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The map label for this gene is rnr [H]

Identifier: 29144666

GI number: 29144666

Start: 4570329

End: 4572767

Strand: Direct

Name: rnr [H]

Synonym: t4419

Alternate gene names: 29144666

Gene position: 4570329-4572767 (Clockwise)

Preceding gene: 29144665

Following gene: 29144667

Centisome position: 95.37

GC content: 55.15

Gene sequence:

>2439_bases
ATGTCACAAGATCCTTTCCAGGAACGCGAAGCAGAAAAATACGCGAATCCTATCCCGAGCCGGGAATTTATCCTCGAACA
TTTAACGAAACGTGAAAAACCGGCCAGTCGCGAAGAACTGGCCGTAGAACTGAATATTGAAGGCGAAGAGCAGCTTGAAG
CCTTGCGTCGCCGCCTGCGCGCGATGGAGCGCGATGGACAACTGGTCTTTACCCGCCGCCAGTGCTATGCGCTGCCGGAA
CGCCTCGACCTGCTGAAAGGCACCGTGATCGGTCATCGTGATGGTTACGGTTTCTTACGTGTCGAAGGCCGCAAAGACGA
TCTGTATCTTTCCAGCGAGCAGATGAAAACCTGTATTCATGGCGATCAGGTGCTGGCGCAGCCGCTGGGCGCCGATCGTA
AAGGTCGCCGCGAAGCGCGTATCGTCCGTGTACTGGTACCGAAAACCAGTCAGATAGTCGGGCGTTATTTCACCGATGCG
GGCGTCGGCTTTGTGGTGCCGGACGACAGCCGTCTCAGCTTCGACATTCTTATCCCGCCAGAAGACGTCATGGGCGCGCG
GATGGGGTTCGTGGTCGTGGTTGAACTGACCCAACGTCCAACTCGCCGTACTAAAGCGGTAGGGAAAATCGTCGAAGTGC
TGGGCGACAATATGGGTACCGGTATGGCGGTTGATATGGCGCTGCGTACCCATGAAATACCCTACATCTGGCCGCAGGCG
GTAGAGCAGCAGGTCGCCGGGCTGAAAGAAGAGGTGCCGGAAGAGGCGAAAGTCGGTCGTGTCGATCTGCGCGATTTGCC
GCTGGTCACGATTGATGGCGAAGATGCCCGTGACTTTGACGACGCGGTTTACTGTGAGAAAAAACGCGGCGGCGGCTGGC
GTTTGTGGGTCGCTATTGCTGACGTGAGCTATTATGTACGGCCGCCAACGCCGTTGGATCGCGAGGCGCGCAATCGCGGC
ACGTCGGTTTACTTCCCGTCACAGGTTGTCCCAATGTTGCCGGAGGTGCTCTCCAACGGCCTGTGTTCGCTAAACCCGCA
GGTTGACAGGCTGTGTATGGTCTGTGAAATGACCATCTCGGCGAAAGGTCGGCTGACCGGCTACAAATTCTATGAAGCGG
TGATGAGCTCCCATGCGCGTCTGACCTATACCAAAGTCTGGCATATGCTGCAGGGCGATCAGGATCTGCGTGAACAATAT
GCGCCGCTGGTGAAGCATATTGAAGAGCTGCACAACCTCTACAAAGTGCTGGATAAAGCGCGTGAAGAACGCGGGGGGAT
CTCGTTTGAGAGCGAAGAGGCGAAGTTTATCTTTAACGCCGAGCGTCGCATTGAGCGTATCGAACAGACCCAGCGTAATG
ACGCGCATAAGCTTATCGAAGAGTGCATGATCATGGCGAATATCTCGGCGGCGCGCTTTGTCGAAAAAGCTAAAGAGCCG
GCGTTATTCCGTATTCATGATAAGCCCACCACCGAAGCGATCACCTCATTCCGCTCCGTACTGGCGGAGCTGGGGTTGGA
GCTGCCGGGCGGAAATAAACCGGAACCGCGCGATTATGCCGAACTGCTTGAATCGATTGCCGACAGGCCGGACGCCGAAA
TGCTGCAAACTATGCTGCTGCGTTCAATGAAGCAGGCGATTTACGATCCGGAAAACCGCGGGCACTTTGGCCTGGCGTTG
CAGTCTTATGCGCACTTTACCTCGCCGATTCGCCGCTATCCGGATCTTTCTTTGCACCGCGCCATTAAGTACCTGCTGGC
TAAAGAGCAAGGGAACAAGGGCAACACCACAGAAACGGGCGGTTATCACTACTCGATGGAAGAGATGTTGCAGCTCGGCC
AGCACTGTTCGATGGCGGAACGCCGCGCTGATGAAGCGACGCGTGATGTCTCCGACTGGCTGAAATGTGACTTTATGCTG
GATCAGGTAGGCAACGTCTTTAAGGGCGTGATTGCCAGCGTCACCGGTTTCGGCTTCTTTGTCCGTCTTGATGAACTGTT
TATCGATGGGCTGGTACACGTTTCCTCACTGGATAACGATTACTATCGCTTCGATCAGGTAGGGCAACGTCTGATTGGCG
AATCCGGCGGGCAGACATATCGCCTGGGCGACCGGGTCGAGGTACGCGTCGAAGCGGTGAATATGGACGAACGGAAAATT
GACTTTAGCTTGATTTCCAGCGAGCGCGCACCGCGTAACGTCGGCAAAACGGCGCGTGAAAAAGCGAAAAAAGGTGAAAG
TAAAAACGCCGGTAAACGTCGTCAGGTAGGTAAAAAGGTTAACTTCGAGCCTGATAGCGCCTTCCGCGGCGAGAAAAAAG
CGAAGCCGAAAGCAGCGAAGAAAGACGCGAGAAAAGCAAAAAAGCCATCGGCTAAAACGCAGAAAATAGCCGCAGCGACC
AAAGCGAAGCGTGCGGCGAAGAAAAAAGCGGCAGAGTGA

Upstream 100 bases:

>100_bases
TACACGCTTGCCGATTTGGTTGAAGAGAATCAACCGCTTTATAAATTATTACTGGTGGAGTGAAGTAAACTTCATTAGAG
ATGACAATGGAGGAACCTCA

Downstream 100 bases:

>100_bases
GCAATACCCTCTTCAAACAGAAGAGGGTCAATTATCTGTAGGCCGGGCAAGCGTAGCGCCCCCGGCAAAACGTAAACAAC
GAGTACATTAATGAGCGAAA

Product: exoribonuclease R

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 812; Mature: 811

Protein sequence:

>812_residues
MSQDPFQEREAEKYANPIPSREFILEHLTKREKPASREELAVELNIEGEEQLEALRRRLRAMERDGQLVFTRRQCYALPE
RLDLLKGTVIGHRDGYGFLRVEGRKDDLYLSSEQMKTCIHGDQVLAQPLGADRKGRREARIVRVLVPKTSQIVGRYFTDA
GVGFVVPDDSRLSFDILIPPEDVMGARMGFVVVVELTQRPTRRTKAVGKIVEVLGDNMGTGMAVDMALRTHEIPYIWPQA
VEQQVAGLKEEVPEEAKVGRVDLRDLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPPTPLDREARNRG
TSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISAKGRLTGYKFYEAVMSSHARLTYTKVWHMLQGDQDLREQY
APLVKHIEELHNLYKVLDKAREERGGISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMIMANISAARFVEKAKEP
ALFRIHDKPTTEAITSFRSVLAELGLELPGGNKPEPRDYAELLESIADRPDAEMLQTMLLRSMKQAIYDPENRGHFGLAL
QSYAHFTSPIRRYPDLSLHRAIKYLLAKEQGNKGNTTETGGYHYSMEEMLQLGQHCSMAERRADEATRDVSDWLKCDFML
DQVGNVFKGVIASVTGFGFFVRLDELFIDGLVHVSSLDNDYYRFDQVGQRLIGESGGQTYRLGDRVEVRVEAVNMDERKI
DFSLISSERAPRNVGKTAREKAKKGESKNAGKRRQVGKKVNFEPDSAFRGEKKAKPKAAKKDARKAKKPSAKTQKIAAAT
KAKRAAKKKAAE

Sequences:

>Translated_812_residues
MSQDPFQEREAEKYANPIPSREFILEHLTKREKPASREELAVELNIEGEEQLEALRRRLRAMERDGQLVFTRRQCYALPE
RLDLLKGTVIGHRDGYGFLRVEGRKDDLYLSSEQMKTCIHGDQVLAQPLGADRKGRREARIVRVLVPKTSQIVGRYFTDA
GVGFVVPDDSRLSFDILIPPEDVMGARMGFVVVVELTQRPTRRTKAVGKIVEVLGDNMGTGMAVDMALRTHEIPYIWPQA
VEQQVAGLKEEVPEEAKVGRVDLRDLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPPTPLDREARNRG
TSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISAKGRLTGYKFYEAVMSSHARLTYTKVWHMLQGDQDLREQY
APLVKHIEELHNLYKVLDKAREERGGISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMIMANISAARFVEKAKEP
ALFRIHDKPTTEAITSFRSVLAELGLELPGGNKPEPRDYAELLESIADRPDAEMLQTMLLRSMKQAIYDPENRGHFGLAL
QSYAHFTSPIRRYPDLSLHRAIKYLLAKEQGNKGNTTETGGYHYSMEEMLQLGQHCSMAERRADEATRDVSDWLKCDFML
DQVGNVFKGVIASVTGFGFFVRLDELFIDGLVHVSSLDNDYYRFDQVGQRLIGESGGQTYRLGDRVEVRVEAVNMDERKI
DFSLISSERAPRNVGKTAREKAKKGESKNAGKRRQVGKKVNFEPDSAFRGEKKAKPKAAKKDARKAKKPSAKTQKIAAAT
KAKRAAKKKAAE
>Mature_811_residues
SQDPFQEREAEKYANPIPSREFILEHLTKREKPASREELAVELNIEGEEQLEALRRRLRAMERDGQLVFTRRQCYALPER
LDLLKGTVIGHRDGYGFLRVEGRKDDLYLSSEQMKTCIHGDQVLAQPLGADRKGRREARIVRVLVPKTSQIVGRYFTDAG
VGFVVPDDSRLSFDILIPPEDVMGARMGFVVVVELTQRPTRRTKAVGKIVEVLGDNMGTGMAVDMALRTHEIPYIWPQAV
EQQVAGLKEEVPEEAKVGRVDLRDLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPPTPLDREARNRGT
SVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISAKGRLTGYKFYEAVMSSHARLTYTKVWHMLQGDQDLREQYA
PLVKHIEELHNLYKVLDKAREERGGISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMIMANISAARFVEKAKEPA
LFRIHDKPTTEAITSFRSVLAELGLELPGGNKPEPRDYAELLESIADRPDAEMLQTMLLRSMKQAIYDPENRGHFGLALQ
SYAHFTSPIRRYPDLSLHRAIKYLLAKEQGNKGNTTETGGYHYSMEEMLQLGQHCSMAERRADEATRDVSDWLKCDFMLD
QVGNVFKGVIASVTGFGFFVRLDELFIDGLVHVSSLDNDYYRFDQVGQRLIGESGGQTYRLGDRVEVRVEAVNMDERKID
FSLISSERAPRNVGKTAREKAKKGESKNAGKRRQVGKKVNFEPDSAFRGEKKAKPKAAKKDARKAKKPSAKTQKIAAATK
AKRAAKKKAAE

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=402, Percent_Identity=31.592039800995, Blast_Score=180, Evalue=5e-45,
Organism=Homo sapiens, GI190014625, Length=402, Percent_Identity=31.592039800995, Blast_Score=180, Evalue=5e-45,
Organism=Homo sapiens, GI134288890, Length=405, Percent_Identity=30.3703703703704, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI19115966, Length=526, Percent_Identity=26.425855513308, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI219521928, Length=526, Percent_Identity=26.425855513308, Blast_Score=143, Evalue=7e-34,
Organism=Escherichia coli, GI87082383, Length=795, Percent_Identity=95.3459119496855, Blast_Score=1533, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=651, Percent_Identity=26.1136712749616, Blast_Score=170, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI212645896, Length=410, Percent_Identity=30.7317073170732, Blast_Score=175, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17553506, Length=560, Percent_Identity=27.3214285714286, Blast_Score=169, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6324552, Length=564, Percent_Identity=26.5957446808511, Blast_Score=154, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6323943, Length=358, Percent_Identity=24.3016759776536, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649634, Length=480, Percent_Identity=28.75, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI19922976, Length=353, Percent_Identity=29.1784702549575, Blast_Score=142, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24654597, Length=353, Percent_Identity=29.1784702549575, Blast_Score=142, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24654592, Length=353, Percent_Identity=29.1784702549575, Blast_Score=141, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 92050; Mature: 91919

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDPFQEREAEKYANPIPSREFILEHLTKREKPASREELAVELNIEGEEQLEALRRRLR
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
AMERDGQLVFTRRQCYALPERLDLLKGTVIGHRDGYGFLRVEGRKDDLYLSSEQMKTCIH
HHCCCCCEEEEHHHHHHCHHHHHHHHCCEEECCCCCEEEEEECCCCCEEECHHHHHHHHC
GDQVLAQPLGADRKGRREARIVRVLVPKTSQIVGRYFTDAGVGFVVPDDSRLSFDILIPP
CHHHHHHCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCEEEEEEECC
EDVMGARMGFVVVVELTQRPTRRTKAVGKIVEVLGDNMGTGMAVDMALRTHEIPYIWPQA
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCCCCHHH
VEQQVAGLKEEVPEEAKVGRVDLRDLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIA
HHHHHHHHHHHCCHHHCCCCCCCCCCCEEEECCCCCCCCCHHHEEECCCCCCEEEEEEEE
DVSYYVRPPTPLDREARNRGTSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTIS
CCEEEECCCCCCCHHHHCCCCEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
AKGRLTGYKFYEAVMSSHARLTYTKVWHMLQGDQDLREQYAPLVKHIEELHNLYKVLDKA
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REERGGISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMIMANISAARFVEKAKEP
HHHHCCCCCCCCCCCEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCC
ALFRIHDKPTTEAITSFRSVLAELGLELPGGNKPEPRDYAELLESIADRPDAEMLQTMLL
CEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RSMKQAIYDPENRGHFGLALQSYAHFTSPIRRYPDLSLHRAIKYLLAKEQGNKGNTTETG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCC
GYHYSMEEMLQLGQHCSMAERRADEATRDVSDWLKCDFMLDQVGNVFKGVIASVTGFGFF
CEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRLDELFIDGLVHVSSLDNDYYRFDQVGQRLIGESGGQTYRLGDRVEVRVEAVNMDERKI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEEEEEECCCCHHH
DFSLISSERAPRNVGKTAREKAKKGESKNAGKRRQVGKKVNFEPDSAFRGEKKAKPKAAK
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
KDARKAKKPSAKTQKIAAATKAKRAAKKKAAE
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQDPFQEREAEKYANPIPSREFILEHLTKREKPASREELAVELNIEGEEQLEALRRRLR
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
AMERDGQLVFTRRQCYALPERLDLLKGTVIGHRDGYGFLRVEGRKDDLYLSSEQMKTCIH
HHCCCCCEEEEHHHHHHCHHHHHHHHCCEEECCCCCEEEEEECCCCCEEECHHHHHHHHC
GDQVLAQPLGADRKGRREARIVRVLVPKTSQIVGRYFTDAGVGFVVPDDSRLSFDILIPP
CHHHHHHCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCEEEEEEECC
EDVMGARMGFVVVVELTQRPTRRTKAVGKIVEVLGDNMGTGMAVDMALRTHEIPYIWPQA
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCCCCHHH
VEQQVAGLKEEVPEEAKVGRVDLRDLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIA
HHHHHHHHHHHCCHHHCCCCCCCCCCCEEEECCCCCCCCCHHHEEECCCCCCEEEEEEEE
DVSYYVRPPTPLDREARNRGTSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTIS
CCEEEECCCCCCCHHHHCCCCEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
AKGRLTGYKFYEAVMSSHARLTYTKVWHMLQGDQDLREQYAPLVKHIEELHNLYKVLDKA
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REERGGISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMIMANISAARFVEKAKEP
HHHHCCCCCCCCCCCEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCC
ALFRIHDKPTTEAITSFRSVLAELGLELPGGNKPEPRDYAELLESIADRPDAEMLQTMLL
CEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RSMKQAIYDPENRGHFGLALQSYAHFTSPIRRYPDLSLHRAIKYLLAKEQGNKGNTTETG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCC
GYHYSMEEMLQLGQHCSMAERRADEATRDVSDWLKCDFMLDQVGNVFKGVIASVTGFGFF
CEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRLDELFIDGLVHVSSLDNDYYRFDQVGQRLIGESGGQTYRLGDRVEVRVEAVNMDERKI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEEEEEECCCCHHH
DFSLISSERAPRNVGKTAREKAKKGESKNAGKRRQVGKKVNFEPDSAFRGEKKAKPKAAK
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
KDARKAKKPSAKTQKIAAATKAKRAAKKKAAE
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]