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The map label for this gene is bisC [H]

Identifier: 29144151

GI number: 29144151

Start: 4001269

End: 4003602

Strand: Direct

Name: bisC [H]

Synonym: t3875

Alternate gene names: 29144151

Gene position: 4001269-4003602 (Clockwise)

Preceding gene: 29144148

Following gene: 29144154

Centisome position: 83.5

GC content: 57.71

Gene sequence:

>2334_bases
TTGACCCACGCACCATCGCGTCATTCGGTATTGACCGCCGCACACTGGGGGCCAGTCCGTGTTGAAACCGACGGAGAACG
CATTTTTGCTTCATATGGCGAACTCCCGACGGCACACCAGAACTCCCTGCAAACCGTTGTGCATGACCAGGTACACAGCA
AAACGCGGGTTCGCTTCCCGATGGTGCGTAAAGGGTTCCTGGCTTCTCCCGATAAGCCGCAAGGCATACGCGGGCAGGAT
GAGTTTGTTCGCGTAAGTTGGGATGACGCGCTGGATCTGATCCACGCTCAGCACAAACGTATTCGTGAAAGTTATGGACC
ATCGTCCATCTTCGCCGGCTCCTACGGTTGGCGTTCGAACGGCGTATTGCATAAAGCGGCTACGCTATTGCAGCGTTACA
TGGCGCTGGCGGGAGGGTATACCGGCCATCTTGGCGATTATTCCACCGGCGCGGCGCAGGCTATCATGCCTTATGTGGTG
GGTGGTAACGAGGTTTACCAGCAGCAGACTAGCTGGCCGGTGGTGCTGGAACATAGCGAGGTGGTGGTGCTCTGGAGCGC
GAACCCGCTGAATACTCTGAAAATTGCCTGGAACGCCTCGGATGAACAGGGGCTCGACTATTTTGCGGCGCTGCGACAAA
GCGGCAAACGCCTGATCTGCATCGATCCGATGCGATCGGAAAGCGTCGACTTTTTTGGCGATAAGATGGAGTGGATCGCC
CCACATATGGGCACCGATGTGGCGTTAATGCTGGGGATCGCTCATACGCTGGTGGAAAACGGTTGGCAGGATGAAGCGTT
CCTTGCCCGCTGCACGACGGGCTATGACCGCTTCGCTGACTATCTTTTGGGCACGACCGACGGTACGGCCAAAACAGCGG
AATGGGCGGCGGAAATTTGCGGCGTTTCTGCGGTGAAAATCCGCGAACTGGCGGAAATATTTCATCATAACACCACCATG
TTGATGGCTGGTTGGGGAATGCAGCGTCAGCAGTTCGGCGAGCAAAAGCACTGGATGATCGTTACGCTGGCCGCAATGCT
GGGGCAAATTGGTACGCCTGGCGGCGGGTTTGGTTTTTCTTATCATTTTGCTAACGGCGGAAACCCGACGCGCCGCGCCG
CCGTGTTAGCGTCGATACAGGGGAGCATCCCTGGCGGGGTCGATGCGGTAGATAAAATACCGGTGGCGCGTATTGTCGAG
GCGCTGGAAAACCCCGGTGGGTTTTACCAACACAATGGGATGGATCGCCGCTTCCCGGATATTCGTTTTATCTGGTGGGC
GGGTGGCGCGAACTTTACCCATCATCAGGATACCAACCGTCTGATTCGTGCGTGGCAAAAACCGGAACTGGTCGTTATCT
CGGAATGTTTCTGGACGGCCGCCGCGAAACACGCGGATATCGTTCTGCCCGCGACCACCAGCTATGAGCGTAACGATTTA
ACCATGACCGGCGACTATAGCAATCAGCATTTGGCGCCGATGAAGCAGGTCGTGTCGCCCCGGTGGGAGGCGCGGAATGA
TTTTGACGTTTTTGCTGAACTGAGCGAACGGTGGGAAGCCGGCGGTTATGCTCGGTTCACCGAAGGAAAAAGCGAGCTGG
CGTGGCTGGAGACCTTCTACAATATTGCCGCCCAGCGTGGCGCCAGCCAGGGGGTGACGCTGCCGCCGTTTGCCGCATTC
TGGCAGGCTAACCGTTTACTGGAGATGCCGGAAAATCCCGCCAACGCGCAGTTTGTGCGCTTCGCGGATTTTCGCCGCGA
TCCTGATAACCATCCGCTAAAAACGGCCAGCGGCAAAATCGAAATCTATTCTGCGCGCATTGCCAGCTATGGTTATGCGG
ATTGTCCCGGTCATCCGATGTGGCTGGCGCCGGATGAGTGGCACGGGAACGCCGATGCGGGGCAGGTTCAGCTACTTTCC
GCGCATCCGGCGCACCGTCTGCATAGCCAGCTCAACTACAGTTCGTTACGGGAGCGGTATGCGGTAGCCGGACGCGAACC
GGTAACGATTCATCCGCAGGATGCGACAACACGCGGAATCGTCGATGGCGATACGGTACGCGTCTGGAATCATCGCGGGC
AGGTTCTGGCGGGCGCGGTCGTTACCGACGGAATTCGGCCTGGCGTTATCTGTATTCACGAAGGCGCATGGCCGGACCCT
GAACCTACCGCAGGCGGCATATGCAAAAACGGCGCGGTAAACGTCCTGACAAAAGATCTTCCCAGTTCCCGGCTGGGGAA
CGGTTGTGCGGGCAACACCGCGCTGGTCTGGTTTGAGAAATATACCGGCCCGGCGCTACCGCTTACGGCGTTTGATCCGC
CTGCCAACTCATAA

Upstream 100 bases:

>100_bases
TATGACGTCTGCACATGAAGAAAATTCCAGGGAAAACTCTGAAATTTGTAAGTAACATTGATCGGCAAAATAAATAATCC
CAATAATTCAGGAGCGAACC

Downstream 100 bases:

>100_bases
TCCAGGTGGGGTGGGAGGTATCCTCCTGCCAGGCGCTATCTTCAATACGAAAACCGAGCGCATGGTAGAAGTTTACGGCG
GATTGATTTTTCTGGTAAAC

Product: biotin sulfoxide reductase

Products: Biotin. [C]

Alternate protein names: BDS reductase; BSO reductase [H]

Number of amino acids: Translated: 777; Mature: 776

Protein sequence:

>777_residues
MTHAPSRHSVLTAAHWGPVRVETDGERIFASYGELPTAHQNSLQTVVHDQVHSKTRVRFPMVRKGFLASPDKPQGIRGQD
EFVRVSWDDALDLIHAQHKRIRESYGPSSIFAGSYGWRSNGVLHKAATLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVV
GGNEVYQQQTSWPVVLEHSEVVVLWSANPLNTLKIAWNASDEQGLDYFAALRQSGKRLICIDPMRSESVDFFGDKMEWIA
PHMGTDVALMLGIAHTLVENGWQDEAFLARCTTGYDRFADYLLGTTDGTAKTAEWAAEICGVSAVKIRELAEIFHHNTTM
LMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGFSYHFANGGNPTRRAAVLASIQGSIPGGVDAVDKIPVARIVE
ALENPGGFYQHNGMDRRFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSYERNDL
TMTGDYSNQHLAPMKQVVSPRWEARNDFDVFAELSERWEAGGYARFTEGKSELAWLETFYNIAAQRGASQGVTLPPFAAF
WQANRLLEMPENPANAQFVRFADFRRDPDNHPLKTASGKIEIYSARIASYGYADCPGHPMWLAPDEWHGNADAGQVQLLS
AHPAHRLHSQLNYSSLRERYAVAGREPVTIHPQDATTRGIVDGDTVRVWNHRGQVLAGAVVTDGIRPGVICIHEGAWPDP
EPTAGGICKNGAVNVLTKDLPSSRLGNGCAGNTALVWFEKYTGPALPLTAFDPPANS

Sequences:

