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The map label for this gene is nuoH

Identifier: 29349472

GI number: 29349472

Start: 5297477

End: 5298553

Strand: Reverse

Name: nuoH

Synonym: BT_4064

Alternate gene names: 29349472

Gene position: 5298553-5297477 (Counterclockwise)

Preceding gene: 29349473

Following gene: 29349471

Centisome position: 84.64

GC content: 46.8

Gene sequence:

>1077_bases
ATGTTCGACTTTAGTATAGTAACAAACTGGATACATGAGATGCTGCTCTCCGTTATGCCGGAGGGATGGGCCATCTTTAT
AGAGTGCATAGCTGTCGGCGTGTGCATCGTTGCACTATATGCTATTCTGGCTATCGTACTGATTTACATGGAACGCAAAG
TCTGTGGTTTCTTCCAGTGCCGCCTCGGTCCGAACCGTGTCGGTAAATGGGGTTCTATTCAAGTGATATGCGACGTACTC
AAGATGCTGACCAAGGAGATTTTCACTCCGAAGGATGCCGACCGCTTCCTCTACAATCTGGCTCCATTCATGGTGATTAT
CGCCTCGTTCCTCACTTTCGCTTGTATTCCTTTTAATAAAGGAGCGGAAATTCTGAATTTTAATGTGGGCGTATTCTTCC
TGCTGGCTGCTTCCAGCATCGGTGTGGTAGGTATTCTGCTTGCCGGTTGGGGTAGTAACAACAAGTTTTCGCTGATCGGT
GCCATGCGAAGCGGCGCACAGATCATCAGTTATGAGTTGTCAGTGGGTATGAGCATCATGACGATGGTCGTACTGATGGG
CACCATGCAGTTCTCCGAAATCGTAGAAGGACAGGCTGACGGATGGTTTATCTTCAAAGGACATATTCCTGCCGTTATCG
CTTTCATCATCTATCTCATTGCCGGAAATGCAGAATGTAACCGTGGCCCGTTCGACCTTCCCGAAGCGGAAAGTGAATTG
ACGGCCGGATATCATACGGAATATTCCGGTATGCACTTCGGTTTCTTTTATCTGGCGGAATATCTGAATCTGTTTATCGT
AGCCAGCGTGGCCGCTACCATCTTTTTGGGAGGCTGGATGCCATTGCATATCATCGGTTTGGACGGATTCAACGCTGTTA
TGGACTATATTCCCGGCTTCATCTGGTTCTTTGCCAAAGCATTCTTCGTTGTGTTCCTCTTAATGTGGATCAAATGGACT
TTCCCACGCCTGCGTATCGACCAGATTCTGAATCTGGAATGGAAATATCTGGTTCCAATTTCTATGGTAAACCTATTATT
AATGGCATGTTGTGTTGCCTTTGGCTTCCACTTCTAA

Upstream 100 bases:

>100_bases
GTATAAAGTAGTAAGTATTAACCGGCTATGCAATATGATATACGCTATATTCCGCATGGAATTAATACTTAATACTTAAA
ACCTAATAATTAAAATATAT

Downstream 100 bases:

>100_bases
AATAAGAATTATGGAATATAAAGATCAAAAATATACGTATTTGGGAGGACTGATACATGGTATCAGCACTCTGGCAACGG
GTATGAAAACCAGTATCAAG

Product: NADH dehydrogenase I subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MFDFSIVTNWIHEMLLSVMPEGWAIFIECIAVGVCIVALYAILAIVLIYMERKVCGFFQCRLGPNRVGKWGSIQVICDVL
KMLTKEIFTPKDADRFLYNLAPFMVIIASFLTFACIPFNKGAEILNFNVGVFFLLAASSIGVVGILLAGWGSNNKFSLIG
AMRSGAQIISYELSVGMSIMTMVVLMGTMQFSEIVEGQADGWFIFKGHIPAVIAFIIYLIAGNAECNRGPFDLPEAESEL
TAGYHTEYSGMHFGFFYLAEYLNLFIVASVAATIFLGGWMPLHIIGLDGFNAVMDYIPGFIWFFAKAFFVVFLLMWIKWT
FPRLRIDQILNLEWKYLVPISMVNLLLMACCVAFGFHF

Sequences:

