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The map label for this gene is adhP

Identifier: 30063225

GI number: 30063225

Start: 1821368

End: 1822378

Strand: Direct

Name: adhP

Synonym: S1880

Alternate gene names: 30063225

Gene position: 1821368-1822378 (Clockwise)

Preceding gene: 30063224

Following gene: 30063226

Centisome position: 39.6

GC content: 52.52

Gene sequence:

>1011_bases
ATGAAGACTGCAGTTGTTACGAAGGATCATCATGTTGACGTTACGGATAAAACACTGCGCTCACTGAAACATGGCGAAGC
CCTGCTGAAAATGGAGTGTTGTGGTGTATGTCATACCGATCTTCATGTTAAGAATGGCGATTTTGGTGACAAAACCGGCG
TAATTCTGGGCCATGAAGGCATCGGTGTGGTGGCAGAAGTTGGCCCAGGTGTCACCTCATTAAAACCAGGCGATCGTGCC
AGCGTGGCGTGGTTTTACGAAGGATGCGGTCATTGCGAATACTGTAACAGTGGTAACGAAACGCTCTGCCGTTCAGTTAA
AAATGCCGGATACAGCGTTGATGGCGGGATGGAGGAAGAGTGCATCGTGGTCGCCGATTACGCGGTAAAAGTGCCAGATG
GTCTGGACTCGGCGGCGCCCAGCAGCATTACCTGTGCGGGGGTCACCACCTACAAAGCCGTTAAACTGTCAAAAATTCGT
CCCGGTCAGTGGATTGCTATCTACGGTCTTGGCGGTCTGGGTAACCTCGCCCTGCAATACGCAAAGAATGTCTTTAACGC
CAAAGTGATCGCCATTGATGTCAATGATGAGCAGTTAAAACTGGCAACCGAAATGGATGCAGATTTAGCGATTAACTCAC
GCACCGAAGACGCCGCCAAAATTGTGCAGGAGAAAACCGGTGGCGCTCACGCTGCGGTGGTAACAGCAGTAGCTAAAGCT
GCGTTTAACTCGGCAGTTGATGCTGTCCGTGCAGGCGGTCGTGTTGTGGCTGTCGGTCTGCCGCCGGAGTCTATGAGCCT
GGATATCCCACGTCTTGTGCTGGATGGCATTGAAGTGGTCGGTTCGCTGGTCGGCACGCGCCAGGATCTAACCGAAGCCT
TCCAGTTTGCCGCCGAAGGCAAAGTGGTGCCGAAAGTCGCCCTGCGTCCGTTAGCGGACATCAACACCATCTTTACCGAG
ATGGAAGAAGGCAAAATCCGTGGCCGTATGGTGATTGATTTCCGTCACTAA

Upstream 100 bases:

>100_bases
TTCCCTCTCCCTTTTTCAGATCTCATCCATACTGGGTAGTGGCGAATAAATCTCATTTGCCTCACCTGCTATGCAGAACA
TCATCCGAAAAGGAGGAACT

Downstream 100 bases:

>100_bases
GAGGTCTTTGCTGCGACTCCCATGTTCGGGTCGCAGCATCGCACACTCTCCAACATGAAATGGCTAAATGGATTATTGTT
GCGTAGGAAGGAACAATAAT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKTAVVTKDHHVDVTDKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMEEECIVVADYAVKVPDGLDSAAPSSITCAGVTTYKAVKLSKIR
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEMDADLAINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLADINTIFTE
MEEGKIRGRMVIDFRH

Sequences:

>Translated_336_residues
MKTAVVTKDHHVDVTDKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMEEECIVVADYAVKVPDGLDSAAPSSITCAGVTTYKAVKLSKIR
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEMDADLAINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLADINTIFTE
MEEGKIRGRMVIDFRH
>Mature_336_residues
MKTAVVTKDHHVDVTDKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMEEECIVVADYAVKVPDGLDSAAPSSITCAGVTTYKAVKLSKIR
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEMDADLAINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLADINTIFTE
MEEGKIRGRMVIDFRH

