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The map label for this gene is gppA [H]

Identifier: 29143705

GI number: 29143705

Start: 3483979

End: 3485460

Strand: Direct

Name: gppA [H]

Synonym: t3383

Alternate gene names: 29143705

Gene position: 3483979-3485460 (Clockwise)

Preceding gene: 29143704

Following gene: 29143710

Centisome position: 72.7

GC content: 55.53

Gene sequence:

>1482_bases
ATGAATTCCACCTCGTTGTATGCCGCCATTGATCTCGGTTCCAATAGTTTTCATATGCTGGTCGTGCGCGAGGCGGCGGG
AAGCATCCAGACGCTGACCCGAATAAAACGCAAGGTGCGTCTGGCCGCGGGTCTGAACAACGACAACCACCTTTCAGCCG
AAGCGATGGAACGCGGCTGGCAATGCCTGCGTCTGTTTGCTGAACGTTTGCAGGATATCCCGCAGCCACAAATCCGCGTG
GTTGCCACCGCAACATTGCGTCTCGCCGTCAATGCAGGTGAATTTATCGCGAAAGCGCAGACTATCCTTGGTTGTCCGGT
GCAGGTTATCAGCGGCGAAGAAGAGGCGCGGCTAATTTATCAGGGGGTCGCTCATACCACCGGCGGCGCAGATCAGCGAC
TGGTGGTGGATATCGGCGGCGCCAGCACTGAACTGGTTACCGGCACTGGCGCGCAAACCACGTCGCTGTTTAGCCTGTCG
ATGGGCTGCGTAACGTGGCTTGAACGCTATTTTAGCGATCGTAATCTGGCGCAAGAAAACTTTGATGATGCGGAGAAAGC
CGCGCGCGATGTACTGCGTCCGGTCGCCGATGAACTGCGTTTTCATGGCTGGAAGGTCTGCGTGGGTGCCTCCGGCACCG
TACAGGCATTGCAGGAAATCATGATGGCGCAGGGGATGGACGAGCGCATTACGCTCGCCAAACTGCAGCAGCTAAAACAA
CGCGCGATACAGTGCGGGCGTCTGGAAGAGCTGGAAATCGAAGGCCTGACGCTGGAGCGCGCGCTGGTTTTCCCAAGCGG
GCTGGCTATTCTAATCGCGATATTTACCGAGCTGAACATCCAGAGCATGACGCTGGCAGGCGGCGCGTTACGCGAAGGGC
TGGTGTATGGGATGTTGCATCTGGCGGTAGATCAGGATATCCGCAGCCGCACGCTGCGAAACATTCAGCGTCGGTTTATC
GTCGATACCGATCAGGCAAATCGTGTGGCGAAGCTGGCAGATAACTTCCTCAAACAGGTAGAAAATGCCTGGCATATTGA
ACCTATCAGTCGTGAACTGTTGCTTAGCGCTTGCCAGTTGCATGAGATCGGTCTGAGCGTTGATTTTAAACAGGCGCCCT
ATCATGCCGCCTATTTAGTACGCCATTTGGATCTGCCTGGCTATACGCCCGCGCAGAAAAAGTTGCTCGCCACCCTCTTA
CTGAATCAGACCAATCCGGTCGATCTCTCTTCGCTTCATCAGCAAAACGCGGTACCGCCCCGTGTTGCGGAACAGCTATG
CCGTTTGCTGCGACTGGCGATTCTTTTTGCCGGTCGCCGTCGTGACGATCTGGTACCAGAAATTACGCTACAGGCGCTAA
ATGAAAATCTGACGTTAACCTTGCCTGGCGACTGGCTGGCGCATCACCCGCTGGGTAAAGAGTTGATTGATCAGGAAAGC
CAGTGGCAAAGCTATGTACACTGGCCGCTGGACGTTCGCTAA

Upstream 100 bases:

>100_bases
CAAAATCATTTAGCCTGTATCAAGGCGGCAAGAAAACAAATCCCGATGAGCTTAGGAAGAGTACGCAGCCAACACGGATA
CAGGTTGAAGGATGAAGTGT

Downstream 100 bases:

>100_bases
CCGTAGTCTGATTGCCGGATGACGCTTCGCTTATCCGGCCTACGATTTCGCTCGCTTTGCCGCCATCATGGCTTTCAGAT
TAGCCAGGTGACTTTGCCCT

Product: guanosine pentaphosphate phosphohydrolase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MNSTSLYAAIDLGSNSFHMLVVREAAGSIQTLTRIKRKVRLAAGLNNDNHLSAEAMERGWQCLRLFAERLQDIPQPQIRV
VATATLRLAVNAGEFIAKAQTILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLS
MGCVTWLERYFSDRNLAQENFDDAEKAARDVLRPVADELRFHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQLKQ
RAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFTELNIQSMTLAGGALREGLVYGMLHLAVDQDIRSRTLRNIQRRFI
VDTDQANRVAKLADNFLKQVENAWHIEPISRELLLSACQLHEIGLSVDFKQAPYHAAYLVRHLDLPGYTPAQKKLLATLL
LNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAILFAGRRRDDLVPEITLQALNENLTLTLPGDWLAHHPLGKELIDQES
QWQSYVHWPLDVR

