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The map label for this gene is hrsA

Identifier: 30062106

GI number: 30062106

Start: 585371

End: 587347

Strand: Reverse

Name: hrsA

Synonym: S0579

Alternate gene names: 30062106

Gene position: 587347-585371 (Counterclockwise)

Preceding gene: 30062108

Following gene: 30062105

Centisome position: 12.77

GC content: 54.53

Gene sequence:

>1977_bases
ATGGTATTGTTTTGTCGGGCACACTGGCGCGACTATAAAAACGATCAAGTGAGGATCATGATGAACCTGACGACTCTGAC
CCACCGCGATGCGTTGTGTCTGAATGCGCGCTTTACCAGCCGTGAAGAGGCCATTCACGCGTTGACTCAACGTCTTGCTG
CTCTGGGGAAAATTTCCAGTACTGAGCAATTTCTGAAAGAAGTGTATCGCCGTGAAAGCCTTGGCCCGACCGCCTTAAGT
GAAGGGTTGGCTGTGCCGCATGGCAAAACTGCTGCGGTAAAAGAAGCGGCGTTTGCGGTCGCCACACTCAGCGAGCCGCT
TCAGTGGGAAGGCGTGGATGGCCCGGAAGCGGTTGATTTAGTGGTGTTGCTGGCGATTCCCCTCAATGAAGCGGGTACTA
CGCACATGCAACTGCTGACAGCGCTGACCACGCGCCTGGCGGATGATGAGATTCGGGCGCGTATACAGTCGGCGACGACG
CCTGATGAATTGCTCTCGGCGCTGGATGACAAGGGAGGCACGCAACCTTCTGCCTCTTTTTCCAACGCGCCAACTATCGT
TTGCGTAACGGCCTGCCCGGCGGGTATTGCTCACACCTACATGGCTGCGGAGTATCTGGAAAAAGCCGGACGCAAACTCG
GCGTGAATGTCTACGTTGAAAAGCAAGGTGCTAACGGTATTGAAGGGCGTTTAACGGCGGATCAACTCAATAGTGCAACT
GCCTGTATTTTTGCGGCTGAAGTCGCCATCAAGGAGAGTGAGCGTTTTAACGGCATTCCTGCGCTTTCTGTGCCTGTTGC
CGAGCCGATTCGCCATGCAGAAGCGTTGATCCAACAATCGCTTACCCTCGAGCGTGGCGATGAGACGCGTACCTTACAGC
AAGATACGCAACCGGTGAAAAGCGTCAAAACGGAGCTGAAACAGGCACTGTTGAGCGGGATCTCTTTTGCCGTACCGTTG
ATTGTCGCGGGGGGGACGGTGCTGGCGGTCGCGGTATTACTGTCGCAAATCTTCGGGCTACAAGATCTGTTTAATGAAGA
AAACTCCTGGCTGTGGATGTACCGCAAACTGGGCGGCGGGCTGCTCGGAATTTTGATGGTACCGGTGCTGGCAGCCTATA
CCGCCTATTCGCTGGCAGATAAACCGGCGTTAGCGCCAGGCTTTGCGGCTGGACTTGCCGCCAACATGATCGGCTCCGGG
TTTCTCGGCGCGGTCGTTGGCGGATTGATAGCCGGTTACTTGATACGCTGGATGAAAAATCACTTGCGTCTTAGCAGTAA
ATTCAATGGCTTCCTGACTTTTTATCTCTACCCGGTGCTCGGTACATTGGGAGCGGGCAGTCTGATGCTGTTTGTGGTGG
GGGAACCTGTCGCCTGGATCAATAACTCGCTTACCGCCTGGCTGAACGGTCTGTCAGGAAGTAACGCGCTGTTGCTGGGT
GCCATTCTCGGTTTTATGTGTTCCTTTGACCTTGGAGGGCCAGTGAATAAAGCCGCTTATGCATTCTGCCTGGGCGCAAT
GGCGAACGGCGTTTACGGCCCGTATGCCATTTTCGCCTCCGTCAAAATGGTTTCGGCATTTACCGTAACCGCTTCCACGA
TGCTCGCACCGCGCCTGTTTAAAGAGTTTGAAATTGAGACCGGGAAATCCACCTGGCTGTTAGGGCTGGCAGGTATTACC
GAAGGGGCGATCCCGATGGCGATTGAAGATCCGCTGCGGGTTATTGGTTCGTTTGTGCTGGGCTCTATGGTAACGGGCGC
TATTGTCGGTGCGATGAATATCGGCCTTTCGACACCCGGTGCTGGCATTTTCTCGCTCTTTTTACTTCATGATAATGGCG
CGGGCGGTGTTATGGCGGCAATTGGCTGGTTTGGTGCGGCATTGGTGGGGGCTGCAATCTCGACTGCAATTCTCCTGATC
TGGCGGCGTCACGCGGTTAAGCATGGCAACTATCTGACTGATGGCGTAATGCCATAA

Upstream 100 bases:

>100_bases
TCTCATTAATACGAATTTAGCCATTATGCCCGATAAACTCATCCTGTAAATAATACAAATAAAATGCAAATAATTTCAAT
CAAGTGAAATTGATTACGCA

Downstream 100 bases:

>100_bases
ACAAAAAGGAAACGACGATGAAAGCGGTATCTCGCGTTCACATCACCCCGCATATGCACTGGGATCGGGAGTGGTATTTC
ACCACCGAAGAGTCACGCAT

Product: PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC

Products: NA

Alternate protein names: Putative PTS system EIIABC component; Phosphotransferase enzyme IIA component; PTS system EIIA component; Phosphotransferase enzyme IIB component; PTS system EIIB component; Permease IIC component; PTS system EIIC component [H]

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MVLFCRAHWRDYKNDQVRIMMNLTTLTHRDALCLNARFTSREEAIHALTQRLAALGKISSTEQFLKEVYRRESLGPTALS
EGLAVPHGKTAAVKEAAFAVATLSEPLQWEGVDGPEAVDLVVLLAIPLNEAGTTHMQLLTALTTRLADDEIRARIQSATT
PDELLSALDDKGGTQPSASFSNAPTIVCVTACPAGIAHTYMAAEYLEKAGRKLGVNVYVEKQGANGIEGRLTADQLNSAT
ACIFAAEVAIKESERFNGIPALSVPVAEPIRHAEALIQQSLTLERGDETRTLQQDTQPVKSVKTELKQALLSGISFAVPL
IVAGGTVLAVAVLLSQIFGLQDLFNEENSWLWMYRKLGGGLLGILMVPVLAAYTAYSLADKPALAPGFAAGLAANMIGSG
FLGAVVGGLIAGYLIRWMKNHLRLSSKFNGFLTFYLYPVLGTLGAGSLMLFVVGEPVAWINNSLTAWLNGLSGSNALLLG
AILGFMCSFDLGGPVNKAAYAFCLGAMANGVYGPYAIFASVKMVSAFTVTASTMLAPRLFKEFEIETGKSTWLLGLAGIT
EGAIPMAIEDPLRVIGSFVLGSMVTGAIVGAMNIGLSTPGAGIFSLFLLHDNGAGGVMAAIGWFGAALVGAAISTAILLI
WRRHAVKHGNYLTDGVMP

Sequences:

>Translated_658_residues
MVLFCRAHWRDYKNDQVRIMMNLTTLTHRDALCLNARFTSREEAIHALTQRLAALGKISSTEQFLKEVYRRESLGPTALS
EGLAVPHGKTAAVKEAAFAVATLSEPLQWEGVDGPEAVDLVVLLAIPLNEAGTTHMQLLTALTTRLADDEIRARIQSATT
PDELLSALDDKGGTQPSASFSNAPTIVCVTACPAGIAHTYMAAEYLEKAGRKLGVNVYVEKQGANGIEGRLTADQLNSAT
ACIFAAEVAIKESERFNGIPALSVPVAEPIRHAEALIQQSLTLERGDETRTLQQDTQPVKSVKTELKQALLSGISFAVPL
IVAGGTVLAVAVLLSQIFGLQDLFNEENSWLWMYRKLGGGLLGILMVPVLAAYTAYSLADKPALAPGFAAGLAANMIGSG
FLGAVVGGLIAGYLIRWMKNHLRLSSKFNGFLTFYLYPVLGTLGAGSLMLFVVGEPVAWINNSLTAWLNGLSGSNALLLG
AILGFMCSFDLGGPVNKAAYAFCLGAMANGVYGPYAIFASVKMVSAFTVTASTMLAPRLFKEFEIETGKSTWLLGLAGIT
EGAIPMAIEDPLRVIGSFVLGSMVTGAIVGAMNIGLSTPGAGIFSLFLLHDNGAGGVMAAIGWFGAALVGAAISTAILLI
WRRHAVKHGNYLTDGVMP
>Mature_658_residues
MVLFCRAHWRDYKNDQVRIMMNLTTLTHRDALCLNARFTSREEAIHALTQRLAALGKISSTEQFLKEVYRRESLGPTALS
EGLAVPHGKTAAVKEAAFAVATLSEPLQWEGVDGPEAVDLVVLLAIPLNEAGTTHMQLLTALTTRLADDEIRARIQSATT
PDELLSALDDKGGTQPSASFSNAPTIVCVTACPAGIAHTYMAAEYLEKAGRKLGVNVYVEKQGANGIEGRLTADQLNSAT
ACIFAAEVAIKESERFNGIPALSVPVAEPIRHAEALIQQSLTLERGDETRTLQQDTQPVKSVKTELKQALLSGISFAVPL
IVAGGTVLAVAVLLSQIFGLQDLFNEENSWLWMYRKLGGGLLGILMVPVLAAYTAYSLADKPALAPGFAAGLAANMIGSG
FLGAVVGGLIAGYLIRWMKNHLRLSSKFNGFLTFYLYPVLGTLGAGSLMLFVVGEPVAWINNSLTAWLNGLSGSNALLLG
AILGFMCSFDLGGPVNKAAYAFCLGAMANGVYGPYAIFASVKMVSAFTVTASTMLAPRLFKEFEIETGKSTWLLGLAGIT
EGAIPMAIEDPLRVIGSFVLGSMVTGAIVGAMNIGLSTPGAGIFSLFLLHDNGAGGVMAAIGWFGAALVGAAISTAILLI
WRRHAVKHGNYLTDGVMP

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane [H]

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1786951, Length=658, Percent_Identity=98.3282674772036, Blast_Score=1310, Evalue=0.0,
Organism=Escherichia coli, GI1788492, Length=473, Percent_Identity=35.3065539112051, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87082348, Length=484, Percent_Identity=32.8512396694215, Blast_Score=223, Evalue=4e-59,
Organism=Escherichia coli, GI1790386, Length=289, Percent_Identity=39.1003460207612, Blast_Score=191, Evalue=2e-49,
Organism=Escherichia coli, GI1788729, Length=392, Percent_Identity=27.5510204081633, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790387, Length=94, Percent_Identity=43.6170212765958, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788730, Length=94, Percent_Identity=37.2340425531915, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI48994992, Length=153, Percent_Identity=24.1830065359477, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789597, Length=159, Percent_Identity=27.0440251572327, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788726, Length=136, Percent_Identity=25.7352941176471, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 69651; Mature: 69651

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLFCRAHWRDYKNDQVRIMMNLTTLTHRDALCLNARFTSREEAIHALTQRLAALGKISS
CEEEEECCCCCCCCCCEEEEEEEEHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCH
TEQFLKEVYRRESLGPTALSEGLAVPHGKTAAVKEAAFAVATLSEPLQWEGVDGPEAVDL
HHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHE
VVLLAIPLNEAGTTHMQLLTALTTRLADDEIRARIQSATTPDELLSALDDKGGTQPSASF
EEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
SNAPTIVCVTACPAGIAHTYMAAEYLEKAGRKLGVNVYVEKQGANGIEGRLTADQLNSAT
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEECCEEEEEECCCCCCCCCEEHHHHCCHH
ACIFAAEVAIKESERFNGIPALSVPVAEPIRHAEALIQQSLTLERGDETRTLQQDTQPVK
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SVKTELKQALLSGISFAVPLIVAGGTVLAVAVLLSQIFGLQDLFNEENSWLWMYRKLGGG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHCCCCCEEEEEHHHCCH
LLGILMVPVLAAYTAYSLADKPALAPGFAAGLAANMIGSGFLGAVVGGLIAGYLIRWMKN
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
HLRLSSKFNGFLTFYLYPVLGTLGAGSLMLFVVGEPVAWINNSLTAWLNGLSGSNALLLG
HHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCHHHHHCCCCCCCHHHHH
AILGFMCSFDLGGPVNKAAYAFCLGAMANGVYGPYAIFASVKMVSAFTVTASTMLAPRLF
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEFEIETGKSTWLLGLAGITEGAIPMAIEDPLRVIGSFVLGSMVTGAIVGAMNIGLSTPG
HHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGIFSLFLLHDNGAGGVMAAIGWFGAALVGAAISTAILLIWRRHAVKHGNYLTDGVMP
CHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVLFCRAHWRDYKNDQVRIMMNLTTLTHRDALCLNARFTSREEAIHALTQRLAALGKISS
CEEEEECCCCCCCCCCEEEEEEEEHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCH
TEQFLKEVYRRESLGPTALSEGLAVPHGKTAAVKEAAFAVATLSEPLQWEGVDGPEAVDL
HHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHE
VVLLAIPLNEAGTTHMQLLTALTTRLADDEIRARIQSATTPDELLSALDDKGGTQPSASF
EEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
SNAPTIVCVTACPAGIAHTYMAAEYLEKAGRKLGVNVYVEKQGANGIEGRLTADQLNSAT
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEECCEEEEEECCCCCCCCCEEHHHHCCHH
ACIFAAEVAIKESERFNGIPALSVPVAEPIRHAEALIQQSLTLERGDETRTLQQDTQPVK
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SVKTELKQALLSGISFAVPLIVAGGTVLAVAVLLSQIFGLQDLFNEENSWLWMYRKLGGG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHCCCCCEEEEEHHHCCH
LLGILMVPVLAAYTAYSLADKPALAPGFAAGLAANMIGSGFLGAVVGGLIAGYLIRWMKN
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
HLRLSSKFNGFLTFYLYPVLGTLGAGSLMLFVVGEPVAWINNSLTAWLNGLSGSNALLLG
HHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCHHHHHCCCCCCCHHHHH
AILGFMCSFDLGGPVNKAAYAFCLGAMANGVYGPYAIFASVKMVSAFTVTASTMLAPRLF
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEFEIETGKSTWLLGLAGITEGAIPMAIEDPLRVIGSFVLGSMVTGAIVGAMNIGLSTPG
HHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGIFSLFLLHDNGAGGVMAAIGWFGAALVGAAISTAILLIWRRHAVKHGNYLTDGVMP
CHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9063979; 9278503; 8905232 [H]