Specific function: Preferred specificity is towards 1-propanol [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=307, Percent_Identity=32.5732899022801, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4501933, Length=297, Percent_Identity=32.6599326599327, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4501929, Length=295, Percent_Identity=32.5423728813559, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI262073058, Length=291, Percent_Identity=29.2096219931272, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI71743840, Length=299, Percent_Identity=29.0969899665552, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71565154, Length=230, Percent_Identity=32.6086956521739, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI156523966, Length=305, Percent_Identity=29.1803278688525, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4501939, Length=323, Percent_Identity=28.4829721362229, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI156627571, Length=269, Percent_Identity=27.8810408921933, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=98.2142857142857, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI1790045, Length=294, Percent_Identity=29.5918367346939, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87082401, Length=318, Percent_Identity=27.3584905660377, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1787863, Length=270, Percent_Identity=30, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1786518, Length=336, Percent_Identity=26.4880952380952, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788073, Length=259, Percent_Identity=29.7297297297297, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI226510992, Length=312, Percent_Identity=27.8846153846154, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790718, Length=331, Percent_Identity=26.8882175226586, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=25.7142857142857, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788075, Length=305, Percent_Identity=25.9016393442623, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786825, Length=278, Percent_Identity=26.6187050359712, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788407, Length=227, Percent_Identity=29.9559471365639, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=313, Percent_Identity=37.0607028753994, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17562584, Length=330, Percent_Identity=35.4545454545455, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17562582, Length=315, Percent_Identity=37.1428571428571, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17562878, Length=195, Percent_Identity=33.8461538461538, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=254, Percent_Identity=29.9212598425197, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI25146526, Length=218, Percent_Identity=30.7339449541284, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=205, Percent_Identity=31.219512195122, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=205, Percent_Identity=30.7317073170732, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=331, Percent_Identity=36.8580060422961, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6323961, Length=317, Percent_Identity=39.4321766561514, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323729, Length=317, Percent_Identity=37.2239747634069, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=35.5882352941176, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319949, Length=318, Percent_Identity=27.0440251572327, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6323980, Length=315, Percent_Identity=26.3492063492064, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=238, Percent_Identity=32.3529411764706, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=287, Percent_Identity=27.8745644599303, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=287, Percent_Identity=27.8745644599303, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=299, Percent_Identity=24.0802675585284, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=222, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137530, Length=235, Percent_Identity=28.5106382978723, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737897, Length=231, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17737895, Length=220, Percent_Identity=30, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35523; Mature: 35523

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAVVTKDHHVDVTDKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
CCCEEECCCCCCCCHHHHHHHHHHCCCEEEEHHCCCCCCCEEEECCCCCCCCCEEEECCC
IGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMEEE
CEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCEECCCCCCCC
CIVVADYAVKVPDGLDSAAPSSITCAGVTTYKAVKLSKIRPGQWIAIYGLGGLGNLALQY
EEEEEEEEEECCCCCCCCCCCCEEEECCCEEEEEEEEECCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNDEQLKLATEMDADLAINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
HHHHCCCEEEEEECCCCCEEEEECCCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVVPKVALRPLADINTIFTEMEEGKIRGRMVIDFRH
CCCHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKTAVVTKDHHVDVTDKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
CCCEEECCCCCCCCHHHHHHHHHHCCCEEEEHHCCCCCCCEEEECCCCCCCCCEEEECCC
IGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMEEE
CEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCEECCCCCCCC
CIVVADYAVKVPDGLDSAAPSSITCAGVTTYKAVKLSKIRPGQWIAIYGLGGLGNLALQY
EEEEEEEEEECCCCCCCCCCCCEEEECCCEEEEEEEEECCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNDEQLKLATEMDADLAINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
HHHHCCCEEEEEECCCCCEEEEECCCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVVPKVALRPLADINTIFTEMEEGKIRGRMVIDFRH
CCCHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 2158980 [H]