Click here to switch to the map view.

The map label for this gene is prlC [H]

Identifier: 29349670

GI number: 29349670

Start: 5611652

End: 5613721

Strand: Reverse

Name: prlC [H]

Synonym: BT_4262

Alternate gene names: 29349670

Gene position: 5613721-5611652 (Counterclockwise)

Preceding gene: 29349671

Following gene: 29349669

Centisome position: 89.67

GC content: 46.52

Gene sequence:

>2070_bases
ATGAACAATATACTGAACGCTCAGAATCCTTTCTTCGGTCAGTATCAGACACCGCATGGGACTGTGCCCTTTGACCGGAT
CAAGACAGAGCATTATGAGCCTGCCATCCTCGAAGGAATCAAACAACAGAATGCGGAACTTGATGCGATCATACAAAACC
CGGAGAAGGCGACATTTACAAATACAATAGAAGCCTACGAACAATCCGGAAGGCTGCTGGACAAAGTAACTGCCGTATTC
GGCAATATGCTTAGTGCTGAAACCAATGACGACTTACAGGCATTGGCTCAGAAAATCATGCCACTACTCAGCGAACACAG
CAACAACATCACACTGAATGAGAAGTTGTTTGCCCGCGTGAAAGAAGTGTACGGACAAAAACAATCTCTGCAACTGACCC
AGGAACAGAATCGCCTGCTAGACGATATATACGACAGTTTTGTACGCCACGGTGCCAACCTCGAAGGAGAAGCCCGTGAA
CAATACCGACAACTGACCAACGAACTGAGCAAACTGACACTCGACTTCAGCGAAAACAACCTGAAGGAGACAAACAGGTA
TCAAATGCTTCTGACAGACAAAGCCAGCATTGCCGGACTGCCGGAAATCATCGTAGAAGCTGCTGCCGAAACAGCCAGAA
GTGAGGATAAAGAAGGATGGGCTTTCACCCTGCACGCTCCAAGTTATGTGCCTTTCATGACTTATGCCGACAACCGCGAG
TTGCGCCATAAGCTCTACATCGCATATAATACAAAGTGTACACACGATAACGAATTCAACAATATCGAAATCGTAAAGAA
GCTGGTTAATACACGCATGAAAATAGCCCAGCTACTAGGATATAAAGATTATGCGGAATATACCCTCAAAAAACGAATGG
CTGAAAACAGCGATGCCGTATATAAGCTGCTCAACCAACTATTGGAAGCCTACACTCCCACCGCACAGAAAGAATATCTC
GAAGTACAGGAACTGGCACGTGAGGAACAAGGTGATGACTTCATTGTCATGCCCTGGGACTGGAGCTACTATTCCAATAA
GCTGAAAAACAAGAAATTCAATATCAATGAAGAAATGCTCCGTCCTTACTTCGAACTGGAACAAGTAAAAAAAGGAGTAT
TCGGACTGGCAGAAAGACTCTACGGAATCACTTTCCGGAAAAATACGGAAATCCCGGTTTATCACAAAGATGTTGAAGCC
TACGAGGTATTCGACAAAGACGGTAAGTTCCTGTCCGTACTGTACACTGACTTCCATCCCCGTCCCGGAAAACGCGCCGG
AGCCTGGATGACCAGCTACAAGGAACAATGGATAGATCCCGTAACCGGTGAAGACAGCCGACCGCATATATCTGTAGTGA
TGAACTTCACCAAGCCAACCGAAAGCAAACCTGCTTTGCTGACTTTCAACGAAGTGGAGACATTCCTGCATGAGTTCGGG
CACAGCCTGCATGGCATGTTTGCCAACTCAACCTATCAGAGCCTAAGCGGAACAAACGTATATTGGGACTTTGTGGAACT
TCCTTCACAGATCATGGAAAACTTTGCCATCGAGAAAGAATTTCTTAATACCTTTGCCCGTCATTATGAAACCGGAGAAG
TGCTTCCGGACGAACTGATACAGAGACTCGTGGATGCTTCGAATTTCAATGCAGCCTATGCCTGCCTGAGACAAGTGAGC
TTCGGGCTGCTCGATATGGCATGGTACACCCGCAACACTCCTTTCGAGGGCGATGTAAAAGCCTATGAACAGGAAGCCTG
GAAAGACGCACAAGTATTGCCGATAGTCAAAGAAGCCTGCATGAGTACACAATTCTCCCATATCTTTGCCGGAGGATATT
CCGCAGGATATTACAGTTATAAATGGGCAGAAGTGCTGGATGCGGATGCGTTCTCACTGTTCAAACAGCAAGGAATCTTC
AACCGTGAAGTAGCAGATTCGTTCCGCAACAATATCCTGTCGAAAGGAGGTACAGAACACCCGATGGTGCTCTACAAGCG
CTTCCGCGGGCAGGAGCCTACCATTGACGCATTGCTGATCCGAAACGGCATAAAGAAACAATACAATTAA

Upstream 100 bases:

>100_bases
AAGGTATTATCCGTGGTATAACCTACAATTTTAGTAGTTTTGTACTTCTATGAAGAGAATTATGAAGAGATTATTAATAA
CATTGATACTAGTTTACACC

Downstream 100 bases:

>100_bases
AAAAGGAGAGAATTGGACATGAAGAAGAGATTGATACTTAAAGTATTAGGATTGCTGTTATTGCTTCCGATGTTTTCCGG
ATGTAATGATACGGATGATG

Product: peptidyl-dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 689

Protein sequence:

>689_residues
MNNILNAQNPFFGQYQTPHGTVPFDRIKTEHYEPAILEGIKQQNAELDAIIQNPEKATFTNTIEAYEQSGRLLDKVTAVF
GNMLSAETNDDLQALAQKIMPLLSEHSNNITLNEKLFARVKEVYGQKQSLQLTQEQNRLLDDIYDSFVRHGANLEGEARE
QYRQLTNELSKLTLDFSENNLKETNRYQMLLTDKASIAGLPEIIVEAAAETARSEDKEGWAFTLHAPSYVPFMTYADNRE
LRHKLYIAYNTKCTHDNEFNNIEIVKKLVNTRMKIAQLLGYKDYAEYTLKKRMAENSDAVYKLLNQLLEAYTPTAQKEYL
EVQELAREEQGDDFIVMPWDWSYYSNKLKNKKFNINEEMLRPYFELEQVKKGVFGLAERLYGITFRKNTEIPVYHKDVEA
YEVFDKDGKFLSVLYTDFHPRPGKRAGAWMTSYKEQWIDPVTGEDSRPHISVVMNFTKPTESKPALLTFNEVETFLHEFG
HSLHGMFANSTYQSLSGTNVYWDFVELPSQIMENFAIEKEFLNTFARHYETGEVLPDELIQRLVDASNFNAAYACLRQVS
FGLLDMAWYTRNTPFEGDVKAYEQEAWKDAQVLPIVKEACMSTQFSHIFAGGYSAGYYSYKWAEVLDADAFSLFKQQGIF
NREVADSFRNNILSKGGTEHPMVLYKRFRGQEPTIDALLIRNGIKKQYN

Sequences:

