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The map label for this gene is wzb

Identifier: 30063510

GI number: 30063510

Start: 2123880

End: 2124323

Strand: Reverse

Name: wzb

Synonym: S2249

Alternate gene names: 30063510

Gene position: 2124323-2123880 (Counterclockwise)

Preceding gene: 30063511

Following gene: 161486469

Centisome position: 46.19

GC content: 53.83

Gene sequence:

>444_bases
ATGTTTAACAACATCTTAGTTGTCTGTGTCGGCAATATTTGCCGTTCCCCGATGGCGGAACGCTTACTGCAACGTTATCA
CCCGGAACTGAAAGTGGAGTCCGCTGGACTCGGCGCGCTGGTCGGTAAGGGCGCTGATCCTACCGCTATCAGCGTCGCCG
CAGAACATCAACTGTCTCTGGAAGGCCACTGTGCACGACAAATCAGCCGCCGCCTGTGTCGCAACTATGACCTGATTTTG
ACCATGGATAAGCGCCATATCGAACGCTTATGCGAGATGGCACCGGAGATGCGCGGCAAAGTGATGCTGTTTGGTCACTG
GGATAACGAATGTGAAATCCCCGATCCGTATCACAAAAGCCGGGAAACGTTTGCAGCGGTGTACACATTACTTGAACGGT
CTGCCCGCCAGTGGGCGCAGGCATTGAACGCAGAGCAGGTATAA

Upstream 100 bases:

>100_bases
TTTCCCGCTGGAACCGTCTGATCAATCAGTTGCTGCCAACTATTAGCGGTGTCCGTTACATGACGGATACAGCCAGCGAC
ATTCATAACTGGTAATCGTC

Downstream 100 bases:

>100_bases
GAATGACAGAAAAAGTAAAACAACATGCCGCTCCGGTAACGGGCAGTGATGAAATCGATATTGGTCGCCTGGTCGGCACC
GTCATTGAAGCGCGCTGGTG

Product: tyrosine phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MFNNILVVCVGNICRSPMAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLIL
TMDKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYHKSRETFAAVYTLLERSARQWAQALNAEQV

Sequences:

>Translated_147_residues
MFNNILVVCVGNICRSPMAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLIL
TMDKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYHKSRETFAAVYTLLERSARQWAQALNAEQV
>Mature_147_residues
MFNNILVVCVGNICRSPMAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLIL
TMDKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYHKSRETFAAVYTLLERSARQWAQALNAEQV

Specific function: Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI6005988, Length=147, Percent_Identity=31.2925170068027, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI4757714, Length=147, Percent_Identity=31.2925170068027, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788375, Length=147, Percent_Identity=97.9591836734694, Blast_Score=301, Evalue=1e-83,
Organism=Escherichia coli, GI87081812, Length=142, Percent_Identity=54.9295774647887, Blast_Score=156, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6325330, Length=151, Percent_Identity=27.8145695364238, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI78706766, Length=139, Percent_Identity=33.0935251798561, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78706768, Length=139, Percent_Identity=33.0935251798561, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78706764, Length=128, Percent_Identity=33.59375, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 16707; Mature: 16707

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNNILVVCVGNICRSPMAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSL
CCCCEEEEEECHHHCCHHHHHHHHHHCCCCEECCCCCCHHHCCCCCCCEEEEEHHCCCCC
EGHCARQISRRLCRNYDLILTMDKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYHKS
CHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHCHHHCCCEEEEEECCCCCCCCCCHHHH
RETFAAVYTLLERSARQWAQALNAEQV
HHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFNNILVVCVGNICRSPMAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSL
CCCCEEEEEECHHHCCHHHHHHHHHHCCCCEECCCCCCHHHCCCCCCCEEEEEHHCCCCC
EGHCARQISRRLCRNYDLILTMDKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYHKS
CHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHCHHHCCCEEEEEECCCCCCCCCCHHHH
RETFAAVYTLLERSARQWAQALNAEQV
HHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]