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The map label for this gene is dapL [H]

Identifier: 29349343

GI number: 29349343

Start: 5109180

End: 5110361

Strand: Reverse

Name: dapL [H]

Synonym: BT_3935

Alternate gene names: 29349343

Gene position: 5110361-5109180 (Counterclockwise)

Preceding gene: 29349344

Following gene: 29349342

Centisome position: 81.63

GC content: 49.24

Gene sequence:

>1182_bases
ATGCAGAAGGAAAGTCAAACGTATAAAATCGCTCCTGCCGAAAGACTGGCAAGTGTCAGCGAATACTACTTCTCAAAGAA
GCTGAAAGAGGTAGCACAAATGAATGCAGAAGGAAAAGACGTTATCAGTCTGGGTATCGGAAGTCCCGATATGCCTCCTT
CAAAGGTTACCATCGAAACATTGTGCAACAATGCTCACGATCCCAACGGACACGGTTACCAACCGTATGTGGGCATACCG
GAACTTCGTAAAGGTTTCGCAGCCTGGTATCAACGCTGGTATGGAGTGGAACTGAATCCGAATACGGAAATACAGCCGCT
GATCGGTTCCAAAGAAGGTATCCTTCACGTCACGCTGGCTTTTGTCAATCCGGGCGAACAGGTACTGGTGCCGAATCCGG
GATACCCCACCTATACTTCTCTGAGTAAAATACTCGGTGCGGAAGTAATCAGCTACGACCTGAAAGAAGAAGACGGCTGG
ATGCCCGATTTCGAAGCATTGGAAAAGATGGACCTGAACCGCGTGAAACTAATGTGGACCAACTATCCGAATATGCCGAC
AGGAGCCAACGCTACTCCGGAACTCTACGAACGTCTGGTAGACTTCGCACGCCGCAAGAATATCGTCATCGTGAATGACA
ACCCGTACAGCTTTATCCTGAACGAAAAGCCGATCAGTATTCTCAGCGTACCGGGAGCCAAAGAGTGCTGCATCGAATTC
AACTCCATGAGCAAGAGCCACAATATGCCGGGATGGCGTATCGGAATGCTGGCTTCGAATGCCGAATTCGTACAATGGAT
ACTGAAAGTAAAAAGCAATATCGACAGCGGTATGTTCCGTGCCATGCAACTGGCAGCCGCCACAGCTCTGGAAGCCGAAG
CGGACTGGTACGAAGGTAACAACCACAACTATCGCGGCCGTCGCCATCTGGCCGGCGAAATCATGAAAACACTGGGGTGT
ACCTACGACGAAAACCAGGTGGGTATGTTCCTTTGGGGAAAGATTCCCGCTTCGTGCAAGGATGTAGAAGAACTGACCGA
AAAAGTATTGCACCAGGCAAGGGTATTTATCACGCCGGGATTCATCTTTGGCAGCAACGGAGCAAGGTTTATCCGTATTT
CCCTTTGTTGCAAGGATGCCAAACTGGCGGAAGCATTGGAAAGAATCAAGAAGCTTTCTTAA

Upstream 100 bases:

>100_bases
CAGTTTTACGTCGATGTATCTTTCAATGATTATCTGAGATATAAACAATCTATAGCAGCAATTACTCCATTAACCAAAGA
ACTTAAAATATTAGGCGAAT

Downstream 100 bases:

>100_bases
AAAGAAAAGACCGATAAAAGTAAATCAGCGGCAGACCAGGAAACGCCTGCCCGAAAGAGTAAGAACAAGAATAAAATAAA
AACAATAAGAATATGGAACT

Product: aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MQKESQTYKIAPAERLASVSEYYFSKKLKEVAQMNAEGKDVISLGIGSPDMPPSKVTIETLCNNAHDPNGHGYQPYVGIP
ELRKGFAAWYQRWYGVELNPNTEIQPLIGSKEGILHVTLAFVNPGEQVLVPNPGYPTYTSLSKILGAEVISYDLKEEDGW
MPDFEALEKMDLNRVKLMWTNYPNMPTGANATPELYERLVDFARRKNIVIVNDNPYSFILNEKPISILSVPGAKECCIEF
NSMSKSHNMPGWRIGMLASNAEFVQWILKVKSNIDSGMFRAMQLAAATALEAEADWYEGNNHNYRGRRHLAGEIMKTLGC
TYDENQVGMFLWGKIPASCKDVEELTEKVLHQARVFITPGFIFGSNGARFIRISLCCKDAKLAEALERIKKLS

Sequences:

>Translated_393_residues
MQKESQTYKIAPAERLASVSEYYFSKKLKEVAQMNAEGKDVISLGIGSPDMPPSKVTIETLCNNAHDPNGHGYQPYVGIP
ELRKGFAAWYQRWYGVELNPNTEIQPLIGSKEGILHVTLAFVNPGEQVLVPNPGYPTYTSLSKILGAEVISYDLKEEDGW
MPDFEALEKMDLNRVKLMWTNYPNMPTGANATPELYERLVDFARRKNIVIVNDNPYSFILNEKPISILSVPGAKECCIEF
NSMSKSHNMPGWRIGMLASNAEFVQWILKVKSNIDSGMFRAMQLAAATALEAEADWYEGNNHNYRGRRHLAGEIMKTLGC
TYDENQVGMFLWGKIPASCKDVEELTEKVLHQARVFITPGFIFGSNGARFIRISLCCKDAKLAEALERIKKLS
>Mature_393_residues
MQKESQTYKIAPAERLASVSEYYFSKKLKEVAQMNAEGKDVISLGIGSPDMPPSKVTIETLCNNAHDPNGHGYQPYVGIP
ELRKGFAAWYQRWYGVELNPNTEIQPLIGSKEGILHVTLAFVNPGEQVLVPNPGYPTYTSLSKILGAEVISYDLKEEDGW
MPDFEALEKMDLNRVKLMWTNYPNMPTGANATPELYERLVDFARRKNIVIVNDNPYSFILNEKPISILSVPGAKECCIEF
NSMSKSHNMPGWRIGMLASNAEFVQWILKVKSNIDSGMFRAMQLAAATALEAEADWYEGNNHNYRGRRHLAGEIMKTLGC
TYDENQVGMFLWGKIPASCKDVEELTEKVLHQARVFITPGFIFGSNGARFIRISLCCKDAKLAEALERIKKLS

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=271, Percent_Identity=23.9852398523985, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI169881279, Length=271, Percent_Identity=23.9852398523985, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI56713254, Length=266, Percent_Identity=22.9323308270677, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI56713256, Length=266, Percent_Identity=22.9323308270677, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4507369, Length=381, Percent_Identity=23.3595800524934, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788722, Length=382, Percent_Identity=32.9842931937173, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1788627, Length=239, Percent_Identity=28.8702928870293, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786816, Length=368, Percent_Identity=23.3695652173913, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787710, Length=317, Percent_Identity=29.3375394321767, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=403, Percent_Identity=25.0620347394541, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71994472, Length=321, Percent_Identity=25.2336448598131, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994476, Length=321, Percent_Identity=25.2336448598131, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17567663, Length=371, Percent_Identity=23.989218328841, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322401, Length=391, Percent_Identity=25.5754475703325, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28573069, Length=264, Percent_Identity=24.2424242424242, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646114, Length=264, Percent_Identity=24.2424242424242, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28573067, Length=264, Percent_Identity=24.2424242424242, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28573065, Length=264, Percent_Identity=24.2424242424242, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI18859735, Length=377, Percent_Identity=23.0769230769231, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 44161; Mature: 44161

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKESQTYKIAPAERLASVSEYYFSKKLKEVAQMNAEGKDVISLGIGSPDMPPSKVTIET
CCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEHHH
LCNNAHDPNGHGYQPYVGIPELRKGFAAWYQRWYGVELNPNTEIQPLIGSKEGILHVTLA
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCEEECCCCCCCEEEEEEE
FVNPGEQVLVPNPGYPTYTSLSKILGAEVISYDLKEEDGWMPDFEALEKMDLNRVKLMWT
EECCCCEEEECCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHCCCCEEEEEEE
NYPNMPTGANATPELYERLVDFARRKNIVIVNDNPYSFILNEKPISILSVPGAKECCIEF
CCCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCEEEEECCCCHHHHEEH
NSMSKSHNMPGWRIGMLASNAEFVQWILKVKSNIDSGMFRAMQLAAATALEAEADWYEGN
HHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
NHNYRGRRHLAGEIMKTLGCTYDENQVGMFLWGKIPASCKDVEELTEKVLHQARVFITPG
CCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCEEEEECC
FIFGSNGARFIRISLCCKDAKLAEALERIKKLS
EEECCCCCEEEEEEEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MQKESQTYKIAPAERLASVSEYYFSKKLKEVAQMNAEGKDVISLGIGSPDMPPSKVTIET
CCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEHHH
LCNNAHDPNGHGYQPYVGIPELRKGFAAWYQRWYGVELNPNTEIQPLIGSKEGILHVTLA
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCEEECCCCCCCEEEEEEE
FVNPGEQVLVPNPGYPTYTSLSKILGAEVISYDLKEEDGWMPDFEALEKMDLNRVKLMWT
EECCCCEEEECCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHCCCCEEEEEEE
NYPNMPTGANATPELYERLVDFARRKNIVIVNDNPYSFILNEKPISILSVPGAKECCIEF
CCCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCEEEEECCCCHHHHEEH
NSMSKSHNMPGWRIGMLASNAEFVQWILKVKSNIDSGMFRAMQLAAATALEAEADWYEGN
HHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
NHNYRGRRHLAGEIMKTLGCTYDENQVGMFLWGKIPASCKDVEELTEKVLHQARVFITPG
CCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCEEEEECC
FIFGSNGARFIRISLCCKDAKLAEALERIKKLS
EEECCCCCEEEEEEEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA