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The map label for this gene is hemH [H]

Identifier: 29349625

GI number: 29349625

Start: 5553618

End: 5554562

Strand: Reverse

Name: hemH [H]

Synonym: BT_4217

Alternate gene names: 29349625

Gene position: 5554562-5553618 (Counterclockwise)

Preceding gene: 29349626

Following gene: 29349624

Centisome position: 88.73

GC content: 46.35

Gene sequence:

>945_bases
ATGAAAGCATTAACAAAAACAGATTTCAACTTTCCGGGACAAAAAAGCGTGTACCACGGAAAAGTGCGCGATGTGTACAA
CATCAACGGCGAAAAACTCGTCATGGTAGCAACCGACCGTATCTCGGCTTTCGATGTGGTTTTACCTGAAGGTATCCCTT
ACAAAGGCCAAATGCTGAATCAGATTGCAGCCAAATTCCTCGATGCCACTACTGACATCTGTCCGAACTGGAAAATGGCT
ACGCCGGACCCGATGGTTACTGTCGGAGTTTTGTGCGAAGGCTTTCCGGTAGAAATGATTGTACGCGGCTATCTGTGCGG
TAGCGCATGGCGTACTTACAAAAGCGGCGTACGCGAAATCTGCGGTGTGAAACTGCCGGATGGTATGCGCGAAAACGAGA
AATTCCCGGAACCGATCGTCACCCCGACAACGAAAGCGGAAATGGGACTGCACGACGAAGATATCTCTAAGGAAGAAATC
CTGAAACAAGGACTCGCTACTCCCGAAGAATATGAGACTCTGGAGAAATATACACTGGCTCTCTTCAAACGTGGAACTGA
AATCGCTGCTGAACGCGGTCTGATCCTCGTTGATACAAAATACGAATTCGGCAAGCACAACGGTACTATCTATCTGATGG
ACGAAATTCATACACCGGATTCAAGCCGTTACTTCTACTCTGACGGCTATCAGGAACGCTTCGAAAAAGGCGAACCTCAA
AAGCAGCTTTCTAAGGAATTCGTTCGTGAATGGCTGATGGAAAATGGTTTCCAAGGCAAGGATGGTCAGAAAGTTCCTGA
AATGACTCCGGCTATCGTACAGAGCATCAGCGATCGTTACATCGAATTGTTCGAGAATATCACCGGTGAGAAATTTGTGA
AAGAAGATACCAGCAACATCGCTGAACGTATCGAAAAGAACGTTATGAATTTCTTGAGCAAATAA

Upstream 100 bases:

>100_bases
AATGAACAACTGGTTATCAACGGCGAACGACCGGTGAAACAGGTCAACAACTAGTCGTTTCTGTGATTTGTAACTTGTAA
TTTGTAATTATAATAAAACA

Downstream 100 bases:

>100_bases
GCATGGATTACCCACAACAACATATCAAGCCTTACAACGAAGACGGTAAGAAAACCGAGCAGGTGGAACGTATGTTCGAT
AACATTGCGCATGCTTACGA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKALTKTDFNFPGQKSVYHGKVRDVYNINGEKLVMVATDRISAFDVVLPEGIPYKGQMLNQIAAKFLDATTDICPNWKMA
TPDPMVTVGVLCEGFPVEMIVRGYLCGSAWRTYKSGVREICGVKLPDGMRENEKFPEPIVTPTTKAEMGLHDEDISKEEI
LKQGLATPEEYETLEKYTLALFKRGTEIAAERGLILVDTKYEFGKHNGTIYLMDEIHTPDSSRYFYSDGYQERFEKGEPQ
KQLSKEFVREWLMENGFQGKDGQKVPEMTPAIVQSISDRYIELFENITGEKFVKEDTSNIAERIEKNVMNFLSK

Sequences:

>Translated_314_residues
MKALTKTDFNFPGQKSVYHGKVRDVYNINGEKLVMVATDRISAFDVVLPEGIPYKGQMLNQIAAKFLDATTDICPNWKMA
TPDPMVTVGVLCEGFPVEMIVRGYLCGSAWRTYKSGVREICGVKLPDGMRENEKFPEPIVTPTTKAEMGLHDEDISKEEI
LKQGLATPEEYETLEKYTLALFKRGTEIAAERGLILVDTKYEFGKHNGTIYLMDEIHTPDSSRYFYSDGYQERFEKGEPQ
KQLSKEFVREWLMENGFQGKDGQKVPEMTPAIVQSISDRYIELFENITGEKFVKEDTSNIAERIEKNVMNFLSK
>Mature_314_residues
MKALTKTDFNFPGQKSVYHGKVRDVYNINGEKLVMVATDRISAFDVVLPEGIPYKGQMLNQIAAKFLDATTDICPNWKMA
TPDPMVTVGVLCEGFPVEMIVRGYLCGSAWRTYKSGVREICGVKLPDGMRENEKFPEPIVTPTTKAEMGLHDEDISKEEI
LKQGLATPEEYETLEKYTLALFKRGTEIAAERGLILVDTKYEFGKHNGTIYLMDEIHTPDSSRYFYSDGYQERFEKGEPQ
KQLSKEFVREWLMENGFQGKDGQKVPEMTPAIVQSISDRYIELFENITGEKFVKEDTSNIAERIEKNVMNFLSK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=301, Percent_Identity=37.8737541528239, Blast_Score=184, Evalue=2e-47,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 35766; Mature: 35766

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTKTDFNFPGQKSVYHGKVRDVYNINGEKLVMVATDRISAFDVVLPEGIPYKGQMLN
CCCCCCCCCCCCCCCCEECCCCHHEEECCCCEEEEEECCCCCEEEEECCCCCCCHHHHHH
QIAAKFLDATTDICPNWKMATPDPMVTVGVLCEGFPVEMIVRGYLCGSAWRTYKSGVREI
HHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CGVKLPDGMRENEKFPEPIVTPTTKAEMGLHDEDISKEEILKQGLATPEEYETLEKYTLA
HCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
LFKRGTEIAAERGLILVDTKYEFGKHNGTIYLMDEIHTPDSSRYFYSDGYQERFEKGEPQ
HHHCCHHHHHHCCEEEEECCHHHCCCCCEEEEEECCCCCCCCCEEECCCHHHHHHCCCCH
KQLSKEFVREWLMENGFQGKDGQKVPEMTPAIVQSISDRYIELFENITGEKFVKEDTSNI
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AERIEKNVMNFLSK
HHHHHHHHHHHHCC
>Mature Secondary Structure
MKALTKTDFNFPGQKSVYHGKVRDVYNINGEKLVMVATDRISAFDVVLPEGIPYKGQMLN
CCCCCCCCCCCCCCCCEECCCCHHEEECCCCEEEEEECCCCCEEEEECCCCCCCHHHHHH
QIAAKFLDATTDICPNWKMATPDPMVTVGVLCEGFPVEMIVRGYLCGSAWRTYKSGVREI
HHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CGVKLPDGMRENEKFPEPIVTPTTKAEMGLHDEDISKEEILKQGLATPEEYETLEKYTLA
HCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
LFKRGTEIAAERGLILVDTKYEFGKHNGTIYLMDEIHTPDSSRYFYSDGYQERFEKGEPQ
HHHCCHHHHHHCCEEEEECCHHHCCCCCEEEEEECCCCCCCCCEEECCCHHHHHHCCCCH
KQLSKEFVREWLMENGFQGKDGQKVPEMTPAIVQSISDRYIELFENITGEKFVKEDTSNI
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AERIEKNVMNFLSK
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA