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The map label for this gene is nuoC [H]

Identifier: 29349473

GI number: 29349473

Start: 5298679

End: 5300295

Strand: Reverse

Name: nuoC [H]

Synonym: BT_4065

Alternate gene names: 29349473

Gene position: 5300295-5298679 (Counterclockwise)

Preceding gene: 29349474

Following gene: 29349472

Centisome position: 84.66

GC content: 47.74

Gene sequence:

>1617_bases
ATGAAGAATGAGGAACGAAGAATTATGCAAGAAATACAATTTATAGTCCCTGCAGCGTTACACGACGAAATGCTGCGCTT
GCGAAATGAAAAACAGATGGACTTCCTTGAAAGCCTCACTGGTATGGACTGGGGAGTAGCAGACGAAAAAGACGCACCGG
AGAAACTCCGTGGTTTAGGCGTTGTCTACCATCTGGAATCGACTGTTACGGGAGAACGGATAGCACTGAAAACAGCCGTT
ACCGACCGTGAACGACCGGAAATTCCGTCAGTCAGCGATATATGGAAAATAGCCGACTTCTACGAACGTGAAGTGTTCGA
CTACTATGGCATTGTTTTCGTAGGGCATCCCGATATGCGCCGCCTTTACTTACGTAATGACTGGGTAGGATACCCCATGC
GTAAAGATAATGATCCGGAGAAAGATAATCCGCTTTGTATGGCTAACGAAGAGACGTTCGATACAACACAGGAAATAGAA
CTTAATCCGGACGGAACGATTAAAAACAGAGAAATGAAACTCTTCGGAGAAGAAGAGTATGTAGTCAACATTGGTCCGCA
ACACCCTGCAACTCACGGTGTAATGCGCTTCCGCGTTTCTCTTGAAGGTGAAATTATTCGTAAGATCGATGCTAACTGCG
GTTATATCCATCGGGGTATCGAGAAAATGAACGAGAGTCTTACATATCCGCAGACATTGGCATTGACTGACCGCCTCGAC
TATCTGGGCGCACATCAGAACCGTCACGCTTTGTGTATGTGCATCGAGAAAGCGATGGGCATCGAAGTGAGTGACCGTGT
CAAATACATTCGTACAATTATGGATGAGCTGCAACGTATCGACTCTCACTTACTGTTCTACTCCGCCCTCGCCATGGACC
TTGGAGCACTGACTGCTTTCTTCTACGGATTCCGTGACCGTGAAAAGATTCTCGATATTTTTGAAGAGACTTGCGGCGGA
CGTCTGATCATGAACTACAATACCATCGGTGGTGTACAGGCCGACCTTCATCCTAACTTCGTCAAGCGGGTAAAAGAATT
TATCCCTTATATGAGAGGTATCATTCACGAATACCACGACATATTTACCGGCAACATTATCGCTCAGAGCCGTATGAAGG
GCGTCGGAGTGTTAAGCCGTGAAGATGCAATCTCATTCGGTTGCACCGGGGGTACAGGCCGTGCTTCGGGTTGGGCTTGC
GATGTACGTAAGCGGATACCGTACGGTGTATATGACAAGGTGGACTTCCAGGAAATTGTTTATACGGAAGGAGACTGTTT
CGCCCGTTATCTGGTACGTATGGACGAAATCATGGAGAGTCTGAAGATTATCGAGCAGTTGATAGACAACATTCCCGAAG
GCCCGTATCAGGAAAAGATGAAACCGATCATCCGCGTTCCCGAAGGCAGTTATTATGCCGCCGTAGAAGGAAGCCGCGGA
GAATTCGGAGTCTTTCTCGAAAGTCAGGGTGACAAGATGCCTTATCGCCTGCACTATCGTGCTACGGGATTGCCACTTGT
TGCTGCAATCGACACGATTTGCCGCGGAGCGAAAATTGCCGACTTGATTGCCATCGGAGGAACACTGGACTATGTAGTTC
CGGACATCGACCGATAA

Upstream 100 bases:

>100_bases
AAGCTTTCTATTACGGCATGATGCAACTACAACGCAAAGTGAAAATAGAGAAATTCTTTGGTGGAACGAACAGAAAAGAG
AAGAAACCGGAATTTATGAA

Downstream 100 bases:

>100_bases
ACAAGAGATAAAAAACAAGTATTAAGTATAAAGTAGTAAGTATTAACCGGCTATGCAATATGATATACGCTATATTCCGC
ATGGAATTAATACTTAATAC

Product: NADH dehydrogenase I subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MKNEERRIMQEIQFIVPAALHDEMLRLRNEKQMDFLESLTGMDWGVADEKDAPEKLRGLGVVYHLESTVTGERIALKTAV
TDRERPEIPSVSDIWKIADFYEREVFDYYGIVFVGHPDMRRLYLRNDWVGYPMRKDNDPEKDNPLCMANEETFDTTQEIE
LNPDGTIKNREMKLFGEEEYVVNIGPQHPATHGVMRFRVSLEGEIIRKIDANCGYIHRGIEKMNESLTYPQTLALTDRLD
YLGAHQNRHALCMCIEKAMGIEVSDRVKYIRTIMDELQRIDSHLLFYSALAMDLGALTAFFYGFRDREKILDIFEETCGG
RLIMNYNTIGGVQADLHPNFVKRVKEFIPYMRGIIHEYHDIFTGNIIAQSRMKGVGVLSREDAISFGCTGGTGRASGWAC
DVRKRIPYGVYDKVDFQEIVYTEGDCFARYLVRMDEIMESLKIIEQLIDNIPEGPYQEKMKPIIRVPEGSYYAAVEGSRG
EFGVFLESQGDKMPYRLHYRATGLPLVAAIDTICRGAKIADLIAIGGTLDYVVPDIDR

Sequences:

>Translated_538_residues
MKNEERRIMQEIQFIVPAALHDEMLRLRNEKQMDFLESLTGMDWGVADEKDAPEKLRGLGVVYHLESTVTGERIALKTAV
TDRERPEIPSVSDIWKIADFYEREVFDYYGIVFVGHPDMRRLYLRNDWVGYPMRKDNDPEKDNPLCMANEETFDTTQEIE
LNPDGTIKNREMKLFGEEEYVVNIGPQHPATHGVMRFRVSLEGEIIRKIDANCGYIHRGIEKMNESLTYPQTLALTDRLD
YLGAHQNRHALCMCIEKAMGIEVSDRVKYIRTIMDELQRIDSHLLFYSALAMDLGALTAFFYGFRDREKILDIFEETCGG
RLIMNYNTIGGVQADLHPNFVKRVKEFIPYMRGIIHEYHDIFTGNIIAQSRMKGVGVLSREDAISFGCTGGTGRASGWAC
DVRKRIPYGVYDKVDFQEIVYTEGDCFARYLVRMDEIMESLKIIEQLIDNIPEGPYQEKMKPIIRVPEGSYYAAVEGSRG
EFGVFLESQGDKMPYRLHYRATGLPLVAAIDTICRGAKIADLIAIGGTLDYVVPDIDR
>Mature_538_residues
MKNEERRIMQEIQFIVPAALHDEMLRLRNEKQMDFLESLTGMDWGVADEKDAPEKLRGLGVVYHLESTVTGERIALKTAV
TDRERPEIPSVSDIWKIADFYEREVFDYYGIVFVGHPDMRRLYLRNDWVGYPMRKDNDPEKDNPLCMANEETFDTTQEIE
LNPDGTIKNREMKLFGEEEYVVNIGPQHPATHGVMRFRVSLEGEIIRKIDANCGYIHRGIEKMNESLTYPQTLALTDRLD
YLGAHQNRHALCMCIEKAMGIEVSDRVKYIRTIMDELQRIDSHLLFYSALAMDLGALTAFFYGFRDREKILDIFEETCGG
RLIMNYNTIGGVQADLHPNFVKRVKEFIPYMRGIIHEYHDIFTGNIIAQSRMKGVGVLSREDAISFGCTGGTGRASGWAC
DVRKRIPYGVYDKVDFQEIVYTEGDCFARYLVRMDEIMESLKIIEQLIDNIPEGPYQEKMKPIIRVPEGSYYAAVEGSRG
EFGVFLESQGDKMPYRLHYRATGLPLVAAIDTICRGAKIADLIAIGGTLDYVVPDIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=383, Percent_Identity=36.8146214099217, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI260898743, Length=373, Percent_Identity=36.7292225201072, Blast_Score=256, Evalue=5e-68,
Organism=Escherichia coli, GI145693162, Length=516, Percent_Identity=33.9147286821705, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1789076, Length=514, Percent_Identity=30.5447470817121, Blast_Score=195, Evalue=7e-51,
Organism=Escherichia coli, GI1788832, Length=541, Percent_Identity=28.2809611829945, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17568379, Length=396, Percent_Identity=37.8787878787879, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17555284, Length=396, Percent_Identity=37.8787878787879, Blast_Score=272, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI71990788, Length=131, Percent_Identity=35.1145038167939, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32563621, Length=131, Percent_Identity=35.1145038167939, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=39.1644908616188, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24638644, Length=383, Percent_Identity=37.3368146214099, Blast_Score=270, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR020396
- InterPro:   IPR022885
- ProDom:   PD001581 [H]

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 61652; Mature: 61652

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00542 COMPLEX1_30K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEERRIMQEIQFIVPAALHDEMLRLRNEKQMDFLESLTGMDWGVADEKDAPEKLRGLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCE
VVYHLESTVTGERIALKTAVTDRERPEIPSVSDIWKIADFYEREVFDYYGIVFVGHPDMR
EEEEECCCCCCCEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCHH
RLYLRNDWVGYPMRKDNDPEKDNPLCMANEETFDTTQEIELNPDGTIKNREMKLFGEEEY
EEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCEECCEEEEECCCEE
VVNIGPQHPATHGVMRFRVSLEGEIIRKIDANCGYIHRGIEKMNESLTYPQTLALTDRLD
EEECCCCCCCCCCEEEEEEECCCHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
YLGAHQNRHALCMCIEKAMGIEVSDRVKYIRTIMDELQRIDSHLLFYSALAMDLGALTAF
HHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYGFRDREKILDIFEETCGGRLIMNYNTIGGVQADLHPNFVKRVKEFIPYMRGIIHEYHD
HHCCCCHHHHHHHHHHHCCCEEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHH
IFTGNIIAQSRMKGVGVLSREDAISFGCTGGTGRASGWACDVRKRIPYGVYDKVDFQEIV
HHCCCHHHHHHHCCCCEEECCCCCEECCCCCCCCCCCCEEHHHHCCCCCCCCCCCHHHHH
YTEGDCFARYLVRMDEIMESLKIIEQLIDNIPEGPYQEKMKPIIRVPEGSYYAAVEGSRG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEECCCCCEEEEEECCCC
EFGVFLESQGDKMPYRLHYRATGLPLVAAIDTICRGAKIADLIAIGGTLDYVVPDIDR
CEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHCCCHHHHHHEECCCHHCCCCCCCC
>Mature Secondary Structure
MKNEERRIMQEIQFIVPAALHDEMLRLRNEKQMDFLESLTGMDWGVADEKDAPEKLRGLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCE
VVYHLESTVTGERIALKTAVTDRERPEIPSVSDIWKIADFYEREVFDYYGIVFVGHPDMR
EEEEECCCCCCCEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCHH
RLYLRNDWVGYPMRKDNDPEKDNPLCMANEETFDTTQEIELNPDGTIKNREMKLFGEEEY
EEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCEECCEEEEECCCEE
VVNIGPQHPATHGVMRFRVSLEGEIIRKIDANCGYIHRGIEKMNESLTYPQTLALTDRLD
EEECCCCCCCCCCEEEEEEECCCHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
YLGAHQNRHALCMCIEKAMGIEVSDRVKYIRTIMDELQRIDSHLLFYSALAMDLGALTAF
HHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYGFRDREKILDIFEETCGGRLIMNYNTIGGVQADLHPNFVKRVKEFIPYMRGIIHEYHD
HHCCCCHHHHHHHHHHHCCCEEEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHH
IFTGNIIAQSRMKGVGVLSREDAISFGCTGGTGRASGWACDVRKRIPYGVYDKVDFQEIV
HHCCCHHHHHHHCCCCEEECCCCCEECCCCCCCCCCCCEEHHHHCCCCCCCCCCCHHHHH
YTEGDCFARYLVRMDEIMESLKIIEQLIDNIPEGPYQEKMKPIIRVPEGSYYAAVEGSRG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEECCCCCEEEEEECCCC
EFGVFLESQGDKMPYRLHYRATGLPLVAAIDTICRGAKIADLIAIGGTLDYVVPDIDR
CEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHCCCHHHHHHEECCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]