Sequences:

>Translated_493_residues
MNSTSLYAAIDLGSNSFHMLVVREAAGSIQTLTRIKRKVRLAAGLNNDNHLSAEAMERGWQCLRLFAERLQDIPQPQIRV
VATATLRLAVNAGEFIAKAQTILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLS
MGCVTWLERYFSDRNLAQENFDDAEKAARDVLRPVADELRFHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQLKQ
RAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFTELNIQSMTLAGGALREGLVYGMLHLAVDQDIRSRTLRNIQRRFI
VDTDQANRVAKLADNFLKQVENAWHIEPISRELLLSACQLHEIGLSVDFKQAPYHAAYLVRHLDLPGYTPAQKKLLATLL
LNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAILFAGRRRDDLVPEITLQALNENLTLTLPGDWLAHHPLGKELIDQES
QWQSYVHWPLDVR
>Mature_493_residues
MNSTSLYAAIDLGSNSFHMLVVREAAGSIQTLTRIKRKVRLAAGLNNDNHLSAEAMERGWQCLRLFAERLQDIPQPQIRV
VATATLRLAVNAGEFIAKAQTILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLS
MGCVTWLERYFSDRNLAQENFDDAEKAARDVLRPVADELRFHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQLKQ
RAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFTELNIQSMTLAGGALREGLVYGMLHLAVDQDIRSRTLRNIQRRFI
VDTDQANRVAKLADNFLKQVENAWHIEPISRELLLSACQLHEIGLSVDFKQAPYHAAYLVRHLDLPGYTPAQKKLLATLL
LNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAILFAGRRRDDLVPEITLQALNENLTLTLPGDWLAHHPLGKELIDQES
QWQSYVHWPLDVR

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=491, Percent_Identity=89.6130346232179, Blast_Score=900, Evalue=0.0,
Organism=Escherichia coli, GI1788848, Length=495, Percent_Identity=37.5757575757576, Blast_Score=317, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6321185, Length=334, Percent_Identity=25.1497005988024, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 54817; Mature: 54817

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTSLYAAIDLGSNSFHMLVVREAAGSIQTLTRIKRKVRLAAGLNNDNHLSAEAMERGW
CCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
QCLRLFAERLQDIPQPQIRVVATATLRLAVNAGEFIAKAQTILGCPVQVISGEEEARLIY
HHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHCCCHHEECCCHHHHHHH
QGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFSDRNLAQEN
HHHHHCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FDDAEKAARDVLRPVADELRFHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQLKQ
CCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFTELNIQSMTLAGGALREGLVYGMLH
HHHHCCCCCEEEECCEEEEHHHCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHH
LAVDQDIRSRTLRNIQRRFIVDTDQANRVAKLADNFLKQVENAWHIEPISRELLLSACQL
HHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
HEIGLSVDFKQAPYHAAYLVRHLDLPGYTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPP
HHCCCEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCH
RVAEQLCRLLRLAILFAGRRRDDLVPEITLQALNENLTLTLPGDWLAHHPLGKELIDQES
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEECCCHHHCCCCCHHHHCCHH
QWQSYVHWPLDVR
HHHHHCCCCCCCC
>Mature Secondary Structure
MNSTSLYAAIDLGSNSFHMLVVREAAGSIQTLTRIKRKVRLAAGLNNDNHLSAEAMERGW
CCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
QCLRLFAERLQDIPQPQIRVVATATLRLAVNAGEFIAKAQTILGCPVQVISGEEEARLIY
HHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHCCCHHEECCCHHHHHHH
QGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFSDRNLAQEN
HHHHHCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FDDAEKAARDVLRPVADELRFHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQLKQ
CCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFTELNIQSMTLAGGALREGLVYGMLH
HHHHCCCCCEEEECCEEEEHHHCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHH
LAVDQDIRSRTLRNIQRRFIVDTDQANRVAKLADNFLKQVENAWHIEPISRELLLSACQL
HHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
HEIGLSVDFKQAPYHAAYLVRHLDLPGYTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPP
HHCCCEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCH
RVAEQLCRLLRLAILFAGRRRDDLVPEITLQALNENLTLTLPGDWLAHHPLGKELIDQES
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEECCCHHHCCCCCHHHHCCHH
QWQSYVHWPLDVR
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA