLKFKINSMVALLVAALSVGMLAGMDLMSLLHTMKAGFGNTLGELAIIVVFGAVIGKLMVD
SGAAHQIAHTLLARLGLRYVQLSVIIIGLIFGLAMFYEVAFIMLAPLVIVIAAEAKIPFLKLAIPAVAAATTAHSLFPPQ
PGPVALVNAYGADMGMVYIYGVLVTIPSVICAGLILPKFLGNLERPTPSFLKADQPVDMNNLPSFGVSILVPLIPAIIMI
STTIANIWLVKDTPAWEVVNFIGSSPIAMFIAMVVAFVLFGTARGHDMQWVMNAFESAVKSIAMVILIIGAGGVLKQTII
DTGIGDTIGMLMSHGNISPYIMAWLITVLIRLATGQGVVSAMTAAGIISAAILDPATGQLVGVNPALLVLATAAGSNTLT
HINDASFWLFKGYFDLSVKDTLKTWGLLELVNSVVGLIIVLIISMVA
>Mature_447_residues
MHVLNILWVVFGIGLMLILNLKFKINSMVALLVAALSVGMLAGMDLMSLLHTMKAGFGNTLGELAIIVVFGAVIGKLMVD
SGAAHQIAHTLLARLGLRYVQLSVIIIGLIFGLAMFYEVAFIMLAPLVIVIAAEAKIPFLKLAIPAVAAATTAHSLFPPQ
PGPVALVNAYGADMGMVYIYGVLVTIPSVICAGLILPKFLGNLERPTPSFLKADQPVDMNNLPSFGVSILVPLIPAIIMI
STTIANIWLVKDTPAWEVVNFIGSSPIAMFIAMVVAFVLFGTARGHDMQWVMNAFESAVKSIAMVILIIGAGGVLKQTII
DTGIGDTIGMLMSHGNISPYIMAWLITVLIRLATGQGVVSAMTAAGIISAAILDPATGQLVGVNPALLVLATAAGSNTLT
HINDASFWLFKGYFDLSVKDTLKTWGLLELVNSVVGLIIVLIISMVA

Specific function: High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose [H]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family [H]

Homologues:

Organism=Escherichia coli, GI1790776, Length=447, Percent_Identity=99.7762863534676, Blast_Score=870, Evalue=0.0,
Organism=Escherichia coli, GI48994935, Length=438, Percent_Identity=40.6392694063927, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1790716, Length=435, Percent_Identity=40.6896551724138, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI2367370, Length=452, Percent_Identity=36.9469026548673, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1788707, Length=446, Percent_Identity=31.8385650224215, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI48994939, Length=431, Percent_Identity=30.8584686774942, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI1789097, Length=442, Percent_Identity=30.7692307692308, Blast_Score=178, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 47153; Mature: 47153

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVLNILWVVFGIGLMLILNLKFKINSMVALLVAALSVGMLAGMDLMSLLHTMKAGFGNT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LGELAIIVVFGAVIGKLMVDSGAAHQIAHTLLARLGLRYVQLSVIIIGLIFGLAMFYEVA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIMLAPLVIVIAAEAKIPFLKLAIPAVAAATTAHSLFPPQPGPVALVNAYGADMGMVYIY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHH
GVLVTIPSVICAGLILPKFLGNLERPTPSFLKADQPVDMNNLPSFGVSILVPLIPAIIMI
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
STTIANIWLVKDTPAWEVVNFIGSSPIAMFIAMVVAFVLFGTARGHDMQWVMNAFESAVK
HHHHHHEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
SIAMVILIIGAGGVLKQTIIDTGIGDTIGMLMSHGNISPYIMAWLITVLIRLATGQGVVS
HHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHH
AMTAAGIISAAILDPATGQLVGVNPALLVLATAAGSNTLTHINDASFWLFKGYFDLSVKD
HHHHHHHHHHHHCCCCCCCEEECCHHHEEEEECCCCCCEEEECCCCEEEEECEECCCHHH
TLKTWGLLELVNSVVGLIIVLIISMVA
HHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MHVLNILWVVFGIGLMLILNLKFKINSMVALLVAALSVGMLAGMDLMSLLHTMKAGFGNT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LGELAIIVVFGAVIGKLMVDSGAAHQIAHTLLARLGLRYVQLSVIIIGLIFGLAMFYEVA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIMLAPLVIVIAAEAKIPFLKLAIPAVAAATTAHSLFPPQPGPVALVNAYGADMGMVYIY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHH
GVLVTIPSVICAGLILPKFLGNLERPTPSFLKADQPVDMNNLPSFGVSILVPLIPAIIMI
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
STTIANIWLVKDTPAWEVVNFIGSSPIAMFIAMVVAFVLFGTARGHDMQWVMNAFESAVK
HHHHHHEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
SIAMVILIIGAGGVLKQTIIDTGIGDTIGMLMSHGNISPYIMAWLITVLIRLATGQGVVS
HHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHH
AMTAAGIISAAILDPATGQLVGVNPALLVLATAAGSNTLTHINDASFWLFKGYFDLSVKD
HHHHHHHHHHHHCCCCCCCEEECCHHHEEEEECCCCCCEEEECCCCEEEEECEECCCHHH
TLKTWGLLELVNSVVGLIIVLIISMVA
HHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; gluconate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]