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The map label for this gene is yjdE

Identifier: 30064684

GI number: 30064684

Start: 3499308

End: 3500645

Strand: Reverse

Name: yjdE

Synonym: S3622

Alternate gene names: 30064684

Gene position: 3500645-3499308 (Counterclockwise)

Preceding gene: 30064685

Following gene: 30064683

Centisome position: 76.11

GC content: 54.33

Gene sequence:

>1338_bases
ATGTCTTCGGATGCTGATGCTCACAAAGTGGGCTTAATCCCCGTCACCCTGATGGTGTCGGGGAATATTATGGGGTCAGG
TGTTTTTCTGTTACCTGCAAACCTGGCCTCCACTGGCGGGATTGCCATTTATGGATGGTTGGTGACGATTATCGGTGCGC
TGGGGCTCTCGATGGTATACGCCAAAATGTCGTTCCTCGACCCAAGTCCTGGTGGTTCTTACGCTTACGCCCGCCGCTGC
TTTGGCCCGTTTCTCGGTTATCAAACCAACGTCCTCTACTGGCTGGCCTGCTGGATCGGCAATATCGCCATGGTGGTCAT
TGGCGTAGGATATTTAAGTTACTTCTTCCCGATTCTGAAAGATCCATTGGTATTAACCATCACCTGCGTCGTGGTGCTGT
GGATCTTCGTCCTGCTGAACATTGTCGGTCCGAAAATGATCACCCGCGTGCAGGCCGTTGCCACTGTGCTGGCGCTGATC
CCCATCGTCGGGATTGCCGTATTTGGCTGGTTCTGGTTCCGTGGTGAAACCTATATGGCGGCATGGAACGTCAGCGGCCT
GGGCACCTTCGGTGCGATTCAAAGTACCCTTAACGTTACGCTGTGGTCGTTCATCGGTGTGGAAAGTGCCTCCGTTGCCG
CAGGTGTGGTGAAAAACCCGAAACGCAATGTCCCTATCGCCACCATTGGTGGGGTATTGATTGCCGCCGTTTGCTATGTG
CTCTCCACCACCGCGATTATGGGGATGATCCCTAATGCCGCACTGCGCGTTTCTGCCTCGCCATTCGGTGATGCCGCACG
GATGGCGTTGGGTGACACCGCTGGGGCCATTGTTTCCTTCTGCGCAGCTGCGGGTTGCTTAGGTTCACTGGGCGGCTGGA
CGTTGCTGGCGGGTCAAACGGCGAAAGCCGCTGCCGATGACGGACTGTTCCCACCGATTTTTGCCCGTGTAAATAAAGCG
GGTACGCCAGTGGCGGGGCTGATTATCGTCGGTATTTTGATGACCATCTTCCAGCTCAGCAGCATTTCACCAAACGCGAC
CAAAGAGTTCGGTCTGGTTTCTTCCGTCTCGGTCATCTTTACACTGGTGCCATATCTTTACACCTGTGCGGCGTTACTGC
TGCTCGGCCACGGTCACTTTGGTAAAGCACGCCCGGCATATCTGGCTGTTACTACCATTGCCTTCCTCTACTGCATTTGG
GCCGTGGTGGGGTCCGGGGCGAAAGAGGTTATGTGGTCATTTGTCACCCTGATGGTCATCACCGCCATGTATGCGCTGAA
TTACAACCGGCTACATAAAAACCCGTATCCCTTAGATGCACCAATAAGCAAAGATTAA

Upstream 100 bases:

>100_bases
ATCAGCGATAACCCGGTCGATAATAATTCAACTATCGAATGCAGGCGTATGATATGACGTAATTTATTGTCACGAAGCTC
GCCTTCGCAGGAGTTTAATT

Downstream 100 bases:

>100_bases
TTCCCCTTAATCCAGCAAACATAAAAGCCAACCTTAAGAACTTAAGGTTGGCTTAATTTTGCTTTGCGAGCATATGCGCA
CTTTGTTCGATGGAAACACC

Product: arginine:agmatin antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRC
FGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALI
PIVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKA
GTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIW
AVVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDAPISKD

Sequences:

>Translated_445_residues
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRC
FGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALI
PIVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKA
GTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIW
AVVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDAPISKD
>Mature_444_residues
SSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVYAKMSFLDPSPGGSYAYARRCF
GPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIP
IVGIAVFGWFWFRGETYMAAWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYVL
STTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKAG
TPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWA
VVGSGAKEVMWSFVTLMVITAMYALNYNRLHKNPYPLDAPISKD

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Homo sapiens, GI115648063, Length=363, Percent_Identity=23.4159779614325, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI115648022, Length=363, Percent_Identity=23.4159779614325, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI2367353, Length=445, Percent_Identity=100, Blast_Score=881, Evalue=0.0,
Organism=Escherichia coli, GI1790575, Length=447, Percent_Identity=38.255033557047, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1786908, Length=437, Percent_Identity=32.7231121281465, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI1787890, Length=431, Percent_Identity=29.4663573085847, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI87082250, Length=349, Percent_Identity=29.2263610315186, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI87081708, Length=410, Percent_Identity=24.8780487804878, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI48994972, Length=455, Percent_Identity=25.0549450549451, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790653, Length=399, Percent_Identity=24.3107769423559, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786789, Length=370, Percent_Identity=21.3513513513514, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786302, Length=398, Percent_Identity=22.8643216080402, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=342, Percent_Identity=25.4385964912281, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71995388, Length=408, Percent_Identity=24.5098039215686, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71995382, Length=408, Percent_Identity=24.5098039215686, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71993915, Length=403, Percent_Identity=24.5657568238213, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=359, Percent_Identity=26.7409470752089, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982608, Length=409, Percent_Identity=23.2273838630807, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982612, Length=410, Percent_Identity=23.4146341463415, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32566699, Length=312, Percent_Identity=22.4358974358974, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221331183, Length=452, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647653, Length=452, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664379, Length=452, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24651635, Length=346, Percent_Identity=23.9884393063584, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24651633, Length=346, Percent_Identity=23.9884393063584, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADIC_ECO57 (P60063)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A91266
- PIR:   F86106
- RefSeq:   NP_290748.1
- RefSeq:   NP_313124.1
- PDB:   3L1L
- PDB:   3LRB
- PDB:   3LRC
- PDBsum:   3L1L
- PDBsum:   3LRB
- PDBsum:   3LRC
- ProteinModelPortal:   P60063
- SMR:   P60063
- DIP:   DIP-48684N
- EnsemblBacteria:   EBESCT00000025185
- EnsemblBacteria:   EBESCT00000059508
- GeneID:   914204
- GeneID:   960009
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5717
- KEGG:   ecs:ECs5097
- GeneTree:   EBGT00050000009006
- HOGENOM:   HBG586921
- OMA:   AITFIAF
- ProtClustDB:   PRK10644
- BioCyc:   ECOL83334:ECS5097-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 46843; Mature: 46712

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: BINDING 22-22 BINDING 26-26 BINDING 93-93 BINDING 208-208 BINDING 365-365

Signals:

None

Transmembrane regions:

HASH(0x158c2364)-; HASH(0x158e627c)-; HASH(0x156b9550)-; HASH(0x13c0a2ac)-; HASH(0x153d26c8)-; HASH(0x14499980)-; HASH(0x155f1304)-; HASH(0x15772af8)-; HASH(0x1571bfc4)-; HASH(0x157ead08)-; HASH(0x158e5020)-; HASH(0x158e3870)-;

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVY
CCCCCCCCEECEEEEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
AKMSFLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILK
HHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIPIVGIAVFGWFWFRGETYMA
CCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
EECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQT
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
AKAAADDGLFPPIFARVNKAGTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIF
HHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWAVVGSGAKEVMWSFVTLMVI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TAMYALNYNRLHKNPYPLDAPISKD
HHHHHHCHHHHCCCCCCCCCCCCCH
>Mature Secondary Structure 
SSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVY
CCCCCCCEECEEEEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
AKMSFLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILK
HHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIPIVGIAVFGWFWFRGETYMA
CCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
EECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQT
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
AKAAADDGLFPPIFARVNKAGTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIF
HHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWAVVGSGAKEVMWSFVTLMVI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TAMYALNYNRLHKNPYPLDAPISKD
HHHHHHCHHHHCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796