>Translated_358_residues
MFDFSIVTNWIHEMLLSVMPEGWAIFIECIAVGVCIVALYAILAIVLIYMERKVCGFFQCRLGPNRVGKWGSIQVICDVL
KMLTKEIFTPKDADRFLYNLAPFMVIIASFLTFACIPFNKGAEILNFNVGVFFLLAASSIGVVGILLAGWGSNNKFSLIG
AMRSGAQIISYELSVGMSIMTMVVLMGTMQFSEIVEGQADGWFIFKGHIPAVIAFIIYLIAGNAECNRGPFDLPEAESEL
TAGYHTEYSGMHFGFFYLAEYLNLFIVASVAATIFLGGWMPLHIIGLDGFNAVMDYIPGFIWFFAKAFFVVFLLMWIKWT
FPRLRIDQILNLEWKYLVPISMVNLLLMACCVAFGFHF
>Mature_358_residues
MFDFSIVTNWIHEMLLSVMPEGWAIFIECIAVGVCIVALYAILAIVLIYMERKVCGFFQCRLGPNRVGKWGSIQVICDVL
KMLTKEIFTPKDADRFLYNLAPFMVIIASFLTFACIPFNKGAEILNFNVGVFFLLAASSIGVVGILLAGWGSNNKFSLIG
AMRSGAQIISYELSVGMSIMTMVVLMGTMQFSEIVEGQADGWFIFKGHIPAVIAFIIYLIAGNAECNRGPFDLPEAESEL
TAGYHTEYSGMHFGFFYLAEYLNLFIVASVAATIFLGGWMPLHIIGLDGFNAVMDYIPGFIWFFAKAFFVVFLLMWIKWT
FPRLRIDQILNLEWKYLVPISMVNLLLMACCVAFGFHF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=300, Percent_Identity=34.3333333333333, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1788618, Length=332, Percent_Identity=39.4578313253012, Blast_Score=254, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_BACTN (Q8A0F7)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_812975.1
- GeneID:   1074675
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_4064
- NMPDR:   fig|226186.1.peg.4062
- HOGENOM:   HBG727670
- OMA:   IFWICAL
- PhylomeDB:   Q8A0F7
- ProtClustDB:   CLSK823771
- BioCyc:   BTHE226186:BT_4064-MONOMER
- BRENDA:   1.6.99.5
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 40161; Mature: 40161

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x126b8348)-; HASH(0x13702ddc)-; HASH(0x1347e608)-; HASH(0x13a4f718)-; HASH(0x134ba67c)-; HASH(0x12c0dbe8)-; HASH(0x135e30fc)-; HASH(0x13f4137c)-;

Cys/Met content:

2.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDFSIVTNWIHEMLLSVMPEGWAIFIECIAVGVCIVALYAILAIVLIYMERKVCGFFQC
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
RLGPNRVGKWGSIQVICDVLKMLTKEIFTPKDADRFLYNLAPFMVIIASFLTFACIPFNK
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GAEILNFNVGVFFLLAASSIGVVGILLAGWGSNNKFSLIGAMRSGAQIISYELSVGMSIM
CCCEEEECHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEHHHCCCCEEEHHHHHHHHHH
TMVVLMGTMQFSEIVEGQADGWFIFKGHIPAVIAFIIYLIAGNAECNRGPFDLPEAESEL
HHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
TAGYHTEYSGMHFGFFYLAEYLNLFIVASVAATIFLGGWMPLHIIGLDGFNAVMDYIPGF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHH
IWFFAKAFFVVFLLMWIKWTFPRLRIDQILNLEWKYLVPISMVNLLLMACCVAFGFHF
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MFDFSIVTNWIHEMLLSVMPEGWAIFIECIAVGVCIVALYAILAIVLIYMERKVCGFFQC
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
RLGPNRVGKWGSIQVICDVLKMLTKEIFTPKDADRFLYNLAPFMVIIASFLTFACIPFNK
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GAEILNFNVGVFFLLAASSIGVVGILLAGWGSNNKFSLIGAMRSGAQIISYELSVGMSIM
CCCEEEECHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEHHHCCCCEEEHHHHHHHHHH
TMVVLMGTMQFSEIVEGQADGWFIFKGHIPAVIAFIIYLIAGNAECNRGPFDLPEAESEL
HHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
TAGYHTEYSGMHFGFFYLAEYLNLFIVASVAATIFLGGWMPLHIIGLDGFNAVMDYIPGF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHH
IWFFAKAFFVVFLLMWIKWTFPRLRIDQILNLEWKYLVPISMVNLLLMACCVAFGFHF
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12663928