Definition Shigella flexneri 2a str. 2457T, complete genome.
Accession NC_004741
Length 4,599,354

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The map label for this gene is ybbO

Identifier: 30061993

GI number: 30061993

Start: 454461

End: 455270

Strand: Reverse

Name: ybbO

Synonym: S0445

Alternate gene names: 30061993

Gene position: 455270-454461 (Counterclockwise)

Preceding gene: 30061995

Following gene: 30061992

Centisome position: 9.9

GC content: 53.7

Gene sequence:

>810_bases
ATGACTCATAAAGCAACGGAGATCCTGACAGGTAAAGTTATGCAAAAATCGGTCTTAATTACCGGATGTTCCAGTGGAAT
TGGCCTGGAAAGCGCGCTCGAATTAAAACGCCAGGGTTTTCATGTGCTGGCAGGTTGCCGAAAACCGAATGATGTTGAGC
GTATGAACAACATGGGATTTACCGGCGTGTTGATCGATCTGGATTCACCAGAAAGTGTTAATCGCGCAGCAGACGAGGTG
ATCGCCCTGACCGATAATTGTCTGTATGGGATCTTTAACAATGCCGGATTCGGCATGTATGGCCCCCTTTCCACCATCAG
CCGTGCGCAGATGGAACAGCAGTTTTCCGCCAACTTTTTCGGCGCACACCAGCTCACCATGCGCCTGTTACCCGCGATGT
TACCGCACGGTGAAGGGCGTATTGTGATGACATCATCGGTGATGGGATTAATCTCCACGCCGGGTCGTGGCGCTTACGCG
GCCAGTAAATATGCGCTGGAGGCGTGGTCAGACGCGCTGCGCATGGAGCTACGCCACAGCGGAATTAAAGTCAGCCTGAT
CGAACCCGGTCCCATTCGTACTCGCTTCACCGACAACGTCAACCAGACGCAAAGTGATAAACCAGTCGAAAATCCCGGCA
TCGCCGCCCGCTTTACGTTGGGACCGGAAGCGGTGGTCGACAAAGTGCGCCATGCTTTTATTAGCGAGAAGCCGAAGATG
CGCTATCCGGTAACGCTGGTGACCTGGGCAGTAATGGTGCTCGAGCGCCTGCTGCCTGGGCGCGTGATGGACAAAATATT
GCAGGGGTGA

Upstream 100 bases:

>100_bases
AAGCCACAATGGATGCAGGATGACGGTATTCATCCCAACCGCGACGCCCAGCCGTTTATTGCCGACTGGATGGCGAAGCA
GTTGCAGCCTTTAGTAAATC

Downstream 100 bases:

>100_bases
GTTGAAGCGCGCGCTTAAGCCCCCATGTCAAAGAAAATATCGACAACAGAGAGCGACTCCATGTCCGTAGAAAATATTGT
CAACATTAACGAATCTAACC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTHKATEILTGKVMQKSVLITGCSSGIGLESALELKRQGFHVLAGCRKPNDVERMNNMGFTGVLIDLDSPESVNRAADEV
IALTDNCLYGIFNNAGFGMYGPLSTISRAQMEQQFSANFFGAHQLTMRLLPAMLPHGEGRIVMTSSVMGLISTPGRGAYA
ASKYALEAWSDALRMELRHSGIKVSLIEPGPIRTRFTDNVNQTQSDKPVENPGIAARFTLGPEAVVDKVRHAFISEKPKM
RYPVTLVTWAVMVLERLLPGRVMDKILQG

Sequences:

>Translated_269_residues
MTHKATEILTGKVMQKSVLITGCSSGIGLESALELKRQGFHVLAGCRKPNDVERMNNMGFTGVLIDLDSPESVNRAADEV
IALTDNCLYGIFNNAGFGMYGPLSTISRAQMEQQFSANFFGAHQLTMRLLPAMLPHGEGRIVMTSSVMGLISTPGRGAYA
ASKYALEAWSDALRMELRHSGIKVSLIEPGPIRTRFTDNVNQTQSDKPVENPGIAARFTLGPEAVVDKVRHAFISEKPKM
RYPVTLVTWAVMVLERLLPGRVMDKILQG
>Mature_268_residues
THKATEILTGKVMQKSVLITGCSSGIGLESALELKRQGFHVLAGCRKPNDVERMNNMGFTGVLIDLDSPESVNRAADEVI
ALTDNCLYGIFNNAGFGMYGPLSTISRAQMEQQFSANFFGAHQLTMRLLPAMLPHGEGRIVMTSSVMGLISTPGRGAYAA
SKYALEAWSDALRMELRHSGIKVSLIEPGPIRTRFTDNVNQTQSDKPVENPGIAARFTLGPEAVVDKVRHAFISEKPKMR
YPVTLVTWAVMVLERLLPGRVMDKILQG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7657478, Length=193, Percent_Identity=39.3782383419689, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI50726952, Length=186, Percent_Identity=38.7096774193548, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI40548397, Length=262, Percent_Identity=30.5343511450382, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI214010158, Length=262, Percent_Identity=30.5343511450382, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI214010156, Length=262, Percent_Identity=30.5343511450382, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI22758144, Length=262, Percent_Identity=30.5343511450382, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI150247226, Length=254, Percent_Identity=32.6771653543307, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI22507405, Length=286, Percent_Identity=30.0699300699301, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI44680136, Length=289, Percent_Identity=28.3737024221453, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI44680133, Length=289, Percent_Identity=28.3737024221453, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI17738292, Length=289, Percent_Identity=28.3737024221453, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI19743808, Length=281, Percent_Identity=30.6049822064057, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI119392083, Length=207, Percent_Identity=36.231884057971, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI223718074, Length=195, Percent_Identity=33.8461538461538, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI7706318, Length=269, Percent_Identity=26.7657992565056, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI20149619, Length=198, Percent_Identity=31.8181818181818, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI157739938, Length=197, Percent_Identity=32.994923857868, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI142976729, Length=260, Percent_Identity=28.0769230769231, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4504503, Length=206, Percent_Identity=31.5533980582524, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40807363, Length=254, Percent_Identity=30.3149606299213, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI210032110, Length=191, Percent_Identity=30.3664921465969, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32483357, Length=189, Percent_Identity=25.3968253968254, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI32455239, Length=190, Percent_Identity=28.4210526315789, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI5031765, Length=190, Percent_Identity=28.4210526315789, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786701, Length=269, Percent_Identity=98.5130111524164, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI87082100, Length=206, Percent_Identity=31.0679611650485, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787335, Length=192, Percent_Identity=26.5625, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115534660, Length=287, Percent_Identity=29.9651567944251, Blast_Score=113, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17507613, Length=303, Percent_Identity=26.7326732673267, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI32563809, Length=303, Percent_Identity=26.7326732673267, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI193210355, Length=259, Percent_Identity=30.1158301158301, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17557780, Length=297, Percent_Identity=27.6094276094276, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17570069, Length=194, Percent_Identity=30.9278350515464, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71997402, Length=194, Percent_Identity=29.8969072164948, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=235, Percent_Identity=26.8085106382979, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=275, Percent_Identity=27.6363636363636, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=265, Percent_Identity=27.1698113207547, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559962, Length=223, Percent_Identity=28.6995515695067, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=189, Percent_Identity=30.6878306878307, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=203, Percent_Identity=28.0788177339901, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21358495, Length=194, Percent_Identity=33.5051546391753, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24651139, Length=237, Percent_Identity=31.6455696202532, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356301, Length=215, Percent_Identity=28.8372093023256, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571526, Length=186, Percent_Identity=30.1075268817204, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45554248, Length=200, Percent_Identity=33, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640117, Length=200, Percent_Identity=33, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643142, Length=207, Percent_Identity=28.5024154589372, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644339, Length=190, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 29437; Mature: 29305

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MTHKATEILTGKVMQKSVLITGCSSGIGLESALELKRQGFHVLAGCRKPNDVERMNNMGF
CCCCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCC
TGVLIDLDSPESVNRAADEVIALTDNCLYGIFNNAGFGMYGPLSTISRAQMEQQFSANFF
EEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCC
GAHQLTMRLLPAMLPHGEGRIVMTSSVMGLISTPGRGAYAASKYALEAWSDALRMELRHS
CHHHHHHHHHHHHCCCCCCCEEEEECHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GIKVSLIEPGPIRTRFTDNVNQTQSDKPVENPGIAARFTLGPEAVVDKVRHAFISEKPKM
CEEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCC
RYPVTLVTWAVMVLERLLPGRVMDKILQG
CCCHHHHHHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure 
THKATEILTGKVMQKSVLITGCSSGIGLESALELKRQGFHVLAGCRKPNDVERMNNMGF
CCCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCC
TGVLIDLDSPESVNRAADEVIALTDNCLYGIFNNAGFGMYGPLSTISRAQMEQQFSANFF
EEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCC
GAHQLTMRLLPAMLPHGEGRIVMTSSVMGLISTPGRGAYAASKYALEAWSDALRMELRHS
CHHHHHHHHHHHHCCCCCCCEEEEECHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GIKVSLIEPGPIRTRFTDNVNQTQSDKPVENPGIAARFTLGPEAVVDKVRHAFISEKPKM
CEEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCC
RYPVTLVTWAVMVLERLLPGRVMDKILQG
CCCHHHHHHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]