| Definition | Shigella flexneri 2a str. 2457T, complete genome. |
|---|---|
| Accession | NC_004741 |
| Length | 4,599,354 |
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The map label for this gene is ccmA
Identifier: 30063641
GI number: 30063641
Start: 2298479
End: 2299102
Strand: Reverse
Name: ccmA
Synonym: S2415
Alternate gene names: 30063641
Gene position: 2299102-2298479 (Counterclockwise)
Preceding gene: 30063642
Following gene: 30063640
Centisome position: 49.99
GC content: 55.61
Gene sequence:
>624_bases GTGGGTATGCTTGAAGCCAGAGAGTTACTTTGTGAGCGGGATGAACGAACCTTATTTAGTGGCTTGTCATTTACGCTGAA CGCAGGAGAGTGGGTACAAATCACCGGTAGCAACGGCGCGGGGAAGACAACGCTTCTCCGTTTGCTGACGGGGTTGTCTC GCCCTGACGCTGGCGAGGTTCTCTGGCAAGGGCAGCCCTTGCATCAGGTACGCGACAGCTACCATCAAACCCTGTTATGG ATAGGCCATCAGCCGGGGATCAAAACCCGGCTGACGGCGTTAGAAAATCTGCACTTTTATCATCGCGATGGCGATGCCGC ACAATGTCTGGAAGCCTTGGCGCAGGCCGGGCTTGCCGGATTCGAAGATATTCCGGTAAATCAACTTTCTGCCGGGCAAC AACGCCGCGTCGCTTTAGCGCGTCTGTGGTTGACCCGTGCCACATTATGGATCCTCGACGAGCCTTTTACCGCGATTGAC GTTAACGGCGTCGATCGTCTGACCCAGCGTATGGCGCAGCATACGGAGCAGGGGGGGATTGTGATTCTGACTACCCACCA GCCGCTCAACGTTGCTGAAAGTAAAATTCGCCGCATTTCACTGACGCAAACGAGGGCCGCATGA
Upstream 100 bases:
>100_bases GGTGAAAGATGGGCAAACCTGTATTGATTGCCATAAAGGGATCGCGCACAAGCTGCCCGATATGCGTGAAGTCGAGCCAG GTTTTTAACAGGGTTATTGC
Downstream 100 bases:
>100_bases TGTTCTGGCGTATTTTCCGTCTTGAACTGCGCGTAGCGTTTCGCCATAGCGCCGAAATCGCCAACCCGCTGTGGTTCTTC CTGATTGTAATTACCCTTTT
Product: cytochrome c biogenesis protein CcmA
Products: NA
Alternate protein names: Heme exporter protein A [H]
Number of amino acids: Translated: 207; Mature: 206
Protein sequence:
>207_residues MGMLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLWQGQPLHQVRDSYHQTLLW IGHQPGIKTRLTALENLHFYHRDGDAAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAID VNGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRAA
Sequences:
>Translated_207_residues MGMLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLWQGQPLHQVRDSYHQTLLW IGHQPGIKTRLTALENLHFYHRDGDAAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAID VNGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRAA >Mature_206_residues GMLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLWQGQPLHQVRDSYHQTLLWI GHQPGIKTRLTALENLHFYHRDGDAAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDV NGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRAA
Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]
COG id: COG4133
COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component
Gene ontology:
Cell location: Cell inner membrane; Peripheral membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ABC transporter domain [H]
Homologues:
Organism=Homo sapiens, GI153792144, Length=201, Percent_Identity=30.3482587064677, Blast_Score=80, Evalue=9e-16, Organism=Homo sapiens, GI27436953, Length=202, Percent_Identity=29.7029702970297, Blast_Score=79, Evalue=2e-15, Organism=Homo sapiens, GI9665248, Length=194, Percent_Identity=30.4123711340206, Blast_Score=77, Evalue=9e-15, Organism=Homo sapiens, GI27477115, Length=210, Percent_Identity=28.0952380952381, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI6005701, Length=202, Percent_Identity=29.2079207920792, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI73747915, Length=161, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI73747917, Length=162, Percent_Identity=30.2469135802469, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI46592964, Length=183, Percent_Identity=29.5081967213115, Blast_Score=67, Evalue=8e-12, Organism=Homo sapiens, GI46592971, Length=183, Percent_Identity=29.5081967213115, Blast_Score=67, Evalue=8e-12, Organism=Homo sapiens, GI46592956, Length=183, Percent_Identity=29.5081967213115, Blast_Score=67, Evalue=8e-12, Organism=Homo sapiens, GI46592915, Length=183, Percent_Identity=29.5081967213115, Blast_Score=67, Evalue=8e-12, Organism=Homo sapiens, GI46592898, Length=183, Percent_Identity=29.5081967213115, Blast_Score=67, Evalue=8e-12, Organism=Homo sapiens, GI46592978, Length=183, Percent_Identity=29.5081967213115, Blast_Score=67, Evalue=8e-12, Organism=Homo sapiens, GI27881501, Length=175, Percent_Identity=27.4285714285714, Blast_Score=67, Evalue=9e-12, Organism=Homo sapiens, GI30795238, Length=175, Percent_Identity=27.4285714285714, Blast_Score=67, Evalue=9e-12, Organism=Homo sapiens, GI11967969, Length=189, Percent_Identity=27.5132275132275, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI255708477, Length=207, Percent_Identity=28.0193236714976, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI148612844, Length=207, Percent_Identity=28.0193236714976, Blast_Score=66, Evalue=2e-11, Organism=Homo sapiens, GI42741659, Length=188, Percent_Identity=26.063829787234, Blast_Score=66, Evalue=2e-11, Organism=Homo sapiens, GI150417984, Length=186, Percent_Identity=26.8817204301075, Blast_Score=64, Evalue=1e-10, Organism=Escherichia coli, GI87082064, Length=207, Percent_Identity=99.0338164251208, Blast_Score=416, Evalue=1e-118, Organism=Escherichia coli, GI87081709, Length=166, Percent_Identity=30.7228915662651, Blast_Score=87, Evalue=8e-19, Organism=Escherichia coli, GI87081834, Length=212, Percent_Identity=28.7735849056604, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI87081791, Length=191, Percent_Identity=30.8900523560209, Blast_Score=85, Evalue=3e-18, Organism=Escherichia coli, GI1788225, Length=203, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=7e-17, Organism=Escherichia coli, GI1787041, Length=205, Percent_Identity=28.780487804878, Blast_Score=80, Evalue=9e-17, Organism=Escherichia coli, GI1788165, Length=153, Percent_Identity=33.9869281045752, Blast_Score=77, Evalue=7e-16, Organism=Escherichia coli, GI1787370, Length=155, Percent_Identity=32.9032258064516, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1786703, Length=188, Percent_Identity=30.8510638297872, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI1788897, Length=212, Percent_Identity=30.6603773584906, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI48994943, Length=204, Percent_Identity=28.4313725490196, Blast_Score=72, Evalue=2e-14, Organism=Escherichia coli, GI1789891, Length=199, Percent_Identity=30.6532663316583, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI1789593, Length=207, Percent_Identity=29.4685990338164, Blast_Score=72, Evalue=4e-14, Organism=Escherichia coli, GI1789991, Length=154, Percent_Identity=31.1688311688312, Blast_Score=70, Evalue=7e-14, Organism=Escherichia coli, GI1787029, Length=180, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=8e-14, Organism=Escherichia coli, GI48995001, Length=180, Percent_Identity=28.3333333333333, Blast_Score=70, Evalue=9e-14, Organism=Escherichia coli, GI87081782, Length=195, Percent_Identity=27.6923076923077, Blast_Score=70, Evalue=9e-14, Organism=Escherichia coli, GI1788761, Length=197, Percent_Identity=27.4111675126904, Blast_Score=69, Evalue=3e-13, Organism=Escherichia coli, GI1787547, Length=178, Percent_Identity=30.3370786516854, Blast_Score=68, Evalue=4e-13, Organism=Escherichia coli, GI1786698, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=7e-13, Organism=Escherichia coli, GI1790544, Length=203, Percent_Identity=28.0788177339901, Blast_Score=67, Evalue=8e-13, Organism=Escherichia coli, GI1787105, Length=197, Percent_Identity=28.4263959390863, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1789032, Length=149, Percent_Identity=28.1879194630872, Blast_Score=66, Evalue=1e-12, Organism=Escherichia coli, GI1786345, Length=191, Percent_Identity=31.413612565445, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI1787164, Length=175, Percent_Identity=32, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI1790190, Length=187, Percent_Identity=26.7379679144385, Blast_Score=65, Evalue=4e-12, Organism=Escherichia coli, GI1789873, Length=201, Percent_Identity=25.8706467661692, Blast_Score=64, Evalue=6e-12, Organism=Escherichia coli, GI1787112, Length=175, Percent_Identity=29.1428571428571, Blast_Score=64, Evalue=8e-12, Organism=Escherichia coli, GI1788210, Length=180, Percent_Identity=26.1111111111111, Blast_Score=64, Evalue=9e-12, Organism=Escherichia coli, GI1786253, Length=145, Percent_Identity=31.7241379310345, Blast_Score=63, Evalue=1e-11, Organism=Escherichia coli, GI1788644, Length=196, Percent_Identity=29.5918367346939, Blast_Score=63, Evalue=1e-11, Organism=Escherichia coli, GI1786563, Length=191, Percent_Identity=30.8900523560209, Blast_Score=62, Evalue=2e-11, Organism=Escherichia coli, GI1788450, Length=174, Percent_Identity=27.5862068965517, Blast_Score=62, Evalue=3e-11, Organism=Escherichia coli, GI1789586, Length=169, Percent_Identity=30.1775147928994, Blast_Score=61, Evalue=4e-11, Organism=Escherichia coli, GI1786975, Length=181, Percent_Identity=29.8342541436464, Blast_Score=61, Evalue=6e-11, Organism=Caenorhabditis elegans, GI71992290, Length=205, Percent_Identity=27.8048780487805, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17558664, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17511077, Length=188, Percent_Identity=27.1276595744681, Blast_Score=70, Evalue=9e-13, Organism=Caenorhabditis elegans, GI193211017, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI193211015, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI71996809, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI115533608, Length=193, Percent_Identity=27.979274611399, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI25146777, Length=186, Percent_Identity=24.7311827956989, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI193202349, Length=186, Percent_Identity=27.4193548387097, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17565586, Length=179, Percent_Identity=27.9329608938547, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17543740, Length=195, Percent_Identity=24.6153846153846, Blast_Score=66, Evalue=1e-11, Organism=Caenorhabditis elegans, GI212646699, Length=186, Percent_Identity=24.1935483870968, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI115535101, Length=193, Percent_Identity=26.4248704663212, Blast_Score=64, Evalue=4e-11, Organism=Caenorhabditis elegans, GI115533592, Length=188, Percent_Identity=26.5957446808511, Blast_Score=63, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6323959, Length=175, Percent_Identity=26.8571428571429, Blast_Score=62, Evalue=6e-11, Organism=Drosophila melanogaster, GI19920532, Length=183, Percent_Identity=25.1366120218579, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24580930, Length=183, Percent_Identity=25.1366120218579, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI116007184, Length=181, Percent_Identity=32.0441988950276, Blast_Score=68, Evalue=5e-12, Organism=Drosophila melanogaster, GI221500365, Length=181, Percent_Identity=32.0441988950276, Blast_Score=67, Evalue=6e-12, Organism=Drosophila melanogaster, GI24641342, Length=179, Percent_Identity=30.7262569832402, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI28574533, Length=188, Percent_Identity=25.531914893617, Blast_Score=66, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR005895 - InterPro: IPR003593 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: =3.6.3.41 [H]
Molecular weight: Translated: 23011; Mature: 22879
Theoretical pI: Translated: 7.22; Mature: 7.22
Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 1.0 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGMLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEV CCCHHHHHHHHCCHHHHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCE LWQGQPLHQVRDSYHQTLLWIGHQPGIKTRLTALENLHFYHRDGDAAQCLEALAQAGLAG EECCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCC FEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGI CCCCCCHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHHHHHHCCCCCE VILTTHQPLNVAESKIRRISLTQTRAA EEEECCCCCHHHHHHHHHHHHHHHCCC >Mature Secondary Structure GMLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEV CCHHHHHHHHCCHHHHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCE LWQGQPLHQVRDSYHQTLLWIGHQPGIKTRLTALENLHFYHRDGDAAQCLEALAQAGLAG EECCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCC FEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGI CCCCCCHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHHHHHHCCCCCE VILTTHQPLNVAESKIRRISLTQTRAA EEEECCCCCHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 7.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]