>Translated_689_residues
MNNILNAQNPFFGQYQTPHGTVPFDRIKTEHYEPAILEGIKQQNAELDAIIQNPEKATFTNTIEAYEQSGRLLDKVTAVF
GNMLSAETNDDLQALAQKIMPLLSEHSNNITLNEKLFARVKEVYGQKQSLQLTQEQNRLLDDIYDSFVRHGANLEGEARE
QYRQLTNELSKLTLDFSENNLKETNRYQMLLTDKASIAGLPEIIVEAAAETARSEDKEGWAFTLHAPSYVPFMTYADNRE
LRHKLYIAYNTKCTHDNEFNNIEIVKKLVNTRMKIAQLLGYKDYAEYTLKKRMAENSDAVYKLLNQLLEAYTPTAQKEYL
EVQELAREEQGDDFIVMPWDWSYYSNKLKNKKFNINEEMLRPYFELEQVKKGVFGLAERLYGITFRKNTEIPVYHKDVEA
YEVFDKDGKFLSVLYTDFHPRPGKRAGAWMTSYKEQWIDPVTGEDSRPHISVVMNFTKPTESKPALLTFNEVETFLHEFG
HSLHGMFANSTYQSLSGTNVYWDFVELPSQIMENFAIEKEFLNTFARHYETGEVLPDELIQRLVDASNFNAAYACLRQVS
FGLLDMAWYTRNTPFEGDVKAYEQEAWKDAQVLPIVKEACMSTQFSHIFAGGYSAGYYSYKWAEVLDADAFSLFKQQGIF
NREVADSFRNNILSKGGTEHPMVLYKRFRGQEPTIDALLIRNGIKKQYN
>Mature_689_residues
MNNILNAQNPFFGQYQTPHGTVPFDRIKTEHYEPAILEGIKQQNAELDAIIQNPEKATFTNTIEAYEQSGRLLDKVTAVF
GNMLSAETNDDLQALAQKIMPLLSEHSNNITLNEKLFARVKEVYGQKQSLQLTQEQNRLLDDIYDSFVRHGANLEGEARE
QYRQLTNELSKLTLDFSENNLKETNRYQMLLTDKASIAGLPEIIVEAAAETARSEDKEGWAFTLHAPSYVPFMTYADNRE
LRHKLYIAYNTKCTHDNEFNNIEIVKKLVNTRMKIAQLLGYKDYAEYTLKKRMAENSDAVYKLLNQLLEAYTPTAQKEYL
EVQELAREEQGDDFIVMPWDWSYYSNKLKNKKFNINEEMLRPYFELEQVKKGVFGLAERLYGITFRKNTEIPVYHKDVEA
YEVFDKDGKFLSVLYTDFHPRPGKRAGAWMTSYKEQWIDPVTGEDSRPHISVVMNFTKPTESKPALLTFNEVETFLHEFG
HSLHGMFANSTYQSLSGTNVYWDFVELPSQIMENFAIEKEFLNTFARHYETGEVLPDELIQRLVDASNFNAAYACLRQVS
FGLLDMAWYTRNTPFEGDVKAYEQEAWKDAQVLPIVKEACMSTQFSHIFAGGYSAGYYSYKWAEVLDADAFSLFKQQGIF
NREVADSFRNNILSKGGTEHPMVLYKRFRGQEPTIDALLIRNGIKKQYN

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=595, Percent_Identity=31.4285714285714, Blast_Score=301, Evalue=9e-82,
Organism=Homo sapiens, GI14149738, Length=659, Percent_Identity=28.9833080424886, Blast_Score=266, Evalue=6e-71,
Organism=Homo sapiens, GI156105687, Length=440, Percent_Identity=27.0454545454545, Blast_Score=197, Evalue=3e-50,
Organism=Escherichia coli, GI1789913, Length=684, Percent_Identity=36.9883040935673, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1787819, Length=685, Percent_Identity=38.3941605839416, Blast_Score=448, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI32565901, Length=576, Percent_Identity=23.0902777777778, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71999758, Length=596, Percent_Identity=22.3154362416107, Blast_Score=102, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6319793, Length=606, Percent_Identity=30.3630363036304, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6322715, Length=650, Percent_Identity=24.3076923076923, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21356111, Length=547, Percent_Identity=23.400365630713, Blast_Score=182, Evalue=9e-46,
Organism=Drosophila melanogaster, GI20129717, Length=412, Percent_Identity=28.6407766990291, Blast_Score=174, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 79648; Mature: 79648

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNILNAQNPFFGQYQTPHGTVPFDRIKTEHYEPAILEGIKQQNAELDAIIQNPEKATFT
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCHHHHHCCCCCHHHH
NTIEAYEQSGRLLDKVTAVFGNMLSAETNDDLQALAQKIMPLLSEHSNNITLNEKLFARV
HHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHH
KEVYGQKQSLQLTQEQNRLLDDIYDSFVRHGANLEGEAREQYRQLTNELSKLTLDFSENN
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCCCC
LKETNRYQMLLTDKASIAGLPEIIVEAAAETARSEDKEGWAFTLHAPSYVPFMTYADNRE
CCCCCCEEEEEECCHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEECCCCC
LRHKLYIAYNTKCTHDNEFNNIEIVKKLVNTRMKIAQLLGYKDYAEYTLKKRMAENSDAV
CEEEEEEEEECEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
YKLLNQLLEAYTPTAQKEYLEVQELAREEQGDDFIVMPWDWSYYSNKLKNKKFNINEEML
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCCHHHH
RPYFELEQVKKGVFGLAERLYGITFRKNTEIPVYHKDVEAYEVFDKDGKFLSVLYTDFHP
HHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEECCCHHHHHHCCCCCEEEEEEECCCC
RPGKRAGAWMTSYKEQWIDPVTGEDSRPHISVVMNFTKPTESKPALLTFNEVETFLHEFG
CCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEHHHHHHHHHHHC
HSLHGMFANSTYQSLSGTNVYWDFVELPSQIMENFAIEKEFLNTFARHYETGEVLPDELI
HHHHHHHHCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
QRLVDASNFNAAYACLRQVSFGLLDMAWYTRNTPFEGDVKAYEQEAWKDAQVLPIVKEAC
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
MSTQFSHIFAGGYSAGYYSYKWAEVLDADAFSLFKQQGIFNREVADSFRNNILSKGGTEH
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
PMVLYKRFRGQEPTIDALLIRNGIKKQYN
HHHHHHHHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNILNAQNPFFGQYQTPHGTVPFDRIKTEHYEPAILEGIKQQNAELDAIIQNPEKATFT
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCHHHHHCCCCCHHHH
NTIEAYEQSGRLLDKVTAVFGNMLSAETNDDLQALAQKIMPLLSEHSNNITLNEKLFARV
HHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHH
KEVYGQKQSLQLTQEQNRLLDDIYDSFVRHGANLEGEAREQYRQLTNELSKLTLDFSENN
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCCCC
LKETNRYQMLLTDKASIAGLPEIIVEAAAETARSEDKEGWAFTLHAPSYVPFMTYADNRE
CCCCCCEEEEEECCHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEECCCCC
LRHKLYIAYNTKCTHDNEFNNIEIVKKLVNTRMKIAQLLGYKDYAEYTLKKRMAENSDAV
CEEEEEEEEECEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
YKLLNQLLEAYTPTAQKEYLEVQELAREEQGDDFIVMPWDWSYYSNKLKNKKFNINEEML
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCCHHHH
RPYFELEQVKKGVFGLAERLYGITFRKNTEIPVYHKDVEAYEVFDKDGKFLSVLYTDFHP
HHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEECCCHHHHHHCCCCCEEEEEEECCCC
RPGKRAGAWMTSYKEQWIDPVTGEDSRPHISVVMNFTKPTESKPALLTFNEVETFLHEFG
CCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEHHHHHHHHHHHC
HSLHGMFANSTYQSLSGTNVYWDFVELPSQIMENFAIEKEFLNTFARHYETGEVLPDELI
HHHHHHHHCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
QRLVDASNFNAAYACLRQVSFGLLDMAWYTRNTPFEGDVKAYEQEAWKDAQVLPIVKEAC
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
MSTQFSHIFAGGYSAGYYSYKWAEVLDADAFSLFKQQGIFNREVADSFRNNILSKGGTEH
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
PMVLYKRFRGQEPTIDALLIRNGIKKQYN
HHHHHHHHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]