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The map label for this gene is yjcE [H]

Identifier: 29144437

GI number: 29144437

Start: 4337375

End: 4339066

Strand: Direct

Name: yjcE [H]

Synonym: t4175

Alternate gene names: 29144437

Gene position: 4337375-4339066 (Clockwise)

Preceding gene: 29144436

Following gene: 29144439

Centisome position: 90.51

GC content: 55.61

Gene sequence:

>1692_bases
ATGATGCCTTTCTCCATCATAAAAAACATCGCAAACAGGGAACGCATGGAAATTTTCTTCACAATACTCATCATGACCCT
TGTGGTCTCGCTGTCGGGGGTATTTACGCGTGTATTACCCTTCCAGCTTCCTTTACCCCTTATGCAGATCGCCATTGGCG
CGCTGTTGGCGTGGCCGACGTTTGGTTTGCATGTGGAATTCGACCCGGAACTCTTCCTGGTGCTGTTTATTCCGCCGCTG
CTGTTTGCGGATGGCTGGAAAACGCCGACCCGTGAATTTCTTGAGCATGGACGAGAGATTTTCGGGCTGGCGCTGGCGCT
GGTCCTGGTAACGGTTGTGGGAATCGGCTTCCTGATTTATTGGCTGGTGCCCGGCATTCCGCTGATCCCCGCATTTGCGC
TGGCCGCCGTGCTGTCGCCGACCGATGCGGTAGCGCTCTCCGGAATTGTGGGCGAGGGGCGTATCCCGAAAAAAATCATG
GGCATTCTGCAGGGAGAGGCGTTAATGAACGACGCCTCCGGTCTGGTATCGCTGAAATTCGCCGTCGCGGTGGCGATGGG
GACGATGGTCTTTACCGTCGGCGGCGCGACGCTGGAATTTTTTAAGGTCGCTATCGGCGGTATTCTGGCGGGTTTTGTAG
TCAGTTGGCTGTATGGCCGCTCGCTGCGTTTTTTGAGCCGCTGGGGCGGCGATGAGCCCGCGACGCAAATCGTCCTGCTG
TTTCTGCTGCCCTTCGCGTCTTACCTGATTGCCGAACATATTGGCGTCTCAGGCATCCTGGCCGCGGTTGCCGCCGGGAT
GACCATCACCCGTTCTGGCGTAATGCGCCGCGCGCCGCTGGCAATGCGTTTGCGCGCGAACAGTACCTGGGCGATGCTGG
AATTTGTCTTTAACGGTATGGTCTTTCTGCTGTTGGGACTGCAATTGCCAGGGATTCTGGAATCTTCGCTGGCGGCGGCG
GAAGCTGACCCGAATGTCGAAACCTGGATGCTCTTTACCGATATCGTGCTGATTTATGCGGCATTGATGCTGGTTCGCTT
CGGCTGGCTGTGGACCATGAAAAAGTTCAGCCTGCGCTTTTTGAAGAAGAAACCGATGGAGTTCGCCAGCTGGACGTCGC
GTGAAATTCTGATTGCTTCCTTCGCTGGCGTTCGTGGGGCGATCACCCTGGCTGGTGTGCTCTCTATACCGTTACTTTTG
CCGGATGGCAGCGGATTTCCGGCGCGTTATGAACTGGTATTCCTGGCGGCTGGCGTCATTCTGTTCTCGTTGTTTGTCGG
CGTGATCATGCTGCCGCTGCTGTTGCAACATCTGGAAGTCGCCGATCATGCGCAACAGTTGAAAGAGGAGCGTATCGCCC
GCGCGGCGACGGCGGAAGTGGCGATTGTTGCCATTCAGAAAATGGAAGAGCGTCTGGCGGCGGATACCGAAGAAAACATC
GATAATCAGTTGCTTACTGAAGTAAGCTCGCGTGTCATTGGTAACTTGCGTCGCCGTGCCGATGGGCGAAACGATGTCGA
AAGCTCCATACAGGAAGAAAACCTGGAGCGACGTTTCCGTCTGGCGGCGCTGCGTTCCGAACGCGCCGAGTTGTATCATC
TGCGCGCCACGCGAGAAATCAGCAATGAAACATTGCAAAAGCTGCTGCACGACCTGGATTTGATGGAAGCTCTACTGATA
GAAAATCAGTAG

Upstream 100 bases:

>100_bases
GCCTTCATTCTGAAAAATGGGCGGCGTTGGTCGCCCGTTTTCATTTTCAGGACACATCACGTTACCTTTTGCGTTAATCT
GAAGAAGGTGAAACCGAGGC

Downstream 100 bases:

>100_bases
TCCTTGTGGCCCGGTGGCGCCATGCTTATCGGGCCTACAAGTAGGCCCGGTAAGGTGCTTGCGCCGCCATCCGGCAAGGG
TTTTAACCCATGGCTTACGG

Product: sodium/hydrogen exchanger family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 563; Mature: 563

Protein sequence:

>563_residues
MMPFSIIKNIANRERMEIFFTILIMTLVVSLSGVFTRVLPFQLPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPL
LFADGWKTPTREFLEHGREIFGLALALVLVTVVGIGFLIYWLVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIM
GILQGEALMNDASGLVSLKFAVAVAMGTMVFTVGGATLEFFKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLL
FLLPFASYLIAEHIGVSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGILESSLAAA
EADPNVETWMLFTDIVLIYAALMLVRFGWLWTMKKFSLRFLKKKPMEFASWTSREILIASFAGVRGAITLAGVLSIPLLL
PDGSGFPARYELVFLAAGVILFSLFVGVIMLPLLLQHLEVADHAQQLKEERIARAATAEVAIVAIQKMEERLAADTEENI
DNQLLTEVSSRVIGNLRRRADGRNDVESSIQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLMEALLI
ENQ

Sequences:

>Translated_563_residues
MMPFSIIKNIANRERMEIFFTILIMTLVVSLSGVFTRVLPFQLPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPL
LFADGWKTPTREFLEHGREIFGLALALVLVTVVGIGFLIYWLVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIM
GILQGEALMNDASGLVSLKFAVAVAMGTMVFTVGGATLEFFKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLL
FLLPFASYLIAEHIGVSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGILESSLAAA
EADPNVETWMLFTDIVLIYAALMLVRFGWLWTMKKFSLRFLKKKPMEFASWTSREILIASFAGVRGAITLAGVLSIPLLL
PDGSGFPARYELVFLAAGVILFSLFVGVIMLPLLLQHLEVADHAQQLKEERIARAATAEVAIVAIQKMEERLAADTEENI
DNQLLTEVSSRVIGNLRRRADGRNDVESSIQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLMEALLI
ENQ
>Mature_563_residues
MMPFSIIKNIANRERMEIFFTILIMTLVVSLSGVFTRVLPFQLPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPL
LFADGWKTPTREFLEHGREIFGLALALVLVTVVGIGFLIYWLVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIM
GILQGEALMNDASGLVSLKFAVAVAMGTMVFTVGGATLEFFKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLL
FLLPFASYLIAEHIGVSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGILESSLAAA
EADPNVETWMLFTDIVLIYAALMLVRFGWLWTMKKFSLRFLKKKPMEFASWTSREILIASFAGVRGAITLAGVLSIPLLL
PDGSGFPARYELVFLAAGVILFSLFVGVIMLPLLLQHLEVADHAQQLKEERIARAATAEVAIVAIQKMEERLAADTEENI
DNQLLTEVSSRVIGNLRRRADGRNDVESSIQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLMEALLI
ENQ

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=464, Percent_Identity=25.4310344827586, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI148727259, Length=464, Percent_Identity=23.7068965517241, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI194239733, Length=500, Percent_Identity=24, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI27734935, Length=342, Percent_Identity=23.0994152046784, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4759144, Length=360, Percent_Identity=26.1111111111111, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI14211919, Length=348, Percent_Identity=23.5632183908046, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI294997330, Length=269, Percent_Identity=22.6765799256506, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI110227626, Length=269, Percent_Identity=22.6765799256506, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI5454070, Length=269, Percent_Identity=22.6765799256506, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1790501, Length=549, Percent_Identity=95.264116575592, Blast_Score=1018, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25150332, Length=383, Percent_Identity=23.4986945169713, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71980847, Length=401, Percent_Identity=24.1895261845387, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71999817, Length=455, Percent_Identity=23.2967032967033, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999819, Length=455, Percent_Identity=23.2967032967033, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999821, Length=400, Percent_Identity=24.25, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71990932, Length=407, Percent_Identity=23.0958230958231, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992107, Length=337, Percent_Identity=21.3649851632047, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=337, Percent_Identity=21.3649851632047, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71990924, Length=407, Percent_Identity=23.0958230958231, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71993590, Length=418, Percent_Identity=22.0095693779904, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71993582, Length=418, Percent_Identity=22.0095693779904, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=370, Percent_Identity=23.2432432432432, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221473222, Length=439, Percent_Identity=20.9567198177677, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281364513, Length=439, Percent_Identity=20.9567198177677, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510738, Length=403, Percent_Identity=22.8287841191067, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221510734, Length=403, Percent_Identity=22.8287841191067, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221473215, Length=441, Percent_Identity=20.8616780045351, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221473212, Length=453, Percent_Identity=20.3090507726269, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221510732, Length=403, Percent_Identity=22.8287841191067, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221510736, Length=403, Percent_Identity=22.8287841191067, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24585580, Length=403, Percent_Identity=22.8287841191067, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24585578, Length=403, Percent_Identity=22.8287841191067, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221510740, Length=403, Percent_Identity=22.8287841191067, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 62090; Mature: 62090

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPFSIIKNIANRERMEIFFTILIMTLVVSLSGVFTRVLPFQLPLPLMQIAIGALLAWPT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
FGLHVEFDPELFLVLFIPPLLFADGWKTPTREFLEHGREIFGLALALVLVTVVGIGFLIY
CCEEEEECCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGLVSLKF
HHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
AVAVAMGTMVFTVGGATLEFFKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FLLPFASYLIAEHIGVSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGM
HHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHCHHHCCCHHEEEECCCHHHHHHHHHHHH
VFLLLGLQLPGILESSLAAAEADPNVETWMLFTDIVLIYAALMLVRFGWLWTMKKFSLRF
HHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKKPMEFASWTSREILIASFAGVRGAITLAGVLSIPLLLPDGSGFPARYELVFLAAGVI
HHHCCCHHHCCCCCHHHHHHHHCHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHH
LFSLFVGVIMLPLLLQHLEVADHAQQLKEERIARAATAEVAIVAIQKMEERLAADTEENI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCH
DNQLLTEVSSRVIGNLRRRADGRNDVESSIQEENLERRFRLAALRSERAELYHLRATREI
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNETLQKLLHDLDLMEALLIENQ
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMPFSIIKNIANRERMEIFFTILIMTLVVSLSGVFTRVLPFQLPLPLMQIAIGALLAWPT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
FGLHVEFDPELFLVLFIPPLLFADGWKTPTREFLEHGREIFGLALALVLVTVVGIGFLIY
CCEEEEECCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGLVSLKF
HHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
AVAVAMGTMVFTVGGATLEFFKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FLLPFASYLIAEHIGVSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGM
HHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHCHHHCCCHHEEEECCCHHHHHHHHHHHH
VFLLLGLQLPGILESSLAAAEADPNVETWMLFTDIVLIYAALMLVRFGWLWTMKKFSLRF
HHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKKPMEFASWTSREILIASFAGVRGAITLAGVLSIPLLLPDGSGFPARYELVFLAAGVI
HHHCCCHHHCCCCCHHHHHHHHCHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHH
LFSLFVGVIMLPLLLQHLEVADHAQQLKEERIARAATAEVAIVAIQKMEERLAADTEENI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCH
DNQLLTEVSSRVIGNLRRRADGRNDVESSIQEENLERRFRLAALRSERAELYHLRATREI
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNETLQKLLHDLDLMEALLIENQ
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]