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The map label for this gene is cpxA [H]

Identifier: 29143864

GI number: 29143864

Start: 3661344

End: 3662717

Strand: Direct

Name: cpxA [H]

Synonym: t3561

Alternate gene names: 29143864

Gene position: 3661344-3662717 (Clockwise)

Preceding gene: 29143863

Following gene: 29143868

Centisome position: 76.41

GC content: 57.21

Gene sequence:

>1374_bases
ATGATAGGAAGTTTAACCGCGCGCATCTTCGCCATCTTCTGGTTGACGCTGGCGCTGGTGCTAATGCTGGTACTGATGTT
GCCCAAGCTCGATTCACGCCAGATGACCGAGCTGCTGGACAGCGAACAGCGCCAGGGATTGATGATAGAGCAACATGTAG
AAGCTGAACTTGCGAACGATCCGCCCAACGACCTGATGTGGTGGCGTCGCCTGTTCCGCGCGATCGATAAGTGGGCGCCG
CCTGGACAGCGGTTATTACTGGTGACCTCTGAAGGACGCGTGATCGGTGCTGAACGCAGCGAAATGCAGATCATTCGTAA
CTTCATTGGTCAGGCGGATAACGCCGATCATCCGCAGAAGAAAAAATATGGCCGCGTAGAGATGGTGGGGCCGTTCTCCG
TTCGCGACGGAGAGGATAATTACCAGCTTTACCTGATTCGACCGGCCAGCAGTTCGCAATCCGATTTTATTAATCTGCTG
TTTGACCGCCCGCTTCTGTTGCTCATTGTCACGATGCTGGTCAGTTCGCCGCTCTTGCTATGGCTGGCATGGAGTCTGGC
GAAACCGGCGCGTAAGTTGAAAAACGCGGCTGATGAAGTGGCGCAAGGCAACCTGCGTCAGCATCCGGAGCTGGAGGCGG
GTCCGCAGGAGTTCCTCGCCGCTGGCGCCAGTTTTAACCAGATGGTGACGGCGCTGGAACGGATGATGACCTCGCAGCAG
CGTTTGCTGTCAGACATCTCCCATGAGCTGCGAACGCCCCTTACGCGCCTGCAACTGGGTACCGCGCTGCTGCGTCGTCG
TGGCGGCGAAAGCAAAGAGCTGGAGCGTATTGAAACCGAAGCGCAGCGTCTGGACAGCATGATCAATGACCTGCTGGTGA
TGTCGCGTAACCAACAGAAAAATGCGCTGGTCAGCGAAACGATGAAAGCCAATCAGCTATGGGGCGAAGTGCTGGATAAC
GCCGCCTTTGAAGCCGAACAGATGGGCAAGTCGTTAACGGTAAATTATCCGCCGGGGCCGTGGCCGCTCTATGGCAACCC
AAACGCACTGGAAAGCGCGCTGGAAAATATTGTTCGTAATGCGCTGCGCTATTCACATACGAAGATTGAAGTCGGCTTCT
CGGTGGATAAAGACGGTATTACGATCACGGTCGATGACGACGGACCGGGCGTAAGCCCTGAAGACCGCGAGCAGATCTTC
CGTCCGTTCTATCGCACTGATGAGGCGCGCGACCGCGAGTCTGGCGGCACCGGGCTGGGGCTGGCGATTGTCGAAAGCGC
CATGCAGCAGCACCGCGGCTGGGTGAAGGCTGACGATAGCCCGCTGGGTGGGTTGCGGCTCACGCTGTGGCTACCGCTGT
ACAAGCGAACCTAA

Upstream 100 bases:

>100_bases
TGCATATTTCTAACCTGCGCCGCAAACTGCCGGAACGCAAAGACGGTCACCCGTGGTTTAAAACATTGCGTGGTCGCGGC
TATCTGATGGTTTCCGCTTC

Downstream 100 bases:

>100_bases
AAACCATCGGCCTGCGAATGCAGGCCGATTTTTTATCTCGCCGTCGAGATTTACCGGGAAATGTCTGGCGCTAAAATCCA
CTCGGCGCTGTCGTTCCACA

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAP
PGQRLLLVTSEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVEMVGPFSVRDGEDNYQLYLIRPASSSQSDFINLL
FDRPLLLLIVTMLVSSPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
RLLSDISHELRTPLTRLQLGTALLRRRGGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETMKANQLWGEVLDN
AAFEAEQMGKSLTVNYPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFSVDKDGITITVDDDGPGVSPEDREQIF
RPFYRTDEARDRESGGTGLGLAIVESAMQQHRGWVKADDSPLGGLRLTLWLPLYKRT

Sequences:

>Translated_457_residues
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAP
PGQRLLLVTSEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVEMVGPFSVRDGEDNYQLYLIRPASSSQSDFINLL
FDRPLLLLIVTMLVSSPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
RLLSDISHELRTPLTRLQLGTALLRRRGGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETMKANQLWGEVLDN
AAFEAEQMGKSLTVNYPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFSVDKDGITITVDDDGPGVSPEDREQIF
RPFYRTDEARDRESGGTGLGLAIVESAMQQHRGWVKADDSPLGGLRLTLWLPLYKRT
>Mature_457_residues
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAP
PGQRLLLVTSEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVEMVGPFSVRDGEDNYQLYLIRPASSSQSDFINLL
FDRPLLLLIVTMLVSSPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
RLLSDISHELRTPLTRLQLGTALLRRRGGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETMKANQLWGEVLDN
AAFEAEQMGKSLTVNYPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFSVDKDGITITVDDDGPGVSPEDREQIF
RPFYRTDEARDRESGGTGLGLAIVESAMQQHRGWVKADDSPLGGLRLTLWLPLYKRT

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=457, Percent_Identity=96.9365426695842, Blast_Score=834, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=300, Percent_Identity=33, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1789808, Length=266, Percent_Identity=31.203007518797, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786783, Length=336, Percent_Identity=30.0595238095238, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=28.8808664259928, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=29.8701298701299, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=27.0916334661355, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788279, Length=276, Percent_Identity=24.2753623188406, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=27.3972602739726, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786912, Length=273, Percent_Identity=30.4029304029304, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=29.9559471365639, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082128, Length=297, Percent_Identity=23.5690235690236, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787374, Length=295, Percent_Identity=26.7796610169492, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1789403, Length=237, Percent_Identity=28.6919831223629, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=279, Percent_Identity=25.8064516129032, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790861, Length=292, Percent_Identity=25, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=27.8008298755187, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788549, Length=234, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=206, Percent_Identity=27.6699029126214, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=25.1028806584362, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790300, Length=250, Percent_Identity=26.4, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51611; Mature: 51611

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELAND
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
PPNDLMWWRRLFRAIDKWAPPGQRLLLVTSEGRVIGAERSEMQIIRNFIGQADNADHPQK
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCCHHHHHHHHHHHCCCCCCCCCHH
KKYGRVEMVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSSPLLL
HHCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCHHHH
WLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
RLLSDISHELRTPLTRLQLGTALLRRRGGESKELERIETEAQRLDSMINDLLVMSRNQQK
HHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
NALVSETMKANQLWGEVLDNAAFEAEQMGKSLTVNYPPGPWPLYGNPNALESALENIVRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ALRYSHTKIEVGFSVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLG
HHHHCCCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHH
LAIVESAMQQHRGWVKADDSPLGGLRLTLWLPLYKRT
HHHHHHHHHHHCCCEECCCCCCCCEEEEEEEHHHHCC
>Mature Secondary Structure
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELAND
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
PPNDLMWWRRLFRAIDKWAPPGQRLLLVTSEGRVIGAERSEMQIIRNFIGQADNADHPQK
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCCHHHHHHHHHHHCCCCCCCCCHH
KKYGRVEMVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSSPLLL
HHCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCHHHH
WLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
RLLSDISHELRTPLTRLQLGTALLRRRGGESKELERIETEAQRLDSMINDLLVMSRNQQK
HHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
NALVSETMKANQLWGEVLDNAAFEAEQMGKSLTVNYPPGPWPLYGNPNALESALENIVRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ALRYSHTKIEVGFSVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLG
HHHHCCCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHH
LAIVESAMQQHRGWVKADDSPLGGLRLTLWLPLYKRT
HHHHHHHHHHHCCCEECCCCCCCCEEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]