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The map label for this gene is cpsG

Identifier: 30063499

GI number: 30063499

Start: 2110007

End: 2111377

Strand: Reverse

Name: cpsG

Synonym: S2234

Alternate gene names: 30063499

Gene position: 2111377-2110007 (Counterclockwise)

Preceding gene: 30063500

Following gene: 30063498

Centisome position: 45.91

GC content: 55.07

Gene sequence:

>1371_bases
ATGAAAAAATTAACCTGCTTTAAAGCCTATGATATTCGCGGGAAATTAGGCGAAGAACTGAATGAAGATATCGCCTGGCG
CATTGGTCGCGCCTATGGCGAATTTCTCAAACCGAAAACCATTGTGTTAGGCGGTGATGTCCGTCTCACCAGCGAAACCT
TAAAACTGGCGCTGGCAAAAGGTTTACAGGATGCGGGCGTCGATGTGCTGGATATCGGTATGTCCGGCACCGAAGAGATC
TATTTCGCCACGTTCCATCTCGGCGTGGATGGCGGCATTGAAGTTACTGCCAGCCATAATCCGATGGATTACAACGGCAT
GAAGCTGGTGCGCGAGGGGGCTCGCACGATCAGCGGTGATACCGGACTGCGCGACGTCCAGCGTCTGGCTGAAGCCAACG
ACTTTCCTCCCGTCGATGAAACCAAACGCGGTCGCTATCAGCAAATCAACCTGCGTGACGCTTACGTTGATCACCTGTTC
GGTTATATCAATGTCAAAAATCTCACGCCGCTCAAGCTGGTGATCAACTCCGGGAATGGCGCAGCGGGTCCGGTGGTGGA
CGCCATTGAAGCCCGCTTTAAAGCCCTCGGCGCGCCCGTGGAATTAATCAAAGTACACAACACACCGGACGGCAATTTCC
CCAACGGTATTCCTAACCCGCTGCTGCCGGAATGTCGCGACGACACCCGCAATGCGGTCATCAAACACGGCGCGGATATG
GGCATTGCCTTTGATGGCGATTTTGACCGCTGTTTTCTGTTTGACGAAAAAGGGCAGTTTATCGAGGGCTACTACATTGT
CGGCCTGCTGGCAGAAGCGTTCCTCGAAAAAAATCCCGGCGCGAAGATCATCCATGATCCGCGTCTCTCTTGGAACACTA
TTGATGTGGTGACTGCTGCAGGCGGCACGCCGGTAATGTCGAAAACCGGACACGCCTTTATTAAAGAACGGATGCGCAAG
GAAGACGCCATCTACGGTGGCGAAATGAGCGCCCACCATTACTTCCGTGATTTCGCTTACTGCGACAGCGGCATGATCCC
GTGGCTGCTGGTCGCCGAACTGGTGTGCCTGAAAGGAAAAACGCTGGGCGAACTGGTGCGCGACCGGATGGCGGCGTTTC
CGGCAAGCGGTGAGATCAACAGCAAACTGGCGCAACCCGTTGAGGCGATTAACCGCGTGGAACAGCATTTTAGCCGTGAG
GCGCTGGCGGTGGATCGCAGCGATGGCATCAGCATGACCTTTGCCGACTGGCGCTTTAACCTGCGCACCTCCAATACCGA
ACCGGTGGTGCGCCTGAATGTGGAATCGCGCGGTGATGTGCCGCTGATGGAAGCGCGAACGCGAACTCTGCTGACGTTGC
TGAACGAGTAA

Upstream 100 bases:

>100_bases
CGCATCAGGCAATGAATGCGAAACCGCGGTGTAAATAACGACAAAAATAAAATTGGCCGTTTCGGTCAGGGCCAACTATT
GCCTGAAAAAGGGTAACGAC

Downstream 100 bases:

>100_bases
TGTCGGATCTTCCCTTACCCCACTGCGGGTAAGGGGCTAATAACAGGAACAACGATGACAAATCTAAAAAAGCGCGAGCG
AGCGAAAACCAATGCATCGT

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAKGLQDAGVDVLDIGMSGTEEI
YFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARTISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLF
GYINVKNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADM
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTIDVVTAAGGTPVMSKTGHAFIKERMRK
EDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKGKTLGELVRDRMAAFPASGEINSKLAQPVEAINRVEQHFSRE
ALAVDRSDGISMTFADWRFNLRTSNTEPVVRLNVESRGDVPLMEARTRTLLTLLNE

Sequences:

>Translated_456_residues
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAKGLQDAGVDVLDIGMSGTEEI
YFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARTISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLF
GYINVKNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADM
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTIDVVTAAGGTPVMSKTGHAFIKERMRK
EDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKGKTLGELVRDRMAAFPASGEINSKLAQPVEAINRVEQHFSRE
ALAVDRSDGISMTFADWRFNLRTSNTEPVVRLNVESRGDVPLMEARTRTLLTLLNE
>Mature_456_residues
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAKGLQDAGVDVLDIGMSGTEEI
YFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARTISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLF
GYINVKNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADM
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTIDVVTAAGGTPVMSKTGHAFIKERMRK
EDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKGKTLGELVRDRMAAFPASGEINSKLAQPVEAINRVEQHFSRE
ALAVDRSDGISMTFADWRFNLRTSNTEPVVRLNVESRGDVPLMEARTRTLLTLLNE

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=456, Percent_Identity=99.1228070175439, Blast_Score=931, Evalue=0.0,
Organism=Escherichia coli, GI1789566, Length=460, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 50409; Mature: 50409

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAK
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECHHHHHHHHHH
GLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARTISGD
CHHHCCCCEEEECCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCC
TGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLFGYINVKNLTPLKLVINSGNG
CCHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHEEEECCCCEEEEEEECCCC
AAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADM
CCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTIDVVTAA
EEEECCCCCEEEEECCCCCEECHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEC
GGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKGK
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
TLGELVRDRMAAFPASGEINSKLAQPVEAINRVEQHFSREALAVDRSDGISMTFADWRFN
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHEEEECCCCCEEEEECEEEE
LRTSNTEPVVRLNVESRGDVPLMEARTRTLLTLLNE
EECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDVRLTSETLKLALAK
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECHHHHHHHHHH
GLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPMDYNGMKLVREGARTISGD
CHHHCCCCEEEECCCCCCEEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCC
TGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLFGYINVKNLTPLKLVINSGNG
CCHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHEEEECCCCEEEEEEECCCC
AAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPECRDDTRNAVIKHGADM
CCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
GIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKIIHDPRLSWNTIDVVTAA
EEEECCCCCEEEEECCCCCEECHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEC
GGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHYFRDFAYCDSGMIPWLLVAELVCLKGK
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
TLGELVRDRMAAFPASGEINSKLAQPVEAINRVEQHFSREALAVDRSDGISMTFADWRFN
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHEEEECCCCCEEEEECEEEE
LRTSNTEPVVRLNVESRGDVPLMEARTRTLLTLLNE
EECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9673232; 10222209; 11206551; 11258796 [H]