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The map label for this gene is sugE

Identifier: 29144639

GI number: 29144639

Start: 4540895

End: 4541212

Strand: Direct

Name: sugE

Synonym: t4390

Alternate gene names: 29144639

Gene position: 4540895-4541212 (Clockwise)

Preceding gene: 29144637

Following gene: 29144645

Centisome position: 94.76

GC content: 53.14

Gene sequence:

>318_bases
ATGTCCTGGATCATTTTATTAATCGCTGGTTTACTTGAAGTGGTATGGGCTGTCGGCCTGAAGTATACCCACGGTTTTTC
TCGTCTGACCCCCAGTATTATCACCATTACGGCCATGGTTATCAGTATGGCGTTACTTTCCTGGGCAATGAAAACGCTGC
CTGTTGGAACGGCGTACGCCATCTGGACCGGCATCGGCGCCGTTGGGGCGGCAATCACCGGTATCCTTCTGCTGGGCGAG
TCTGCCTCACCGGCGCGTTTGCTCAGTCTTGGCTTGATCGTCGCGGGTATCATTGGGCTAAAACTCAGTGCGCATTAA

Upstream 100 bases:

>100_bases
TCTCTCAGGCAAGAATGGCTTTTCATCCGTATACGTTACAGGACGACCTGTAAACGCTATTCTCACCGGGGACGGCCCCA
TTAATTATCTGGAGCCTGCT

Downstream 100 bases:

>100_bases
TTCGTCGCTGACATTGCTACGAACCTGATTGTTTTACCCAAATTAATTTATTGACGTCAAACCCCTCCCGGGTCGCGACG
GCCAGCATTTGCTGTTTTAT

Product: quaternary ammonium compound-resistance protein SugE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MSWIILLIAGLLEVVWAVGLKYTHGFSRLTPSIITITAMVISMALLSWAMKTLPVGTAYAIWTGIGAVGAAITGILLLGE
SASPARLLSLGLIVAGIIGLKLSAH

Sequences:

>Translated_105_residues
MSWIILLIAGLLEVVWAVGLKYTHGFSRLTPSIITITAMVISMALLSWAMKTLPVGTAYAIWTGIGAVGAAITGILLLGE
SASPARLLSLGLIVAGIIGLKLSAH
>Mature_104_residues
SWIILLIAGLLEVVWAVGLKYTHGFSRLTPSIITITAMVISMALLSWAMKTLPVGTAYAIWTGIGAVGAAITGILLLGES
ASPARLLSLGLIVAGIIGLKLSAH

Specific function: Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. SugE (TC 2.A.7.1.4) subfamily

Homologues:

Organism=Escherichia coli, GI87082378, Length=105, Percent_Identity=85.7142857142857, Blast_Score=176, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SUGE_SALTI (Q8XGT8)

Other databases:

- EMBL:   AE014613
- EMBL:   AL627283
- RefSeq:   NP_458777.1
- RefSeq:   NP_807981.1
- ProteinModelPortal:   Q8XGT8
- GeneID:   1068462
- GeneID:   1250899
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t4390
- KEGG:   sty:STY4698
- HOGENOM:   HBG740972
- OMA:   DMSWIIL
- ProtClustDB:   PRK11431
- BioCyc:   SENT209261:T4390-MONOMER
- BioCyc:   SENT220341:STY4698-MONOMER
- GO:   GO:0006810
- InterPro:   IPR000390

Pfam domain/function: PF00893 Multi_Drug_Res

EC number: NA

Molecular weight: Translated: 10869; Mature: 10738

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12cd6f38)-; HASH(0x132a7148)-; HASH(0x137a34c8)-; HASH(0x133add30)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWIILLIAGLLEVVWAVGLKYTHGFSRLTPSIITITAMVISMALLSWAMKTLPVGTAYA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IWTGIGAVGAAITGILLLGESASPARLLSLGLIVAGIIGLKLSAH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
SWIILLIAGLLEVVWAVGLKYTHGFSRLTPSIITITAMVISMALLSWAMKTLPVGTAYA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IWTGIGAVGAAITGILLLGESASPARLLSLGLIVAGIIGLKLSAH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12644504; 11677608