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The map label for this gene is patB [H]

Identifier: 29144203

GI number: 29144203

Start: 4070623

End: 4071789

Strand: Reverse

Name: patB [H]

Synonym: t3933

Alternate gene names: 29144203

Gene position: 4071789-4070623 (Counterclockwise)

Preceding gene: 29144204

Following gene: 29144202

Centisome position: 84.97

GC content: 43.27

Gene sequence:

>1167_bases
ATGAAATACGATTTTAATGAAATCTATCAGAGAATAGCATCAGAAAAATGGGAATATGACAGTGTCATTAATGGATTTCC
AGTAATACCTATGTCTGTTGCAGATACCGATTTAGTTTCTCCCGTGGAGGTTCGTCAGGCACTGATTGAAGTCTGTAACC
GCAGAGAATTCGGATATCCGGCCTATCATGATGATTTTAAGGATGTGCTGGCATCCTGGTATGATCGATATTATGACTGG
CGGCCGGATACGGCTGATATTATTGAAACACCGCCTTTACTGATGACGATGGGCGCTTTTATCAGGGGAATGACACAGTG
TAATGAATCCGTTGTGGTTATGACACCGGTCTATCATTCTTTTGCCAGAACCATCCGTGAAAACCACCGTGCTGTAACTG
AGTGTGATCTGCTGCGTGATGAAAACAATCATTACACTATTGATTTTGAAAAGCTGGAAGATACCTGTTCACGCCCGGAG
AATAAGATTCTGATTTTCTGTAACCCTCATAATCCGGTAGGTCGTTGCTGGACTGAAGAGGAAGTCAGGAAAGTCGCCGC
AATTGCCCAGAAAACAGGAACAATCCTGATTTCTGACGAAATTCATGCAGATTTTGTCTATGACGAAAAATGCTATACGC
CGGTCATGAAAGCTGCGGAAAATTTAAATGGCATTATCGTTTTTTTATCCGGAGGGAAGCTGTTTAACATTGGCGGTATT
TTTAGTTCCTATGTCTTCACGGCCGATCCTGTATTTAAAAAACAGATGGCAGTTGTCCTGAAAGAATTACATTTTCAGCC
CACTGCGTTCGCGCATGAAGCCGCCTATGCCGGATATAAATATTACCATGACTATCGTGAAGAGGTGGTGAATCATATCC
GTAAAATGCAGATTAAACTGGTTAACGGGCTCAATAACATGCCATATCCGGTAAAAGCCAATCTGCCGGAAGCCACTTAT
CTTGTATGGGCCGACTTTAATGATACGGGCTGGTCAGGTGATCGCATTCAGGAATTTTTAGTGCAGGATGCGGGACTCGG
ATTTAACCGGGGAGATCAGTTTGGTGTTGCCGGTACCGGATTTGCCCGAATTAACTGTGGTGTTCCGGAGTCACGTATTG
ATGAAGCACTGAGTCGTCTGGAAAAGGCATTCAGTAAGTATTTTTAA

Upstream 100 bases:

>100_bases
ACTTTTACTTCTCCGCAATGCCAAAACGGCATTTAAGAAAATGGATGGTAAACCGGCAGATACTTTCCGGACTGCGGCTG
AATAAATTAAGGAAAATAAA

Downstream 100 bases:

>100_bases
GGAACAGAAGTGAAAGAGATTATTTTTACAGAAACAGCACCGGCAGCAATTGGCTCATACAGTCAGGGCAATGCGATGGG
TAATTTAATTTTTACCTCCG

Product: aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKYDFNEIYQRIASEKWEYDSVINGFPVIPMSVADTDLVSPVEVRQALIEVCNRREFGYPAYHDDFKDVLASWYDRYYDW
RPDTADIIETPPLLMTMGAFIRGMTQCNESVVVMTPVYHSFARTIRENHRAVTECDLLRDENNHYTIDFEKLEDTCSRPE
NKILIFCNPHNPVGRCWTEEEVRKVAAIAQKTGTILISDEIHADFVYDEKCYTPVMKAAENLNGIIVFLSGGKLFNIGGI
FSSYVFTADPVFKKQMAVVLKELHFQPTAFAHEAAYAGYKYYHDYREEVVNHIRKMQIKLVNGLNNMPYPVKANLPEATY
LVWADFNDTGWSGDRIQEFLVQDAGLGFNRGDQFGVAGTGFARINCGVPESRIDEALSRLEKAFSKYF

Sequences:

>Translated_388_residues
MKYDFNEIYQRIASEKWEYDSVINGFPVIPMSVADTDLVSPVEVRQALIEVCNRREFGYPAYHDDFKDVLASWYDRYYDW
RPDTADIIETPPLLMTMGAFIRGMTQCNESVVVMTPVYHSFARTIRENHRAVTECDLLRDENNHYTIDFEKLEDTCSRPE
NKILIFCNPHNPVGRCWTEEEVRKVAAIAQKTGTILISDEIHADFVYDEKCYTPVMKAAENLNGIIVFLSGGKLFNIGGI
FSSYVFTADPVFKKQMAVVLKELHFQPTAFAHEAAYAGYKYYHDYREEVVNHIRKMQIKLVNGLNNMPYPVKANLPEATY
LVWADFNDTGWSGDRIQEFLVQDAGLGFNRGDQFGVAGTGFARINCGVPESRIDEALSRLEKAFSKYF
>Mature_388_residues
MKYDFNEIYQRIASEKWEYDSVINGFPVIPMSVADTDLVSPVEVRQALIEVCNRREFGYPAYHDDFKDVLASWYDRYYDW
RPDTADIIETPPLLMTMGAFIRGMTQCNESVVVMTPVYHSFARTIRENHRAVTECDLLRDENNHYTIDFEKLEDTCSRPE
NKILIFCNPHNPVGRCWTEEEVRKVAAIAQKTGTILISDEIHADFVYDEKCYTPVMKAAENLNGIIVFLSGGKLFNIGGI
FSSYVFTADPVFKKQMAVVLKELHFQPTAFAHEAAYAGYKYYHDYREEVVNHIRKMQIKLVNGLNNMPYPVKANLPEATY
LVWADFNDTGWSGDRIQEFLVQDAGLGFNRGDQFGVAGTGFARINCGVPESRIDEALSRLEKAFSKYF

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787909, Length=388, Percent_Identity=25.2577319587629, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71994476, Length=252, Percent_Identity=25, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=252, Percent_Identity=25, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17567369, Length=230, Percent_Identity=23.4782608695652, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=242, Percent_Identity=23.5537190082645, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44540; Mature: 44540

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYDFNEIYQRIASEKWEYDSVINGFPVIPMSVADTDLVSPVEVRQALIEVCNRREFGYP
CCCCHHHHHHHHHHCCCCHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCCCC
AYHDDFKDVLASWYDRYYDWRPDTADIIETPPLLMTMGAFIRGMTQCNESVVVMTPVYHS
CCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECHHHHH
FARTIRENHRAVTECDLLRDENNHYTIDFEKLEDTCSRPENKILIFCNPHNPVGRCWTEE
HHHHHHHHCCHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHH
EVRKVAAIAQKTGTILISDEIHADFVYDEKCYTPVMKAAENLNGIIVFLSGGKLFNIGGI
HHHHHHHHHHHCCEEEEECCCCCCEEECCHHHHHHHHHHCCCCEEEEEEECCCEEECCHH
FSSYVFTADPVFKKQMAVVLKELHFQPTAFAHEAAYAGYKYYHDYREEVVNHIRKMQIKL
HHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNGLNNMPYPVKANLPEATYLVWADFNDTGWSGDRIQEFLVQDAGLGFNRGDQFGVAGTG
HHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
FARINCGVPESRIDEALSRLEKAFSKYF
EEEEECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYDFNEIYQRIASEKWEYDSVINGFPVIPMSVADTDLVSPVEVRQALIEVCNRREFGYP
CCCCHHHHHHHHHHCCCCHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCCCC
AYHDDFKDVLASWYDRYYDWRPDTADIIETPPLLMTMGAFIRGMTQCNESVVVMTPVYHS
CCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECHHHHH
FARTIRENHRAVTECDLLRDENNHYTIDFEKLEDTCSRPENKILIFCNPHNPVGRCWTEE
HHHHHHHHCCHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHH
EVRKVAAIAQKTGTILISDEIHADFVYDEKCYTPVMKAAENLNGIIVFLSGGKLFNIGGI
HHHHHHHHHHHCCEEEEECCCCCCEEECCHHHHHHHHHHCCCCEEEEEEECCCEEECCHH
FSSYVFTADPVFKKQMAVVLKELHFQPTAFAHEAAYAGYKYYHDYREEVVNHIRKMQIKL
HHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNGLNNMPYPVKANLPEATYLVWADFNDTGWSGDRIQEFLVQDAGLGFNRGDQFGVAGTG
HHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
FARINCGVPESRIDEALSRLEKAFSKYF
EEEEECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]