>Translated_777_residues
MTHAPSRHSVLTAAHWGPVRVETDGERIFASYGELPTAHQNSLQTVVHDQVHSKTRVRFPMVRKGFLASPDKPQGIRGQD
EFVRVSWDDALDLIHAQHKRIRESYGPSSIFAGSYGWRSNGVLHKAATLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVV
GGNEVYQQQTSWPVVLEHSEVVVLWSANPLNTLKIAWNASDEQGLDYFAALRQSGKRLICIDPMRSESVDFFGDKMEWIA
PHMGTDVALMLGIAHTLVENGWQDEAFLARCTTGYDRFADYLLGTTDGTAKTAEWAAEICGVSAVKIRELAEIFHHNTTM
LMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGFSYHFANGGNPTRRAAVLASIQGSIPGGVDAVDKIPVARIVE
ALENPGGFYQHNGMDRRFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSYERNDL
TMTGDYSNQHLAPMKQVVSPRWEARNDFDVFAELSERWEAGGYARFTEGKSELAWLETFYNIAAQRGASQGVTLPPFAAF
WQANRLLEMPENPANAQFVRFADFRRDPDNHPLKTASGKIEIYSARIASYGYADCPGHPMWLAPDEWHGNADAGQVQLLS
AHPAHRLHSQLNYSSLRERYAVAGREPVTIHPQDATTRGIVDGDTVRVWNHRGQVLAGAVVTDGIRPGVICIHEGAWPDP
EPTAGGICKNGAVNVLTKDLPSSRLGNGCAGNTALVWFEKYTGPALPLTAFDPPANS
>Mature_776_residues
THAPSRHSVLTAAHWGPVRVETDGERIFASYGELPTAHQNSLQTVVHDQVHSKTRVRFPMVRKGFLASPDKPQGIRGQDE
FVRVSWDDALDLIHAQHKRIRESYGPSSIFAGSYGWRSNGVLHKAATLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVG
GNEVYQQQTSWPVVLEHSEVVVLWSANPLNTLKIAWNASDEQGLDYFAALRQSGKRLICIDPMRSESVDFFGDKMEWIAP
HMGTDVALMLGIAHTLVENGWQDEAFLARCTTGYDRFADYLLGTTDGTAKTAEWAAEICGVSAVKIRELAEIFHHNTTML
MAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGFSYHFANGGNPTRRAAVLASIQGSIPGGVDAVDKIPVARIVEA
LENPGGFYQHNGMDRRFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSYERNDLT
MTGDYSNQHLAPMKQVVSPRWEARNDFDVFAELSERWEAGGYARFTEGKSELAWLETFYNIAAQRGASQGVTLPPFAAFW
QANRLLEMPENPANAQFVRFADFRRDPDNHPLKTASGKIEIYSARIASYGYADCPGHPMWLAPDEWHGNADAGQVQLLSA
HPAHRLHSQLNYSSLRERYAVAGREPVTIHPQDATTRGIVDGDTVRVWNHRGQVLAGAVVTDGIRPGVICIHEGAWPDPE
PTAGGICKNGAVNVLTKDLPSSRLGNGCAGNTALVWFEKYTGPALPLTAFDPPANS

Specific function: This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI145693196, Length=777, Percent_Identity=85.5855855855856, Blast_Score=1405, Evalue=0.0,
Organism=Escherichia coli, GI87081994, Length=774, Percent_Identity=64.9870801033592, Blast_Score=1066, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=792, Percent_Identity=44.0656565656566, Blast_Score=606, Evalue=1e-174,
Organism=Escherichia coli, GI87081797, Length=749, Percent_Identity=32.1762349799733, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1787870, Length=752, Percent_Identity=30.8510638297872, Blast_Score=288, Evalue=1e-78,
Organism=Escherichia coli, GI171474008, Length=743, Percent_Identity=30.2826379542396, Blast_Score=259, Evalue=5e-70,
Organism=Escherichia coli, GI3868721, Length=474, Percent_Identity=23.4177215189873, Blast_Score=106, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 85706; Mature: 85575

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHAPSRHSVLTAAHWGPVRVETDGERIFASYGELPTAHQNSLQTVVHDQVHSKTRVRFP
CCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEECH
MVRKGFLASPDKPQGIRGQDEFVRVSWDDALDLIHAQHKRIRESYGPSSIFAGSYGWRSN
HHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
GVLHKAATLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGNEVYQQQTSWPVVLEHSE
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCEEECCHHHHHHCCCCCEEEECCC
VVVLWSANPLNTLKIAWNASDEQGLDYFAALRQSGKRLICIDPMRSESVDFFGDKMEWIA
EEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCHHHHC
PHMGTDVALMLGIAHTLVENGWQDEAFLARCTTGYDRFADYLLGTTDGTAKTAEWAAEIC
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHH
GVSAVKIRELAEIFHHNTTMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGFS
CCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCHHEEHHHHHHCCCCCCCCCCEE
YHFANGGNPTRRAAVLASIQGSIPGGVDAVDKIPVARIVEALENPGGFYQHNGMDRRFPD
EEECCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCCCCCC
IRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSYERNDL
EEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCC
TMTGDYSNQHLAPMKQVVSPRWEARNDFDVFAELSERWEAGGYARFTEGKSELAWLETFY
EEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHH
NIAAQRGASQGVTLPPFAAFWQANRLLEMPENPANAQFVRFADFRRDPDNHPLKTASGKI
HHHHHCCCCCCCCCCCHHHHHHCCCCEECCCCCCCCEEEEEEHHCCCCCCCCCCCCCCEE
EIYSARIASYGYADCPGHPMWLAPDEWHGNADAGQVQLLSAHPAHRLHSQLNYSSLRERY
EEEEEEHHCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHH
AVAGREPVTIHPQDATTRGIVDGDTVRVWNHRGQVLAGAVVTDGIRPGVICIHEGAWPDP
HHCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCEEECHHHHCCCCCCEEEEECCCCCCC
EPTAGGICKNGAVNVLTKDLPSSRLGNGCAGNTALVWFEKYTGPALPLTAFDPPANS
CCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
THAPSRHSVLTAAHWGPVRVETDGERIFASYGELPTAHQNSLQTVVHDQVHSKTRVRFP
CCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEECH
MVRKGFLASPDKPQGIRGQDEFVRVSWDDALDLIHAQHKRIRESYGPSSIFAGSYGWRSN
HHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
GVLHKAATLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGNEVYQQQTSWPVVLEHSE
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCEEECCHHHHHHCCCCCEEEECCC
VVVLWSANPLNTLKIAWNASDEQGLDYFAALRQSGKRLICIDPMRSESVDFFGDKMEWIA
EEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCHHHHC
PHMGTDVALMLGIAHTLVENGWQDEAFLARCTTGYDRFADYLLGTTDGTAKTAEWAAEIC
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHH
GVSAVKIRELAEIFHHNTTMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGFS
CCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCHHEEHHHHHHCCCCCCCCCCEE
YHFANGGNPTRRAAVLASIQGSIPGGVDAVDKIPVARIVEALENPGGFYQHNGMDRRFPD
EEECCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCCCCCC
IRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSYERNDL
EEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCC
TMTGDYSNQHLAPMKQVVSPRWEARNDFDVFAELSERWEAGGYARFTEGKSELAWLETFY
EEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHH
NIAAQRGASQGVTLPPFAAFWQANRLLEMPENPANAQFVRFADFRRDPDNHPLKTASGKI
HHHHHCCCCCCCCCCCHHHHHHCCCCEECCCCCCCCEEEEEEHHCCCCCCCCCCCCCCEE
EIYSARIASYGYADCPGHPMWLAPDEWHGNADAGQVQLLSAHPAHRLHSQLNYSSLRERY
EEEEEEHHCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHH
AVAGREPVTIHPQDATTRGIVDGDTVRVWNHRGQVLAGAVVTDGIRPGVICIHEGAWPDP
HHCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCEEECHHHHCCCCCCEEEEECCCCCCC
EPTAGGICKNGAVNVLTKDLPSSRLGNGCAGNTALVWFEKYTGPALPLTAFDPPANS
CCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: Reduction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2180922; 8041620; 9278503 [H]