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The map label for this gene is livH [H]

Identifier: 29144227

GI number: 29144227

Start: 4098312

End: 4099238

Strand: Direct

Name: livH [H]

Synonym: t3959

Alternate gene names: 29144227

Gene position: 4098312-4099238 (Clockwise)

Preceding gene: 29144226

Following gene: 29144228

Centisome position: 85.52

GC content: 56.09

Gene sequence:

>927_bases
ATGTCCGAGCAGTTTCTCTATTTCTTGCAGCAGATGTTTAACGGCGTCACGCTGGGGAGCACCTACGCGCTGATTGCTAT
CGGTTATACGATGGTGTACGGCATTATCGGCATGATCAACTTCGCTCATGGCGAGGTGTATATGATCGGCAGCTACGTCT
CTTTTATGATCATCGCCGCGCTAATGATGATGGGAATAGACACCAGTTGGCTACTGGTGGCCGCCGGATTTATCGGCGCG
ATTATTATTGCCAGCGCCTACGGCTGGAGTATCGAGCGAGTCGCTTACCGGCCTGTGCGCAATTCCAAGCGCCTGATCGC
CCTGATTTCCGCCATCGGGATGTCCATCTTTCTGCAAAACTACGTCAGCCTGACGGAAGGTTCGCGCGACGTGGCGTTAC
CCAGCCTGTTTAACGGCCAGTGGATTGTGGGCAGCAGCGAAAACTTTTCCGCGTCCATCACCACCATGCAGGCGGTTATC
TGGATAGTCACCTTTCTGGCTATGCTGGCGCTCACCATTTTCATTCGCTACTCCCGGATGGGCCGCGCCTGCCGCGCCTG
CGCGGAGGATCTGAAAATGGCCAGCCTGCTCGGCATTAATACCGACCGCGTCATTGCGCTAACGTTTGTTATCGGCGCGG
CAATGGCGGCGGTGGCGGGCGTGCTGCTCGGTCAGTTCTATGGCGTGATTAACCCCTACATCGGTTTTATGGCCGGGATG
AAAGCGTTCACCGCGGCGGTGCTGGGCGGTATTGGCAGCATTCCGGGCGCGATGATCGGCGGTCTGATTTTGGGCGTCGC
CGAAGCGCTCTCGTCTGCATATTTAAGTACCGAATATAAAGATGTCGTGTCGTTCGCTCTGCTGATTCTGGTACTGCTGG
TGATGCCGACCGGTATCCTGGGGCGTCCGGAGGTAGAGAAAGTATGA

Upstream 100 bases:

>100_bases
TCCAGTGGCACGCCGACGGCTCGTCAACCGTCGCGAAGTAATGCCAGAAGATAAGTTATCCCACCGCCCGCACGCCGGGC
GGGTTTAAAAAGGTTACCTT

Downstream 100 bases:

>100_bases
AACCGATGCATATTGCGATGGCTCTGTTCTCTGCGGCGATGTTCTTCGTTCTGGCTGGCGTCTTTATGGGCGTACAACTG
GAGCTGGACGGCACCAAACT

Product: branched-subunit Amino acid transporter permease LivH

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSEQFLYFLQQMFNGVTLGSTYALIAIGYTMVYGIIGMINFAHGEVYMIGSYVSFMIIAALMMMGIDTSWLLVAAGFIGA
IIIASAYGWSIERVAYRPVRNSKRLIALISAIGMSIFLQNYVSLTEGSRDVALPSLFNGQWIVGSSENFSASITTMQAVI
WIVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGM
KAFTAAVLGGIGSIPGAMIGGLILGVAEALSSAYLSTEYKDVVSFALLILVLLVMPTGILGRPEVEKV

Sequences:

>Translated_308_residues
MSEQFLYFLQQMFNGVTLGSTYALIAIGYTMVYGIIGMINFAHGEVYMIGSYVSFMIIAALMMMGIDTSWLLVAAGFIGA
IIIASAYGWSIERVAYRPVRNSKRLIALISAIGMSIFLQNYVSLTEGSRDVALPSLFNGQWIVGSSENFSASITTMQAVI
WIVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGM
KAFTAAVLGGIGSIPGAMIGGLILGVAEALSSAYLSTEYKDVVSFALLILVLLVMPTGILGRPEVEKV
>Mature_307_residues
SEQFLYFLQQMFNGVTLGSTYALIAIGYTMVYGIIGMINFAHGEVYMIGSYVSFMIIAALMMMGIDTSWLLVAAGFIGAI
IIASAYGWSIERVAYRPVRNSKRLIALISAIGMSIFLQNYVSLTEGSRDVALPSLFNGQWIVGSSENFSASITTMQAVIW
IVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGMK
AFTAAVLGGIGSIPGAMIGGLILGVAEALSSAYLSTEYKDVVSFALLILVLLVMPTGILGRPEVEKV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=308, Percent_Identity=98.0519480519481, Blast_Score=600, Evalue=1e-173,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32991; Mature: 32860

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQFLYFLQQMFNGVTLGSTYALIAIGYTMVYGIIGMINFAHGEVYMIGSYVSFMIIAA
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
LMMMGIDTSWLLVAAGFIGAIIIASAYGWSIERVAYRPVRNSKRLIALISAIGMSIFLQN
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
YVSLTEGSRDVALPSLFNGQWIVGSSENFSASITTMQAVIWIVTFLAMLALTIFIRYSRM
HHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGM
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAFTAAVLGGIGSIPGAMIGGLILGVAEALSSAYLSTEYKDVVSFALLILVLLVMPTGIL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GRPEVEKV
CCCCCCCC
>Mature Secondary Structure 
SEQFLYFLQQMFNGVTLGSTYALIAIGYTMVYGIIGMINFAHGEVYMIGSYVSFMIIAA
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
LMMMGIDTSWLLVAAGFIGAIIIASAYGWSIERVAYRPVRNSKRLIALISAIGMSIFLQN
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
YVSLTEGSRDVALPSLFNGQWIVGSSENFSASITTMQAVIWIVTFLAMLALTIFIRYSRM
HHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGM
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAFTAAVLGGIGSIPGAMIGGLILGVAEALSSAYLSTEYKDVVSFALLILVLLVMPTGIL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GRPEVEKV
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]